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DocumentEffect of Deep Brain Stimulation of the Nucleos Accumbens on Affective Picture Processingn.d.

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-054
Location: Arquivo PCA - Pasta 3/2008
Title:
054 - Brain activity during remote information access
Duration: 2009-10 - 2011-06
Researcher(s):
Jérôme Daltrozzo, Boris Kotchoubey, Ahmed A. Karim
Institution(s): Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls-University, Tübingen (Germany)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Articles
Language: eng
Author:
Daltrozzo, J.
Secondary author(s):
Kotchoubey, B., Karim, A. A.
Number of reproductions:
1
Keywords:
Psychophysiology / Out-of-body experience (OBE) / Brain structure and function / Sleep and dreams / Body awareness

Reference code: PT/FB/BL-2008-054.05
Location: Arquivo PCA - Pasta 3/2008
Title:
Effect of Deep Brain Stimulation of the Nucleos Accumbens on Affective Picture Processing
Publication year: n.d.
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Bauer, R.
Secondary author(s):
Schwipel, T., Narios, G., Karim, A. A., Gharabaghi, A.
Document type:
Unpublished document
Number of reproductions:
1
Indexed document:
No
Keywords: Deep brain stimulation / Neurosurgery / Skin conductance response (SCR) / Electroencephalogram (EEG) / Nucleus accumbens

Novo ficheiro

Novo ficheiro
DocumentCaracterizing the spiking properties of human nucleus accumbens neurons and their responses to novelty2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.02
Location: Arquivo PCA - Pastas 20/2012
Title:
Caracterizing the spiking properties of human nucleus accumbens neurons and their responses to novelty
Publication year: 2014
Accessibility:
Document exists in file
Language:
eng
Author:
Kroe, M.
Secondary author(s):
Lopez-Sosa, F., Avecillas, J., Acedo, V. M., Gonzalez-Hidalgo, M., Lopez-Ibor, J., Battaglia, F., Barcia, J., Strange, B.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Kroe, M., Lopez-Sosa, F., Avecillas, J., Acedo, V. M., Gonzalez-Hidalgo, M., Lopez-Ibor, J., Battaglia, F., Barcia, J., & Strange, B. (2014, June). Caracterizing the spiking properties of human nucleus accumbens neurons and their responses to novelty. Poster presented at the Organization for Human Brain Mapping, Hamburg, Germany.
Indexed document: No
Keywords: Novelty / Nucleus accumbens

Caracterizing the spiking properties of human nucleus accumbens neurons and their responses to novelty

Caracterizing the spiking properties of human nucleus accumbens neurons and their responses to novelty
DocumentMemory enhancement via deep brain stimulation of human nucleus accumbens2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.03
Location: Arquivo PCA - Pastas 20/2012
Title:
Memory enhancement via deep brain stimulation of human nucleus accumbens
Publication year: 2014
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Galarza-Vallejo, A.
Secondary author(s):
Gonzalez-Rosa, J., Arza, R., Reneses, P., Barcia, J., Strange, B.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Galarza-Vallejo, A., Gonzalez-Rosa, J., Arza, R., Reneses, P., Barcia, J., & Strange, B. (2014, June). Memory enhancement via deep brain stimulation of human nucleus accumbens. Poster presented at the Organization for Human Brain Mapping, Hamburg, Germany.
Indexed document: No
Keywords: Episodic memory / Nucleus accumbens / Obsessive-compulsive disorders

Memory enhancement via deep brain stimulation of human nucleus accumbens

Memory enhancement via deep brain stimulation of human nucleus accumbens
DocumentDynamic risk control by human nucleus accumbens2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.04
Location: Arquivo PCA - Pastas 20/2012
Title:
Dynamic risk control by human nucleus accumbens
Publication year: 2014
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Nachev, P.
Secondary author(s):
Lopez-Sosa, F., Gonzalez-Rosa, J., Rascon, F., Lopez-Ibor, J., Barcia, J., Strange, B.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Nachev, P., Lopez-Sosa, F., Gonzalez-Rosa, J., Rascon, F., Lopez-Ibor, J., Barcia, J., & Strange, B. (2014, June). Dynamic risk control by human nucleus accumbens. Poster presented at the Organization for Human Brain Mapping, Hamburg, Germany.
Indexed document: No
Keywords: Decision-making / Nucleus accumbens / Deep brain stimulation

