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DocumentProgress reports - Emotional factors in placebo analgesia: Psychophysiological Experiments 2004

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2002
Location: Arquivo PCA - Pastas 1 a 21/2002
Title:
2002 Grants
Start date: 2003-01 - 2009-11
Dimension/support:
21 caixas de arquivo

Reference code: PT/FB/BL-2002-028
Location: Arquivo PCA - Pasta 10/2002
Title:
028 - Emotional factors in placebo analgesia: Psychophysiological Experiments
Duration: 2003-03 - 2006-10
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Jan Brox, Arnstein Finset
Institution(s): Department of Clinical Research, University Hospital of North Norway (Norway)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Brox, J., Finset, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Emotion

Reference code: PT/FB/BL-2002-028.01
Location: Arquivo PCA - Pasta 10/2002
Title:
Progress reports - Emotional factors in placebo analgesia: Psychophysiological Experiments
Publication year: 2004
URL:
http://www.bial.com/imagem/Bolsa%202802.pdf
Abstract/Results: RESULTS:
Placebo analgesia is the reduction in pain after administration of an inert substance together with information that the substance is a painkiller.
EXP 1: Do positive expectations of drug treatment lead to decreased stress that mediate placebo analgesia? Stress was not affected. Placebo analgesia was seen in males only. All the experimenters were female nurses. Exp. 2 investigated whether the presence of a male or female experimenter modulated pain report in males and females.
EXP 2: Males who reported pain to females reported lower pain compared to males reporting to males. Females reported similar pain to both male and females. To investigate whether males who report lower pain to females feel less pain, or just report lower pain, Exp. 3 investigated the physiological response to pain in males and females tested by males and females.
EXP 3: Measures of heart rate variability (HRV), indicating autonomic response, were included. HRV to pain stimuli was similar in males reporting to females and males reporting to males, indicating that the response to pain was the same in both females and males. Thus, social context modulated pain report but not pain sensation.
EXP 4: Nocebo hyperalgesia is increased pain after administration of treatment signalling increased pain. A conditioned stimulus (CS) signalled the onset of pain. The CS increased pain report compared to control. The CS also increased stress and sympathetic response.
CONCLUSION:
Placebo analgesia is not related to decreased stress. Nocebo hyperalgesia is related to increased stress. Social context influences pain report. The effect of social context must be taken into consideration in all studies where pain is subjectively recorded.
Language: eng
Notes:
There is no final report. Progress reports in attachment.
Author: Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Brox, J., Finset, A.
Document type:
Progress report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Emotion / Placebo analgesia / Nocebo hyperalgesia / Stress

Novo ficheiro

Novo ficheiro

DocumentEmotional factors in placebo analgesia: Psychophysiological Experiments2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2002
Location: Arquivo PCA - Pastas 1 a 21/2002
Title:
2002 Grants
Start date: 2003-01 - 2009-11
Dimension/support:
21 caixas de arquivo

Reference code: PT/FB/BL-2002-028
Location: Arquivo PCA - Pasta 10/2002
Title:
028 - Emotional factors in placebo analgesia: Psychophysiological Experiments
Duration: 2003-03 - 2006-10
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Jan Brox, Arnstein Finset
Institution(s): Department of Clinical Research, University Hospital of North Norway (Norway)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Brox, J., Finset, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Emotion

Reference code: PT/FB/BL-2002-028.05
Location: Arquivo PCA - Pasta 10/2002
Title:
Emotional factors in placebo analgesia: Psychophysiological Experiments
Publication year: 2006
URL:
http://www.bial.com/imagem/1178809516livroactas.pdf
Accessibility: Document exists in file
Language:
eng
Author:
Flaten, A.
Secondary author(s):
Johansen, O., Simonsen, T., Brox, J., Finset, A.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Flaten, A., Johansen, O., Simonsen, T., Brox, J., Finset, A. (2006). Emotional factors in placebo analgesia: Psychophysiological Experiments. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 6th Symposium of Fundação Bial (pp. 236-237). Porto: Fundação Bial.
Indexed document: No
Keywords: Psychophysiology / Emotion / Placebo analgesia / Placebo response

Novo ficheiro

Novo ficheiro

DocumentFinal report - The relation of mind to body. Psychophysiological studies of the placebo effect2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.01
Location: Arquivo PCA - Pasta 12/2006
Title:
Final report - The relation of mind to body. Psychophysiological studies of the placebo effect
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa14406_28012014.pdf
Abstract/Results: ABSTRACT:
Placebo analgesia is the reduction in pain after administration of a placebo with information that it will reduce pain. We have shown that placebo analgesia can be objectively recorded by physiological measures (electromyography, heart rate variability, and event-related potentials (ERP)). Reduced ERPs indicate that placebos activate descending pain inhibitory pathways. The placebo response, or more precisely, the expectation of drug effects, can add to the effect of the drug. There is some evidence that placebo effects are strongest when expectations are reinforced by administration of an active drug. Of special importance to the present project was the investigation of the role of stress and negative emotions in placebo analgesia. Our hypothesis was that the placebo reduced stress and nervousness, and thereby reduced pain. Fear of pain was positively related to stress both during pain and in the anticipation of pain, and negatively related to placebo analgesia. However, other factors also contribute to the placebo analgesia. The present findings suggest that decreased stress may strengthen the placebo response. This may have important clinical consequences, as stress reduction could aid in treatment of pain. Furthermore, male subjects responded with lower stress after placebo medication, and larger placebo responses. These findings suggest that males respond differently to verbal placebo information compared to females. It is not know whether this is due to more effective pain inhibitory mechanisms in males, or to cognitive factors. In sum, there is a contribution of reduced stress to placebo analgesia, and for reasons unknown this effect is larger in males.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Flaten, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Placebo effect / Placebo analgesia / Pain / Event-related potential (ERP) / Emotion / Stress

