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BIAL Foundation
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DE:"Neurodegeneration"
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DocumentFinal report - Proteotoxic insults and synaptic dysfunction in the aging brain2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-343
Location: BF-GMS
Title:
343 - Proteotoxic insults and synaptic dysfunction in the aging brain
Duration: 2015-06 - 2019-01
Researcher(s):
Cláudio Emanuel Moreira Gomes, Andreas Martin Grabrucker, Joana Margarida Lopes da Silva Cristóvão, Sónia Cristina Alves Dickson Leal Solano
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Neurocenter of Ulm University (Germany)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Gomes, C.
Secondary author(s):
Grabrucker, A., Cristóvão, J., Solano, S.
Number of reproductions:
1
Keywords:
Protein homeostasis / Brain biometals / Neuroinflammation / Synaptic Biochemistry / Psychophysiology

Reference code: PT/FB/BL-2014-343.01
Location: BF-GMS
Title:
Final report - Proteotoxic insults and synaptic dysfunction in the aging brain
Publication year: 2019
Abstract/Results:
ABSTRACT:
This project sought to investigate the hypothesis that age-related altered metallostasis and neuroinflammation-related proteotoxic seeds induce changes in synaptic protein networks that are critical to neuronal function. For this we studied mechanisms through which pro-inflammatory S100 proteins modulate synaptic processes, related to metal ion homeostasis and proteotoxic insults.
We demonstrated that inflammatory S100 proteins influence metal ion homeostasis at the synapse. We showed that extracellular levels of S100B are not toxic and are taken up by neurons. We proved that S100B, either expressed in cells or added extracellular, scavenges zinc ions through specific binding resulting in a redistribution of the intracellular zinc pool. Then we gather evidence that increased neuronal S100B only significantly affects calcium levels upon zinc scavenging in vitro. This led to the proposal of a new role of S100B as a neuro-protective mediator acting on excitotoxicity via its effects on calcium and zinc homeostasis. Indeed, we established that zinc binding to S100B mediates anti-excitotoxic activity effects.
We also characterized protein interactions between S100B and neuronal aggregation-prone proteins. We demonstrated that monomeric Aß42 interacts preferentially with calcium-bound S100B and pinpointed the interaction at promiscuous peptide-binding region within the interfacial cleft of the protein. We showed that this results in a delay of aggregation and in a decrease in the toxicity to neuroblastoma derived cell cultures. This resulted in a clear demonstration of a relationship between protein aggregation and inflammatory processes that take place in the synaptic milieu and are critical to neuronal function.
Accessibility: Document exists in file
Language:
eng
Author:
Gomes, C.
Secondary author(s):
Cristóvão, J., Martinez, J., Leal, S., Romão, M., David, R., Hagmeyer, S., Grabrucker, A.
Document type:
Final report
Number of reproductions:
1
Reference:
Gomes, C., Cristóvão, J., Martinez, J., Leal, S., Romão, M., David, R., Hagmeyer, S., & Grabrucker, A. (2019). Final report - Proteotoxic insults and synaptic dysfunction in the aging brain
Indexed document: No
Keywords: Synaptic biochemistry / Brain proteostasis / Neurometals / Neurodegeneration / Neuroinflammation

Final report - Proteotoxic insults and synaptic dysfunction in the aging brain

Final report - Proteotoxic insults and synaptic dysfunction in the aging brain
DocumentThe pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-361
Location: BF-GMS
Title:
361 - When style matters: Do oculomotor fingerprint and brain dynamics explain visual exploration and memory strategies?
Duration: 2019-04 - 2023-11
Researcher(s):
Maurizio Corbetta, Andrea Zangrossi
Institution(s): Venetian Institute of Molecular Medicine - VIMM, Fondazione per la Ricerca Biomedica Avanzata, Padova (Italy); Padova Neuroscience Center – PNC, Università di Padova (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Corbetta, M.
Secondary author(s):
Zangrossi, A.
Number of reproductions:
1
Keywords:
Inter-individual variability / Memory / Visual exploration / Brain dynamics / Psychophysiology