Dynamic risk control by human nucleus accumbens

Dynamic risk control by human nucleus accumbens
DocumentSleep and Emotional Functions2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-225
Location: Arquivo PCA - Pasta 12/2012
Title:
225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration: 2013-10 - 2016-02
Researcher(s):
Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s): Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Schwartz, S.
Secondary author(s):
Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code: PT/FB/BL-2012-225.02
Location: Arquivo PCA - Pasta 12/2012
Title:
Sleep and Emotional Functions
Publication year: 2014
URL:
http://link.springer.com/chapter/10.1007%2F7854_2013_271
Abstract/Results: ABSTRACT:
In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Perogamvros, L.
Secondary author(s):
Schwartz, S.
Document type:
Article
Number of reproductions:
1
Reference:
Perogamvros, L., & Schwartz, S. (2014). Sleep and Emotional Functions. Current Topics in Behavioral Neurosciences, 25, 411-431. https://doi.org/10.1007/7854_2013_271
2-year Impact Factor: N/A
Times cited: N/A
Indexed document: Yes
Quartile: N/A
Keywords: Sleep / Sleep deprivation / Dreaming / Emotion / Cognition / Reward / Sexual function / Creativity / Memory consolidation / Brain development / Amygdala / Prefrontal cortex / Hippocampus / Ventral tegmental area / Striatum / Nucleus accumbens / Dopamine / Limbic / Mesolimbic

Sleep and Emotional Functions

Sleep and Emotional Functions
DocumentDynamic risk control by human nucleus accumbens2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.05
Location: Arquivo PCA - Pastas 20/2012
Title:
Dynamic risk control by human nucleus accumbens
Publication year: 2015
URL:
http://brain.oxfordjournals.org/content/early/2015/10/01/brain.awv285#ack-1
Abstract/Results: ABSTRACT:
Real-world decisions about reward often involve a complex counterbalance of risk and value. Although the nucleus accumbens has been implicated in the underlying neural substrate, its criticality to human behaviour remains an open question, best addressed with interventional methodology that probes the behavioural consequences of focal neural modulation. Combining a psychometric index of risky decision-making with transient electrical modulation of the nucleus accumbens, here we reveal profound, highly dynamic alteration of the relation between probability of reward and choice during therapeutic deep brain stimulation in four patients with treatment-resistant psychiatric disease. Short-lived phasic electrical stimulation of the region of the nucleus accumbens dynamically altered risk behaviour, transiently shifting the psychometric function towards more risky decisions only for the duration of stimulation. A critical, on-line role of human nucleus accumbens in dynamic risk control is thereby established.
Accessibility: Document exist in file
Language:
eng
Author:
Nachev, P.
Secondary author(s):
Lopez-Sosa, F., Gonzalez-Rosa, J., Galarza, A., Avecillas, J., Pineda-Pardo, J. A., Lopez-Ibor, J., Reneses, B., Barcia, J., Strange, B.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Nachev, P., Lopez-Sosa, F., Gonzalez-Rosa, J., Galarza, A., Avecillas, J., ..., Strange, B. (2015). Dynamic risk control by human nucleus accumbens. Brain, 138(12), 3496-3502. https://doi.org/10.1093/brain/awv285
2-year Impact Factor: 10.103|2015
Times cited: 10|2024-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Risk / Reward / Decision-making / Subcortical electrical stimulation

