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File031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2007-042010-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation
DocumentFinal report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3106.pdf
Abstract/Results: RESULTS:
The overall aim of this study was to investigate the influence of serotonin and dopamine receptor gene polymorphisms on various parameters relevant to the successful participation of obese people taking part in a diet and exercise obesity intervention. We demonstrated that serotonin receptor gene genotype has a significant influence on perception of hunger. We also showed that dopamine receptor gene polymorphisms significantly influence the drop out rate from an obesity intervention study, and suggest that this is due to the influence of these polymorphisms both on motivation to exercise and on restrained eating behaviours. Finally we demonstrated the efficacy of motivational interviewing in an obesity intervention programme and have shown that motivational interviews influence the relationship between measures of motivation or eating behaviours and weight loss measured by BMI change These novel findings indicate that serotonin plays a key role in determining appetite. They also indicate that extent of dopamine signalling may influence an individual's motivation to engage in weight-loss programmes. Further studies are required to confirm these findings and investigate the underlying mechanisms involved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Genotype / Obesity / Motivation / Intervention program / Serotonin / Dopamine / Weight loss

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
DocumentThe use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.02
Location: Arquivo PCA - Pasta 17/2006
Title:
The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
To determine whether polymorphisms in serotonin or dopamine receptor genes influence changes in body mass index (BMI) or waist/hip ratio in participants of a diet and exercise programme, the extent of motivation of the participants in relation to exercise, and the participants eating behaviour scores.
METHODS:
100 obese participants of a 12-week exercise and diet intervention programme took part in the study. BMI and waist/hip ratio data were collected. The Three-factor Eating Questionnaire (TFEQ) was used to quantify eating behaviours, and the BREQ-2 questionnaire to quantify motivation in relation to exercise. Measures and questionnaires were repeated at the end of the programme. DNA was extracted from a buccal swab and genotyped for polymorphisms in serotonin and dopamine receptor genes.
RESULTS:
The results indicate that polymorphisms in serotonin receptor genes influence BMI and waist/hip ratio changes in the participants. Subjects with favourable combinations of serotonin receptor genotypes were more likely to reduce their BMI waist/hip ratio than subjects with the opposing genotypes. In addition dopamine receptor genotype influences the motivation of the participants to engage in exercise. Subjects with unfavourable genotypes were less likely to have improved their motivation score measured by the BREQ-2 questionnaire by the end of the study than those participants with a favourable genotype. Finally, both serotonin and dopamine receptor genotypes influence the subjects’ eating behaviour. Subjects with combinations of unfavourable genotypes were more likely to have eating behaviours known to be associated with weight gain compared to subjects with more favourable genotype combinations.
CONCLUSIONS:
These findings suggest that success when attempting to lose weight is influenced by polymorphisms in serotonin and dopamine receptor genes. This influence is mediated by the effect of these genes on eating behaviours and on motivation to participate in exercise. Further studies are required to investigate ways of personalising diet and exercise programmes to take into account the influence of these genetic factors.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Abstract and respective poster in attachment
Author: Dalton, C.
Secondary author(s):
Breckon, J., Silva, N., Copeland, R., Hall, A., Kesterton, S., Reynolds, G.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Dalton, C., Breckon, J., Copeland, R., Hall, B., & Reynolds, G. (2010). The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 202). Porto: Fundação Bial.
Indexed document: No
Keywords: Genotype / Obesity / Motivation / Three-factor eating questionnaire (TFEQ) / Behavioral regulation in exercise questionnaire-2 (BREQ-2)

Polymorphisms in serotonin and dopamine receptor genes influence weight loss, motivation and eating behaviours

