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BIAL Foundation
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DocumentFinal report - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction consolidation2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-160
Location: BF-GMS
Title:
160 - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction learning
Duration: 2019-04
Researcher(s):
Carmelo Vicario, Michael A Nitsche, Vuk Markovic
Institution(s): Department of Psychology and Neuroscience, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany); Department of Cognitive Science, University of Messina (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Notes:
Ongoing project
Author: Vicario, C.
Secondary author(s):
Nitsche, M. A., Markovic, V.
Number of reproductions:
1
Keywords:
tDCS / Fear extinction learning / Pre-frontal cortex / Psychophysiology

Reference code: PT/FB/BL-2018-160.01
Location: BF-GMS
Title:
Final report - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction consolidation
Publication year: 2024
Abstract/Results:
ABSTRACT:
Background
PTSD affects about 6.8% of people during their lifetime, often developing after severe trauma. One key factor in recovery failure is the inability to extinguish traumatic memories. Trauma-focused exposure therapy is effective for PTSD, as it promotes fear extinction, with the ventromedial prefrontal cortex (vmPFC) playing a central role.
Aims
This study aims to explore new avenues to promote fear extinction learning with the use of a non-invasive brain stimulation namely transcranial direct current stimulation (tDCS). We plan to test whether a prefrontal (PFC) modulation via tDCS, during sleep, boosts extinction learning. Moreover, we planned to investigate the neural correlates related to such extinction learning response.
Method
In all experiments, tDCS will be delivered during a nap of 90 minutes duration. In a first experiment, participants were exposed to a conditioning/extinction protocol combined with one non-invasive brain stimulation session (e.g., active or sham tDCS, depending on the experimental group) over the left vmPFC. The stimulation was delivered during the REM sleep stage. In a second experiment, applying a similar methodology, we investigated respective neural correlates using fMRI.
Results
The results of the first experiment show that real tDCS effectively enhanced fear extinction memory consolidation during REM sleep. These results are confirmed by the second experiment, with the tDCS group exhibiting greater activation in areas associated with motor control, sensory processing, and emotional regulation, particularly in the context of REM sleep.
Conclusions
Overall, the reported findings suggest that tDCS may enhance the neural substrates involved in fear extinction learning during REM sleep.
Accessibility: Document exists in file
Language:
eng
Author:
Vicario, C. M.
Document type:
Final report
Number of reproductions:
1
Reference:
Vicario, C. M. (2024). Final report - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction consolidation.
Indexed document: No
Keywords: Fear extinction / REM Sleep / tDCS / PFC

Final report - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction consolidation

Final report - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction consolidation