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BIAL Foundation
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DE:"Neural dynamics"
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Type Title Begin End
DocumentStriatal dynamics explain duration judgments2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-188
Location: Arquivo PCA - Pasta 17/2012
Title:
188 - Embodied cognition: the nature of time encoding in the brain?
Duration: 2013-06 - 2016-09
Researcher(s):
Joseph James Paton, Tiago Monteiro, Thiago Gouvêa, Sofia Soares
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Paton, J.
Secondary author(s):
Monteiro, T., Gouvêa, T., Soares, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognition / Learning

Reference code: PT/FB/BL-2012-188.03
Location: Arquivo PCA - Pasta 17/2012
Title:
Striatal dynamics explain duration judgments
Publication year: 2015
URL:
https://elifesciences.org/content/4/e11386
Abstract/Results: ABSTRACT:
The striatum is an input structure of the basal ganglia implicated in several time-dependent functions including reinforcement learning, decision making, and interval timing. To determine whether striatal ensembles drive subjects' judgments of duration, we manipulated and recorded from striatal neurons in rats performing a duration categorization psychophysical task. We found that the dynamics of striatal neurons predicted duration judgments, and that simultaneously recorded ensembles could judge duration as well as the animal. Furthermore, striatal neurons were necessary for duration judgments, as muscimol infusions produced a specific impairment in animals' duration sensitivity. Lastly, we show that time as encoded by striatal populations ran faster or slower when rats judged a duration as longer or shorter, respectively. These results demonstrate that the speed with which striatal population state changes supports the fundamental ability of animals to judge the passage of time.
Accessibility: Document exists in file
Language:
eng
Author:
Gouvêa, T.
Secondary author(s):
Monteiro, T., Motiwala, A., Soares, S., Machens, C., Paton, J.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Gouvêa, T., Monteiro, T., Motiwala, A., Soares, S., Machens, C., & Paton, J. (2015). Striatal dynamics explain duration judgments. eLife, 4:e11386. https://doi.org/10.7554/eLife.11386
2-year Impact Factor: 8.282|2015
Times cited: 102|2024-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Interval timing / Neural dynamics / Neuroscience / Population code / Rat / Striatum

Striatal dynamics explain duration judgments

Striatal dynamics explain duration judgments

DocumentFinal report - Mapping the neurophenomenology of the wake-sleep transition2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-312
Location: BF-GMS
Title:
312 - Mapping the neurophenomenology of the wake-sleep transition
Duration: 2019-01 - 2024-01
Researcher(s):
Tristan Bekinschtein, Alejandro Ezquerro-Nassar, Jon Simons, Valdas Noreika
Institution(s): Consciousness and Cognition Laboratory, Department of Psychology, University of Cambridge (UK)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Notes:
Inconclusive project
Author: Bekinschtein, T.
Secondary author(s):
Ezquerro-Nassar, A., Simons, J., Noreika, V.
Number of reproductions:
1
Keywords:
Hypnagogia / Reality monitoring / Phenomenology / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2018-312.01
Location: BF-GMS
Title:
Final report - Mapping the neurophenomenology of the wake-sleep transition
Publication year: 2023
Abstract/Results:
ABSTRACT:
Background
Little is known about human capacity and the contents of our mind during hypnagogic transitions, first due to high variability in subjective reports and other limitations associated with first person accounts of mental states, and second from the difficulty in capturing cognition during sleep transitions. Refined methods controlling biases of self-report and sleep onset probing open the door to the evaluation of thought during transitions of consciousness.
Aims
1) To investigate the sources of thought and memory in hypnagogic transitions, 2) its neurophenomenological trajectories, 3) neural dynamics of microdreams; and 4) modulations of the hypnagogic experience by sleep deprivation.
Method
Participants completed the reality monitoring task (RM) in awake/drowsy conditions and memory recollection after in three experiments. Brain activity determined drowsiness levels. A Follow up study with at home measures of dreams and mindwandering, was performed to further probe Aims 2 and 4.
Results
RTs for RM were slower than those for recognition memory and for drowsy states, suggesting that reality monitoring is a higher-level memory process requiring a greater degree of cognitive processing. However, no robust effects of alertness and sleep quantity could be identified as the second and third studies didn’t converge.
Conclusions
While probing thoughts and memory with a structured task proved difficult in the transitions and due to data acquisition during the pandemic, the evaluation of phenomenological dimensions during drowsy mindwandering led to both the characterization of aspects of emotion and thought, its bizarreness, and the mathematical structure of dreams and mindwandering.
Accessibility: Document exits in file
Language:
eng
Author:
Bekinschtein, T.
Secondary author(s):
Noreika, V., Simons, J., Ezquerro-Nassar, A.
Document type:
Final report
Number of reproductions:
1
Reference:
Ezquerro-Nassar, A., Noreika, V., Simons, J., & Bekinschtein, T. (2023). Final report - Mapping the neurophenomenology of the wake-sleep transition.
Indexed document: No
Keywords: Hypnagogic imagery / Reality monitoring / Sleep onset / Mindwandering / Neural dynamics

