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BIAL Foundation
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DE:"Nociception coma scale-revised"
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DocumentNociception Coma Scale-Revised allows to identify patients with preserved neural basis for pain experience2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-47
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Nociception Coma Scale-Revised allows to identify patients with preserved neural basis for pain experience
Publication year: 2020
URL:
https://www.jpain.org/article/S1526-5900(19)30063-X/abstract
Abstract/Results: ABSTRACT:
The Nociception Coma Scale-Revised (NCS-R) was developed to help assess pain in patients with disorders of consciousness (DOC). Several studies have shown its sensitivity in assessing response to acute noxious stimuli. However, they failed to determine a reliable cut-off score that could be used to infer pain processing in these patients.
This retrospective cross-sectional study aimed to determine a NCS-R cut-off score supporting preserved neural basis for pain experience, based on brain metabolism preservation as measured by fluorodeoxyglucose positron emission tomography (FDG-PET).
We included patients in unresponsive wakefulness syndrome (UWS) confirmed by the FDG-PET and examined the NCS-R total scores. As the highest score was 4, we defined the cut-off to be 5 and compared the brain metabolism of these patients to matched patients with DOC and a NCS-R cut-off score = 5 (i.e., potential pain), as well as healthy subjects.
We found a higher global cerebral metabolism in healthy subjects compared to both patient groups and also in patients with potential pain compared with FDG-PET confirmed UWS. We observed a preserved metabolism in the left insula in patients with potential pain compared with FDG-PET confirmed UWS.
Perspectives: Our data suggest that using the cut-off score of 5 could be helpful to improve pain management in patients with DOC. Future studies should focus on patients showing scores below this cut-off to better characterize their profile and improve care.
The Nociception Coma Scale-Revised (NCS-R) was developed to help assess pain in patients with disorders of consciousness (DOC). Several studies have shown its sensitivity in assessing response to acute noxious stimuli. However, they failed to determine a reliable cut-off score that could be used to infer pain processing in these patients.
This retrospective cross-sectional study aimed to determine a NCS-R cut-off score supporting preserved neural basis for pain experience, based on brain metabolism preservation as measured by fluorodeoxyglucose positron emission tomography (FDG-PET).
Accessibility: Document does not exist in file
Language:
eng
Author:
Bonin, E.
Secondary author(s):
Lejeune, N., Thibaut, A., Cassol, H., Antanopoulos, G., Wannez, S., Martial, C., Schnakers, C., S., Laureys, S., Chatelle, C.
Document type:
Article
Number of reproductions:
3
Reference:
Bonin, E., Lejeune, N., Thibaut, A., Cassol, H., Antanopoulos, G., Wannez, S., Martial, C., Schnakers, C., S., Laureys, S., & Chatelle, C. (2020). Nociception Coma Scale-Revised allows to identify patients with preserved neural basis for pain experience. Journal of Pain, 21(5-6), 742-750. https://doi.org/10.1016/j.jpain.2019.11.004
2-year Impact Factor: 5.820|2020
Times cited: 8|2025-09-18
Indexed document: Yes
Quartile: Q1
Keywords: Nociception / Pain / Cut-off score / Nociception coma scale-revised / Disorders of consciousness

Nociception Coma Scale-Revised allows to identify patients with preserved neural basis for pain experience

Nociception Coma Scale-Revised allows to identify patients with preserved neural basis for pain experience