| Reference code: | PT/FB/BL-2006-035.04 |
| Location: | Arquivo PCA - Pasta 17/2006
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Title:
| Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia
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| Publication year: | 2010
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URL:
| http://www.sciencedirect.com/science/article/pii/S0920996410013551
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| Abstract/Results: | ABSTRACT:
BACKGROUND:
We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia.
METHODS:
Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition.
RESULTS:
Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size=0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p<0.05). The severity of problems on each of the individual antecedents comprising the antecedent triad did not relate strongly to performance on the neurocognitive domains.
CONCLUSIONS:
Children aged 9-12 years who present multiple antecedents of schizophrenia display poorer neurocognition than healthy peers on several domains showing pronounced deficits in schizophrenia, first-episode psychosis, and youth with prodromal symptoms. Longitudinal follow-up is necessary to determine the extent to which poorer neurocognitive performance is specific to those who develop schizophrenia.
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| Accessibility: | Document exists in file (previous version submitted for publication)
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Copyright/Reproduction:
| By permission
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Language:
| eng
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Author:
| Cullen, A. E.
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Secondary author(s):
| Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., Laurens, K. R.
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Document type:
| Article
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Number of reproductions:
| 1
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Percentiles:
| 63.83|0.80
|
Reference:
| Cullen, A. E., Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., & Laurens, K. R. (2010). Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia. Schizophrenia Research, 121(1-3), 15-23. https://doi.org/10.1016/j.schres.2010.05.034
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| 2-year Impact Factor: | 4.374|2010
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| Times cited: | 35|2026-02-05
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| Indexed document: | Yes
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| Quartile: | Q1
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| Keywords: | High-risk / Psychosis / Intelligence / Executive function / Memory / Scholastic achievement
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Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia |