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BIAL Foundation
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DE:"Novel approaches to disorders of consciousness"
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Type Title Begin End
DocumentNeurophysiological Markers of (Dis)Connectedness: Insights from Ketamine2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-065
Location: BF-GMS
Title:
065 - Unintended returns of awareness during cardiopulmonary resuscitation
Duration: 2023-02
Researcher(s):
Charlotte Martial, Pauline Fritz, Alice Clerget
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Language: eng
Notes:
Ongoing project
Author: Martial, C.
Secondary author(s):
Fritz, P., Clerget, A.
Number of reproductions:
3
Keywords:
Disconnected consciousness / Connected consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2022-065.13
Location: BF-GMS
Title:
Neurophysiological Markers of (Dis)Connectedness: Insights from Ketamine
Publication year: 2025
URL:
https://doi.org/10.1007/978-1-0716-4603-8_8
Abstract/Results: ABSTRACT:
Ketamine is a versatile N-methyl-D-aspartate (NMDA)-antagonist used in various clinical settings. Ketamine dose-dependently induces psychoactive effects: at low, anti-hyperalgesic doses, these are minor or not detectable, but at subanesthetic doses, they may include dissociative, psychotomimetic, and psychedelic events. At an anesthetic dose, ketamine leads to a state of “(full) dissociation” or disconnection rather than unconsciousness, setting it apart from other anesthetics. This unique set of characteristics makes ketamine a particularly interesting substance for studying consciousness in clinical settings. Our chapter reviews ketamine’s neurophysiological effects and neuroimaging data, its potential to inform consciousness research, and its relevance in studying brain disorders involving altered states of consciousness. We trace recent advancements in understanding ketamine’s unique brain effects and report investigations that have developed neurophysiological indexes for consciousness without behavioral output (e.g., disconnected consciousness). Specifically, we discuss the most recent tool, the Explainable Consciousness Indicator (ECI), which uses machine learning to assess the presence of awareness and wakefulness. Finally, we look at future investigations that may utilize ketamine as therapeutic approach to neurological conditions, such as disorders of consciousness.
Accessibility: Document does not exist in file
Language:
Eng
Author:
Alnagger, N.
Secondary author(s):
Cardone, P., Montupil, J., Annen, J., Martial, C., Bonhomme, V., Gosseries, O.
Document type:
Book chapter
Number of reproductions:
3
Reference:
Alnagger, N. L. N., Cardone, P., Montupil, J., Annen, J., Martial, C., Bonhomme, V., & Gosseries, O. (2025). Neurophysiological markers of (dis)connectedness: Insights from ketamine. In S. Himmelseher (Ed.), Ketamine (Neuromethods, Vol. 224). Humana. https://doi.org/10.1007/978-1-0716-4603-8_8
Indexed document: No
Keywords: Ketamine / Neurophysiological markers / Disconnected consciousness / Behavioral responsiveness / Complexity / Machine Learning / Novel approaches to disorders of consciousness