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BIAL Foundation
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DE:"Salience network"
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DocumentI keep a close watch on this heart of mine: increased interoception in insomnia2016

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Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

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Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

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Reference code: PT/FB/BL-2012-252
Location: SEC PCA 252/12
Title:
252 - Sleep state misperception mispercieved
Duration: 2014-06 - 2017-01
Researcher(s):
Eus J. W. Van Someren, J. Ramautar
Institution(s): Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress reports
Final reports
2 Articles
Language: eng
Author:
Van Someren, E.
Secondary author(s):
Ramautar, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Cognitive processes / Memory / Consciousness

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Reference code: PT/FB/BL-2012-252.03
Location: SEC PCA 252/12
Title:
I keep a close watch on this heart of mine: increased interoception in insomnia
Publication year: 2016
URL:
https://www.ncbi.nlm.nih.gov/pubmed/27634787
Abstract/Results: ABSTRACT:
STUDY OBJECTIVES:
Whereas both insomnia and altered interoception are core symptoms in affective disorders, their neural mechanisms remain insufficiently understood and have not previously been linked. Insomnia Disorder (ID) is characterized by sensory hypersensitivity during wakefulness and sleep. Previous studies on sensory processing in ID addressed external stimuli only, but not interoception. Interoceptive sensitivity can be studied quantitatively by measuring the cerebral cortical response to one's heartbeat (heartbeat-evoked potential, HEP). We here investigated whether insomnia is associated with increased interoceptive sensitivity as indexed by the HEP amplitude.
METHODS:
Sixty-four participants aged 21-70 years were recruited through www.sleepregistry.nl including 32 people suffering from ID and 32 age- and sex-matched controls without sleep complaints. HEPs were obtained from resting-state high-density electroencephalography (HD-EEG) recorded during evening wakeful rest in eyes-open (EO) and eyes-closed (EC) conditions of 5-minute duration each. Significance of group differences in HEP amplitude and their topographical distribution over the scalp were assessed by means of cluster-based permutation tests.
RESULTS:
In particular during EC, and to a lesser extent during EO, people with ID had a larger amplitude late HEP component than controls at frontal electrodes 376-500 ms after the R-wave peak. Source localization suggested increased neural activity time-locked to heartbeats in people with ID mainly in anterior cingulate/medial frontal cortices.
CONCLUSIONS:
People with insomnia show insufficient adaptation of their brain responses to the ever-present heartbeats. Abnormalities in the neural circuits involved in interoceptive awareness including the salience network may be of key importance to the pathophysiology of insomnia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Ramautar, J., Colombo, M., Stoffers, D., Gomez-Herrero, G., van der Meijden, W. P., Te Lindert, B. H., van der Werf, Y., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Percentiles:
91.42|2.16
Reference:
Wei, Y., Ramautar, J., Colombo, M., Stoffers, D., Gomez-Herrero, G., van der Meijden, W. P., Te Lindert, B. H., van der Werf, Y., & Van Someren, E. (2016). I keep a close watch on this heart of mine: increased interoception in insomnia. Sleep, 39(12), 2113-2124. https://doi.org/10.5665/sleep.6308
Impact Factor: 4.923|2016
Times cited: 70|2026-02-06
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia disorder / Interoception / Heartbeat-evoked potential / Event-related potential / High-density EEG / Hyperarousal / Resting state / Salience network

<!-- mm occ=1 guid=[830221deee6558172ee47aa49a3e6bb7] WebBehavior$=[2] -->
DocumentThe role of the insula in intuitive expert bug detection in computer code: an fMRI study2019

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2014-373
Location: BF-GMS
Title:
373 - Multimodal Mapping of Visual Motion Perceptual Decision: Dissecting the Role of Different Motion Integration Areas in Visual Surface Reconstruction
Duration: 2016-02 - 2017-10
Researcher(s):
Miguel de Sá e Sousa de Castelo Branco, Gabriel Nascimento Ferreira da Costa, Gilberto Silva, João Valente Duarte, Ricardo Martins
Institution(s): ICNAS - Institute for Nuclear Sciences Applied to Health, Coimbra, Portugal; IBILI - Institute for Biomedical Imaging and Life Sciences, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Castelo-Branco, M.
Secondary author(s):
Costa, G., Silva, G., Duarte, J., Martins, R.
Number of reproductions:
1
Keywords:
Motion perception / Decision-making / Perceptual Ambiguity / Decision Models / Psychophysiology

