Reference code: | PT/FB/BL-2010-215.09 |
Location: | Arquivo PCA - Pasta 7/2010
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Title:
| [PH 399] Vestibular stimulation modulates early cortical responses to nociceptive stimuli
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Publication year: | 2012
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URL:
| http://www.abstracts2view.com/iasp/lookup_view.php?word=Ferr[egrave]&where=authors&return=%2Fiasp%2Fauthorindex.php%3Fnum%3DF%26page%3D2%26start%3D51
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Abstract/Results: | ABSTRACT:
AIM OF INVESTIGATION:
No unimodal vestibular cortex has been identified in the mammalian brain, yet vestibular input projects to several cortical areas. Therefore vestibular input could influence processing in other sensory modalities. We recently observed that caloric vestibular stimulation (CVS) decreases perceptual thresholds for touch, but increases thresholds for pain, thus suggesting a direct role of vestibular inputs in multisensory interactions with pain. The neural mechanisms of such vestibular-induced analgesia remain unclear.
METHODS:
To address this issue we delivered nociceptive laser stimuli to the left hand dorsum before ('Baseline' condition) and immediately after left CVS ('CVS' condition), and recorded the corresponding brain responses (laser-evoked potentials, LEPs) together with the single-trial ratings of subjective pain intensity. To control for non-specific effects (e.g. time-dependent habituation) both LEPs and intensity ratings were also recorded one hour after CVS ('Post' condition).
RESULTS:
CVS induced a significant analgesic effect, with lower pain ratings in 'CVS' compared to both 'Baseline' and 'Post' (p=0.016 and p=0.001, respectively). There were no differences in pain ratings between 'Baseline' and 'Post'. CVS reduced the amplitude of standard LEP peaks, relative to 'Pre' and 'Post', both in the early time-window of the N1 wave (all p<0.01) and in the later time-windows of the N2 (all p<0.005) and P2 waves (all p<0.05). There were trends for habituation of the N2 and P2 peaks between 'Pre' and 'Post' conditions (p=0.06 and p=0.10, respectively). Thus, the most striking effect of the CVS was a strong reduction of cortical responses to nociceptive laser stimulation, including components localised to the primary somatosensory cortex.
CONCLUSIONS:
These results provide the first evidence that CVS modulates cortical responses elicited by nociceptive stimuli. The analgesic effect of CVS could involve either subcortical gating of the nociceptive input, or a direct modulation of evoked somatosensory cortex activity, by concurrent vestibular inputs to the same area.
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Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Ferrè, E. R.
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Secondary author(s):
| Haggard, P., Bottini, G., Iannetti, G. D.
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Document type:
| Online abstract
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Number of reproductions:
| 1
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Reference:
| Ferrè, E. R., Haggard, P., Bottini, G., & Iannetti, G. D. (2012, August). [PH 399] Vestibular stimulation modulates early cortical responses to nociceptive stimuli. Poster presented at the 14th World Congress on Pain, Milan, Italy. Abstract retrieved from http://www.abstracts2view.com/iasp/lookup_view.php?word=Ferr[egrave]&where=authors&return=%2Fiasp%2Fauthorindex.php%3Fnum%3DF%26page%3D2%26start%3D51
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Indexed document: | No
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Keywords: | Caloric vestibular stimulation / Multisensory integration / Pain / Analgesia / Somatosensory evoked potentials
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