Reference code: PT/FB/BL-2018-361.13
Location: BF-GMS
Title:
The pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S1568163723000260?via=ihub
Abstract/Results: ABSTRACT:
he study of pollutant effects is extremely important to address the epochal challenges we are facing, where world populations are increasingly moving from rural to urban centers, revolutionizing our world into an urban world. These transformations will exacerbate pollution, thus highlighting the necessity to unravel its effect on human health. Epidemiological studies have reported that pollution increases the risk of neurological diseases, with growing evidence on the risk of neurodegenerative disorders. Air pollution and water pollutants are the main chemicals driving this risk. These chemicals can promote inflammation, acting in synergy with genotype vulnerability. However, the biological underpinnings of this association are unknown. In this review, we focus on the link between pollution and brain network connectivity at the macro-scale level. We provide an updated overview of epidemiological findings and studies investigating brain network changes associated with pollution exposure, and discuss the mechanistic insights of pollution-induced brain changes through neural networks. We explain, in detail, the pollutome-connectome axis that might provide the functional substrate for pollution-induced processes leading to cognitive impairment and neurodegeneration. We describe this model within the framework of two pollutants, air pollution, a widely recognized threat, and polyfluoroalkyl substances, a large class of synthetic chemicals which are currently emerging as new neurotoxic source.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pini, L.
Secondary author(s):
Salvalaggio, A., Wennberg, A. M., Dimakou, A., Matteoli, M., Corbetta, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
66.08|0.75
Reference:
Pini, L., Salvalaggio, A., Wennberg, A. M., Dimakou, A., Matteoli, M., & Corbetta, M. (2023). The pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration. Ageing Research Reviews, 86, 101867. https://doi.org/10.1016/j.arr.2023.101867
2-year Impact Factor: 12.5|2023
Times cited: 18|2026-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Alzheimer's disease / Brain connectivity / Connectome / Neurodegeneration / Parkinson's disease / Pollutome
DocumentNavigating neurodegeneration: Integrating biomarkers, neuroinflammation, and imaging in Parkinson’s, Alzheimer’s, and motor neuron disorders2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-235
Location: BF-GMS
Title:
235 - SPARKS: Driving associative plasticity in the cortically blind brain to promote recovery of visual awareness
Duration: 2023-10
Researcher(s):
Simone Battaglia, Matteo Diano, Marco Tamietto
Institution(s): Department of Psychology, University of Turin (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Article
Language: eng
Notes:
Ongoing project
Author: Battaglia, S.
Secondary author(s):
Diano, M., Tamietto, M.
Number of reproductions:
1
Keywords:
Visual perception / Neuroimaging / Visual perception / Blindsight / Psychophysiology

Reference code: PT/FB/BL-2022-235.04
Location: BF-GMS
Title:
Navigating neurodegeneration: Integrating biomarkers, neuroinflammation, and imaging in Parkinson’s, Alzheimer’s, and motor neuron disorders
Publication year: 2025
URL:
https://doi.org/10.3390/biomedicines13051045
Accessibility: Document exists in file
Language:
eng
Author:
Tanaka, M.
Secondary author(s):
Battaglia, S., Liloia, D.
Document type:
Article
Number of reproductions:
1
Percentiles:
99.82|27.88
Reference:
Tanaka, M., Battaglia, S., & Liloia, D. (2025). Navigating neurodegeneration: Integrating biomarkers, neuroinflammation, and imaging in Parkinson’s, Alzheimer’s, and motor neuron disorders. Biomedicines, 13(5), 1045. https://doi.org/10.3390/biomedicines13051045
2-year Impact Factor: 3.9|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 14|2026-02-17
Indexed document: Yes
Quartile: Q1
Keywords: Neurodegeneration / Parkinson Disorder / Alzheimer Disorder / Motor Neuron Disorder

Navigating neurodegeneration: Integrating biomarkers, neuroinflammation, and imaging in Parkinson’s, Alzheimer’s, and motor neuron disorders

Navigating neurodegeneration: Integrating biomarkers, neuroinflammation, and imaging in Parkinson’s, Alzheimer’s, and motor neuron disorders