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DocumentStress and the psyche: methodological innovations in psychoneuroimmunology2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-077
Location: Arquivo PCA - Pasta 11/2004
Title:
077 - Stress and the psyche: methodological innovations in psychoneuroimmunology
Duration: 2005-03 - 2007-06
Researcher(s):
Matt Bristow, Rachel Cook
Institution(s): Department of Psychology, APU, Cambridge (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
3 unpublished documents (2 posters and 1 paper)
Language: eng
Author:
Bristow, M.
Secondary author(s):
Cook, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Psychoneuroimmunology / Endocrinology / Immunology / Assessment tools

Reference code: PT/FB/BL-2004-077.05
Location: Arquivo PCA - Pasta 11/2004
Title:
Stress and the psyche: methodological innovations in psychoneuroimmunology
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
There is an inconsistency within the literature concerning whether acute stress leads to an increase or decrease in mucosal immunity. One reason for the inconsistent findings is the use of laboratory ‘stress’ tasks that lack ecological validity. In addition, the majority of research has focussed on immune changes immediately before or after the stress-inducing task. In this research we used parachute jumping as an ecologically valid method of inducing acute stress coupled with psychological and physiological measures of stress on the day of the jump and seven days before and after it.
METHODS:
28 novice tandem jumpers participated in this study along with 31 non-parachute controls. The parachutists completed a daily questionnaire assessing levels of stress and provided a 2-minute unstimulated saliva sample on each of the seven days before the parachute jump, the day of the jump and the seven days after the jump. The control participants also completed the daily stress questionnaire and provided a saliva sample for 15 consecutive days. A sub-group of 12 parachutists provided saliva samples before and after the parachute jump. Saliva samples were analysed for cortisol, a measure of physiological stress, and immunoglobulin A (IgA), a measure of mucosal immunity.
RESULTS:
There were significant and substantial increases in IgA and cortisol following the jump indicating that the
parachutists found the experience stressful and that this lead to an increase in mucosal immunity. These increases seem transient as there was no indication of any physiological or psychological change in the evening measures on the day of the jump or the days that followed.
CONCLUSIONS:
Using an ecologically valid acute stressor we found evidence of a substantial increase in mucosal immunity. This increase is brief and within an hour IgA levels are back to normal with no evidence of suppressed IgA in the days that follow. Acute stressful situations appear to provide a brief enhancement of the mucosal immune system with no evidence of any detrimental effects.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bristow, M.
Secondary author(s):
Cook, R.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Bristow, M., & Cook, R. (2008). Stress and the psyche: methodological innovations in psychoneuroimmunology. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Stress / Mucosal immunity / Cortisol / Salivette / Saliva

Stress and the psyche: methodological innovations in psychoneuroimmunology

Stress and the psyche: methodological innovations in psychoneuroimmunology
DocumentSeasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-057
Location: Arquivo PCA - Pasta 6/2006
Title:
057 - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Duration: 2007-02 - 2009-05
Researcher(s):
Angela Clow, Phil Evans, Frank Hucklebridge, Lisa Thorn
Institution(s): Psychophysiology and Stress Research Group, Dep. of Psychology and Human and Health Sciences, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health / Mood disorders