Dynamic risk control by human nucleus accumbens

Dynamic risk control by human nucleus accumbens
DocumentFinal report - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.01
Location: Arquivo PCA - Pastas 20/2012
Title:
Final report - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Publication year: 2016
Abstract/Results:
ABSTRACT:
BACKGROUND
Deep-brain stimulation (DBS) is being increasingly used to treat medication resistant neurological and psychiatric diseases. However, the cognitive effects of DBS are not well understood.
AIM OF THE STUDY
To determine the effects of DBS to the human nucleus accumbens (NAc) on cognitive function.
METHOD
During the project period, 11 patients (10 with obsessive-compulsive disorder and 1 with major depression) underwent bilateral implantation of DBS electrodes. Intra-operatively, we recorded single-unit activity from the NAc during an auditory oddball task. Post-operatively, patients performed 3 behavioural tasks, with NAc DBS (130Hz, 3.5V, 60µs pulse-width) applied at 2 intervals during the task (On/Off design). In the third study, we simultaneously acquired scalp electroencephalography (EEG) recordings.
RESULTS & CONCLUSIONS
Intra-operative recordings - Different forms of salience evoke a change in human NAc single neuron firing rate, at a latency ~200 ms. Risky decision-making - We found that NAc DBS disrupts the normal relation between probability of reward and choice in 4 patients, resulting in a shift towards more risk seeking behaviour. Memory encoding - In all 6 patients tested, we found that NAc DBS during encoding of images increases the probability that these images will be later recognised. The magnitude of this memory enhancement predicts memory improvement in a neuropsychological test of verbal memory after 2 months of chronic DBS. Target detection during sustained attention - In 6 patients tested with the AX-type continuous performance task (AX-CPT), NAc DBS evoked a reduction of total numbers of errors in the ON relative to OFF state. In the EEG, NAc DBS produced an increase in the distribution of sources generating the P3 potential during Go trials. NAc DBs has profound effects on cognitive function.
Accessibility: Deocument exists in file
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Deep-brain stimulation, Intracranial recordings, Nucleus accumbens, Electroencephalogram (EEG)
Author: Strange, B.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Deep brain stimulation / Intracranial recordings / Nucleus accumbens / Electroencephalogram (EEG)
DocumentDeep-brain stimulation of human nucleus accumbens dynamically alters risky decision-making2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.06
Location: Arquivo PCA - Pastas 20/2012
Title:
Deep-brain stimulation of human nucleus accumbens dynamically alters risky decision-making
Publication year: 2015
URL:
http://www.brainstimjrnl.com/article/S1935-861X(15)00671-3/abstract
Abstract/Results: ABSTRACT:
Activity in human nucleus accumbens (NAc) is known to covary with risk when choosing between uncertain rewards. Whether this activity is critical to human behaviour remains, however, an open question, best addressed with methodology that probes the behavioural consequences of focal functional disruption of the region. Here we combine a behavioural index of risky decision-making with dynamic disruption of the NAc during therapeutic deep brain stimulation (DBS) to determine the critical relation between the two.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Nachev, P.
Secondary author(s):
Lopez-Sosa, F., Gonzalez-Rosa, J., Avecillas, J., Lopez-Ibor, J., Barcia, J., Strange, B.
Document type:
Abstract
Number of reproductions:
1
Reference:
Nachev, P., Lopez-Sosa, F., Gonzalez-Rosa, J., Avecillas, J., Lopez-Ibor, J., Barcia, J., & Strange, B. (2015). Deep-brain stimulation of human nucleus accumbens dynamically alters risky decision-making. Brain stimulation, 8(2), 390. https://doi.org/10.1016/j.brs.2015.01.247
Indexed document: Yes
Keywords: Deep brain stimulation / Nucleus accumbens
File296 - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens2017-092021-11

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-296
Location: BF-GMS
Title:
296 - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens
Duration: 2017-09 - 2021-11
Researcher(s):
Stephen Martin, Rosalina Fonseca
Institution(s): Division of Neuroscience, School of Medicine, University of Dundee (UK); Centro de Estudos de Doenças Crónicas, NOVA Medical School, Faculdade de Ciências Médicas – Universidade NOVA de Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Martin, S. J.
Secondary author(s):
Fonseca, R.
Number of reproductions:
1
Keywords:
Nucleus accumbens / Hippocampus / Prefrontal cortex / Synaptic plasticity / Psychophysiology
DocumentNucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.03
Location: BF-GMS
Title:
Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation
Publication year: 2018
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957524/
Abstract/Results: ABSTRACT:
The nucleus accumbens (NAc) plays a central role in reinforcement and motivation. Around 95% of the NAc neurons are medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R). Optogenetic activation of D2-MSNs increased motivation, whereas inhibition of these neurons produced the opposite effect. Yet, it is still unclear how activation of D2-MSNs affects other local neurons/interneurons or input terminals and how this contributes for motivation enhancement. To answer this question, in this work we combined optogenetic modulation of D2-MSNs with in loco pharmacological delivery of specific neurotransmitter antagonists in rats. First, we showed that optogenetic activation of D2-MSNs increases motivation in a progressive ratio (PR) task. We demonstrated that this behavioral effect relies on cholinergic-dependent modulation of dopaminergic signalling of ventral tegmental area (VTA) terminals, which requires D1R and D2R signalling in the NAc. D2-MSN optogenetic activation decreased ventral pallidum (VP) activity, reducing the inhibitory tone to VTA, leading to increased dopaminergic activity. Importantly, optogenetic activation of D2-MSN terminals in the VP was sufficient to recapitulate the motivation enhancement. In summary, our data suggests that optogenetic stimulation of NAc D2-MSNs indirectly modulates VTA dopaminergic activity, contributing for increased motivation. Moreover, both types of dopamine receptors signalling in the NAc are required in order to produce the positive behavioral effects.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Soares-Cunha, C., Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., & Rodrigues, A. J. (2018). Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation. eNeuro, 5(2), e0386-18. https://doi.org/10.1523/ENEURO.0386-18.2018
2-year Impact Factor: 3.544|2019
Impact factor notes: Impact factor computed since 2019
Times cited: 47|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Basal ganglia / Medium spiny neurons / Motivation / Nucleus accumbens / Optogenetics / Reward

Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation

Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation
DocumentNucleus accumbens medium spiny neurons subtypes signal both reward and aversion2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.04
Location: BF-GMS
Title:
Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
Publication year: 2020
URL:
https://www.nature.com/articles/s41380-019-0525-y
Abstract/Results: ABSTRACT:
Deficits in decoding rewarding (and aversive) signals are present in several neuropsychiatric conditions such as depression
and addiction, emphasising the importance of studying the underlying neural circuits in detail. One of the key regions of the
reward circuit is the nucleus accumbens (NAc). The classical view on the field postulates that NAc dopamine receptor D1-
expressing medium spiny neurons (D1-MSNs) convey reward signals, while dopamine receptor D2-expressing MSNs (D2-
MSNs) encode aversion. Here, we show that both MSN subpopulations can drive reward and aversion, depending on their
neuronal stimulation pattern. Brief D1- or D2-MSN optogenetic stimulation elicited positive reinforcement and enhanced
cocaine conditioning. Conversely, prolonged activation induced aversion, and in the case of D2-MSNs, decreased cocaine
conditioning. Brief stimulation was associated with increased ventral tegmenta area (VTA) dopaminergic tone either directly
(for D1-MSNs) or indirectly via ventral pallidum (VP) (for D1- and D2-MSNs). Importantly, prolonged stimulation of either
MSN subpopulation induced remarkably distinct electrophysiological effects in these target regions. We further show that
blocking ?-opioid receptors in the VTA (but not in VP) abolishes the behavioral effects induced by D1-MSN prolonged
stimulation. In turn, blocking d-opioid receptors in the VP (but not in VTA) blocks the behavioral effects elicited by D2-
MSN prolonged stimulation. Our findings demonstrate that D1- and D2-MSNs can bidirectionally control reward and
aversion, explaining the existence of controversial studies in the field, and highlights that the proposed striatal functional
opposition needs to be reconsidered.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Vasconcelos, N., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., Gaspar, R., Sotiropoulos, I., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Soares-Cunha, C., Vasconcelos, N., Coimbra, B., Domingues, A. V., Silva, J. M., Loureiro-Campos, E., ... Rodrigues, A. J. (2020). Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Molecular Psychiatry, 25(12), 3241-3255. https://doi.org/10.1038/s41380-019-0484-3
2-year Impact Factor: 15.992|2020
Times cited: 98|2024-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Reward

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion

Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion
DocumentFinal report - Exploring the neural basis of motivation2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.01
Location: BF-GMS
Title:
Final report - Exploring the neural basis of motivation
Publication year: 2020
URL:
https://www.bial.com/media/3214/exploring-the-neural-basis-of-motivation.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
Optimal decision-making requires that individuals evaluate the costs and benefits of potential choices and this is highly dependent on the value attributed to the outcome but also individual motivational status. Evidence in both animal models and humans has highlighted the nucleus accumbens (NAc) as a core brain region in the neural circuitry underlying motivation. One anatomical study has shown that the laterodorsal tegmentum (LDT) directly projects to the NAc, though the nature and biological role of such connections remains completely unknown.
AIMS:
Determine the role of the LDT-NAc network in the modulation of motivation.
METHOD:
We performed a detailed characterization of the LDT-NAc rodent circuit using viral transynaptic markers and in vivo electrophysiological recordings. We also used optogenetics to modulate LDT-NAc different types of projections and evaluate their impact in motivation in rodents.
RESULTS:
Our results show that the majority of LDT-NAc inputs are cholinergic, but there is also GABAergic and glutamatergic innervation; activation of LDT induces a predominantly excitatory response in the NAc. Specific activation of LDT-NAc cholinergic inputs (but not glutamatergic or GABAergic) is sufficient to shift preference, increase motivation, and drive positive reinforcement in different behavioral paradigms in rodents.
CONCLUSIONS:
These results provide evidence that LDT-NAc projections play an important role in motivated behaviors and positive reinforcement, and that distinct neuronal populations differentially contribute for these behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Rodrigues, A. J.
Document type:
Final report
Number of reproductions:
1
Reference:
Rodrigues, A. J. (2020). Final report - Exploring the neural basis of motivation.
Indexed document: No
Keywords: Motivation / Neuronal circuits / Nucleus accumbens / Laterodorsal tegmentum