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Reference code: PT/FB/BL-2014-373.19
Location: BF-GMS
Title:
The role of the insula in intuitive expert bug detection in computer code: an fMRI study
Publication year: 2019
URL:
https://link.springer.com/article/10.1007%2Fs11682-018-9885-1#citeas
Abstract/Results: ABSTRACT:
Software programming is a complex and relatively recent human activity, involving the integration of mathematical, recursive thinking and language processing. The neural correlates of this recent human activity are still poorly understood. Error monitoring during this type of task, requiring the integration of language, logical symbol manipulation and other mathematical skills, is particularly challenging. We therefore aimed to investigate the neural correlates of decision-making during source code understanding and mental manipulation in professional participants with high expertise. The present fMRI study directly addressed error monitoring during source code comprehension, expert bug detection and decision-making. We used C code, which triggers the same sort of processing irrespective of the native language of the programmer. We discovered a distinct role for the insula in bug monitoring and detection and a novel connectivity pattern that goes beyond the expected activation pattern evoked by source code understanding in semantic language and mathematical processing regions. Importantly, insula activity levels were critically related to the quality of error detection, involving intuition, as signalled by reported initial bug suspicion, prior to final decision and bug detection. Activity in this salience network (SN) region evoked by bug suspicion was predictive of bug detection precision, suggesting that it encodes the quality of the behavioral evidence. Connectivity analysis provided evidence for top-down circuit “reutilization” stemming from anterior cingulate cortex (BA32), a core region in the SN that evolved for complex error monitoring such as required for this type of recent human activity. Cingulate (BA32) and anterolateral (BA10) frontal regions causally modulated decision processes in the insula, which in turn was related to activity of math processing regions in early parietal cortex. In other words, earlier brain regions used during evolution for other functions seem to be reutilized in a top-down manner for a new complex function, in an analogous manner as described for other cultural creations such as reading and literacy.
Accessibility: Document exists in file
Language:
eng
Author:
Castelhano, J.
Secondary author(s):
Duarte, I. C., Ferreira, C., Durães, J., Madeira, H., Castelo-Branco, M.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
86.47|1.75
Reference:
Castelhano, J., Duarte, I. C., Ferreira, C., Durães, J., Madeira, H., & Castelo-Branco, M. (2019). The role of the insula in intuitive expert bug detection in computer code: an fMRI study. Brain Imaging and Behavior, 13(3), 623-637. https://doi.org/10.1007/s11682-018-9885-1
Impact Factor: 3.391|2019
Times cited: 52|2026-02-11
Indexed document: Yes
Quartile: Q2
Keywords: fMRI / Brain mapping / Insula / Informatics / Error monitoring / Salience network / Computer code understanding

<!-- mm occ=1 guid=[72a0b4b96ae967855cf3aa88856e47d7] WebBehavior$=[0] -->

The role of the insula in intuitive expert bug detection in computer code: an fMRI study

The role of the insula in intuitive expert bug detection in computer code: an fMRI study