Polymorphisms in serotonin and dopamine receptor genes influence weight loss, motivation and eating behaviours
File176 - Dopaminergic regulation of dietary learning in humans and rodents2011-072014-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function
DocumentThe (un)pleasant intensity of taste: a glimpse into obesity2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.03
Location: Arquivo PCA - Pasta 14/2010
Title:
The (un)pleasant intensity of taste: a glimpse into obesity
Publication year: 2012
URL:
http://www.iaso.org/site_media/uploads/CON_OMH_program_F_6.pdf
Abstract/Results: ABSTRACT:
The relevance of orosensory factors for the pathophysiology of obesity were suggested by the report of changes in taste sensitivity in obese patients, after gastric bypass surgery. However, it is unclear if such changes are specific to this intervention. Here we report on taste intensity and pleasantness for sweet (sucrose), bitter (quinine), sour (citric acid) and salty (sodium chloride tastants, measured in severely obese patients, before and/or after a diet and exercise weight-loss program. Other measurements, such as the Beck Depression Scale, were also conducted. When compared to non-obese controls, we found that quinine and sucrose have a more intense and, respectively, unpleasant (bitter) or pleasant (sweet) taste in obese subjects. However, the effect for sweet taste seems to be, at least partially, dependent on the relationship between obesity and depression. Preliminary analyses in patients tested before and after weightloss further suggest that these taste changes are reversible. Additional experiments are now necessary to directly compare taste changes after surgical and behavioral weight-loss programs.
Accessibility: Document does not exist in file
Language:
eng
Author:
Fernandes, A.
Secondary author(s):
Paixão, V., Branco, T., Martins, S., Costa, R. M., Oliveira-Maia, A. J.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Fernandes, A., Paixão, V., Branco, T., Martins, S., Costa, R. M., & Oliveira-Maia, A. J. (2012). The (un)pleasant intensity of taste: a glimpse into obesity. In Conference program of Hot Topic Conference Obesity & Mental Health (p. 10). Toronto, Canada: International Association for the Study of Obesity (IASO)
Indexed document: No
Keywords: Obesity / Taste sensitivity / Depression / Weight loss

The (un)pleasant intensity of taste: a glimpse into obesity

The (un)pleasant intensity of taste: a glimpse into obesity
DocumentDiabesidade: A obesidade na prática clínica

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/E
Entity holding: BIAL Foundation
Title: Documentation and Information Center
History: Books that are part of the documentation center

Reference code: PT/FB/E/057
Title: Diabesidade: A obesidade na prática clínica
Número de inventário: M-0058
Local: Porto
Publisher: Laboratórios Bial
Date: 2012
Pag., vols.: 267 p.
Illustration: il.
Dimension/support: 24 cm
Accessibility: Document exists in archive
Copyright/Reproduction:
By permission
Language:
por
Notes:
Prémio Bial 2010 - Menção Honrosa
Edition: 1ª ed.
Collection: (Bial ; 43)
Author: Carmo, I.
Secondary author(s):
Fagundes, M. J., Brito, M. J.
Document type:
Book
Keywords:
Obesity / Clinical problems / Comorbidity / Psychological aspects
DocumentObesidade: Compreender e intervir2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/E
Entity holding: BIAL Foundation
Title: Documentation and Information Center
History: Books that are part of the documentation center

Reference code: PT/FB/E/111
Title: Obesidade: Compreender e intervir
Publication year: 2014
Número de inventário:
M-0113
Local: Lisboa
Publisher: Sociedade Portuguesa de Cardiologia
Pag., vols.: 128p.
Dimension/support: 24cm
URL: http://www.spc.pt/DL/RFR/FR34_OutDez14.pdf
Accessibility: Document exists in archive
Language:
por
Collection: ( ;
Vol. 34(9), October/December 2014)
Document type: Journal
Reference:
Sociedade Portuguesa de Cardiologia (2014). Obesidade: Compreender e intervir. Revista Factores de Risco, 34(9).
Keywords: Obesity / Intervention

Obesidade - Compreender e intervir

Obesidade - Compreender e intervir
DocumentAssociation between hedonic hunger and body-mass index versus obesity status2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.06
Location: Arquivo PCA - Pasta 14/2010
Title:
Association between hedonic hunger and body-mass index versus obesity status
Publication year: 2018
URL:
https://www.nature.com/articles/s41598-018-23988-x
Abstract/Results: ABSTRACT:
Obesity-associated differences in hedonic hunger, while consistently reported, have not been adequately quantified, with most studies failing to demonstrate strong correlations between Body Mass Index (BMI) and hedonic hunger indicators. Here, we quantified and assessed the nature of the relationship between hedonic hunger and BMI, in a cross-sectional study using the Portuguese version of the PFS (P-PFS) to measure hedonic hunger. Data were collected from 1266 participants belonging to non-clinical, clinical (candidates for weight-loss surgery) and population samples. Across samples, significant but weak positive associations were found between P-PFS scores and BMI, in adjusted linear regression models. However, in logistic regression models of data from the clinical and non-clinical samples, the P-PFS Food Available domain score was significantly and robustly associated with belonging to the clinical sample (OR=1.8, 95%CI: 1.2–2.8; p=0.008), while in the population sample it was associated to being obese (OR=2.1, 95%CI: 1.6–2.7; p<0.001). Thus, hedonic hunger levels are associated with obesity status with the odds of being obese approximately doubling for each unit increase in the P-PFS Food Available score.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, G.
Secondary author(s):
Camacho, M., Santos, O., Pontes, C., Torres, S., Oliveira-Maia, A.
Document type:
Article
Number of reproductions:
1
Reference:
Ribeiro, G., Camacho, M., Santos, O., Pontes, C., Torres, S., & Oliveira-Maia, A. (2018). Association between hedonic hunger and body-mass index versus obesity status. Scientific Reports, 8: 5857. https://doi.org/10.1038/s41598-018-23988-x
2-year Impact Factor: 4.011|2018
Times cited: 39|2025-09-17
Indexed document: Yes
Quartile: Q1
Keywords: Obesity / Hedonic hunger

Association between hedonic hunger and body-mass index versus obesity status

Association between hedonic hunger and body-mass index versus obesity status
DocumentEnhanced sweet taste sensitivity in candidates for bariatric surgery2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.07
Location: Arquivo PCA - Pasta 14/2010
Title:
Enhanced sweet taste sensitivity in candidates for bariatric surgery
Publication year: 2019
URL:
https://www.karger.com/Article/PDF/497797
Abstract/Results: ABSTRACT
INTRODUCTION
While taste has been suggested as a potential determinant of feeding behavior in obesity, the supporting evidence, namely of altered sensitivity for sweet taste in obese relative to lean individuals, is inconsistent. Furthermore, such evidence has typically been obtained in studies including only small sample sizes, and with substantial methodological heterogeneity. Importantly, potential associations between taste perception and measures of reward-related feeding behavior remain undetermined.
METHODS
A cross-sectional study was conducted to compare 212 patients with severe obesity, on the waiting list for bariatric surgery, and 94 healthy individuals. Psychophysical gustatory parameters, namely intensity and pleasantness ratings of sour, salt, sweet and bitter tastants, and taste thresholds as assessed with electrogustometry, were determined. Reward-related feeding behavior was assessed using self-rated psychometric scales.
RESULTS
In addition to having a higher BMI, bariatric patients were older, more frequently female and had higher self-rated depression scores than their respective controls. Logistic regressions to assess the likelihood of belonging to the bariatric group were thus adjusted for age and gender, in addition to type II diabetes, education level and research center. In these analyses we found that higher taste thresholds and higher sweet intensity ratings were associated with belonging to the bariatric group (1.03<OR=1.04, both p<0.05), as were higher ratings for hedonic hunger, food addiction symptom scores, restrained and emotional eating (1.94<OR=4.27, all p<0.01), and lower alcohol acceptance (OR = 0.91, p = 0.001). In final exploratory analyses of potential linear relationships between the variables associated with the obese status, while hedonic hunger, food addiction or emotional eating were strongly inter-related, they were not associated with sweet intensity, that in turn had a closer relationship with restrained eating and alcohol acceptance.
CONCLUSION
Here we found that subjects with severe obesity report higher sweet taste intensity ratings than healthy study volunteers. Furthermore, while self-report measures of reward-related feeding behavior seem to assess a similar construct, sweet intensity was not associated with these variables, and may represent a separate obesity-related dimension.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, G.
Secondary author(s):
Torres, S., Fernandes, A. B., Camacho, M., Oliveira Maia, A. J., Study Group, F.
Document type:
Abstract
Number of reproductions:
1
Reference:
Ribeiro, G., Torres, S., Fernandes, A. B., Camacho, M., Oliveira Maia, A. J., & Study Group, F. (2019). Enhanced sweet taste sensitivity in candidates for bariatric surgery. Obesity Facts, 12(Suppl.1), 22-23.
Indexed document: Yes
Keywords: Obesity / Sweet taste

Enhanced sweet taste sensitivity in candidates for bariatric surgery

Enhanced sweet taste sensitivity in candidates for bariatric surgery
DocumentPsychometric properties of the Portuguese version of the Yale Food Addiction Scale2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.09
Location: Arquivo PCA - Pasta 14/2010
Title:
Psychometric properties of the Portuguese version of the Yale Food Addiction Scale
Publication year: 2017
URL:
https://link.springer.com/article/10.1007/s40519-016-0349-6
Abstract/Results: ABSTRACT:
PURPOSE:
Rising rates of obesity have been recently associated to the novel concept of food addiction (FA). The Yale Food Addiction Scale (YFAS) is the most widely used measure for examining FA (1) and analysis of its reliability and validity is expected to facilitate empirical research on the construct. Here, we tested the psychometric properties of a Portuguese version of the YFAS (P-YFAS), establishing its factor structure, reliability and construct validity.
METHODS:
Data were obtained from 468 Portuguese individuals, 278 sampled from non-clinical populations, and 190 among obese candidates for weight-loss surgery. A battery of self-report measures of eating behavior was applied.
RESULTS:
Confirmatory factor analysis verified a one-factor structure with acceptable fit, with item analysis suggesting the need to eliminate item 24 from the P-YFAS. Internal consistency (KR-20 = .82) and test-retest stability were adequate. Correlation analyses supported convergent and divergent validity of the P-YFAS, particularly in the clinical sample. Both FA symptom count and diagnosis, according to the P-YFAS, adequately discriminated between samples, with classification of FA met by 2.5 and 25.8% of the participants in the non-clinical and clinical samples, respectively.
CONCLUSIONS:
These findings reinforce the use of P-YFAS in non-clinical and clinical populations. Future directions for extending YFAS validation are discussed.
Accessibility: Document exists in file
Language:
eng
Author:
Torres, S.
Secondary author(s):
Camacho, M. , Costa, P. , Ribeiro, G. , Santos, O. , Vieira, F. M., Brandão, I. , Sampaio, D. , Oliveira-Maia, A.
Document type:
Article
Number of reproductions:
1
Reference:
Torres, S., Camacho, M., Costa, P., Ribeiro, G., Santos, O., Vieira, F. M., ... Oliveira-Maia, A. (2017). Psychometric properties of the Portuguese version of the Yale Food Addiction Scale. Eating and Weight Disorders, 22, 259–267. https://doi.org/10.1007/s40519-016-0349-6
2-year Impact Factor: 2.154|2017
Times cited: 29|2025-09-16
Indexed document: Yes
Quartile: Q3
Keywords: Food addiction / Obesity / Psychometrics / Reward

Psychometric properties of the Portuguese version of the Yale Food Addiction Scale