Final report - The relation of mind to body. Psychophysiological studies of the placebo effect

Final report - The relation of mind to body. Psychophysiological studies of the placebo effect

DocumentThe roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.02
Location: Arquivo PCA - Pasta 12/2006
Title:
The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain
Publication year: 2008
URL:
http://www.ncbi.nlm.nih.gov/pubmed/18725424
Abstract/Results: ABSTRACT:
OBJECTIVE:
To examine whether reduction of negative emotions and associated autonomic activity could explain placebo analgesia, and to test the effect of experimenter gender on the placebo analgesic response.
METHODS:
Sixty-three (n = 32 females) students participated in a within-subjects design where subjects were tested on two separate days, one day for the experimental condition (placebo) and one day for the natural history condition. In the experimental condition, the participants received capsules containing lactose with information that the capsules were a high dose of a potent painkiller. In the natural history condition, the procedures were identical except that the placebo capsules were not administrated. The experimenters were blinded to the fact that all participants received placebo. Pain was induced by a thermode holding +46 degrees C with duration of 240 seconds to the forearm. Electrocardiogram was measured to obtain data for analysis of heart rate variability. Subjective measurements consisted of pain intensity, pain unpleasantness, stress, arousal, and mood.
RESULTS:
The results showed a placebo effect on pain intensity and a concomitant reduction in subjective stress and cardiac activity. Stepwise regressions revealed that reduced subjective stress was the only predictor for the placebo analgesic response. Contrary to our hypothesis, male subjects displayed increased placebo analgesia when a male acted as experimenter.
CONCLUSIONS:
The results indicate that reduced negative emotional activation could be a mechanism in placebo analgesia and that experimenter gender is probably not systematically related to placebo analgesia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Aslaksen, P., & Flaten, M. (2008). The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain. Psychosomatic Medicine, 70(7), 811-818. https://doi.org/10.1097/PSY.0b013e31818105ed
2-year Impact Factor: 3.460|2008
Times cited: 82|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Pain / Gender / Negative emotions / Autonomic activation

The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

The roles of physiological and subjective stress in the effectiveness of a placebo on experimentally induced pain

DocumentDrug effects: agonistic and antagonistic processes2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.03
Location: Arquivo PCA - Pasta 12/2006
Title:
Drug effects: agonistic and antagonistic processes
Publication year: 2009
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1467-9450.2009.00776.x/pdf
Abstract/Results: ABSTRACT:
The research presented here has shown that tolerance to drugs can be accelerated by conditioning processes. Placebo effects may be considered the opposite of tolerance, and we have shown that placebo effects may be objectively recorded by physiological measures (electromyography, skin conductance responses, and event-related potentials), as well as by behavioral and subjective methods. The placebo response, or more precisely, the expectation of drug effects, can add to the effect of the drug. Drug antagonistic expectations can also reverse the effect of the drug. There is some evidence that placebo effects are strongest when expectations are reinforced by administration of an active drug. Expectations have graded effects and may affect symptoms to a smaller or larger degree. Although drug effects can be considered stimuli, the investigation of the role of classical conditioning in drug use and drug effects involves special issues that must be carefully considered.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Flaten, M. A. (2009). Drug effects: agonistic and antagonistic processes. Scandinavian Journal of Psychology, 50(6), 652-659. https://doi.org/10.1111/j.1467-9450.2009.00776.x
2-year Impact Factor: 1.148|2009
Times cited: 9|2025-02-07
Indexed document: Yes
Quartile: Q2
Keywords: Placebo response / Placebo effect / Placebo analgesia / Startle / Classical conditioning / Expectancy

Drug effects: agonistic and antagonistic processes

Drug effects: agonistic and antagonistic processes

DocumentIs fear of pain related to placebo analgesia?2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.04
Location: Arquivo PCA - Pasta 12/2006
Title:
Is fear of pain related to placebo analgesia?
Publication year: 2010
URL:
http://www.sciencedirect.com/science/article/pii/S0022399909004553
Abstract/Results: ABSTRACT:
OBJECTIVE:
Verbal information that a painkiller has been administered generates an expectation of pain relief which in turn decreases pain. This expectation-based pain reduction is termed placebo analgesia. We hypothesized that fear of pain would be related to higher stress and pain intensity and to reduced placebo analgesia.
METHODS:
Sixty-three students (30 females) participated in a Two-Condition (placebo, natural history)xFive-Test (one pretest, four post-tests) within-subjects design. Heat pain was induced by a 30x30-mm contact thermode to the medial volar forearm. Each pain test lasted for 4 min at a temperature of 46 degrees C. Stress, arousal, and pain intensity and pain unpleasantness were rated on 100-mm visual analogue scales.
RESULTS:
Fear of pain was related to higher anticipatory stress and to higher stress and pain intensity during pain. Fear of pain was also related to reduced placebo analgesic responding.
CONCLUSION:
Fear of pain was positively related to stress both during pain and in the anticipation of pain, and negatively related to placebo analgesia. Previous research has indicated a role for increased stress in the nocebo response, and the present findings suggest that decreased stress may strengthen the placebo response.
Accessibility: Document exist in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Aslaksen, P., Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Lyby, P., Aslaksen, P., & Flaten, M. (2010). Is fear of pain related to placebo analgesia? Journal of Psychosomatic Research, 68(4), 369-377. https://doi.org/10.1016/j.jpsychores.2009.10.009
2-year Impact Factor: 2.842|2010
Times cited: 71|2025-02-07
Indexed document: Yes
Quartile: Q2
Keywords: Placebo analgesia / Expectancy / Fear of pain / Stress

Is fear of pain related to placebo analgesia?

Is fear of pain related to placebo analgesia?

DocumentGender differences in placebo analgesia: event-related potentials and emotional modulation2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.05
Location: Arquivo PCA - Pasta 12/2006
Title:
Gender differences in placebo analgesia: event-related potentials and emotional modulation
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21217098
Abstract/Results: ABSTRACT:
OBJECTIVES:
To examine whether there are gender differences in event-related potential (ERP) responses to painful stimulation after administration of placebo medication; and to investigate whether placebo medication reduces anticipatory stress and if this reduction can explain the placebo analgesic response. Several experimental and clinical studies have shown that males report lower pain compared with females. There are, however, few reports of gender differences in placebo analgesia.
METHODS:
All subjects (n = 33; 17 women) participated in both a natural history and a placebo condition. ERPs were evoked by heat pulses with a peak at 52 °C.
RESULTS:
The results showed that pain unpleasantness and the N2/P2 ERP components were reduced in the placebo condition compared with the natural history condition. Only men displayed placebo responses in pain report and in the P2 component. Anticipatory stress was reduced after placebo administration, and the reduction in anticipatory stress was significantly related to the placebo effect on pain. Regression analyses revealed that the interaction of gender by anticipatory stress was significantly related to the mean placebo response, with men responding with lower stress after placebo medication, and larger placebo responses.
CONCLUSIONS:
A placebo response on pain unpleasantness was observed in men only, and reduced stress after placebo administration was observed in males only. Thus, reduced stress may be a mechanism for placebo responses in pain.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.06
Author: Aslaksen, P.
Secondary author(s):
Vambheim, S., Bystad, M., Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Aslaksen, P., Vambheim, S., Bystad, M., & Flaten, M. (2011). Gender differences in placebo analgesia: event-related potentials and emotional modulation. Psychosomatic Medicine, 73(2), 193-199. https://doi.org/10.1097/PSY.0b013e3182080d73
2-year Impact Factor: 3.968|2011
Times cited: 88|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Pain / Placebo analgesia / Event-related potential (ERP) / Gender differences / Emotions

Gender differences in placebo analgesia: event-related potentials and emotional modulation

Gender differences in placebo analgesia: event-related potentials and emotional modulation

DocumentInteraction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.06
Location: Arquivo PCA - Pasta 12/2006
Title:
Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pubmed/21384106
Abstract/Results: ABSTRACT:
RATIONALE:
In a randomised placebo-controlled clinical trial it is assumed that psychosocial effects of the treatment, regression to the mean and spontaneous remission are identical in the drug and placebo group. Consequently, any difference between the groups can be ascribed to the pharmacological effects. Previous studies suggest that side effects of drugs can enhance expectancies of treatment effects in the drug group compared to the placebo group, and thereby increase placebo responses in the drug group compared to the placebo group.
OBJECTIVES:
The hypothesis that side effects of drugs can enhance expectancies and placebo responses was tested.
METHOD:
Painful laser stimuli were delivered to 20 healthy subjects before and after administration of a drink with 0 or 4 mg/kg caffeine. The drink was administered either with information that it contained a painkiller or that it was a placebo. Laser-evoked potentials and reports of pain, expectancy, arousal and stress were measured.
RESULTS:
Four milligrammes per kilogramme of caffeine reduced pain. Information that a painkiller was administered increased the analgesic effect of caffeine compared to caffeine administered with no drug information. This effect was mediated by expectancies. Information and expectancies had no effect on pain intensity when 0 mg/kg was administered.
CONCLUSION:
The analgesic effect of caffeine was increased by information that a painkiller was administered. This was due to an interaction of the pharmacological action of the drug and expectancies. Hence, psychosocial effects accompanying a treatment can differ when an active drug is administered compared to a placebo.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.07
Author: Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Bjørkedal, E., & Flaten, M. (2011). Interaction between expectancies and drug effects: An experimental investigation of placebo analgesia with caffeine as an active placebo. Psychopharmacology, 215(3), 537-548. https://doi.org/10.1007/s00213-011-2233-4
2-year Impact Factor: 4.077|2011
Times cited: 38|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Pain / Expectancies / Laser-evoked potentials / Active placebo / Caffeine / Arousal / Balanced placebo design

Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo

Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo

DocumentThe relation of emotions to placebo responses2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.07
Location: Arquivo PCA - Pasta 12/2006
Title:
The relation of emotions to placebo responses
Publication year: 2011
URL:
http://rstb.royalsocietypublishing.org/content/366/1572/1818.full.pdf
Abstract/Results: ABSTRACT:
The hypothesis put forth is that expectations of treatment effects reduce negative emotions and thereby reduce symptoms, e.g. pain. Negative emotions increase pain, and it is hypothesized that placebos reduce pain by reducing negative emotions, i.e. feelings of nervousness, fear and anxiety. Placebo analgesia has been shown to be mediated via opioid activity, and relaxation increases opioid activity. The placebo acquires its relaxing effect due to verbal information that pain will be reduced, or due to associations between the placebo and the reduction in pain after effective treatment. Thus, the placebo signals that unpleasantness will be less after administration of the placebo. This involves negative reinforcement which is due to activation of a dopaminergic system that has been found to be activated during placebo analgesia and is involved in positive emotions. The nocebo effect of increased pain is, consistent with this model, because of increased fear and anxiety. The new aspect of the presented model is the hypothesis that expectations reduce negative emotions, and that negative reinforcement that involves the dopaminergic reinforcement system should be a contributor to placebo responses.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2010-186.08
Author: Flaten, M.
Secondary author(s):
Aslaksen, P., Lyby, P., Bjørkedal, E.
Document type:
Article
Number of reproductions:
1
Reference:
Flaten, M., Aslaksen, P., Lyby, P., & Bjørkedal, E. (2011). The relation of emotions to placebo responses. Philosophical Transactions of the Royal Society B, 366, 1818–1827. https://doi.org/10.1098/rstb.2010.0407
2-year Impact Factor: 6.401|2011
Times cited: 109|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo effect / Placebo analgesia / Pain / Emotion / Classical conditioning / Operant conditioning

The relation of emotions to placebo responses

The relation of emotions to placebo responses

DocumentVariability in placebo analgesia and the role of fear of pain - an ERP study2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.08
Location: Arquivo PCA - Pasta 12/2006
Title:
Variability in placebo analgesia and the role of fear of pain - an ERP study
Publication year: 2011
URL:
http://www.painjournalonline.com/article/S0304-3959(11)00450-7/abstract
Abstract/Results: ABSTRACT:
Fear of pain (FOP) and its effect on placebo analgesia was investigated. It was hypothesized that FOP should interfere with placebo-mediated pain inhibition and result in weaker placebo responding in pain intensity, pain unpleasantness, stress, and event-related potentials to contact heat pain. Thirty-three subjects participated in a balanced 2 condition (natural history, placebo)×3 test (pretest, posttest 1, posttest 2) within-subject design, tested on 2 separate days. FOP was measured by the Fear of Pain Questionnaire and subjective stress by the Short Adjective Check List. Placebo effects were found on reported pain unpleasantness and N2 and P2 amplitudes. FOP was related to reduced placebo responding in pain unpleasantness, but this was only evident for the subjects who received the placebo condition on day 1. Subjects who received the placebo condition on day 1 experienced more pretest stress than those who received the placebo condition on day 2 (ie, reversed condition order), and this explained the interaction effect on placebo responding. FOP was related to reduced placebo responding on P2 amplitude, whereas placebo responding on N2 amplitude was unaffected by FOP. Higher placebo responses on N2 and P2 amplitudes were both related to higher placebo analgesic magnitude in pain unpleasantness. In conclusion, increased FOP was found to reduce subjective and electrophysiological placebo analgesic responses.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
PT/FB/BL-2010-186.09
Author: Lyby, P.
Secondary author(s):
Aslaksen, P., Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Lyby, P., Aslaksen, P., & Flaten, M. (2011). Variability in placebo analgesia and the role of fear of pain - an ERP study. Pain, 152(10), 2405-2412. https://doi.org/10.1016/j.pain.2011.07.010
2-year Impact Factor: 5.777|2011
Times cited: 79|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Placebo analgesia / Individual differences / Fear of pain / Event-related potential (ERP) / Contact heat-evoked potentials

Variability in placebo analgesia and the role of fear of pain—an ERP study

Variability in placebo analgesia and the role of fear of pain—an ERP study

DocumentThe role of subject and experimenter gender in pain and placebo analgesia2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.12
Location: Arquivo PCA - Pasta 12/2006
Title:
The role of subject and experimenter gender in pain and placebo analgesia
Publication year: 2007
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/2007Abstracts.pdf
Abstract/Results: ABSTRACT:
In a previous experiment (Flaten et al. 2006, J Psychosom Res) placebo analgesia was observed in males only, whereas females did not display a placebo response. One possible explanation for this may have been the social context since all procedures were administrated by female experimenters. Follow-up studies showed that reported pain was significantly reduced in males when the report was given to a female experimenter compared to pain reported to a male experimenter. Pain report in females, on the other hand,
was not modulated by social context. Verbal report of arousal was also modulated the same way as pain, i.e., males reported being more calm in the presence of a female experimenter compared to arousal reported in the presence of a male experimenter. However, heart rate variability indicated increased sympathetic activation in males when a female experimenter was present. These results suggest that verbal report in males is heavily influenced by social context, and that additional measures, less affected by social context,
need to be used in the study of pain and placebo analgesia. Data will be presented showing the roles of subject and experimenter gender in placebo analgesia.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Document type:
Abstract
Number of reproductions:
1
Reference:
Flaten, M. (2007). The role of subject and experimenter gender in pain and placebo analgesia. Meeting abstracts. Psychosomatic Medicine, 69(1), A-78.
Indexed document: Yes
Keywords: Experimenter gender / Pain report / Heart rate variability (HRV) / Placebo analgesia / Gender roles

The role of subject and experimenter gender in pain and placebo analgesia

The role of subject and experimenter gender in pain and placebo analgesia

DocumentThe effect of subject and experimenter gender on pain and placebo analgesia2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.13
Location: Arquivo PCA - Pasta 12/2006
Title:
The effect of subject and experimenter gender on pain and placebo analgesia
Publication year: 2007
URL:
http://www.placebo-vw.unito.it/Immagini/Tutzing-program.pdf
Abstract/Results: ABSTRACT:
Pain report has in several reports been shown to be modulated by the interaction of subject gender with experimenter gender. Our studies showed that male subjects reported less pain to female experimenters compared with pain reported to male experimenters. The social context also modulated subjective reports of stress and arousal, with male subjects reporting less stress and arousal to female experimenters. These findings show the importance of objective measurement of pain and stress, alternatively that relevant controls for social context are used in the experiment.
As the pain report is a central element in placebo analgesia, gender could also play a role in placebo analgesia. Two experiments tested whether gender modulated placebo analgesia induced by verbal information or by classical conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Aslaksen, P., & Flaten, M. (2007). The effect of subject and experimenter gender on pain and placebo analgesia. In Abstract book of the Symposium on Mechanisms of Placebo/Nocebo Responses (p. 18). Tutzing, Germany.
Indexed document: No
Keywords: Experimenter gender / Pain report / Stress / Arousal / Placebo analgesia

The effect of subject and experimenter gender on pain and placebo analgesia

The effect of subject and experimenter gender on pain and placebo analgesia

DocumentEmotional factors in placebo analgesia2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.14
Location: Arquivo PCA - Pasta 12/2006
Title:
Emotional factors in placebo analgesia
Publication year: 2007
URL:
http://www.placebo-vw.unito.it/Immagini/Tutzing-program.pdf
Abstract/Results: ABSTRACT:
Treatment for pain induces an expectation that pain will be reduced after the treatment. Research has shown that the expectation alone can reduce pain, and this has been termed placebo analgesia. However, expectation of reduced pain may also have other consequences, one of them being a reduction in stress or negative emotion. Stress and negative emotions have been found to increase pain, and it could be hypothesized that placebo analgesia is mediated via a reduction in stress. Experiments that test the hypothesis will be presented. Subjects scoring high on the Fear of Pain questionnaire displayed high levels of stress before application of the pain stimuli, as expected, and data from these subjects are of special interest for the hypothesis.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Secondary author(s):
Aslaksen, P.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Flaten, M., & Aslaksen, P. (2007). Emotional factors in placebo analgesia. In Abstract book of the Symposium on Mechanisms of Placebo/Nocebo Responses (p. 22). Tutzing, Germany.
Indexed document: No
Keywords: Placebo analgesia / Fear of pain / Stress / Negative emotions

Emotional factors in placebo analgesia

Emotional factors in placebo analgesia

DocumentThe effect of gender on placebo analgesia after classical conditioning2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.16
Location: Arquivo PCA - Pasta 12/2006
Title:
The effect of gender on placebo analgesia after classical conditioning
Publication year: 2008
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={DEE465B2-6FF9-405C-B44F-BFDF087CA098}&SKey={4B674E01-8788-4BD6-89B1-6B8A26E1329D}&MKey={C9574065-70A7-4248-B115-6786733F7556}&AKey={51FD9D5C-B558-4333-95E6-175995909423}
Abstract/Results: ABSTRACT:
AIM OF INVESTIGATION:
Previous studies have shown that placebo analgesia can occur after both classical conditioning and verbal information. Placebo analgesic responding to verbal information has been reported to be increased in males. The effect of subject gender on placebo analgesic responding after conditioning has not been investigated.
METHODS:
69 subjects (38 females) participated. Pain was induced by a thermode attached to the right forearm. Pain was induced 4 times for 2 minutes. In the Conditioned group, temperatures were increased from -100C to 0 and +50C after administration of placebo capsules. A conditioned stimulus (CS) control group received the capsules (CSs) but temperatures were kept constant at -100C after administration of the capsules. An unconditioned stimulus (US) control group did not receive the capsules, but the temperatures were increased as in the Conditioned group. Placebo analgesic responding was assessed when pain at -100C was applied in all groups at the end of the experiment. Placebo analgesic responding, i.e., reports of lower pain to -100C was expected in the Conditioned group, but not in the two control groups. The experimenters (two females and two males) were blind to whether the subjects received a placebo or an actual painkiller.
RESULTS:
There were no significant differences in the pre-test between the groups. There was a main effect of groups in the pain unpleasantness data (p<0.001) due to lower pain ratings in the Conditioned group compared to the US control group (p=0.02). There was no difference in pain unpleasantness between the Conditioned group and the CS control group. Cold pain thresholds were lower in the Conditioned and CS control group compared to the US control group (p=0.036). Females reported lower pain unpleasantness to male experimenters compared to female experimenters in the post-test in the Conditioned group (p=0.005). There were no other significant gender effects of conditioning on placebo analgesia. Male subjects displayed lower cold pain thresholds (p=0.03) than females regardless of group allocation. There was a main effect of gender on stress across groups, with male subjects reporting lower stress than females (p<0.01). There were no significant placebo effects on pain intensity, arousal or cortisol.
CONCLUSIONS:
Administration of placebo capsules in the Conditioned group decreased pain compared to the US control group that received identical pain stimulation but no capsules. However, administration of placebo capsules decreased pain even when the capsules were not related to a decrease in pain. Most likely this was due to the participants previous history with painkillers. There were no effects of subject gender on placebo analgesia after conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Lyby, P., Bjørkedal, E., Flaten, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Aslaksen, P., Lyby, P., Bjørkedal, E., & Flaten, M. (2008, August). The effect of gender on placebo analgesia after classical conditioning. Poster presented at the 12th World Congress on Pain, Glasgow, UK. Abstract retrieved from http://www.abstractsonline.com/viewer/?mkey=%7BC9574065%2D70A7%2D4248%2DB115%2D6786733F7556%7D
Indexed document: No
Keywords: Placebo analgesia / Pain

DocumentIs there a placebo responder?2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.18
Location: Arquivo PCA - Pasta 12/2006
Title:
Is there a placebo responder?
Publication year: 2008
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={B3B9FDB9-2CE9-4F65-968D-B9668D1589B2}&SKey={140A3D71-1A65-43A4-BA8D-1D19B9481117}&MKey={C9574065-70A7-4248-B115-6786733F7556}&AKey={51FD9D5C-B558-4333-95E6-175995909423}
Abstract/Results: ABSTRACT:
AIM OF INVESTIGATION:
Both verbally induced expectation and conditioning procedures have been reported as important underlying psychological mechanisms of placebo analgesia. There is great variability in this analgesic response, suggesting a role for individual differences. The present study investigated the relation of personality factors to placebo analgsia. Placebo analgesic responses were classically conditioned by pairing administration of placebo capsules with surreptitious lowering of pain intensity in one group. In one control group, placebo capsules were administrated while pain intensity was kept unchanged. In a second control group, placebo capsules were not administrated while pain intensity was lowered.
METHODS:
69 subjects (38 females) participated in the study. The subjects were randomly assigned to three groups where cold pain was induced by a thermode attached to the right volar forearm. Cold pain was delivered four times, each exposure lasting for 2 minutes. In the conditioned group temperatures increased from -100C to 00C to +50C across the three first pain exposures after the administration of placebo capsules. A conditioned stimulus (CS) control group also received the capsules but the temperatures were kept constant (-100C) after the administration of the capsules. An unconditioned (US) control group received the same temperatures as the conditioned group but did not receive the capsules. The placebo analgesic response was assessed by adding a fourth cold pain induction at -100C at the end of the experiments in all three groups. We hypothesized that placebo analgesic responding would occur in the conditioned group but not in the other two. The Cattell 16PF and the Fear of Pain Questionnaire were administered prior to the experimental procedures. Placebo analgesia was defined as a reduction in pain from the first to the last pain induction.
RESULTS:
Placebo analgesia was observed in the conditioned group, and somewhat surprisingly also in the CS control group, compared to the US control group. No personality factors predicted the placebo analgesic response. The anxiety factor on the 16PF inventory positively predicted cortisol levels (ß = .26, t = 2.2, p = .031). Fear of pain positively predicted pain intensity (ß = .2, t = 2.51, p = .014), pain unpleasantness (ß = .25, t = 2.16, p = .034), and stress scores (ß = .27, t = 2.3, p = .024).
CONCLUSIONS:
A placebo responder subtype could not be identified in the personality tests used in the present study. This supports the idea that variability in placebo responses are not due to personality traits, but are due to past experiences and situational factors.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Bjørkedal, E., Aslaksen, P., Flaten, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Lyby, P., Bjørkedal, E., Aslaksen, P., & Flaten, M. (2008). Is there a placebo responder? Poster presented at the 12th World Congress on Pain, Glasgow, UK. Abstract retireved from http://www.abstractsonline.com/viewer/?mkey=%7BC9574065%2D70A7%2D4248%2DB115%2D6786733F7556%7D
Indexed document: No
Keywords: Placebo analgesia / Classical conditioning / Fear of pain / Personality / Stress

DocumentEvent-related potentials to painful stimuli are reduced during placebo analgesia2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.19
Location: Arquivo PCA - Pasta 12/2006
Title:
Event-related potentials to painful stimuli are reduced during placebo analgesia
Publication year: 2009
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/meeting2009/meetingAbstract2009.pdf
Abstract/Results: ABSTRACT:
PURPOSE:
Placebo analgesia refers to a reduction in recorded pain after administration of a capsule containing an inactive ingredient, with the information that it is a powerful painkiller. The present study investigated if placebo analgesia could be observed as reduced cortical response to heat stimuli. If placebo analgesia was associated with a reduced cortical response, this would indicate that the pain signal was reduced prior to cortical processing. A capsule containing an inactive ingredient was administrated with information that it was a powerful painkiller in the Placebo condition. Contact heat stimulation was administrated to the arm before and after the administration of the capsule. In the Natural History condition, heat stimuli were administrated without the capsule and the information.
SUBJECTS:
Forty (20 females) healthy volunteers aged 19 to 40 years.
METHODS:
Painful heat stimuli at 51 C with abrupt rise time and duration of less than 0.1sec were administrated by a thermode applied to the lower arm. Pain was recorded by a visual analogue scale, and by 32 channel electroencephalography. Event-related potentials (ERPs) to painful stimulation were computed by the Vision Analyzer software. A withinsubject design was used. All subjects were run in a Placebo condition where pain was applied before and after administration of a capsule with information that it was a painkiller, and a Natural History condition where pain was applied, but no capsule was administrated. The order of the conditions was counterbalanced.
RESULTS:
Pain unpleasantness was reduced in the Placebo condition compared to the Natural History condition (F = 7.95, p = .01). The P2 component in the ERP data was reduced in the Placebo condition compared to the Natural History condition (F = 3.39, p = .045).
CONCLUSIONS:
Placebo analgesic responding was observed as reduced pain report and as reduced cortical response to painful stimuli. This indicates that the pain signal to the brain is reduced by information that a powerful painkiller has been administrated, and that the placebo response is not due to response bias.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract
Number of reproductions:
1
Reference:
Aslaksen, P., & Flaten, M. (2009). Event-related potentials to painful stimuli are reduced during placebo analgesia. Psychosomatic Medicine, 71(3), A - 103.
Indexed document: Yes
Keywords: Placebo analgesia / Heat pain / Cortical response / Event-related potential (ERP)

Event-related potentials to painful stimuli are reduced during placebo analgesia

Event-related potentials to painful stimuli are reduced during placebo analgesia

DocumentPlacebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.21
Location: Arquivo PCA - Pasta 12/2006
Title:
Placebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress
Publication year: 2009
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=c1d0bb63-590d-4b97-b41b-1109ba7db4d1&cKey=89a4f0b3-17b0-4dea-8b65-4043ea5c50be&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d
Abstract/Results: ABSTRACT:
Placebo analgesia refers to reduced pain report after administration of a placebo with information that it is a painkiller. This study investigated whether placebo analgesia could be observed as a reduced cortical response to pain, and whether placebo analgesia could be related to reduction in stress. Thirty-three participants (17 females) were exposed to phasic contact heat pain at 510C before and 10-30 minutes after administration of capsules containing lactose with information that the capsules contained a powerful painkiller. In a control condition the participants were exposed to the same painful stimuli, but the capsules were not administrated. The placebo and control conditions were separated by a minimum of 24 hours, and the order of the conditions was balanced. Pain report was recorded on a visual analogue scale, and cortical activity to painful stimulation was recorded by electroencephalography from 32 electrodes with linked ears reference. Only data from the Cz electrode are reported here. Phasic painful stimulation reliably generates cortical activity that can be observed as a positive component at about 200-300 ms after stimulus onset in the event related potential. The results showed significantly lower pain unpleasantness, and a significantly reduced P2 component in the placebo condition. Placebo analgesia was also related to a decrease in stress levels. The findings indicate that placebo analgesia is due to a reduced nociceptive signal to the cortex, or to reduced processing of the nociceptive signal in the cortex.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Vambheim, S., Bystad, M., Solbakken, L., Sjølie, E., Thorvaldsen, J., Flaten, M., Aslaksen, P.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Lyby, P., Vambheim, S., Bystad, M., Solbakken, L., Sjølie, E., Thorvaldsen, J., Flaten, M., & Aslaksen, P. (2009). Placebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress. Program No. 654.20/Z31. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. Online.
Indexed document: No
Keywords: Pain / Placebo analgesia / Electroencephalogram (EEG) / Cortical response

DocumentGender effects in classical conditioning of placebo analgesia2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.24
Location: Arquivo PCA - Pasta 12/2006
Title:
Gender effects in classical conditioning of placebo analgesia
Publication year: 2010
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/meeting2010/abstract2010.pdf
Abstract/Results: ABSTRACT:
PURPOSE:
Studies where placebo analgesia has been induced by verbal information have shown larger placebo analgesic responses in males compared to females. In the present study, the role of subject gender in classical conditioning of placebo analgesia was investigated. The Conditioned group received capsules containing an inactive ingredient with subsequent reduction in the intensity of a painful stimulus. Two other groups controlled for reduced pain intensity, and whether administration of the capsules decreased pain in the absence of programmed pairings of capsules with reduced pain. It was predicted that placebo analgesia should be observed in the Conditioned group compared to the control groups.
SUBJECTS AND METHODS:
Sixty-nine participants (38 females) received -10 degrees C to the arm for two minutes in a pre-test. The subjects were told that the capsules may or may not contain a painkiller. Thereafter, the Conditioned group
received one capsule, followed after 10 minutes by application of 0 degrees C for two minutes. After a brief pause the subjects received one more capsule followed after 10 minutes by application of +5 degrees C to the arm. Thereafter, a third capsule was administrated. Finally, a post-test identical to the pre-test was administrated. The Capsule control group received the same capsules as the Conditioned group, but -10 degrees C in all stimulations. The Pain control group did not receive the capsules, but received the same painful stimulation as the Conditioned group. The post-test was identical in all groups.
RESULTS:
Pain unpleasantness: main effect of Group (F=6.53, p =.003) due to lower pain ratings in the Conditioned group compared to the Pain control group. Similar findings for pain intensity. Lower pain in the Capsule control group compared to the Pain control group. Cortisol: Lower in males in the Conditioned group (F=2.56, p=.043). The results showed no clear relation between gender and placebo analgesic responding. Administration of capsules induced placebo analgesia in the absence of conditioning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Secondary author(s):
Bjørkedal, E., Lyby, P., Figenschau, Y., Aslaksen, P.
Document type:
Abstract
Number of reproductions:
1
Reference:
Flaten, M., Bjørkedal, E., Lyby, P., Figenschau, Y., & Aslaksen, P. (2010). Gender effects in classical conditioning of placebo analgesia. Psychosomatic Medicine, 72(3), A - 91.
Indexed document: Yes
Keywords: Placebo analgesia / Classical conditioning / Subject gender / Pain