DocumentFinal report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep2019

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-190.01
Location: BF-GMS
Title:
Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Publication year: 2019
Abstract/Results:
ABSTRACT:
BACKGROUND
Sleep and interoception are important regulating processes of physiological homeostasis and of consciousness. However, few studies have investigated the relationship between them. People with insomnia chronically experience their sleep as conscious wakefulness, which we hypothesize could involve interoception-related neural dysfunctions.
AIMS
By incorporating EEG, neuroimaging, and questionnaire data, we aim to establish direct links between interoception and the experience of (un)consciousness during sleep.
METHOD
Measures of brain network activity including EEG microstate properties and BOLD functional connectivity variability, as well as brain connectivity networks derived from diffusion MRI tractography, were compared between people with insomnia and people without sleep complaints. Self-reported measures were collected in a community-based sample and used to investigate the relationship between somatic complaints and insomnia severity.
RESULTS
The mean duration of a particular class of EEG microstates previously linked to salience network activity is reduced in people with insomnia. Functional connectivity variability between the anterior salience network and the left executive control network is reduced in people with insomnia. People with insomnia show brain structural hyperconnectivity in a subnetwork anchored at the right angular gyrus. Poor sleep and somatic complaints mutually reinforce each other while their relationship is modulated by habitual insomnia severity.
CONCLUSIONS
There is a tight relationship between sleep and interoception. Experience of consciousness during sleep involves aberrant dynamics of the salience network, a key network for interoception
Accessibility: Document exists in file
Language:
eng
Author:
Van Someren, E.
Secondary author(s):
Wei, Y.
Document type:
Final report
Number of reproductions:
1
Reference:
Van Someren, E., & Wei, Y. (2019). Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep.
Indexed document: No
Keywords: Sleep / Insomnia / Consciousness / Interoception / Salience network

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Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep

Final report - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep

DocumentReduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder2019

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-190.06
Location: BF-GMS
Title:
Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
Publication year: 2019
URL:
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12953
Abstract/Results: ABSTRACT:
Research into insomnia disorder has pointed to large-scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between-network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve-minute resting-state functional magnetic resonance images and T1-weighed images were acquired in 65 people diagnosed with insomnia disorder (21–69 years, 48 female) and 65 matched controls without sleep complaints (22–70 years, 42 female). Pairwise correlations between the activity time series of 14 resting-state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between-network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive-control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2012-253.09
Author: Wei, Y.
Secondary author(s):
Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., Van Someren, E. J. W.
Document type:
Article
Number of reproductions:
1
Percentiles:
84.55|1.48
Reference:
Wei, Y., Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., & Van Someren, E. J. W. (2019). Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder. Journal of Sleep Research, e12953. https://doi.org/10.1111/jsr.12953
Impact Factor: 3.623|2019
Times cited: 34|2026-02-11
Indexed document: Yes
Quartile: Q2
Keywords: Dynamic functional connectivity / Insomnia disorder / Resting-state functional magnetic resonance imaging / Salience network

<!-- mm occ=1 guid=[6762d0c7f8c5bffac08c856e6e43a9c3] WebBehavior$=[0] -->

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

DocumentThe role of the insula in intuitive expert bug detection in computer code: an fMRI study2019

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

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Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-207
Location: BF-GMS
Title:
207 - The role of motion adaptation in bottom-up mechanisms of perceptual decision-making
Duration: 2017-11 - 2019-10
Researcher(s):
Miguel Castelo-Branco, João Duarte, Ricardo Martins, Teresa Sousa, Gabriel Costa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final Report
Articles
Author: Castelo-Branco, M.
Secondary author(s):
Duarte, J., Martins, R., Sousa, T., Costa, G.
Number of reproductions:
1
Keywords:
Adaptation / Neuroimaging / Perceptual decision / Electroencephalogram (EEG) / Psychophysiology