Reference code: PT/FB/BL-2006-057.02
Location: Arquivo PCA - Pasta 6/2006
Title:
Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder
Publication year: 2011
URL:
http://www.sciencedirect.com/science/article/pii/S0306453010002817
Abstract/Results: ABSTRACT:
This study compared the daily pattern of free salivary cortisol secretion in winter and in summer between two groups; participants with self-assessed seasonal affective disorder (SAD) and age- and sex-matched healthy controls. Fifty-two participants completed the study with an equal number in each group. The diurnal pattern of cortisol secretion was assessed across two consecutive weekdays in summer, and two in winter, with conditions being counterbalanced. On each study day participants collected multiple saliva samples in the domestic setting to capture the cortisol awakening response (CAR) and declining levels across the day. In addition, perceived stress, anxiety, depression, state stress and state arousal were assessed using validated questionnaires. There was no evidence for any seasonal changes in psychological data or cortisol pattern for the healthy control population. In summer, self-assessed SAD and control participants had similar psychological and cortisol profiles. In winter however, SAD participants reported greater depression, stress and anxiety, and lower levels of arousal. Furthermore, the CAR was significantly attenuated in SAD participants during winter months. There was no difference in cortisol levels during the rest of the day between controls and SAD participants in winter. In line with the above findings and previous research, there was an inverse relationship between the increase in cortisol following awakening and a measure of seasonality in winter. Furthermore in winter, a general dysphoria construct correlated inversely with the CAR, indicating that participants reporting greater depression, stress and anxiety and lower arousal, exhibited lower CARs. In conclusion, during the shortened photoperiod in winter, the cortisol response to awakening is attenuated in participants with self-assessed SAD in comparison to controls. These findings contribute to the understanding of the physiology of SAD.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Thorn, L.
Secondary author(s):
Evans, P., Cannon, A., Hucklebridge, F., Clow, A.
Document type:
Article
Number of reproductions:
1
Reference:
Thorn, L., Evans, P., Cannon, A., Hucklebridge, F., & Clow, A. (2011). Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder. Psychoneuroendocrinology, 36(6), 816–823. https://doi.org/10.1016/j.psyneuen.2010.11.003
2-year Impact Factor: 5.809|2011
Times cited: 39|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Saliva / Cortisol awakening response / Diurnal cortisol / Seasonal differences / Seasonality / Seasonal affective disorder

Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder

Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder
DocumentDelays of 5-15min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.02
Location: Arquivo PCA - Pasta 8/2010
Title:
Delays of 5-15min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S030645301200426X
Abstract/Results: ABSTRACT:
Linking psychosocial measures to the cortisol awakening response (CAR) demands accurate saliva sampling times. Monitoring adherence to the saliva sampling protocol requires electronic monitoring of both awakening and sampling times since self-reported times are inaccurate. Delays greater than 15min between awakening and commencement of saliva sampling reduce CAR magnitude. Less delay has been judged tolerable but remains unexplored for different magnitude measures, and for timing of the CAR peak.
Study 1: Fifty healthy females (21±4 years) were instructed to collect saliva on four days at 0, 15, 30 and 45min post-awakening (samples 1-4). Both self-reported awakening and sampling times were electronically monitored using actigraphy and track caps. Self-reported awakening was later than actigraph estimated awakening (median difference of 4min). Estimates of CAR magnitude were significantly greater on non-adherent days (delay of 5-15min) compared to adherent days (delay<5min). On non-adherent compared to adherent days cortisol on average peaked earlier, at sample 3 rather than at sample 4.
Study 2: Accurately timed cortisol values were obtained in an intensive investigation of 10 participants who collected saliva on 2 days every 5min for 30min post-awakening. Cortisol did not significantly increase until 10min post-awakening, suggesting a time lag may be typical between awakening and observation of a cortisol increase. We conclude that moderate delays between awakening and collection of saliva samples previously considered tolerable result in erroneous estimation of CAR magnitude and timing of the peak. These results are attributed to an approximate 10min time lag between awakening and the start of the cortisol rise. The absence of this latent period in calculations leads to overestimation of the CAR magnitude on moderately non-adherent sampling days. These findings, if more universally generalizable, will further theoretical understanding of the physiology of the CAR, but are methodologically challenging for researchers since self-reported awakening times are not accurate enough to override the concerns raised. However accurate electronic measurement of adherence to protocol would enable sampling delays to be taken into account in computing CAR estimates.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Clow, A., Thorn, L., Hucklebridge, F., Evans, P.
Document type:
Article
Number of reproductions:
1
Reference:
Smyth, N., Clow, A., Thorn, L., Hucklebridge, F., & Evans, P. (2013). Delays of 5-15min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response. Psychoneuroendocrinology, 38(9), 1476-1483. https://doi.org/10.1016/j.psyneuen.2012.12.013
2-year Impact Factor: 5.591|2013
Times cited: 64|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Saliva / Cortisol awakening response / Non-adherence / Awakening / Actigraphy / Track caps / Time lag / Sampling delay
DocumentDiscrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.05
Location: Arquivo PCA - Pasta 8/2010
Title:
Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)
Publication year: 2012
URL:
http://www.psychosomatic.org/anmeeting/PastEvents/meeting2012/abstractbooklet.pdf
Abstract/Results: ABSTRACT:
The CAR is frequently studied in participants’ natural environment using self-collection of saliva samples. For measurement of the CAR accurate timing of saliva sampling is crucial; poor adherence to sampling protocol leads to misleading assessments of the CAR. Studies often rely on self-report and exclude samples rated as 10-15 minutes late. This study compared actimeter-determined awakening and electronic monitoring of sampling times with self-reported awakening and sampling times. It also explored demographic, situational or psychosocial correlates of delayed self-report of both awakening and sampling times. Fifty students (mean 21±4.4 y) collected saliva samples on 4 days at 0, 15, 30 and 45 minutes post awakening. Awakening times were determined by wrist-worn actimeters and sampling was monitored by electronic devices (Medication Event Monitoring: MEM). Participants were informed that these devices monitored their adherence to the protocol. Participants also reported their awakening and sample collection times using the usual diary report method. Actimeter-determined awakening was significantly earlier than self-reported awakening - average difference was 8.0±1.5 minutes, (F(1,25)=37.666, p<0.001, K² =.601). Sampling delay was calculated as the average delay for all 4 samples, objective sampling delay was derived from actimeter-determined awakening and MEM. Self-reported delay was derived from self-reported awakening and sampling. Figure 1 shows that objective sampling delay was significantly longer than self-reported delay, (F(1,25)=22.838,p<0.001,K²=.477). Across the 4 days the average objective delay was 10.0±3.6 minutes. Age, social-economic status, trait and state well-being and ill-being, busyness, sleep quality, waking time, and ease were not significantly correlated with either objective or self-reported delay for awakening and sampling. Results suggest that
self-reported awakening and sampling delay differs to that determined by electronic monitoring, this was largely attributable to inaccuracy in determining awakening. Also, no measured variable was related to awakening and sampling delay, suggesting that it may be related to other factors such as sleep inertia following awakening.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Thorn, L., Evans, P., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Evans, P., Hucklebridge, F., & Clow, A. (2012). Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR). Abstracts of the American Psychosomatic Society 70th Annual Meeting: “Symptoms and patient reported outcomes” (A - 58). Athens, Greece.
Indexed document: No
Keywords: Cortisol awakening response / Saliva / Actimeter-determined awakening / Self-reported awakening

Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)

Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)
DocumentThe cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.08
Location: Arquivo PCA - Pasta 8/2010
Title:
The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed
Publication year: 2013
URL:
http://www.psychosomatic.org/anmeeting/PDF/2013abstractBooklet.pdf
Abstract/Results: ABSTRACT:
Research linking the Cortisol Awakening Response (CAR) to psychosocial and health domains needs CAR measures to be based on
accurately timed saliva samples. How accurate? Typically a CAR is big and brief, and even quite modest delays between awakening and initial saliva sample might theoretically be expected to compromise accuracy; but delays up to 15 min reportedly do not do so. This paradox is explored and predictions examined in new data for effects of moderate delays (5-15 min) on several different CAR magnitude measures, and on timing of the CAR peak. Both self-reported awakening and sampling times were objectively checked by actigraphy and track caps. 50 healthy females (21±4 years) were told to collect saliva on 4 days at 0, 15, 30 and 45 min post-awakening. Self-reports were significantly later by 8 (±11) min than objective estimates of awakening. Selfreported sampling time intervals were accurate (< 2 min mean error). Minimally delayed data (< 5 min) were compared with moderately delayed (5-15 min). CAR magnitude was significantly greater for delayed data and peaked earlier. Plots of cortisol values in real time suggested effects were due to a time lag between awakening and start of cortisol rise; cortisol rise was not linear. Further evidence for this was sought and found in an intensive investigation of 10 participants who collected saliva every 5 min from 0-30 min post-awakening. We conclude that moderate delays in saliva sampling previously thought tolerable lead to errors in estimating CAR magnitude and peak-timing, due to an approximate 10 min lag between awakening and cortisol rise. Ignoring this lag in calculations leads to overestimation of CAR magnitude, even if sampling is only moderately delayed. These findings, if generalizable, clarify how the physiology of the CAR unfolds, but are methodologically challenging for researchers since self-reported awakening times are not accurate enough to override concerns raised. Objective measurement of sampling time would, however, permit known delays to be taken into account when computing CAR estimates.
Accessibility: Document does not exist in file
Language:
eng
Author:
Evans, P.
Secondary author(s):
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Evans, P., Smyth, N., Thorn, L., Hucklebridge, F., & Clow, A. (2013). The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed. Abstracts of the American Psychosomatic Society 71st Annual Meeting: “Impact and Innovation” (A - 48). Miami, FL.
Indexed document: No
Keywords: Cortisol awakening response / Saliva / Sampling delay / Actigraphy / Track caps / Time lag / Sampling delay

The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed

The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed
DocumentAnxious attachment style predicts an enhanced cortisol response to group psychosocial stress2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-072
Location: Arquivo PCA - Pasta 8/2012
Title:
072 - The psychophysiology of human attachment and stress
Duration: 2013-10 - 2015-09
Researcher(s):
Angela Clow, Lisa Thorn, Andrea Oskis, Nina Smyth
Institution(s): Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
2 Articles
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Oskis, A., Smyth, N.
Number of reproductions:
1
Keywords:
Psychophysiology / Affective and social behavior / Attachment / Psychoneuroimmunology / Endocrinology / Stress and health

Reference code: PT/FB/BL-2012-072.02
Location: Arquivo PCA - Pasta 8/2012
Title:
Anxious attachment style predicts an enhanced cortisol response to group psychosocial stress
Publication year: 2015
URL:
http://informahealthcare.com/doi/abs/10.3109/10253890.2015.1021676?journalCode=sts
Abstract/Results: ABSTRACT:
Insecure attachment style is associated with poor health outcomes. A proposed pathway implicates the hypothalamic-pituitary-adrenal axis (HPA-axis), dysregulation of which is associated with a wide range of mental and physical ill-health. However, data on stress reactivity in relation to attachment style is contradictory. This relationship was examined using the novel Trier Social Stress Test for groups (TSST-G): a group-based acute psychosocial stressor. Each participant, in the presence of other group members, individually performed public speaking and mental arithmetic tasks. Seventy-eight healthy young females (20.2?±?3.2 years), in groups of up to six participants completed demographic information and the Vulnerable Attachment Style Questionnaire (VASQ), and were then exposed to the TSST-G. Physiological stress reactivity was assessed using salivary cortisol concentrations, measured on seven occasions at 10-min intervals. Vulnerable attachment predicted greater cortisol reactivity independent of age, smoking status, menstrual phase and body mass index. Supplementary analysis indicated that insecure anxious attachment style (high scores on the insecurity and proximity-seeking sub-scales of the VASQ) showed greater cortisol reactivity than participants with secure attachment style. Avoidant attachment style (high scores for insecurity and low scores for proximity seeking) was not significantly different from the secure attachment style. Attachment style was not associated with the timing of the cortisol peak or post-stress recovery in cortisol concentrations. These findings in healthy young females indicate subtle underlying changes in HPA axis function in relation to attachment style and may be important for future mental health and well-being.
Accessibility: Document exist in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Thorn, L., Oskis, A., Clow, A.
Document type:
Article
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Oskis, A., Hucklebridge, F., Evans, P., & Clow, A. (2015). Anxious attachment style predicts an enhanced cortisol response to group psychosocial stress. Stress: The International Journal on the Biology of Stress, 18(2), 143-148. https://doi.org/10.3109/10253890.2015.1021676
2-year Impact Factor: 2.383|2015
Times cited: 27|2025-02-10
Indexed document: Yes
Quartile: Q2
Keywords: Group stressor / HPA Axis / Healthy females / Stress reactivity / Saliva / Trier social stress test

Anxious attachment style predicts an enhanced cortisol response to group psychosocial stress

Anxious attachment style predicts an enhanced cortisol response to group psychosocial stress
DocumentPost awakening salivary cortisol secretion and trait well-being: The importance of sample timing accuracy2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.09
Location: Arquivo PCA - Pasta 8/2010
Title:
Post awakening salivary cortisol secretion and trait well-being: The importance of sample timing accuracy
Publication year: 2015
URL:
http://www.psyneuen-journal.com/article/S0306-4530(15)00169-9/abstract
Abstract/Results: ABSTRACT:
Indices of post awakening cortisol secretion (PACS), include the rise in cortisol(cortisol awakening response: CAR) and overall cortisol concentrations (e.g. area under thecurve with reference to ground: AUCg) in the first 30—45 min. Both are commonly investi-gated in relation to psychosocial variables. Although sampling within the domestic setting isecologically valid, participant non-adherence to the required timing protocol results in erro-neous measurement of PACS and this may explain discrepancies in the literature linking thesemeasures to trait well-being (TWB). We have previously shown that delays of little over 5 min(between awakening and the start of sampling) to result in erroneous CAR estimates. In thisstudy, we report for the first time on the negative impact of sample timing inaccuracy (verifiedby electronic-monitoring) on the efficacy to detect significant relationships between PACS andTWB when measured in the domestic setting.Healthy females (N = 49, 20.5 ± 2.8 years) selected for differences in TWB collected salivasamples (S1—4) on 4 days at 0, 15, 30, 45 min post awakening, to determine PACS. Adherence tothe sampling protocol was objectively monitored using a combination of electronic estimatesof awakening (actigraphy) and sampling times (track caps).Relationships between PACS and TWB were found to depend on sample timing accuracy. LowerTWB was associated with higher post awakening cortisol AUCg in proportion to the mean sampletiming accuracy (p < .005). There was no association between TWB and the CAR even taking intoaccount sample timing accuracy. These results highlight the importance of careful electronicmonitoring of participant adherence for measurement of PACS in the domestic setting. Meansample timing inaccuracy, mainly associated with delays of >5 min between awakening andcollection of sample 1 (median = 8 min delay), negatively impacts on the sensitivity of analysisto detect associations between PACS and TWB.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Thorn, L., Hucklebridge, F., Evans, P., Clow, A.
Document type:
Article
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Hucklebridge, F., Evans, P., & Clow, A. (2015). Post awakening salivary cortisol secretion and trait well-being: The importance of sample timing accuracy. Psychoneuroendocrinology, 58, 141-151. https://doi.org/10.1016/j.psyneuen.2015.04.019
2-year Impact Factor: 4.704|2015
Times cited: 9|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Saliva / CAR / AUCg / Awakening / Non-adherence / Trait well-being (TWB)
DocumentRelationship between post-awakening salivary cortisol and melatonin secretion in healthy participants2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-072
Location: Arquivo PCA - Pasta 8/2012
Title:
072 - The psychophysiology of human attachment and stress
Duration: 2013-10 - 2015-09
Researcher(s):
Angela Clow, Lisa Thorn, Andrea Oskis, Nina Smyth
Institution(s): Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
2 Articles
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Oskis, A., Smyth, N.
Number of reproductions:
1
Keywords:
Psychophysiology / Affective and social behavior / Attachment / Psychoneuroimmunology / Endocrinology / Stress and health

Reference code: PT/FB/BL-2012-072.04
Location: Arquivo PCA - Pasta 8/2012
Title:
Relationship between post-awakening salivary cortisol and melatonin secretion in healthy participants
Publication year: 2016
URL:
http://www.tandfonline.com/doi/abs/10.3109/10253890.2016.1146671
Abstract/Results: ABSTRACT:
We report the relationship between patterns of post-awakening salivary melatonin and cortisol secretion in healthy participants (n=51; mean age 21.6 ± 5.0 years). Saliva samples were collected within the domestic setting, at 0, 15, 30 and 45 min post-awakening on 2 consecutive typical weekdays. Analyses were undertaken on data with electronically verified sample timing accuracy (<?5 min delay between awakening and the start of saliva sampling). Melatonin secretion declined linearly by an average of 29% within the first 45 minutes post-awakening. In contrast there was a marked 112% surge in cortisol, characteristic of the cortisol awakening response. No day-differences in melatonin or cortisol secretion were observed but melatonin concentrations were lower with later awakening. Despite contrasting post-awakening changes in these hormones there was a lack of relationship between overall levels or patterns of melatonin and cortisol during this period.
Accessibility: Document does not exist in file
Language:
eng
Author:
Ramachandran, N.
Secondary author(s):
Smyth, L., Thorn, L., Eardley, A., Evans, P., Clow, A.
Document type:
Article
Number of reproductions:
1
Reference:
Ramachandran, N., Smyth, N., Thorn, L., Eardley, A., Evans, P., & Clow, A. (2016). Relationship between post-awakening salivary cortisol and melatonin secretion in healthy participants. Stress: The International Journal on the Biology of Stress, 19(2), 260-263. https://doi.org/10.3109/10253890.2016.1146671
2-year Impact Factor: 2.590|2016
Times cited: 9|2025-02-11
Indexed document: Yes
Quartile: Q2
Keywords: Saliva / CAR / Awakening / Circadian / Biological dawn / Diurnal
DocumentAssessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-072
Location: Arquivo PCA - Pasta 8/2012
Title:
072 - The psychophysiology of human attachment and stress
Duration: 2013-10 - 2015-09
Researcher(s):
Angela Clow, Lisa Thorn, Andrea Oskis, Nina Smyth
Institution(s): Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
2 Articles
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Oskis, A., Smyth, N.
Number of reproductions:
1
Keywords:
Psychophysiology / Affective and social behavior / Attachment / Psychoneuroimmunology / Endocrinology / Stress and health

Reference code: PT/FB/BL-2012-072.06
Location: Arquivo PCA - Pasta 8/2012
Title:
Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy
Publication year: 2016
URL:
http://www.psyneuen-journal.com/article/S0306-4530(16)30489-9/fulltext
Abstract/Results: ABSTRACT:
The cortisol awakening response (CAR) is typically measured in the domestic setting. Moderate sample timing inaccuracy has been shown to result in erroneous CAR estimates and such inaccuracy has been shown partially to explain inconsistency in the CAR literature. The need for more reliable measurement of the CAR has recently been highlighted in expert consensus guidelines where it was pointed out that less than 6% of published studies provided electronic-monitoring of saliva sampling time in the post-awakening period. Analyses of a merged data-set of published studies from our laboratory are presented. To qualify for selection, both time of awakening and collection of the first sample must have been verified by electronic-monitoring and sampling commenced within 15min of awakening. Participants (n=128) were young (median age of 20 years) and healthy. Cortisol values were determined in the 45min post-awakening period on 215 sampling days. On 127days, delay between verified awakening and collection of the first sample was less than 3min ('no delay' group); on 45days there was a delay of 4-6min ('short delay' group); on 43days the delay was 7-15min ('moderate delay' group). Cortisol values for verified sampling times accurately mapped on to the typical post-awakening cortisol growth curve, regardless of whether sampling deviated from desired protocol timings. This provides support for incorporating rather than excluding delayed data (up to 15min) in CAR analyses. For this population the fitted cortisol growth curve equation predicted a mean cortisol awakening level of 6nmols/l (±1 for 95% CI) and a mean CAR rise of 6nmols/l (±2 for 95% CI). We also modelled the relationship between real delay and CAR magnitude, when the CAR is calculated erroneously by incorrectly assuming adherence to protocol time. Findings supported a curvilinear hypothesis in relation to effects of sample delay on the CAR. Short delays of 4-6min between awakening and commencement of saliva sampling resulted in an overestimated CAR. Moderate delays of 7-15min were associated with an underestimated CAR. Findings emphasize the need to employ electronic-monitoring of sampling accuracy when measuring the CAR in the domestic setting.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2010-096.11
Author: Smyth, N.
Secondary author(s):
Thorn, L., Hucklebridge, F., Clow, A., Evans, P.
Document type:
Article-d
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A., & Evans, P. (2016). Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy. Psychoneuroendocrinology, 74, 380-386. https://doi.org/10.1016/j.psyneuen.2016.09.026
2-year Impact Factor: 4.788|2016
Times cited: 23|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: CAR / Cortisol / Cortisol awakening response / Growth cortisol curve / Saliva / Sample timing inaccuracy
DocumentAssessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.11
Location: Arquivo PCA - Pasta 8/2010
Title:
Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy
Publication year: 2016
URL:
http://www.psyneuen-journal.com/article/S0306-4530(16)30489-9/fulltext
Abstract/Results: ABSTRACT:
The cortisol awakening response (CAR) is typically measured in the domestic setting. Moderate sample timing inaccuracy has been shown to result in erroneous CAR estimates and such inaccuracy has been shown partially to explain inconsistency in the CAR literature. The need for more reliable measurement of the CAR has recently been highlighted in expert consensus guidelines where it was pointed out that less than 6% of published studies provided electronic-monitoring of saliva sampling time in the post-awakening period. Analyses of a merged data-set of published studies from our laboratory are presented. To qualify for selection, both time of awakening and collection of the first sample must have been verified by electronic-monitoring and sampling commenced within 15min of awakening. Participants (n=128) were young (median age of 20 years) and healthy. Cortisol values were determined in the 45min post-awakening period on 215 sampling days. On 127days, delay between verified awakening and collection of the first sample was less than 3min ('no delay' group); on 45days there was a delay of 4-6min ('short delay' group); on 43days the delay was 7-15min ('moderate delay' group). Cortisol values for verified sampling times accurately mapped on to the typical post-awakening cortisol growth curve, regardless of whether sampling deviated from desired protocol timings. This provides support for incorporating rather than excluding delayed data (up to 15min) in CAR analyses. For this population the fitted cortisol growth curve equation predicted a mean cortisol awakening level of 6nmols/l (±1 for 95% CI) and a mean CAR rise of 6nmols/l (±2 for 95% CI). We also modelled the relationship between real delay and CAR magnitude, when the CAR is calculated erroneously by incorrectly assuming adherence to protocol time. Findings supported a curvilinear hypothesis in relation to effects of sample delay on the CAR. Short delays of 4-6min between awakening and commencement of saliva sampling resulted in an overestimated CAR. Moderate delays of 7-15min were associated with an underestimated CAR. Findings emphasize the need to employ electronic-monitoring of sampling accuracy when measuring the CAR in the domestic setting.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2012-072.06
Author: Smyth, N.
Secondary author(s):
Thorn, L., Hucklebridge, F., Clow, A., Evans, P.
Document type:
Article
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A., & Evans, P. (2016). Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy. Psychoneuroendocrinology, 74, 380-386. https://doi.org/10.1016/j.psyneuen.2016.09.026
2-year Impact Factor: 4.788|2016
Times cited: 23|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: CAR / Cortisol / Cortisol awakening response / Growth cortisol curve / Saliva / Sample timing inaccuracy
DocumentSalience versus magnitude in the measurement of the cortisol awakening response2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.12
Location: Arquivo PCA - Pasta 8/2010
Title:
Salience versus magnitude in the measurement of the cortisol awakening response
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S0306453018309922
Abstract/Results: ABSTRACT
Pulsatile ultradian secretion of cortisol, rarely studied in salivary data, has functional importance in hypothalamic pituitary adrenal (HPA) axis regulation. The first daily ultradian episode, the cortisol awakening response (CAR), was examined in healthy adults, in 5-min secretion rates of salivary cortisol from electronically monitored awakening time to 1.25?h. Aggregated rates revealed a cubic trend, with wave-length of almost exactly 1?h, as predicted from known ultradian periodicity. Peak secretion rate occurred 20-min post-awakening. Peak (20-min) to trough (59-min) amplitude (PTA) expressed a salient signal shape. Rates rose steeply to and from peak, and major secretion was packaged into a few 5-min intervals, inconsistent with normal or uniform distribution of 5-min rates, but consistent with known pulsatile cortisol delivery. Null hypotheses asserting normal or uniform distributions were rejected. Maximal rates overwhelmingly occurred before and minimal rates after 30-mins, with degree of extremity at each polarity significantly positively correlated.
To demonstrate utility and reliability of PTA estimation in a clinically relevant domain, re- analyses of a previously published study were conducted. Data from only three saliva samples were used, given importance of cost considerations for many CAR researchers. Difference between mean rates before and after 30-min yielded a simple salience index, highly correlated with PTA derived from full 5-min interval data. CAR salience performed significantly better than traditional AUCi magnitude in discriminating control cases (higher inferred amplitude) and cases with Seasonal Affective Disorder (lower inferred amplitude). Evidence suggested that low AUCi may be more sensitive in identifying within-subject changes (e.g. more depressed mood in winter among SAD cases) and low CAR salience better at revealing enduring between-subjects associations (e.g. underlying disorder vulnerability). Since both PTA salience and AUCi magnitude can be analysed and compared using exactly the same data from the same commonly used saliva sampling points, further research is warranted into the importance of individual differences in patterns of cortisol delivery, not just how much is delivered.
Accessibility: Document exists in file
Language:
eng
Author:
Evans, P.
Secondary author(s):
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A.
Document type:
Article
Number of reproductions:
1
Reference:
Evans, P., Smyth, N., Thorn, L., Hucklebridge, F., & Clow, A. (2019). Salience versus magnitude in the measurement of the cortisol awakening response. Psychoneuroendocrinology, 103, 249-258. https://doi.org/10.1016/j.psyneuen.2019.01.023
2-year Impact Factor: 4.732|2019
Times cited: 10|2025-02-13
Indexed document: Yes
Quartile: Q1
Keywords: CAR / HPA axis / Pulsatility / Secretion rate / Ultradian / Saliva

Salience versus magnitude in the measurement of the cortisol awakening response

Salience versus magnitude in the measurement of the cortisol awakening response
DocumentSalivary oxytocin after play with parents predicts behavioural problems in preschool children2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-158
Location: Arquivo PCA - Pasta 28/2012
Title:
158 - Neuroendocrine underpinnings of social bonds to parents and peers in preschool children. Oxytocin and Cortisol on adopted children and non-adopted controls
Duration: 2013-09 - 2018-10
Researcher(s):
Nuno Manuel Correia Torres, Manuela Veríssimo, Antonio J. Santos, Jaak Panksepp, Lígia Monteiro, Leandra Marília Marques Coelho
Institution(s): Research Group on Developmental Psychology of UIPCDE (Unidade de Investigação em Psicologia Cognitiva, do Desenvolvimento e da Educação) of ISPA-IU, Lisboa (Portugal) and Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Neuroscience Program. Washington State University (USA)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
1 Article
Language: eng
Author:
Torres, N.
Secondary author(s):
Veríssimo, M., Santos, A., Panksepp, J., Monteiro, L., Coelho, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Affective and social behavior / Attachment / Developmental psychology / Cognitive development / Psychosocial development / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health

Reference code: PT/FB/BL-2012-158.03
Location: BF-GMS
Title:
Salivary oxytocin after play with parents predicts behavioural problems in preschool children
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S0306453021004832?via%3Dihub
Abstract/Results: ABSTRACT:
Background:
Oxytocin (OXT) has attracted research interest for its potential involvement in many of the behavioural problems observed in childhood. Due to its logistical advantages, saliva is an attractive fluid to quantify neuropeptides in children. Salivary OXT has been suggested as a potential biomarker for psychopathology during childhood. However, several questions still remain about the extent to which, and under what conditions, concentrations of OXT in saliva can be reliably measured and are related to behavioural problems in preschool age children.
Methods:
Seven samples of saliva from 30 preschool children (17 girls) were collected in five different days at their homes. Three of the samples were collected by the children's parents at baseline daily routine conditions, and four of the samples were collected by researchers during two home-visits: before and after two 15-minute dyadic play sessions (one with mothers and one fathers) between each individual parent and the child. Oxytocin concentrations were quantified by Radioimmunoassay with prior extraction. Children's behavioural problems were assessed by the Caregiver-Teacher Report Form (C-TRF) questionnaire, completed by the child's' preschool teacher.
Results:
Salivary OXT measured in baseline samples could not predict any of the behavioural problems measured by the C-TRF. However, when measured after playing with parents salivary OXT showed a stronger pattern of negative correlations, specially with the depression and opposition scales of the C-TRF. Furthermore, salivary OXT was unlikely to be reliably measured using single sampling, but acceptable reliabilities were achieved when averaging several samples. Finally, the single measures of salivary OXT evoked after an episode of play with parents showed better reliabilities than collected at baseline.
Conclusion:
Measurements of OXT evoked after positive affect interactions with parents seem to capture aspects of the OXT system in young children that might be relevant for understanding the role of this system in children's social behaviour.
Accessibility: Document exists in file
Language:
eng
Author:
Torres, N.
Secondary author(s):
Martins, D., Monteiro, L., Santos, A. J., Vaughn, B. E., Veríssimo, M.
Document type:
Article
Number of reproductions:
1
Reference:
Torres, N., Martins, D., Monteiro, L., Santos, A. J., Vaughn, B. E., & Veríssimo, M. (2022). Salivary oxytocin after play with parents predicts behavioural problems in preschool children. Psychoneuroendocrinology, 136, 105609. https://doi.org/10.1016/j.psyneuen.2021.105609
2-year Impact Factor: 3.700|2022
Times cited: 2|2025-02-17
Indexed document: Yes
Quartile: Q2
Keywords: Behavioural problems / Children / Oxytocin / Radioimmunoassay / Saliva