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File283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging2015-052017-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology
DocumentFinal report - Exploring the neural basis of motivation2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.01
Location: BF-GMS
Title:
Final report - Exploring the neural basis of motivation
Publication year: 2020
URL:
https://www.bial.com/media/3214/exploring-the-neural-basis-of-motivation.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
Optimal decision-making requires that individuals evaluate the costs and benefits of potential choices and this is highly dependent on the value attributed to the outcome but also individual motivational status. Evidence in both animal models and humans has highlighted the nucleus accumbens (NAc) as a core brain region in the neural circuitry underlying motivation. One anatomical study has shown that the laterodorsal tegmentum (LDT) directly projects to the NAc, though the nature and biological role of such connections remains completely unknown.
AIMS:
Determine the role of the LDT-NAc network in the modulation of motivation.
METHOD:
We performed a detailed characterization of the LDT-NAc rodent circuit using viral transynaptic markers and in vivo electrophysiological recordings. We also used optogenetics to modulate LDT-NAc different types of projections and evaluate their impact in motivation in rodents.
RESULTS:
Our results show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms in rodents.
CONCLUSIONS:
These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Rodrigues, A. J.
Document type:
Final report
Number of reproductions:
1
Reference:
Rodrigues, A. J. (2020). Final report - Exploring the neural basis of motivation.
Indexed document: No
Keywords: Motivation / Neuronal circuits / Nucleus accumbens / Laterodorsal tegmentum

Final report - Exploring the neural basis of motivation

Final report - Exploring the neural basis of motivation
DocumentFinal report - The influence of maternal bonding in neuroimmune synaptic sculpting2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-264
Location: BF-GMS
Title:
264 - The influence of maternal bonding in neuroimmune synaptic sculpting
Duration: 2017-01 - 2020-09
Researcher(s):
Ana Luísa Cardoso, João Peça, Joana Guedes, Ana Silvestre Cardoso, Ana Viegas, Elisabete Ferreiro
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Cardoso, A. L.
Secondary author(s):
Peça, J., Guedes, J., Cardoso, A. S., Viegas, A. , Ferreiro, E.
Number of reproductions:
1
Keywords:
Maternal bonding / Pre-frontal cortex / Synaptic pruning / Neuroimmunity / Psychophysiology

Reference code: PT/FB/BL-2016-264.01
Location: BF-GMS
Title:
Final report - The influence of maternal bonding in neuroimmune synaptic sculpting
Publication year: 2020
URL:
https://www.bial.com/media/3332/the-influence-of-maternal-bonding-in-neuroimmune-synaptic-sculpting.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Exposure to early-life stress (ELS), such as that caused by maternal separation can induce maladaptive behaviors and increase the vulnerability to neurological disorders later in life. In addition to having a direct impact in neuronal function, stress can also trigger neuroinflammatory events that impact microglia activity.
AIMS
With this work, we aim to elucidate what is the acute and long-term impact of ELS exposure and how it interferes with key microglia functions which are crucial for correct circuit wiring during the post-natal period.
METHOD
Towards this purpose, we have used a paradigm of maternal separation and maternal stress (MSUS), that allows to mimic early life adversity in the form of maternal neglect. We have investigated consequences of ELS to social behavior, as well as its impact on microglia phenotype. We have focused our evaluation in the medial pre-frontal cortex (mPFC), a brain region implicated in social interaction and impulse control that is often implicated in neuropsychiatric disorders.
RESULTS
We have observed that exposure to MSUS causes changes in social interaction, in the form of a reduction in ultravocalizations, as early as P5. In addition, we observed changes in social preference and an increase in submissive behaviors in adolescent and adult male mice, but no significant behavior changes in females. Exposure to ELS also leads to sex-dependent morphological and gene expression changes that are more profound in male microglia and that originate an hyperramified phenotype in adolescent mice. Male MSUS mice also present an increase in the number of PV+ inhibitory neurons in the mPFC, that is not observed in females and that leads to an increase in spontaneous IPSCs in this region.
CONCLUSIONS
Taken together, ours results point towards a higher susceptibility of male mice to the negative impacts of ELS exposure. This feature may be directly connected with the different and delayed response of male microglia to this type of stress.
Accessibility: Document exists in file
Language:
eng
Author:
Cardoso, A. L.
Document type:
Final report
Number of reproductions:
1
Reference:
Cardoso, A. L. (2020). Final report - The influence of maternal bonding in neuroimmune synaptic sculpting.
Indexed document: No
Keywords: Early life stress / Microglia / Neuronal circuits / Maternal bonding / Neuroinflammation

Final report - The influence of maternal bonding in neuroimmune synaptic sculpting