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Reference code: PT/FB/BL-2016-207.05
Location: BF-GMS
Title:
The role of the insula in intuitive expert bug detection in computer code: an fMRI study
Publication year: 2019
URL:
https://link.springer.com/article/10.1007/s11682-018-9885-1#citeas
Abstract/Results: ABSTRACT:
Software programming is a complex and relatively recent human activity, involving the integration of mathematical, recursive thinking and language processing. The neural correlates of this recent human activity are still poorly understood. Error monitoring during this type of task, requiring the integration of language, logical symbol manipulation and other mathematical skills, is particularly challenging. We therefore aimed to investigate the neural correlates of decision-making during source code understanding and mental manipulation in professional participants with high expertise. The present fMRI study directly addressed error monitoring during source code comprehension, expert bug detection and decision-making. We used C code, which triggers the same sort of processing irrespective of the native language of the programmer. We discovered a distinct role for the insula in bug monitoring and detection and a novel connectivity pattern that goes beyond the expected activation pattern evoked by source code understanding in semantic language and mathematical processing regions. Importantly, insula activity levels were critically related to the quality of error detection, involving intuition, as signalled by reported initial bug suspicion, prior to final decision and bug detection. Activity in this salience network (SN) region evoked by bug suspicion was predictive of bug detection precision, suggesting that it encodes the quality of the behavioral evidence. Connectivity analysis provided evidence for top-down circuit “reutilization” stemming from anterior cingulate cortex (BA32), a core region in the SN that evolved for complex error monitoring such as required for this type of recent human activity. Cingulate (BA32) and anterolateral (BA10) frontal regions causally modulated decision processes in the insula, which in turn was related to activity of math processing regions in early parietal cortex. In other words, earlier brain regions used during evolution for other functions seem to be reutilized in a top-down manner for a new complex function, in an analogous manner as described for other cultural creations such as reading and literacy.
Accessibility: Document exists in file
Language:
eng
Author:
Castelhano, J.
Secondary author(s):
Duarte, I. C., Ferreira, C., Duraes, J., Madeira, H., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
86.47|1.75
Reference:
Castelhano, J., Duarte, I. C., Ferreira, C., Duraes, J., Madeira, H., & Castelo-Branco, M. (2019). The role of the insula in intuitive expert bug detection in computer code: an fMRI study. Brain Imaging and Behavior, 3(3), 623-637. https://doi.org/10.1007/s11682-018-9885-1
Impact Factor: 3.391|2019
Times cited: 52|2026-02-11
Indexed document: Yes
Quartile: Q2
Keywords: fMRI / Brain mapping / Insula / Informatics / Error monitoring / Salience network / Computer code understanding

<!-- mm occ=1 guid=[7d825b15e80e88fc20f8cc367f28906a] WebBehavior$=[0] -->

The role of the insula in intuitive expert bug detection in computer code: an fMRI study

The role of the insula in intuitive expert bug detection in computer code: an fMRI study

DocumentBrain correlates of hypnosis: A systematic review and meta-analytic exploration2017

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

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Reference code: PT/FB/BL-2014-118
Location: BF-GMS
Title:
118 - Recursive consciousness training: Using neurofeedback to induce altered states
Duration: 2015-09 - 2017-11
Researcher(s):
Amir Raz, Niels Birbaumer, Robert T Thibault
Institution(s): Montreal Neurological Institute, McGill University (Canada); Institute of Medical Psychology and Behavioral Neurobiology, University of Tübingen (Germany)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Raz, A.
Secondary author(s):
Birmaumer, N., Thibault, R. T.
Number of reproductions:
3
Keywords:
Brain Self-Regulation / Altered States of Consciousness / Neurofeedback / Meditation / Psychophysiology and Parapsychology

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2014-118.16
Location: BF-GMS
Title:
Brain correlates of hypnosis: A systematic review and meta-analytic exploration
Publication year: 2017
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0149763416306030
Abstract/Results: ABSTRACT:
Imaging of the living human brain elucidates the neural dynamics of hypnosis; however, few reliable brain patterns emerge across studies. Here, we methodically assess neuroimaging assays of hypnosis to uncover common neural configurations using a twofold approach. First, we systematically review research on the neural correlates of hypnotic phenomena; then, we meta-analyze these collective data seeking specific activation and deactivation patterns that typify hypnosis. Anchored around the role of top-down control processes, our comprehensive examination focuses on the involvement of intrinsic brain networks known to support cognitive control and self-referential cognition, including the executive, salience, and default networks. We discuss how these neural dynamics may relate to contemporary theories of hypnosis and show that hypnosis correlates with activation of the lingual gyrus a brain region involved in higher order visual processing and mental imagery. Our findings help to better understand the neurobiological substrates comprising the appellation hypnosis.
Accessibility: Document does not exist in file
Language:
eng
Author:
Landry, M.
Secondary author(s):
Lifshitz, M., Raz, A.
Document type:
Article
Number of reproductions:
3
Percentiles:
89.67|2.10
Reference:
Landry, M., Lifshitz, M., & Raz, A. (2017). Brain correlates of hypnosis: A systematic review and meta-analytic exploration. Neuroscience & Biobehavioral Reviews, 81(Pt A), 75-98. https://doi.org/10.1016/j.neubiorev.2017.02.020
Impact Factor: 8.037|2017
Times cited: 161|2026-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Hypnosis / Neuroimaging; / Attention / Consciousness / Central executive network / Salience network / Default network / Activation likelihood estimates