Psychometric properties of the Portuguese version of the Yale Food Addiction Scale
DocumentSweet taste and obesity2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.11
Location: Arquivo PCA - Pasta 14/2010
Title:
Sweet taste and obesity
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S0953620521000236
Abstract/Results: ABSTRACT:
For more than 50 years, there has been evidence for greater consumption of sweet- foods in overweight humans and animals, relative to those that have a normal weight. Furthermore, it has long been suggested that energy deficit resulting from dieting, while moving the individual from a higher weight set point, would result in heightened susceptibility to palatable tastants, namely to sweet tastants. This was the motivation behind the first studies comparing sweet taste perception between individuals with obesity and those of a normal weight. These studies, using direct measures of taste, have been characterized by significant methodological heterogeneity, contributing towards variability in results and conclusions. Nevertheless, some of these findings have been used to support the theory that patients with obesity have decreased taste perception, particularly for sweet tastants. A similar hypothesis has been proposed regarding evidence for reduced brain dopamine receptors in obesity and, in both cases, it is proposed that increased food consumption, and associated weight gain, result from the need to increase sensory and brain stimulation. However, the available literature is not conclusive on the association between obesity and reduced sweet taste perception, with both negative and contradictory findings in comparisons between individuals with obesity and normal weight control subjects, as well as within-subject comparisons before and after bariatric surgery. Nevertheless, following either Roux-en-Y gastric bypass or sleeve gastrectomy, there is evidence of changes in taste perception, particularly for reward-related measures of sweet tastants, that should be further tested and confirmed in large samples, using consensual methodology.
Accessibility: Document exists in file
Language:
eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Ribeiro, G.
Document type:
Article
Number of reproductions:
1
Reference:
Oliveira-Maia, A. J., & Ribeiro, G. (2021). Sweet taste and obesity. European Journal of Internal Medicine, 92, 3–10. https://doi.org/10.1016/j.ejim.2021.01.023
2-year Impact Factor: 7.749|2021
Times cited: 26|2025-09-20
Indexed document: Yes
Quartile: Q1
Keywords: Obesity / Bariatric surgery / Taste perception / Psychophysics / Reward-related feeding behavior

Sweet taste and obesity

Sweet taste and obesity
DocumentEnhanced sweet taste perception in obesity: Joint analysis of gustatory data from multiple studies2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.12
Location: BF-GMS
Title:
Enhanced sweet taste perception in obesity: Joint analysis of gustatory data from multiple studies
Publication year: 2022
URL:
https://www.frontiersin.org/articles/10.3389/fnut.2022.1028261/full
Abstract/Results: ABSTRACT:
INTRODUCTION:
While sweet taste perception is a potential determinant of feeding behavior in obesity, the supporting evidence is inconsistent and is typically associated with methodological limitations. Notably, possible associations between sweet taste perception and measures of food reward remain undetermined.
MATERIALS AND METHODS:
We conducted a cross-sectional analysis comparing 246 individuals with severe obesity and 174 healthy volunteers using a validated method for taste perception assessment. We included gustatory variables, namely intensity and pleasantness ratings of sour, salt, sweet, and bitter tastants, and taste thresholds assessed by electrogustometry. Reward-related feeding behavior, including hedonic hunger, food addiction, feeding behavior traits, and acceptance of foods and alcohol, was evaluated using self-rated scales for comparison with gustatory measures.
RESULTS:
In logistic regressions adjusted for age, gender, educational level, and research center, we found that a greater likelihood of belonging to the obesity group was associated with higher sweet intensity ratings (OR = 1.4, P = 0.01), hedonic hunger, food addiction symptoms, restrained and emotional eating (1.7 < OR = 4.6, all P = 0.001), and lower alcohol acceptance (OR = 0.6, P = 0.0002). Using principal component analysis, we found that while hedonic hunger, food addiction, and emotional eating were strongly interrelated, they were not associated with sweet intensity perception that, in turn, had a closer relationship with alcohol acceptance and restrained eating.
CONCLUSIONS:
We found that individuals with obesity report higher sweet taste intensity ratings than healthy controls. Furthermore, while psychological measures of reward-related feeding behavior assess a common construct, sweet intensity perception may represent a different obesity-related dimension.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, G.
Secondary author(s):
Torres, S., Fernandes, A. B., Camacho, M., Branco, T. L, Martins, S. S., Raimundo, A., Oliveira-Maia, A. J., Food Reward in Bariatric Surgery Portuguese Study Group
Document type:
Article
Number of reproductions:
1
Reference:
Ribeiro, G., Torres, S., Fernandes, A. B., Camacho, M., Branco, T. L., Martins, S. S., Raimundo, A., Oliveira-Maia, A. J., & Food Reward in Bariatric Surgery Portuguese Study Group (2022). Enhanced sweet taste perception in obesity: Joint analysis of gustatory data from multiple studies. Frontiers in Nutrition, 9, 1028261. https://doi.org/10.3389/fnut.2022.1028261
2-year Impact Factor: 5.000|2022
Times cited: 4|2025-09-24
Indexed document: Yes
Quartile: Q2
Keywords: Food reward / Gustation / Hedonic hunger / Obesity / Reward-related feeding behavior / Sweet taste / Taste perception

