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DocumentCognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.05
Location: Arquivo PCA - Pasta 19/2004
Title:
Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain
Publication year: 2009
URL:
http://www.sciencedirect.com/science/article/pii/S0306452209005909
Abstract/Results: ABSTRACT:
Forced choice between alternative options of unpredictable outcome is a complex task that requires continual update of the value associated with each option. Prefrontal areas such as the orbitofrontal cortex (OFC) have been shown to play a major role in performance on ambiguous decision-making tasks with substantial risk component, broadly named as “gambling tasks.” We have recently demonstrated that rats display complex decision-making behavior in a rodent gambling task based on serial choices between rewards of different value and probability. This rodent task retains many of the key characteristics of the human Iowa Gambling Task (IGT), and performance in this novel task is also disrupted by OFC or amygdalar lesioning. In the present study we addressed if rat models of chronic pain would have impaired performance in this gambling task, since it is already known that the IGT response patterns of human pain patients are comparable to individuals with OFC lesions. We found that animals with a monoarthritic inflammatory model of chronic pain systematically preferred the lever associated with larger but infrequent rewards. In addition, we measured the neurochemical content of the OFC, amygdala and nucleus accumbens using HPLC, and found that in prolonged chronic pain animals there was a decrease in the tonic levels of dopamine, DOPAC (3,4-hydroxyphenyl-acetic acid) and 5-HIAA (5-hydroxyindole-3-acetic acid) in the OFC. This is the first report of the effect of chronic pain in rat decision-making processes and supports the notion that pain may have profound effects on the functioning of the reward-aversion circuitry relevant to strategic planning.
Accessibility: Document exists in file (previous version submitted for publication/ in attachment to the final report)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pais-Vieira, M.
Secondary author(s):
Mendes-Pinto, M., Lima, D., Galhardo, V.
Document type:
Article
Number of reproductions:
1
Reference:
Pais-Vieira, M., Mendes-Pinto, M. M., Lima, D., & Galhardo, V. (2009). Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain. Neuroscience, 161(3), 671-679. https://doi.org/10.1016/j.neuroscience.2009.04.011
2-year Impact Factor: 3.292|2009
Times cited: 95|2025-02-07
Indexed document: Yes
Quartile: Q2
Keywords: Orbitofrontal cortex / Uncertainty / Monoarthritis / Reward / Gambling

Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain

Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain
DocumentLearning impairments and dopaminergic changes in monoarthritic rats2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.11
Location: Arquivo PCA - Pasta 19/2004
Title:
Learning impairments and dopaminergic changes in monoarthritic rats
Publication year: 2008
Accessibility:
Document exists in file (in attachment to the final report)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pais-Vieira, M.
Secondary author(s):
Mendes-Pinto, M., Lima, D., Galhardo, V.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Pais-Vieira, M., Mendes-Pinto, M., Lima, D., & Galhardo, V. (2008). Learning impairments and dopaminergic changes in monoarthritic rats [Unpublished document].
Indexed document: No
Keywords: Monoarthritis / Complete Freund's adjuvant / Dopamine / Hippocampus / Orbitofrontal cortex / Learning / Working memory / Reference memory

Learning impairments and dopaminergic changes in monoarthritic rats

Learning impairments and dopaminergic changes in monoarthritic rats
DocumentA neuropsychological examination of specific and global frontal lobe functions in siblings with and without eating disorders2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-061
Location: Arquivo PCA - Pasta 4/2004
Title:
061 - A neuropsychological examination of specific and global frontal lobe functions in siblings with and without eating disorders
Duration: 2005-08 - 2006-11
Researcher(s):
Ulrike Schmidt, Kate Tchanturia, Pei-Chi (Thomas) Liao
Institution(s): Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
3 Articles
1 Chapter book
Magazine of Eating Disorders Research Unit (2 copies)
Language: eng
Related objects:
PT/FB/BL-2002-88
Author: Schmidt, U.
Secondary author(s):
Tchanturia, K., Liao, P.-C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Mental health / Eating disorders / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2004-061.11
Location: Arquivo PCA - Pasta 4/2004
Title:
A neuropsychological examination of specific and global frontal lobe functions in siblings with and without eating disorders
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Patients with eating disorders favour immediate gratification and ignore long term negative consequences. These behaviours are reflected in data showing that individuals with anorexia nervosa (AN) have impaired decision-making (DM) ability. This study aimed to investigate DM in individuals with bulimia nervosa (BN) using the Iowa Gambling Task (IGT) and skin conductance responses (SCR).
METHODS:
A total of 26 BN patients and 51 healthy controls were recruited. Participants completed the IGT while
their SCR were recorded. Published data of 29 patients with AN were included as an additional clinical comparison group.
RESULTS:
Both of the AN and the BN groups performed poorly in the IGT in comparison with the HC group. The BN patients showed no decrease in SCR relative to the HC group whereas a markedly diminished SCR was seen in the AN group.
CONCLUSION:
Individuals with BN perform poorly on the IGT just like AN patients, but unlike the AN group, people with BN do not show diminished SCR. The divergence between SCR and the IGT performance is not consistent with the Somatic Marker Hypothesis. Impaired DM may be related to personality factors such as obsessive-compulsive traits.
PUBLICATIONS:
Tchanturia, K., Liao, P., Uher, R., Lawrence, N., Treasure, J., & Campbell, I. C. (2007): An investigation of decision making in anorexia nervosa using the Iowa Gambling Task and skin conductance measurements. Journal of International, Neuropsychological Society13:1-7. Liao, P., Uher R., Lawrence, N., Treasure, J., Schmidt, U., Campbell, I. C., Collier, D. A., & Tchanturia, K. (Submitted). An examination of decision-making ability in bulimia nervosa.
Accessibility: Document does not exist in file
Language:
eng
Author:
Schmidt, U.
Secondary author(s):
Tchanturia, K., Liao, P.-C.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Schmidt, U., Tchanturia, K., & Liao, P.-C. (2008). A neuropsychological examination of specific and global frontal lobe functions in siblings with and without eating disorders. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Orbitofrontal cortex / Iowa Gambling Task (IGT) / Somatic marker hypothesis / Anorexia Nervosa / Bulimia Nervosa