Final report - Mapping the neurophenomenology of the wake-sleep transition

Final report - Mapping the neurophenomenology of the wake-sleep transition

DocumentFinal report - Frontostriatal neurophysiological underpins of decision-making2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-331
Location: BF-GMS
Title:
331 - Frontostriatal neurophysiological underpins of decision-making
Duration: 2020-02
Researcher(s):
Hugo Leite-Almeida, Madalena Esteves, Marco Rafael Guimarães, Ana Margarida Cunha, Joana Mendes, Armando Almeida
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Language: eng
Author:
Leite-Almeida, H.
Secondary author(s):
Esteves, M., Guimarães, M. R., Cunha, A. M., Mendes, J., Almeida, A.
Number of reproductions:
1
Keywords:
Cognitive flexibility / Impulsivity / Network activity / Local field potentials / Psychophysiology

Reference code: PT/FB/BL-2018-331.01
Location: BF-GMS
Title:
Final report - Frontostriatal neurophysiological underpins of decision-making
Publication year: 2024
Local:
BF-GMS
Abstract/Results: Abstract:
Background Decision-making processes are critical for adaptive behavior and dysfunctions in these processes underly various neuropsychiatric disorders. Previous studies have shown that the frontostriatal circuits play a vital role in mediating decision-making including inhibitory control and impulsive decision-making.
Aims In this project we investigated frontostriatal neurophysiological mechanisms underpinning impulsive vs timed decisions.
Method Using male rats with chronically implanted electrodes in the prelimbic cortex (PrL), orbitofrontal cortex (OFC), striatum (Str), and nucleus accumbens (NAcc), local field potentials (LFPs) were recorded while performing tasks designed to assess impulsivity and delay tolerance, namely the variable delay-to-signal (VDS) protocol. Data analysis involved power and coherence measurements in frequency ranges (theta, beta, low gamma, high gamma).
Results Key findings include distinct neural signatures associated with timed versus premature responses and a distinct PrL involvement predicting impulsive behavior. Logistic regression models indicated both electrophysiological and behavioral factors, such as high gamma power in the PrL and NAcc, previous session prematurity, and feeding perseverance, influenced premature responses. PrL manipulation using an inhibitory pharmacogenetic strategy (DREADDs) did not show significant effects on behavior and in the neural dynamics through LFPs.
Conclusions The study concludes that frontostriatal activity is crucial for decision-making, particularly the involvement of PrL and NAcc just prior to the decision processes. Future research will focus on refining neural manipulation techniques and further exploring the decision-specific network dynamics.
Accessibility: Document exists in file
Language:
eng
Author:
Leite-Almeida, H.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Behavioral neuroscience / Cognitive control / Impulsivity / Neural dynamics / Rodents

Final report - Frontostriatal neurophysiological underpins of decision-making

Final report - Frontostriatal neurophysiological underpins of decision-making