Enhanced sweet taste perception in obesity: Joint analysis of gustatory data from multiple studies

Enhanced sweet taste perception in obesity: Joint analysis of gustatory data from multiple studies
DocumentOpen-label placebos enhance test performance and reduce anxiety in learner drivers: A randomized controlled trial2024

Reference code: PT/FB/BL-2022-098.02
Location: BF-GMS
Title:
Open-label placebos enhance test performance and reduce anxiety in learner drivers: A randomized controlled trial
Publication year: 2024
URL:
https://doi.org/10.1038/s41598-024-56600-6
Abstract/Results: ABSTRACT:
Passing the driving school test can be very challenging, especially in big cities, where up to 52% of all students fail this test. Consequently, many learner drivers experience stress and anxiety. For some learner drivers these feelings can be extreme and negatively affect the performance in the driving test. Different strategies to face anxiety and stress are known, including, for example, psychological or pharmacological approaches and even placebo pills. Recent intriguing findings have also demonstrated that placebos without deception, so-called open-label placebos, successfully reduce anxiety. Here we aimed to test effects of this novel treatment for learner drivers. We investigated whether open-label placebos affect test performance and feelings of anxiety in learner drivers. Sixty-eight healthy participants (mean age 21.94 years, 26 females) were randomized into two groups. The open-label placebo group received placebo pills two weeks before the driving test (two pills each day). The control group received no treatment. Results revealed that the open-label placebo group experienced significantly less anxiety than the control group before the test (measured with the State-Trait-Anxiety-Inventory, STAI-S, and the German Test Anxiety Inventory, PAF). Moreover, in the open-label placebo group less learner drivers failed the driving test (29.41% vs. 52.95%). The results suggest that open-label placebos may provide an ethical unproblematic way to experience less anxiety and might also enhance the probability to pass the driving test. We discuss possible mechanisms of open-label placebos and limitations of our findings.
Accessibility: Document exists in file
Language:
eng
Author:
Schaefer, M.
Secondary author(s):
Enge, S.
Document type:
Article
Number of reproductions:
1
Reference:
Schaefer, M., & Enge, S. (2024). Open-label placebos enhance test performance and reduce anxiety in learner drivers: A randomized controlled trial. Scientific Reports, 14, 6684. https://doi.org/10.1038/s41598-024-56600-6
2-year Impact Factor: 3.9|2024
Times cited: 0|2025-09-26
Indexed document: Yes
Quartile: Q1
Keywords: Open-label placebo / Placebo / Anxiety / Test anxiety / Distress

Open-label placebos enhance test performance and reduce anxiety in learner drivers: A randomized controlled trial

Open-label placebos enhance test performance and reduce anxiety in learner drivers: A randomized controlled trial
DocumentOpen-label placebos reduce weight in obesity: A randomized controlled trial2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-098
Location: BF-GMS
Title:
098 - Neural correlates of open-label placebo effects in emotional distress
Duration: 2023-09
Researcher(s):
Michael Schaefer
Institution(s): Medical School Berlin (Germany)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Language: eng
Notes:
Ongoing project
Author: Schaefer, M.
Number of reproductions:
1
Keywords:
Emotion / Functional magnetic resonance imaging (fMRI) / Distress / Open-label placebo / Psychophysiology