DocumentPlacebo effects in the context of religious beliefs and practices: A resting-state functional connectivity study2021

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

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Reference code: PT/FB/BL-2018-002
Location: BF-GMS
Title:
002 - Neurobiological effects of Lourdes water: An fMRI study
Duration: 2019-01 - 2021-09
Researcher(s):
Anne Schienle, Albert Wabnegger
Institution(s): Clinical Psychology, University of Graz (Austria)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Schienle, A.
Secondary author(s):
Wabnegger, A.
Number of reproductions:
3
Keywords:
Lourdes water / Placebo / Resting state connectivity / fMRI / Psychophysiology and Parapsychology

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Reference code: PT/FB/BL-2018-002.03
Location: BF-GMS
Title:
Placebo effects in the context of religious beliefs and practices: A resting-state functional connectivity study
Publication year: 2021
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2021.653359/full
Abstract/Results: ABSTRACT:
BACKGROUND
Placebos (inert substances or procedures) can positively influence a person’s psychological and physical well-being, which is accompanied by specific changes in brain activity. There are many different types of placebos with different effects on health-related variables. This study investigated placebo effects in the context of religious beliefs and practices. The participants received an inert substance (tap water) along with the verbal suggestion that the water would come from the sanctuary in Lourdes (a major Catholic pilgrimage site with reports of miracle cures). We investigated changes in resting-state functional connectivity (rsFC) in three brain networks (default-mode, salience, cognitive control) associated with the drinking of the placebo water.
METHODS
A total of 37 females with the belief that water from the sanctuary in Lourdes has positive effects on their spiritual, emotional, and physical well-being participated in this placebo study with two sessions. The participants drank tap water that was labeled “Lourdes water” (placebo) before a 15-min resting-state scan in one session. In the other (control) session, they received tap water labeled as tap water. The participants rated their affective state (valence, arousal) during the session and were interviewed concerning specific thoughts, feelings, and bodily sensations directly after each of the two sessions.
RESULTS
The placebo reduced rsFC in the frontoparietal cognitive control network and increased rsFC in the salience network (insular-cerebellar connectivity). During the session, the participants rated their affective state as very pleasant and calm. The ratings did not differ between the two conditions. Immediately after the session, the participants reported increased intensity of pleasant bodily sensations (e.g., feelings of warmth, tingling) and feelings (e.g., gratefulness) for the “Lourdes water” condition.
CONCLUSIONS
The present findings provide the first evidence that placebos in the context of religious beliefs and practices can change the experience of emotional salience and cognitive control which is accompanied by connectivity changes in the associated brain networks.
Accessibility: Document exists in file
Language:
eng
Author:
Schienle, A.
Secondary author(s):
Gremsl, A., Wabnegger, A.
Document type:
Article
Number of reproductions:
3
Percentiles:
35.55|0.44
Reference:
Schienle, A., Gremsl, A., & Wabnegger, A. (2021). Placebo effects in the context of religious beliefs and practices: A resting-state functional connectivity study. Frontiers in Behavioral Neuroscience, 15: 653359. https://doi.org/10.3389/fnbeh.2021.653359
Impact Factor: 3.617|2021
Times cited: 6|2026-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Resting-state functional connectivity / Religious belief / Fronto-parietal cognitive control network / Salience network / Placebo

<!-- mm occ=1 guid=[4a4917c3523865444bdafdee8b7e5360] WebBehavior$=[0] -->

Placebo effects in the context of religious beliefs and practices: A resting-state functional connectivity study

Placebo effects in the context of religious beliefs and practices: A resting-state functional connectivity study