Final report - The influence of maternal bonding in neuroimmune synaptic sculpting
FileFinal report - Early life stress and social hierarchies: The role of cortico-striatal circuits2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-266
Location: BF-GMS
Title:
266 - Early life stress and social hierarchies: The role of cortico-striatal circuits
Duration: 2017-01 - 2021-01
Researcher(s):
João Peça, Joana Guedes, Ana Luísa Cardoso, Mohammed Hussien, Lara Franco, Mário Carvalho
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Peça, J.
Secondary author(s):
Guedes, J., Cardoso, A. L., Hussien, M., Franco, L., Carvalho, M.
Number of reproductions:
1
Keywords:
Animal behavior / Social hierarchy / Stress / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2016-266.01
Location: BF-GMS
Title:
Final report - Early life stress and social hierarchies: The role of cortico-striatal circuits
Publication year: 2021
URL:
https://www.bial.com/media/3490/early-life-stress-and-social-hierarchies.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Social behaviors are critical to the survival of most animal species. Gregarious behaviors strengthen social groups, reduce stress and increase fitness. However, the genetic and circuit basis of the regulation of social behaviors are not well understood.
AIMS
We aimed to dissect the influence of specific genes in social behaviors and their influence in neuronal circuits. One part of our project aimed at discovering, in an unbiased manner, which genetic elements could regulate social subordinance when animals experience early life stress. A second project investigated the role of GPRASP2, a gene known to influence sociability and autism in humans, in order to best understand its role in the brain.
METHOD
To dissect which genetic elements are responsible to induce social subordination following early life stress, we used a maternal deprivation protocol in C57BL6 mice. We also used a genetically engineered mouse model to understand the role of GPRASP2 in the regulation of social behaviors. For both approaches we employed a range of behavioral, histological and electrophysiological characterization.
RESULTS
This work sheds light on ethologically relevant processes with impact on biomedical sciences. Specifically, we found that the NPYergic system is important in the regulation of cortical circuits and the expression of social subordinate behavior. We also found that loss of GPRASP2 leads to altered social behaviors, deficits in social recognition and increased dominate behavior.
CONCLUSIONS
Our work identified novel genetic elements that play a significant role in the regulation of social behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Peça, J.
Secondary author(s):
Edfawy, M., Guedes, J., Franco, L., Cardoso, A. L., Carvalho, M.
Document type:
Final report
Number of reproductions:
1
Reference:
Peça, J., Edfawy, M., Guedes, J., Franco, L., Cardoso, A. L., & Carvalho, M. (2021). Final report - Early life stress and social hierarchies: The role of cortico-striatal circuits
Indexed document: No
Keywords: Social behaviour / Social hierarchy / Animal model / Electrophysiology / Neuronal circuits

Final report - Early life stress and social hierarchies: The role of cortico-striatal circuits

Final report - Early life stress and social hierarchies: The role of cortico-striatal circuits
DocumentLaterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.10
Location: BF-GMS
Title:
Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals
Publication year: 2021
URL:
https://onlinelibrary.wiley.com/doi/10.1002/jnr.24931
Abstract/Results: ABSTRACT:
The laterodorsal tegmentum (LDT) is a brainstem nucleus classically involved in REM sleep and attention, and that has recently been associated with reward-related behaviors, as it controls the activity of ventral tegmental area (VTA) dopaminergic neurons, modulating dopamine release in the nucleus accumbens. To further understand the role of LDT-VTA inputs in reinforcement, we optogenetically manipulated these inputs during different behavioral paradigms in male rats. We found that in a two-choice instrumental task, optical activation of LDT-VTA projections shifts and amplifies preference to the laser-paired reward in comparison to an otherwise equal reward; the opposite was observed with inhibition experiments. In a progressive ratio task, LDT-VTA activation boosts motivation, that is, enhances the willingness to work to get the reward associated with LDT-VTA stimulation; and the reverse occurs when inhibiting these inputs. Animals abolished preference if the reward was omitted, suggesting that LDT-VTA stimulation adds/decreases value to the stimulation-paired reward. In addition, we show that LDT-VTA optical activation induces robust preference in the conditioned and real-time place preference tests, while optical inhibition induces aversion. The behavioral findings are supported by electrophysiological recordings and c-fos immunofluorescence correlates in downstream target regions. In LDT-VTA ChR2 animals, we observed an increase in the recruitment of lateral VTA dopamine neurons and D1 neurons from nucleus accumbens core and shell; whereas in LDT-VTA NpHR animals, D2 neurons appear to be preferentially recruited. Collectively, these data show that the LDT-VTA inputs encode positive reinforcement signals and are important for different dimensions of reward-related behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Coimbra, B.
Secondary author(s):
Domingues, A. V., Soares-Cunha, C., Correia, R., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Coimbra, B., Domingues, A. V., Soares-Cunha, C., Correia, R., Pinto, L., Sousa, N., & Rodrigues, A. J. (2021). Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals. Journal of Neuroscience Research. https://doi.org/10.1002/jnr.24931
2-year Impact Factor: 4.433|2021
Times cited: 2|2024-02-14
Indexed document: Yes
Quartile: Q2
Keywords: LDT / Motivation / Neuronal circuits / Optogenetics / Reward

Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals

Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals
DocumentThe neural circuit architecture of social hierarchy in rodents and primates2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-074
Location: BF-GMS
Title:
074 - The social code in cingulate-hippocampal circuits: The role of memory in social contests
Duration: 2021-02 - 2024-09
Researcher(s):
Emanuel Fernandes, João Peça, Carolina Kunicki, Joana Guedes, Ana Cardoso
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Final Report
Article
Language: eng
Author:
Fernandes, E.
Secondary author(s):
Peça, J., Kunicki, C., Guedes, J., Cardoso, A. L.
Number of reproductions:
1
Keywords:
Cingulate-hippocampal circuits / Social cognition / In vivo electrophysiology / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2020-074.02
Location: BF-GMS
Title:
The neural circuit architecture of social hierarchy in rodents and primates
Publication year: 2022
URL:
https://www.frontiersin.org/articles/10.3389/fncel.2022.874310/full
Abstract/Results: Social status is recognized as a major determinant of social behavior and health among animals; however, the neural circuits supporting the formation and navigation of social hierarchies remain under extensive research. Available evidence suggests the prefrontal cortex is a keystone in this circuit, but upstream and downstream candidates are progressively emerging. In this review, we compare and integrate findings from rodent and primate studies to create a model of the neural and cellular networks supporting social hierarchies, both from a macro (i.e., circuits) to a micro-scale perspective (microcircuits and synapses). We start by summarizing the literature on the prefrontal cortex and other relevant brain regions to expand the current “prefrontal-centric” view of social hierarchy behaviors. Based on connectivity data we also discuss candidate regions that might inspire further investigation, as well as the caveats and strategies that have been used to further our understanding of the biological substrates underpinning social hierarchy and dominance.
Accessibility: Document exists in file
Language:
eng
Author:
Ferreira-Fernandes, E.
Secondary author(s):
Peça, J.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Ferreira-Fernandes, E. & Peça, J. (2022). The neural circuit architecture of social hierarchy in rodents and primates. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.874310
2-year Impact Factor: 5.300|2022
Times cited: 4|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Social hierarchies / Neuronal circuits / Dominance / Status syndrome / Microcircuitry / Social status

The neural circuit architecture of social hierarchy in rodents and primates

The neural circuit architecture of social hierarchy in rodents and primates
DocumentThe neural circuit architecture of social hierarchy in rodents and primates2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-266
Location: BF-GMS
Title:
266 - Early life stress and social hierarchies: The role of cortico-striatal circuits
Duration: 2017-01 - 2021-01
Researcher(s):
João Peça, Joana Guedes, Ana Luísa Cardoso, Mohammed Hussien, Lara Franco, Mário Carvalho
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Peça, J.
Secondary author(s):
Guedes, J., Cardoso, A. L., Hussien, M., Franco, L., Carvalho, M.
Number of reproductions:
1
Keywords:
Animal behavior / Social hierarchy / Stress / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2016-266.08
Location: BF-GMS
Title:
The neural circuit architecture of social hierarchy in rodents and primates
Publication year: 2022
URL:
https://www.frontiersin.org/articles/10.3389/fncel.2022.874310/full
Abstract/Results: Social status is recognized as a major determinant of social behavior and health among animals; however, the neural circuits supporting the formation and navigation of social hierarchies remain under extensive research. Available evidence suggests the prefrontal cortex is a keystone in this circuit, but upstream and downstream candidates are progressively emerging. In this review, we compare and integrate findings from rodent and primate studies to create a model of the neural and cellular networks supporting social hierarchies, both from a macro (i.e., circuits) to a micro-scale perspective (microcircuits and synapses). We start by summarizing the literature on the prefrontal cortex and other relevant brain regions to expand the current “prefrontal-centric” view of social hierarchy behaviors. Based on connectivity data we also discuss candidate regions that might inspire further investigation, as well as the caveats and strategies that have been used to further our understanding of the biological substrates underpinning social hierarchy and dominance.
Accessibility: Document exists in file
Language:
eng
Author:
Ferreira-Fernandes, E.
Secondary author(s):
Peça, J.
Document type:
Article-d
Number of reproductions:
1
Reference:
Ferreira-Fernandes, E. & Peça, J. (2022). The neural circuit architecture of social hierarchy in rodents and primates. Frontiers in Cellular Neuroscience, 16. https://doi.org/10.3389/fncel.2022.874310
2-year Impact Factor: 5.300|2022
Times cited: 4|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Social hierarchies / Neuronal circuits / Dominance / Status syndrome / Microcircuity / Social status

The neural circuit architecture of social hierarchy in rodents and primates

The neural circuit architecture of social hierarchy in rodents and primates