Final report - Exploring the neural basis of motivation

Final report - Exploring the neural basis of motivation
Document175 - The role of nucleus accumbens in the perception of natural rewards2021-06

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-175
Location: BF-GMS
Title:
175 - The role of nucleus accumbens in the perception of natural rewards
Duration: 2021-06
Researcher(s):
Carina Cunha, Ana João Rodrigues, Nivaldo Vasconcelos, Rodrigo Oliveira, Bárbara Coimbra, Ana Verónica Domingues, Gabriela Martins
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal); Zuckerman Institute, Columbia University, New York City (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Cunha, C.
Secondary author(s):
Rodrigues, A. J., Vasconcelos, N., Oliveira, R., Coimbra, B., Domingues, A. V., Martins, G.
Number of reproductions:
1
Keywords:
Nucleus accumbens / Reward / Calcium imaging / Optogenetics / Psychophysiology
DocumentResilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.07
Location: BF-GMS
Title:
Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S2352289521000102
Abstract/Results: ABSTRACT:
Prenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders.
Synthetic GC such as dexamethasone (DEX) are commonly prescribed in case of preterm risk labour in order to promote fetal lung maturation. Recently, we reported long-lasting differences in microglia morphology in a model of in utero exposure to DEX (iuDEX), that presents an anxious phenotype. However, it is still unclear if stress differentially affects iuDEX males and females.
In this work, we evaluated how iuDEX animals of both sexes cope with chronic mild stress for 2 weeks. We evaluated emotional behavior and microglia and neuronal morphology in the dorsal hippocampus (dHIP) and nucleus accumbens (NAc), two brain regions involved in emotion-related disorders. We report that males and females prenatally exposed to DEX have better performance in anxiety- and depression-related behavioral tests after chronic stress exposure in adulthood than non-exposed animals. Interestingly, iuDEX animals present sex-dependent changes in microglia morphology in the dHIP (hypertrophy in females) and in the NAc (atrophy in females and hypertrophy in males). After chronic stress, these cells undergo sex-specific morphological remodeling. Paralleled to these alterations in cytoarchitecture of microglia, we report inter-regional differences in dendritic morphology in a sex-specific manner. iuDEX females present fewer complex neurons in the NAc, whereas iuDEX males presented less complex neuronal morphology in the dHIP. Interestingly, these alterations were modified by stress exposure.
Our work shows that stressful events during pregnancy can exert a preserved sex-specific effect in adulthood. Although the role of the observed cellular remodeling is still unknown, sex-specific differences in microglia plasticity induced by long-term stress exposure may anticipate differences in drug efficacy in the context of stress-induced anxiety- or depression-related behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Gaspar, R.
Secondary author(s):
Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto. L., Ambrósio, A. F., Rodrigues, A. J., Gomes, C. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Gaspar, R., Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto. L., Ambrósio, A. F., Rodrigues, A. J., & Gomes, C. A. (2021). Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia. Neurobiology of Stress, 14, 100302. https://doi.org/10.1016/j.ynstr.2021.100302
2-year Impact Factor: 7.142|2021
Times cited: 20|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Prenatal stress / Chronic stress / Microglia morphology / Sex / Nucleus accumbens / Dorsal hippocampus