DocumentInterplay between the salience and the default mode network in a social-cognitive task toward a close other2022

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2016-217
Location: BF-GMS
Title:
217 - Physiological indices of the deleterious effects of unrealistic media images on body satisfaction: A cross-cultural investigation
Duration: 2018-06 - 2023-07
Researcher(s):
Clédna Patrícia de Oliveira-Silva, Rachel Rodgers, Óscar Gonçalves, Pedro Dias, Rosana Magalhães, Eugénia Fernandes, Bárbara Machado, Joana Coutinho, Paulo Boggio
Institution(s): Centre for Studies in Human Development, Faculty of Education and Psychology, Universidade Católica Portuguesa, Porto (Portugal); Department of Applied Psychology, Northeastern University, Boston (USA)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Oliveira-Silva, P.
Secondary author(s):
Rodgers, R., Gonçalves, O., Dias, P., Magalhães, R., Fernandes, E., Machado, B., Coutinho, J., Boggio, P.
Number of reproductions:
1
Keywords:
Disclaimer labels / Body image / Emotion dysregulation / Cross-cultural / Psychophysiology

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Reference code: PT/FB/BL-2016-217.05
Location: BF-GMS
Title:
Interplay between the salience and the default mode network in a social-cognitive task toward a close other
Publication year: 2022
URL:
https://pubmed.ncbi.nlm.nih.gov/35197871/
Abstract/Results: Abstract
Social cognition relies on two main subsystems to construct the understanding of others, which are sustained by different social brain networks. One of these social networks is the default mode network (DMN) associated with the socio-cognitive subsystem (i.e., mentalizing), and the other is the salience network (SN) associated with the socio-affective route (i.e., empathy). The DMN and the SN are well-known resting state networks that seem to constitute a baseline for the performance of social tasks. We aimed to investigate both networks' functional connectivity (FC) pattern in the transition from resting state to social task performance. A sample of 38 participants involved in a monogamous romantic relationship completed a questionnaire of dyadic empathy and underwent an fMRI protocol that included a resting state acquisition followed by a task in which subjects watched emotional videos of their romantic partner and elaborated on their partner's (Other condition) or on their own experience (Self condition). Independent component and ROI-to-ROI correlation analysis were used to assess alterations in task-independent (Rest condition) and task-dependent (Self and Other conditions) FC. We found that the spatial FC maps of the DMN and SN evidenced the traditional regions associated with these networks in the three conditions. Anterior and posterior DMN regions exhibited increased FC during the social task performance compared to resting state. The Other condition revealed a more limited SN's connectivity in comparison to the Self and Rest conditions. The results revealed an interplay between the main nodes of the DMN and the core regions of the SN, particularly evident in the Self and Other conditions.
Accessibility: Document exists in file
Language:
eng
Author:
Costa, C.
Secondary author(s):
Soares, J., Oliveira-Silva, P., Sampaio, A., Coutinho, J.
Document type:
Article
Number of reproductions:
1
Percentiles:
69.76|1.10
Reference:
Costa, C., Soares, J., Oliveira-Silva, P., Sampaio, A., & Coutinho, J. (2022). Interplay between the salience and the default mode network in a social-cognitive task toward a close other. Frontiers in Psychiatry, 12, 718400. https://doi.org/10.3389/fpsyt.2021.718400
Impact Factor: 4.700|2022
Times cited: 11|2026-02-13
Indexed document: Yes
Quartile: Q2
Keywords: Default mode network / Functional connectivity / Resting state / Salience network / Self/other processing / Social cognition

<!-- mm occ=1 guid=[f67aed17bde1ba4195b78c50de72117c] WebBehavior$=[0] -->

Interplay between the salience and the default mode network in a social-cognitive task toward a close other

Interplay between the salience and the default mode network in a social-cognitive task toward a close other

DocumentReduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder2019

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-253.09
Location: BF-GMS
Title:
Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder
Publication year: 2019
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154624/
Abstract/Results: Research into insomnia disorder has pointed to large-scale brain network dysfunctions. Dynamic functional connectivity is instrumental to cognitive functions but has not been investigated in insomnia disorder. This study assessed between-network functional connectivity strength and variability in patients with insomnia disorder as compared with matched controls without sleep complaints. Twelve-minute resting-state functional magnetic resonance images and T1-weighed images were acquired in 65 people diagnosed with insomnia disorder (21–69 years, 48 female) and 65 matched controls without sleep complaints (22–70 years, 42 female). Pairwise correlations between the activity time series of 14 resting-state networks and temporal variability of the correlations were compared between cases and controls. After false discovery rate correction for multiple comparisons, people with insomnia disorder and controls did not differ significantly in terms of mean between-network functional connectivity strength; people with insomnia disorder did, however, show less functional connectivity variability between the anterior salience network and the left executive-control network. The finding suggests less flexible interactions between the networks during the resting state in people with insomnia disorder.
Accessibility: Document exists in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., Van Someren, E.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
84.55|1.48
Reference:
Wei, Y., Leerssen, J., Wassing, R., Stoffers, D., Perrier, J., & Van Someren, E. J. W. (2019). Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder. Journal of Sleep Research, e12953. https://doi.org/10.1111/jsr.12953
Impact Factor: 3.623|2019
Times cited: 34|2026-02-12
Indexed document: Yes
Quartile: Q2
Keywords: Dynamic functional connectivity / Insomnia disorder / Resting-state functional magnetic resonance imaging / Salience network

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Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

Reduced dynamic functional connectivity between salience and executive brain networks in insomnia disorder

DocumentResting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis2022

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Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

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Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

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Reference code: PT/FB/BL-2020-099
Location: BF-GMS
Title:
099 - Beyond "mindfulness" and toward a modern science of meditative mastery and spiritual transformation
Duration: 2021-03 - 2024-02
Researcher(s):
Matthew Sacchet, Diego Pizzagalli, Remko van Lutterveld, Marta Bianciardi
Institution(s): Center for Depression, Anxiety, and Stress Research - CDASR, McLean Hospital, Belmont (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Sacchet, M.
Secondary author(s):
Pizzagalli, D., van Lutterveld, R., Bianciardi, M.
Number of reproductions:
3
Keywords:
Advanced meditation / Enlightenment / Neuroimaging / Mindfulness meditation / Psychophysiology and Parapsychology

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Reference code: PT/FB/BL-2020-099.03
Location: BF-GMS
Title:
Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S0149763422000720
Abstract/Results: This review synthesizes relations between mindfulness and resting-state fMRI functional connectivity of brain networks. Mindfulness is characterized by present-moment awareness and experiential acceptance, and relies on attention control, self-awareness, and emotion regulation. We integrate studies of functional connectivity and (1) trait mindfulness and (2) mindfulness meditation interventions. Mindfulness is related to functional connectivity in the default mode (DMN), frontoparietal (FPN), and salience (SN) networks. Specifically, mindfulness-mediated functional connectivity changes include (1) increased connectivity between posterior cingulate cortex (DMN) and dorsolateral prefrontal cortex (FPN), which may relate to attention control; (2) decreased connectivity between cuneus and SN, which may relate to self-awareness; (3) increased connectivity between rostral anterior cingulate cortex region and dorsomedial prefrontal cortex (DMN) and decreased connectivity between rostral anterior cingulate cortex region and amygdala region, both of which may relate to emotion regulation; and lastly, (4) increased connectivity between dorsal anterior cingulate cortex (SN) and anterior insula (SN) which may relate to pain relief. While further study of mindfulness is needed, neural signatures of mindfulness are emerging.
Accessibility: Document exists in file
Language:
eng
Author:
Sezer, I.
Secondary author(s):
Pizzagalli, D., Sacchet, M.
Document type:
Article
Number of reproductions:
3
Percentiles:
98.59|5.32
Reference:
Sezer, I., Pizzagalli, D. & Sacchet, M. (2022). Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis. Neuroscience & Biobehavioral Reviews, 135, 104583. https://doi.org/10.1016/j.neubiorev.2022.104583
Impact Factor: 8.200|2022
Times cited: 138|2026-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Mindfulness / Meditation / Resting-state fMRI / Functional connectivity / Default mode network / Salience network / Frontoparietal network / Attention control / Emotion regulation / Self-awareness / Posterior cingulate cortex / Anterior cingulate cortex / Cuneus / MBSR