Reference code: PT/FB/BL-2022-098.03
Location: BF-GMS
Title:
Open-label placebos reduce weight in obesity: A randomized controlled trial
Publication year: 2024
URL:
https://doi.org/10.1038/s41598-024-69866-7
Abstract/Results: ABSTRACT:
Obesity is a major public health problem worldwide. Different approaches are known to face this problem, for example, dieting, surgery, or drug interventions. It has also been shown that placebos may help to reduce weight and hunger feelings, but the use of placebos is linked to problems with respect to the patient-healthcare-provider relationship. However, recent studies demonstrated that even placebos without deception (open-label placebos) affect symptoms such as pain, anxiety, or emotional distress. Here we aimed to examine whether an open-label placebo may help to lose weight in obesity. Our study included fifty-seven overweight and obese patients who aimed to lose weight using a combination of diet and sports. Patients were randomly divided into two groups. Participants in the open-label placebo group received two placebos each day. A treatment-as-usual group received no pills. Primary outcome included changes of body weight. Secondary outcomes were change of eating behavior and self-management abilities. After 4 weeks we found that participants in the open-label placebo condition lost more weight than the treatment-as-usual group. Furthermore, OLP treatment affected eating behavior. No effects for self-management abilities were found. Although further research is necessary, open-label placebos might help individuals to lose weight.
Accessibility: Document exists in file
Language:
eng
Author:
Schaefer, M.
Secondary author(s):
Kühnel, A., Enge, S.
Document type:
Article
Number of reproductions:
1
Reference:
Schaefer, M., Kühnel, A., & Enge, S. (2024). Open-label placebos reduce weight in obesity: A randomized controlled trial. Scientific Reports, 14(1), 21311. https://doi.org/10.1038/s41598-024-69866-7
2-year Impact Factor: 3.9|2024
Times cited: 2|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Obesity / Overweight / Placebo / Open-label placebo / Eating behavior

Open-label placebos reduce weight in obesity: A randomized controlled trial

Open-label placebos reduce weight in obesity: A randomized controlled trial
DocumentPostingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.13
Location: BF-GMS
Title:
Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery
Publication year: 2024
URL:
https://doi.org/10.1371/journal.pbio.3002936
Abstract/Results: ABSTRACT:
Postingestive nutrient stimulation conditions food preferences through striatal dopamine and may be associated with blunted brain responses in obesity. In a cross-sectional study, we tested flavor-nutrient conditioning (FNC) with maltodextrin-enriched yogurt, with maltodextrin previously optimized for concentration and dextrose equivalents (n = 57), and to mask texture cues (n = 102). After conditioning, healthy volunteers (n = 52) increased preference for maltodextrin-paired (+102 kcal, CS+), relative to control (+1.8 kcal, CS-) flavors, as assessed according to intake, but not pleasantness. In a clinical study (n = 61), behavioral conditioning without effects on pleasantness was confirmed across pre-bariatric candidates with obesity, weight-stable post-surgery patients, and healthy controls, without significant differences between groups. Striatal dopamine D2-like receptor (DD2lR) availability, assessed with [123I]IBZM SPECT, was reduced in the obesity group and strongly correlated with conditioning strength and a measure of restrained eating in patients with gastric bypass. These results show that postingestive nutrient stimulation influences human food choices through behavioral reinforcement, and is conserved in obesity and after bariatric surgery.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, G.
Secondary author(s):
Fernandes, A. B., Oliveira, F. P. M., Duarte, J. S., Oliveira, M., Limbert, C., Costa, R. M., Costa, D. C., Oliveira-Maia, A. J.
Document type:
Article
Number of reproductions:
1
Reference:
Ribeiro, G., Fernandes, A. B., Oliveira, F. P. M., Duarte, J. S., Oliveira, M., Limbert, C., Costa, R. M., Costa, D. C., & Oliveira-Maia, A. J. (2024). Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery. PLoS Biology, 22(12), e3002936. https://doi.org/10.1371/journal.pbio.3002936
2-year Impact Factor: 7.2|2024
Times cited: 5|2025-09-27
Indexed document: Yes
Quartile: Q1
Keywords: Postingestive nutrient stimulation / Behavioral reinforcement / Flavor-nutrient conditioning (FNC) / Obesity / Bariatric surgery

Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery

Postingestive reward acts through behavioral reinforcement and is conserved in obesity and after bariatric surgery