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia
DocumentA ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.08
Location: Arquivo PCA - Pastas 20/2012
Title:
A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation
Publication year: 2021
URL:
https://www.brainstimjrnl.com/article/S1935-861X(21)00099-1/fulltext
Abstract/Results: ABSTRACT:
BACKGROUND
Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized.
OBJECTIVE/HYPOTHESIS
The primary goal of this study was to investigate the neuronal synchronization in OCD patients. We predicted aberrant oscillatory activity in frontal regions compared to healthy control subjects, which would be alleviated by deep brain stimulation (DBS) of the nucleus accumbens (NAc).
METHODS
We compared scalp EEG recordings from nine patients with OCD treated with NAc-DBS with recordings from healthy controls, matched for age and gender. Within the patient group, EEG activity was compared with DBS turned off vs. stimulation at typical clinical settings (3.5 V, frequency of stimulation 130 Hz, pulse width 60 µs). In addition, intracranial EEG was recorded directly from depth macroelectrodes in the NAc in four OCD patients.
RESULTS
Cross-frequency coupling between the phase of alpha/low beta oscillations and amplitude of high gamma was significantly increased over midline frontal and parietal electrodes in patients when stimulation was turned off, compared to controls. Critically, in patients, beta (16–25 Hz) -gamma (110–166 Hz) phase amplitude coupling source localized to the ventromedial prefrontal cortex, and was reduced when NAc-DBS was active. In contrast, intracranial EEG recordings showed no beta-gamma phase amplitude coupling. The contribution of non-sinusoidal beta waveforms to this coupling are reported.
CONCLUSION
We reveal an increased beta-gamma phase amplitude coupling in fronto-central scalp sensors in patients suffering from OCD, compared to healthy controls, which may derive from ventromedial prefrontal regions implicated in OCD and is normalized by DBS of the nucleus accumbens. This aberrant cross-frequency coupling could represent a biomarker of OCD, as well as a target for novel therapeutic approaches.
Accessibility: Document exits in file
Language:
eng
Author:
Treu, S.
Secondary author(s):
Gonzalez-Rosa, J. J., Soto-Leon, V., Lozano-Soldevilla, D., Oliviero, A., Lopez-Sosa, F., Reneses-Prieto, B., Barcia, J. A., Strange, B. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Treu, S., Gonzalez-Rosa, J. J., Soto-Leon, V., Lozano-Soldevilla, D., Oliviero, A., Lopez-Sosa, F., …, Strange, B. A. (2021). A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation. Brain Stimulation, 14(4), 761-770. https://doi.org/10.1016/j.brs.2021.04.028
2-year Impact Factor: 9.184|2021
Times cited: 7|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Obsessive-compulsive disorder / Deep brain stimulation / EEG / Nucleus accumbens / Ventromedial frontal cross-frequency coupling

A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation

A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation
DocumentFinal report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-296
Location: BF-GMS
Title:
296 - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens
Duration: 2017-09 - 2021-11
Researcher(s):
Stephen Martin, Rosalina Fonseca
Institution(s): Division of Neuroscience, School of Medicine, University of Dundee (UK); Centro de Estudos de Doenças Crónicas, NOVA Medical School, Faculdade de Ciências Médicas – Universidade NOVA de Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Martin, S. J.
Secondary author(s):
Fonseca, R.
Number of reproductions:
1
Keywords:
Nucleus accumbens / Hippocampus / Prefrontal cortex / Synaptic plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-296.01
Location: BF-GMS
Title:
Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens
Publication year: 2021
Abstract/Results:
ABSTRACT:
BACKGROUND
Synaptic changes underlie memory formation in many brain areas; ventral hippocampal (vHPC) and prefrontal cortex (PFC) projections to the nucleus accumbens (NAc) are a potential site of storage for associations between environmental stimuli and reward.
AIMS
Our goals were to identify learning-related changes in synaptic strength in inputs to the NAc during associative learning, and to characterise the interactions between PFC and vHPC projections.
METHOD
Rats were implanted with electrodes to record synaptic potentials in the vHPC-NAc pathway, and spontaneous oscillatory activity. They underwent place-preference training in which a distinctive context was associated with morphine injection. In parallel experiments, fluorescent viral constructs were injected into vHPC or PFC. Rats were later sacrificed, and their brains were sectioned and imaged to determine the distribution of projections from vHPC and PFC to the NAc.
RESULTS
Training did not cause an overall change in synaptic strength, but morphine caused an acute increase in evoked responses, and a progressive increase in gamma-frequency activity. The tracing experiments revealed that vHPC projects almost exclusively to the NAc shell, whereas the PFC projects predominantly to the core.
CONCLUSIONS
Our results do not support the idea that changes in synaptic strength in the vHPC-NAc projection underlie context-reward associations. However, the morphine-induced increase in gamma-frequency activity may be related to the ‘incentive sensitisation’ that occurs with repeated opioid administration. Fluorescent tracing indicates that there is limited overlap between vHPC and PFC inputs to the NAc; direct interactions between these inputs are thus unlikely to mediate the formation of context-reward associations.
Accessibility: Document exists in file
Language:
eng
Author:
Martin, S. J.
Secondary author(s):
Fonseca, R.
Document type:
Final report
Number of reproductions:
1
Reference:
Martin, S. J., & Fonseca, R. (2021). Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens.
Indexed document: No
Keywords: Hippocampus / Nucleus accumbens / Prefrontal cortex / Reward / Synaptic plasticity

Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens

Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens
Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-175
Location: BF-GMS
Title:
175 - The role of nucleus accumbens in the perception of natural rewards
Duration: 2021-06
Researcher(s):
Carina Cunha, Ana João Rodrigues, Nivaldo Vasconcelos, Rodrigo Oliveira, Bárbara Coimbra, Ana Verónica Domingues, Gabriela Martins
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho, Braga (Portugal); Zuckerman Institute, Columbia University, New York City (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Cunha, C.
Secondary author(s):
Rodrigues, A. J., Vasconcelos, N., Oliveira, R., Coimbra, B., Domingues, A. V., Martins, G.
Number of reproductions:
1
Keywords:
Nucleus accumbens / Reward / Calcium imaging / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2020-175.02
Location: BF-GMS
Title:
Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2211124722001012
Abstract/Results: The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement, but recent evidence suggests a more complex role for D2-MSNs. Here, we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery decreases motivation; optical inhibition triggers the opposite behavioral effect. In addition, in a free-choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different, and even opposing, roles in distinct phases of motivated behavior.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Domingues. A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Soares-Cunha, C., Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N. & Rodrigues, A. J. (2022). Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports, 38, 7 https://doi.org/10.1016/j.celrep.2022.110380
2-year Impact Factor: 8.800|2022
Times cited: 12|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Ventral pallidum / Reward / Motivation / Medium spiny neurons / D2 / Striatum

Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Distinct roles of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
DocumentDistintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.11
Location: BF-GMS
Title:
Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S2211124722001012
Abstract/Results: The nucleus accumbens (NAc) is a key region in motivated behaviors. NAc medium spiny neurons (MSNs) are divided into those expressing dopamine receptor D1 or D2. Classically, D1- and D2-MSNs have been described as having opposing roles in reinforcement, but recent evidence suggests a more complex role for D2-MSNs. Here, we show that optogenetic modulation of D2-MSN to ventral pallidum (VP) projections during different stages of motivated behavior has contrasting effects in motivation. Activation of D2-MSN-VP projections during a reward-predicting cue results in increased motivational drive, whereas activation at reward delivery decreases motivation; optical inhibition triggers the opposite behavioral effect. In addition, in a free-choice instrumental task, animals prefer the lever that originates one pellet in opposition to pellet plus D2-MSN-VP optogenetic activation and vice versa for optogenetic inhibition. In summary, D2-MSN-VP projections play different, and even opposing, roles in distinct phases of motivated behavior.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N., Rodrigues, A. J.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
4
Reference:
Soares-Cunha, C., Domingues, A. V., Correia, R., Coimbra, B., Vieitas-Gaspar, N., Vasconcelos, N., Pinto, L., Sousa, N. & Rodrigues, A. J. (2022). Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports, 38, 7. https://doi.org/10.1016/j.celrep.2022.110380
2-year Impact Factor: 8.800|2022
Times cited: 12|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Ventral pallidum / Reward / Motivation / Medium spiny neurons / D2 / Striatum

Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior

Distintic role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior
DocumentThe duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.12
Location: BF-GMS
Title:
The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia
Publication year: 2022
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8940280/
Abstract/Results: Stress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that microglia, the immune cells of the brain, play a significant role in determining neuronal and behavioral responses to chronic stress and also contribute to the development of stress-related psychopathologies. However, little is known about the impact of the duration of stress exposure upon microglia and neurons morphology, particularly considering sex differences. This issue deserves particular investigation, considering that the process of morphologic remodeling of neurons and microglia is usually accompanied by functional changes with behavioral expression. Here, we examine the effects of short and long unpredictable chronic mild stress (uCMS) protocols on behavior, evaluating in parallel microglia and neurons morphology in the dorsal hippocampus (dHIP) and in the nucleus accumbens (NAc), two brain regions involved in the etiology of depression. We report that long-term uCMS induced more behavioral alterations in males, which present anxiety and depression-like phenotypes (anhedonia and helplessness behavior), while females only display anxiety-like behavior. After short-term uCMS, both sexes presented anxiety-like behavior. Microglia cells undergo a process of morphologic adaptation to short-term uCMS, dependent on sex, in the NAc: we observed a hypertrophy in males and an atrophy in females, transient effects that do not persist after long-term uCMS. In the dHIP, the morphologic adaptation of microglia is only observed in females (hypertrophy) and after the protocol of long uCMS. Interestingly, males are more vulnerable to neuronal morphological alterations in a region-specific manner: dendritic atrophy in granule neurons of the dHIP and hypertrophy in the medium spiny neurons of the NAc, both after short- or long-term uCMS. The morphology of neurons in these brain regions were not affected in females. These findings raise the possibility that, by differentially affecting neurons and microglia in dHIP and NAc, chronic stress may contribute for differences in the clinical presentation of stress-related disorders under the control of sex-specific mechanisms.
Accessibility: Document exists in file
Language:
eng
Author:
Gaspar, R.
Secondary author(s):
Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto, L., Ambrósio, A. F., Rodrigues, A. J., Gomes, C. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Gaspar, R., Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto, L., Ambrósio, A. F., Rodrigues, A. J. & Gomes, C. A. (2022). The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia. Frontiers in Behavioral Neuroscience, 16, 834821. https://doi.org/10.3389/fnbeh.2022.834821
2-year Impact Factor: 3.000|2022
Times cited: 4|2024-02-20
Indexed document: Yes
Quartile: Q2
Keywords: Chronic stress / Microglia morphology / Sex differences / Dorsal hippocampus / Nucleus accumbens / Neurons morphology

The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia

The duration of stress determines sex specificities in the vulnerability to depression and in the morphologic remodeling of neurons and microglia
DocumentPrenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rates2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.14
Location: BF-GMS
Title:
Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rates
Publication year: 2022
URL:
https://www.nature.com/articles/s41398-022-02043-4
Abstract/Results: Abstract
Daily, individuals select actions based on cost-benefit to allocate resources into goal-directed actions. Different brain regions coordinate this complex decision, including the nucleus accumbens (NAc), anterior cingulate cortex (ACC), and ventral tegmental area (VTA). In utero exposure to synthetic glucocorticoids (iuGC), such as dexamethasone, triggers prominent motivation deficits but the impact of this exposure in the ACC-NAc and/or ACC-VTA circuits is unknown. Here, we show that iuGC exposure causes decreased motivation for natural rewards (food) and impaired effort-based decision-making. Importantly, reduced neuronal activation (number of c-fos+ neurons) was observed in the NAc core and ACC of iuGC rats in comparison to CTR rats after performing the effort-based decision-making task. In addition, iuGC treatment led to increased NAc and ACC basal neuronal activity. Electrophysiological recordings during optogenetic modulation of ACC terminals in the NAc revealed that the ACC-NAc circuit is dysfunctional in iuGC animals. These data suggest that iuGC animals present motivational and effort-based decision-making deficits that can be associated with the observed ACC-NAc dysfunction.
Accessibility: Document exists in file
Language:
eng
Author:
Domingues, A. V.
Secondary author(s):
Coimbra, B., Correia, R., Deseyve, C., Vieitas-Gaspar, N., Floresco, S., Sousa, N., Soares-Cunha, C., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Domingues, A. V., Coimbra, B., Correia, R., Deseyve, C., Vieitas-Gaspar, N., Floresco, S., Sousa, N., Soares-Cunha, C., & Rodrigues, A. J. (2022). Prenatal dexamethasone exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes in male rates. Translational Psychiatry, 12, 338. https://doi.org/10.1038/s41398-022-02043-4
2-year Impact Factor: 6.800|2022
Times cited: 1|2024-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Nucleus accumbens / Anterior cingulate cortex / Functional changes / Decision making