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Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis

Resting-state fMRI functional connectivity and mindfulness in clinical and non-clinical contexts: A review and synthesis

DocumentA link between error monitoring and basal ganglia-dependent learning in autism2025

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

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Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

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Reference code: PT/FB/BL-2018-306
Location: BF-GMS
Title:
306 - The neural circuitry underlying error monitoring during social cognition
Duration: 2019-10 - 2022-09
Researcher(s):
Teresa Sousa, Miguel Castelo-Branco, João Castelhano, Verónica Figueiredo, Andreia Pereira
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Sousa, T.
Secondary author(s):
Castelo-Branco, M., Castelhano, J., Figueiredo, V., Pereira, A.
Number of reproductions:
1
Keywords:
Error metacognition / Social error monitoring / Cognitive control / Electroencephalogram (EEG) / Functional magnetic resonance imaging (fMRI) / Psychophysiology

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Reference code: PT/FB/BL-2018-306.07
Location: BF-GMS
Title:
A link between error monitoring and basal ganglia-dependent learning in autism
Publication year: 2025
URL:
https://academic.oup.com/braincomms/article/7/6/fcaf414/8369254
Abstract/Results: ABSTRACT:
Altered error monitoring mechanisms may contribute to the neurobehavioral manifestations of autism, particularly those affecting trial-and-error learning. In this study, we examined how error-related neural responses relate to learning processes in autistic individuals. To address this, we employed a paradigm designed to assess both error monitoring and the learning of socioemotional orienting cues. Fifteen autistic and fifteen non-autistic adult males performed a challenging functional MRI task that required the integration of facial expression and gaze cues to extract the correct social-orienting direction. We evaluated how error-related neural responses evolved with learning and compared these dynamics across groups. We hypothesized differences in key error monitoring regions—the anterior cingulate cortex and anterior insula—and in the putamen, which is implicated in trial-and-error learning. Behaviourally, both groups exhibited similar learning rates, but the autistic group showed significantly lower accuracy (P = 9.60 × 10-5). At the neural level, although the progression of error-related activity throughout learning was similar across both groups, autistic individuals demonstrated attenuated differentiation between correct responses and errors in the dorsal anterior cingulate cortex (F(2, 53.23) = 9.68, P = 0.001) and anterior insula (F(2, 54.21) = 25.48, P = 6.32 × 10-8). Reduced neural responses to errors were predictive of higher error rates (P = 0.02) and elevated Autism Diagnostic Observation Schedule scores (P = 0.02). Importantly, autistic individuals also showed a diminished increase in putamen activity as learning progressed (F(6, 7808.01) = 6.84, P = 1.20 × 10-6). Finally, attenuated changes in error-related functional connectivity during learning were found in the autistic group and correlated with Autism Quotient scores (r(22) = -0.58, P = 0.04). Our findings suggest diminished error-related neural responses and weakened neural progress with learning in autism, associated with increased error rates and autistic traits. These results highlight a potential link between disrupted error monitoring mechanisms and basal ganglia-dependent learning in autism.
Accessibility: Document exists in file
Language:
eng
Author:
Dias, C.
Secondary author(s):
Sousa, T., Mouga, S., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
N/Y
Reference:
Dias, C., Sousa, T., Mouga, S., & Castelo-Branco, M. (2025). A link between error monitoring and basal ganglia-dependent learning in autism. Brain Communications, 7(6), fcaf414. https://doi.org/10.1093/braincomms/fcaf414
Impact Factor: 4.5|2025
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2026-07-23
Indexed document: Yes
Quartile: Q1
Keywords: Autism / Error monitoring / Learning / Salience network / Putamen

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A link between error monitoring and basal ganglia-dependent learning in autism

A link between error monitoring and basal ganglia-dependent learning in autism