A neuropsychological examination of specific and global frontal lobe functions in siblings with and without eating disorders

A neuropsychological examination of specific and global frontal lobe functions in siblings with and without eating disorders
DocumentAltered processing in orbitofrontal cortex activity in monoarthritic rats during a rodent gambling task2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.19
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Altered processing in orbitofrontal cortex activity in monoarthritic rats during a rodent gambling task
Publication year: 2009
URL:
http://www.frontiersin.org/10.3389/conf.neuro.01.2009.11.030/event_abstract
Abstract/Results: ABSTRACT:
The orbitofrontal cortex (OFC) is fundamental for the update of reward value in decision making tasks in humans and animals. Previous works in rats have shown that lesions of the OFC, as well as chronic pain lead to impairment in the Rodent Gambling Task akin to the Iowa Gambling Task (Bechara et al., 1994). Here we used multielectrode recordings to study orbitofrontal cortex activity in rats performing this task during control and chronic pain conditions. As expected, control animals developed preference for low risk choices while monoarthritic rats developed preference for high risk choices. Neuronal activity showed that control animals present a higher proportion of cells that differentially fire for high and low risk choices during the whole task, while monoarthritic animals only present this differential activity in the beginning of the task. Comparison of neuronal responses to rewards showed that control animals presented a higher proportion of cells with different firing rates for high and low risk rewards, but that the pain group presented an increased number of cells that differentially fired for rewarded and non rewarded trials in the low risk lever. These results show for the first time altered orbitofrontal cortex processing during decision-making deficits in chronic pain conditions and support the notion that chronic pain alters the reward/aversion system.
Accessibility: Document does not exist in file
Language:
eng
Author:
Pais-Vieira, M.
Secondary author(s):
Aguiar, P., Lima, D., Galhardo, V.
Document type:
Abstract
Number of reproductions:
1
Reference:
Pais-Vieira, M., Lima, D., & Galhardo, V. (2009). Altered processing in orbitofrontal cortex activity in monoarthritic rats during a rodent gambling task. Frontiers in Neuroscience. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. https://doi.org/10.3389/conf.neuro.01.2009.11.030
Indexed document: No
Keywords: Orbitofrontal cortex / Decision-making / Rat / Iowa gambling task (IGT) / Chronic pain
DocumentGaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-106
Location: BF-GMS
Title:
106 - Gaze-centered decision making
Duration: 2023-02 - 2025-02
Researcher(s):
Rubén Moreno Bote, Benjamin Hayden, Demetrio Ferro
Institution(s): Center for Brain and Cognition, University Pompeu Fabra, Barcelona (Spain); Neuroscience Department, University of Minnesota (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Moreno-Bote, R.
Secondary author(s):
Hayden, B., Ferro, D.
Number of reproductions:
1
Keywords:
Imagination / Decision making / Gaze / Look-at-nothing

Reference code: PT/FB/BL-2022-106.02
Location: BF-GMS
Title:
Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex
Publication year: 2024
URL:
https://doi.org/10.1038/s41467-024-50214-2
Abstract/Results: ABSTRACT:
During economic choice, options are often considered in alternation, until commitment. Nonetheless, neuroeconomics typically ignores the dynamic aspects of deliberation. We trained two male macaques to perform a valuebased decision-making task in which two risky offers were presented in sequence at the opposite sides of the visual field, each followed by a delay epochwhere offerswere invisible. Surprisingly, during the two delays, subjects tend to look at empty locations where the offers had previously appeared, with longer fixations increasing the probability of choosing the associated offer. Spiking activity in orbitofrontal cortex reflects the value of the gazed offer, or of the offer associated with the gazed empty spatial location, even if it is not the most recent. This reactivation reflects a reevaluation process, as fluctuations in neural spiking correlate with upcoming choice. Our results suggest that look-at-nothing gazing triggers the reactivation of a previously seen offer for further evaluation.
Accessibility: Document exists in file
Language:
eng
Author:
Ferro, D.
Secondary author(s):
Cash-Padgett, T., Wang, M. Z., Hayden, B. Y., Moreno-Bote, R.
Document type:
Article
Number of reproductions:
1
Reference:
Ferro, D., Cash-Padgett, T., Wang, M. Z., Hayden, B. Y., & Moreno-Bote, R. (2024). Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex. Nature Communications, 15(1). https://doi.org/10.1038/s41467-024-50214-2
2-year Impact Factor: 14.7|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2025-02-19
Indexed document: Yes
Quartile: Q1
Keywords: Gaze-centered gating / Reactivation / Reevaluation / Orbitofrontal cortex

Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex

Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex