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DocumentFinal report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.01
Location: Arquivo PCA - Pasta 18/2006
Title:
Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3606_16102013.pdf
Abstract/Results: RESULTS:
This study evaluated 54 first psychotic episode patients and 46 healthy controls, using multimodal imaging (structural and functional), to identify the neuroanatomical and functional correlates of neurological performance.
Patients showed more neurological signs than controls. There were no significant differences in grey and white matter volumes between patients and controls, although patients had larger, at trend-level, CSF volumes. Global brain volumes were not correlated with performance at any of the neurological subscales.
Preliminary analysis of white matter tracts in patients showed that a worse performance in Primary signs, reflecting more “hard” neurological abnormalities, was associated with disruption of tracts integrity, and specifically with: increased Fractional Anisotropy (FA) of the Corpus Callosum, both Uncinate fasciculi, right Inferior Fronto-Occipital fasciculus (IFOF); left Inferior Longitudinal fasciculus (ILF). A worse performance on Motor Sequencing was associated with a shorter length of the right IFOF, and a worse performance in Sensory Integration was correlated with a reduction in right Mean Diffusivity of this fasciculus.
An Audio-Visual task was successfully developed to investigate sensory integration during functional MRI. Patients had longer reaction time, and gave more incorrect answers, and had larger frontal lobe activation than healthy controls, particularly so if they had a poorer response to treatment.
In conclusion, morpho-anatomical information alone are not sufficient to define the substrate of neurological dysfunction in psychosis, which is likely to reflect an altered structural, and possibly functional connectivity.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dazzan, P.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Psychosis / Neurological signs / Functional magnetic resonance imaging (fMRI) / Sensory integration

Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imagin

Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imagin
DocumentNeurological abnormalities and cognitive ability in first-episode psychosis2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.03
Location: Arquivo PCA - Pasta 18/2006
Title:
Neurological abnormalities and cognitive ability in first-episode psychosis
Publication year: 2008
URL:
http://bjp.rcpsych.org/content/193/3/197.full.pdf+html
Abstract/Results: ABSTRACT:
BACKGROUND:
It remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis.
AIMS:
To investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and cognitive ability (IQ).
METHOD:
Evaluation of types of neurological soft signs in a prospective cohort of all individuals presenting with psychoses over 2 years (n=310), and in a control group from the general population (n=239).
RESULTS:
Primary (P<0.001), motor coordination (P<0.001), and motor sequencing (P<0.001) sign scores were significantly higher in people with any psychosis than in the control group. However, only primary and motor coordination scores remained higher when individuals with psychosis and controls were matched for premorbid and current IQ.
CONCLUSIONS:
Higher rates of primary and motor coordination signs are not associated with lower cognitive ability, and are specific to the presence of psychosis.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
Lloyd, T., Morgan, K., Zanelli, J., Morgan, C., Orr, K., Hutchinson, G., Fearon, P., Allin, M., Rifkin, L., McGuire, P., Doody, G. A., Holloway, J., Leff, J., Harrison, G., Jones, P., Murray, R.
Document type:
Article
Number of reproductions:
1
Percentiles:
75.99|1.25
Reference:
Dazzan, P., Lloyd, T., Morgan, K., Zanelli, J., Morgan, C., ... Murray, R. (2008). Neurological abnormalities and cognitive ability in first-episode psychosis. British Journal of Psychiatry, 193(3), 197-202. https://doi.org/10.1192/bjp.bp.107.045450
2-year Impact Factor: 5.007|2008
Times cited: 59|2026-02-05
Indexed document: Yes
Quartile: Q1
Keywords: Psychophysiology / Psychosis / Neurological signs / Cognitive ability

Neurological abnormalities and cognitive ability in first-episode psychosis

Neurological abnormalities and cognitive ability in first-episode psychosis
DocumentPsychosis, neurological soft signs and their meaning2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.11
Location: Arquivo PCA - Pasta 18/2006
Title:
Psychosis, neurological soft signs and their meaning
Publication year: 2009
URL:
http://library.wfsbp.org/fileadmin/user_upload/wfsbp2009-abstracts.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure.
METHODS:
We evaluated 49 individuals (mean age 27 years +-8; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods.
RESULTS:
Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (p=0.007).
Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (p=0.05 and p=0.072 respectively).
CONCLUSIONS:
Primary and motor coordination deficits may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dazzan, P.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Dazzan, P. (2009). Psychosis, neurological soft signs and their meaning. In Abstracts of the 9th World Congress of Biological Psychiatry (pp. 47-48). Paris, France: World Federation of Societies of Biological Psychiatry. https://doi.org/10.3284/wfsbp.2009.1
Indexed document: No
Keywords: Neurological signs / Psychosis / Brain structure / Functional magnetic resonance imaging (fMRI)

Psychosis, neurological soft signs and their meaning

Psychosis, neurological soft signs and their meaning
DocumentChanges in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.12
Location: Arquivo PCA - Pasta 18/2006
Title:
Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results: ABSTRACT:
Introduction: An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure. Methods: We evaluated 49 individuals (mean age 27 years 68; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods. Results: Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (P = .007). Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (P = .05 and P = .07 respectively). Conclusions: Primary and motor coordination deficits
may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., Hutchinson, G., McGuire, P., Jones, P., Leff, J., Fearon, P., Murray, R., Lappin, J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dazzan, P., Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., . . . Lappin, J. (2009). Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode. Schizophrenia Bulletin, 35(Suppl. 1), 207-207.
Indexed document: Yes
Keywords: Neurological signs / Psychosis / Schizophrenia / Functional magnetic resonance imaging (fMRI) / Trait markers

Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode

Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode
DocumentThe psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.18
Location: Arquivo PCA - Pasta 18/2006
Title:
The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
This project investigated the anatomical and functional correlates of one of the few objective clinical correlate of psychosis, neurological abnormalities. These are abnormalities of sensory and motor function found in excess in patients with psychosis, and, to a lesser extent, in the general population. These neurological abnormalities may represent a specific clinical sign of the perturbed cortical-subcortical connectivity that putatively underlies psychotic disorders.
METHODS:
In a sample of patients at the first-episode of psychosis and in healthy controls we evaluated neurological function in four functional areas: 1) “Primary neurological dysfunction” (dysfunction that can be identified by a standard neurological examination); 2) “Sensory integration dysfunction” (dysfunction in the integration of sensory information); 3) “Motor coordination dysfunction” (motor incoordination); 4) “Motor sequencing dysfunction” (performance of complex motor sequences). We also used: structural Magnetic Resonance Imaging (sMRI) to estimate volumes of grey and white matter, and cerebro-spinal fluid (CSF); Diffusion Tensor Imaging (DTI) and DTI Tractography to estimate white matter integrity of Corpus Callosum, Uncinate Fasciculus, Inferior Fronto-occipital Fasciculus, Inferior Longitudinal Fasciculus; functional Magnetic Resonance Imaging (fMRI) for brain activation during an Audio-visual integration task and a Motor movement task.
RESULTS:
A total of 54 patients and 46 healthy individuals were recruited in the study. Patients showed significantly higher scores than healthy individuals in all areas of neurological performance (p<0.05), with the exception of motor coordination. Global volumes of grey and white matter, and CSF were not correlated with performance on any neurological subscale. In contrast, a worse performance in Primary signs was consistently associated with disruption of white matter integrity of the Corpus Callosum (p=0.05), Uncinate fasciculus (p=0.059), Inferior Fronto-Occipital fasciculus (p=0.049), and Inferior Longitudinal fasciculus (p=0.01).
CONCLUSIONS:
Neurological signs in psychoses are likely to reflect the alteration in connectivity that has been suggested to be one of the key pathophysiological processes occurring in these disorders. In the next step, the analysis will focus on the functional data, to evaluate whether the areas connected by these tracts are also impaired in function.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Dazzan, P., McGuire, P., Pariante, C., Di Forti, M., Lappin, J., & Mondelli, V. (2010). The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 204). Porto: Fundação Bial.
Indexed document: No
Keywords: Neurological signs / Schizophrenia / Psychosis / Functional magnetic resonance imaging (fMRI) / Diffusion tensor imaging (DTI)

The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
DocumentDifferential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.22
Location: Arquivo PCA - Pasta 18/2006
Title:
Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals
Publication year: 2012
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0920996412005683?via%3Dihub
Abstract/Results: ABSTRACT:
The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are specific to psychosis is essential to inform the pathophysiology of this disorder. We evaluated a large epidemiological sample of patients with first episode psychosis (n = 242) and a population-based sample of healthy individuals (n = 155), as part of the AESOP study. We examined neurological soft signs using the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989), and generalized and specific cognitive deficits (memory; verbal abilities; attention, concentration and mental speed; executive functions and working memory; language; visual constructual/perceptual abilities). In patients, more neurological signs across all subscales were associated with worse general cognitive function, while in controls this was only present for sensory integration and sequencing signs. Furthermore, in patients, but not in healthy individuals, more sensory integrative signs were associated with deficits in specific cognitive domains, such as memory, verbal abilities, language, visual/perceptual, executive function (p ranging <0.001-0.002); sequencing signs with language, executive function, and attention (p<0.001-0.004); and motor signs with poorer verbal abilities (p=0.001). These findings indicate the presence of specific associations between neurological and cognitive deficits in psychosis that are distinct from those of healthy individuals. (C) 2012 Elsevier B.V. All rights reserved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Mellacqua, Z.
Secondary author(s):
Eyeson, J., Orr, K. D., Morgan, K. D., Zanelli, J., Lloyd, T., Morgan, C., Fearon, P., Hutchinson, G., Doody, G. A., Chan, R. C., Harrison, G., Jones, P. B., Murray, R. M., Reichenberg, A., Dazzan, P.
Document type:
Article
Number of reproductions:
1
Percentiles:
25.26|0.21
Reference:
Mellacqua, Z., Eyeson, J., Orr, K. D., Morgan, K. D., Zanelli, J., Lloyd, T., Morgan, C., Fearon, P., Hutchinson, G., Doody, G. A., Chan, R. C., Harrison, G., Jones, P. B., Murray, R. M., Reichenberg, A., & Dazzan, P. (2012). Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals. Schizophrenia Research, 142(1-3), 159-164. https://doi.org/10.1016/j.schres.2012.09.016
2-year Impact Factor: 4.590|2012
Times cited: 8|2026-02-06
Indexed document: Yes
Quartile: Q1
Keywords: Schizophrenia / Neurological signs / IQ / Motor coordination / Executive function / First episode psychosis / Healthy individuals