Gender effects in classical conditioning of placebo analgesia

Gender effects in classical conditioning of placebo analgesia

DocumentThe relation of mind to body. Psychophysiological studies of the placebo effect2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.25
Location: Arquivo PCA - Pasta 12/2006
Title:
The relation of mind to body. Psychophysiological studies of the placebo effect
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Placebo analgesia refers to the observation that pain is often reduced after administration of a placebo with information that it contains a powerful painkiller. The information has been found to generate an expectation of reduced pain, hypothesized to activate descending, endorphin mediated pain inhibitory mechanisms. This series of experiments tested the idea that reduced stress and negative emotions mediate the effect of the expectation of pain relief.
METHODS:
In all studies, placebo analgesic responding was defined as the difference in pain levels between a group or condition were subjects received inactive treatment with information that it reduced pain, and a group or condition where no treatment and no information was administrated. Pain was induced in healthy volunteers via a thermode where temperatures were increased (Experiments 1-4) or decreased (Experiment 5) to painful levels. Pain was recorded by visual analogue scales (VAS), by event related potentials (ERPs), or heart rate variability. Emotions were recorded by VAS and the Fear of Pain Questionnaire. Expectations were induced via information (Experiment 1-4) or via a classical conditioning procedure where pain levels were reduced after administration of placebo capsules to induce an expectation of reduced pain after intake of the capsules (Experiment 5). Placebos were capsules containing lactose (Experiments 1,2,4,5) or other procedures that could affect pain (diffuse noxious inhibitory control, Experiment 3).
RESULTS:
Information that a painkiller had been administrated reduced pain and event related potentials to painful stimulation. Regression analyses found that high levels of stress or negative emotions prior to onset of the experiment, predicted reduced placebo analgesia. Individuals that were fearful of pain had higher stress levels, more pain, and displayed reduced placebo analgesia. Increased pain after placebo administration was
observed in some of these individuals. Fear of pain predicted event related potential amplitude.
CONCLUSIONS:
Placebo responses could be seen in subjective and neurophysiological response to painful stimulation. Higher levels of negative emotions prior to painful stimulation reduced placebo analgesic responding, and subjective stress levels were lower in subjects receiving placebo compared to subjects not receiving any treatment. Thus, reduced negative emotions could be one mechanism in placebo analgesia.
Accessibility: Document does not exist in file
Language:
eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Flaten, M., Johansen, O, Simonsen, T., Aslaksen, P., Lyby, P., & Bjørkedal, E. (2010). The relation of mind to body. Psychophysiological studies of the placebo effect. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (pp. 238-239). Porto: Fundação Bial.
Indexed document: No
Keywords: Placebo effect / Placebo analgesia / Pain / Event-related potential (ERP) / Emotion

The relation of mind to body. Psychophysiological studies of the placebo effect

The relation of mind to body. Psychophysiological studies of the placebo effect

DocumentExpectations of increased and decreased pain explain the effect of conditioned pain modulation in females2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.27
Location: Arquivo PCA - Pasta 12/2006
Title:
Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females
Publication year: 2012
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442740/pdf/jpr-5-289.pdf
Abstract/Results: ABSTRACT:
OBJECTIVE:
Chronic pain is believed to be related to a dysfunction of descending pain modulatory mechanisms. Functioning of descending pain modulation can be assessed by various methods, including conditioned pain modulation (CPM). CPM refers to the inhibition of one source of pain by a second noxious stimulus, termed the conditioning stimulus. This procedure can activate an endogenous pain inhibitory mechanism that inhibits early nociceptive processing. Chronic pain and anxiety disorders are more prevalent among females and it has been hypothesized that females react with more negative emotions towards unpleasant stimuli and this might be part of the explanation of greater pain sensitivity in females. The present study investigated whether expectations modulate the effect of conditioning stimulation on pain, subjective stress, and heart rate. In addition, we investigated whether the modulation of CPM by expectations differed between males and females.
METHODS:
Seventy-two subjects (including 36 women) received six noxious heat stimuli to the forearm. During three of these stimuli, a conditioning stimulus (cold-water bath) was applied to the contralateral arm in order to activate CPM. One third of the subjects were told that this would reduce pain (analgesia group), one-third that it would increase pain (hyperalgesia group), and one third received no information about its effect (no info group).
RESULTS:
Information that conditioning stimulation decreased or enhanced pain had the corresponding effect in females, but not in males. Conditioning stimulation increased stress, but not heart rate in females in the hyperalgesia group. A higher expectation of analgesia and lower stress during conditioning stimulation was associated with larger inhibitory CPM.
CONCLUSION:
These results suggest that reduced inhibitory CPM can be due to contextually induced cognitive and emotional factors and not necessarily a dysfunction of descending inhibitory pathways.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Bjørkedal, E., & Flaten, M. (2012). Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females. Journal of Pain Research, 5, 289-300. https://doi.org/10.2147/JPR.S33559
2-year Impact Factor: N/A
Impact factor notes: Impact factor computed since 2015
Times cited: N/A
Indexed document: Yes
Quartile: N/A
Keywords: Pain / Conditioned pain modulation / Expectancy / Placebo analgesia / Nocebo hyperalgesia