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DocumentFinal report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3106.pdf
Abstract/Results: RESULTS:
The overall aim of this study was to investigate the influence of serotonin and dopamine receptor gene polymorphisms on various parameters relevant to the successful participation of obese people taking part in a diet and exercise obesity intervention. We demonstrated that serotonin receptor gene genotype has a significant influence on perception of hunger. We also showed that dopamine receptor gene polymorphisms significantly influence the drop out rate from an obesity intervention study, and suggest that this is due to the influence of these polymorphisms both on motivation to exercise and on restrained eating behaviours. Finally we demonstrated the efficacy of motivational interviewing in an obesity intervention programme and have shown that motivational interviews influence the relationship between measures of motivation or eating behaviours and weight loss measured by BMI change These novel findings indicate that serotonin plays a key role in determining appetite. They also indicate that extent of dopamine signalling may influence an individual's motivation to engage in weight-loss programmes. Further studies are required to confirm these findings and investigate the underlying mechanisms involved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Genotype / Obesity / Motivation / Intervention program / Serotonin / Dopamine / Weight loss

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
DocumentRodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.03
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189637/
Abstract/Results: ABSTRACT:
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive–compulsive disorder, mania, drug addiction, eating disorders, and substance abuse as well as in chronic pain. To ensure progress in the understanding of the neuropathophysiology of these disorders, animal models with good construct and predictive validity are indispensable. Many human studies aimed at measuring decision-making capacities use the Iowa gambling task (IGT), a task designed to model everyday life choices through a conflict between immediate gratification and long-term outcomes. Recently, new rodent models based on the same principle have been developed to investigate the neurobiological mechanisms underlying IGT-like decision-making on behavioral, neural, and pharmacological levels. The comparative strengths, as well as the similarities and differences between these paradigms are discussed. The contribution of these models to elucidate the neurobehavioral factors that lead to poor decision-making and to the development of better treatments for psychiatric illness is considered, along with important future directions and potential limitations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
De Visser, L.
Secondary author(s):
Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., Fitoussi, A., Galhardo, V., Van den Boos, R., Winstanley, C., Dellu-Hagedorn, F.
Document type:
Article
Number of reproductions:
1
Reference:
De Visser, L., Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., ..., Dellu-Hagedorn, F. (2011). Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making. Frontiers in Neuroscience, 5, 109. https://doi.org/10.3389/fnins.2011.00109
2-year Impact Factor: N/A
Impact factor notes: Impact factor computed since 2014
Times cited: 90|2025-02-24
Indexed document: Yes
Quartile: N/A
Keywords: Iowa gambling task (IGT) / Animal models / Validity / Dopamine / Serotonin / Neurobiology

Novo ficheiro

Novo ficheiro
DocumentThe Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.06
Location: BF-GMS
Title:
The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies
Publication year: 2021
URL:
https://www.frontiersin.org/articles/10.3389/fphar.2021.739053/full
Abstract/Results: ABSTRACT:
There is an increasing interest in the neural effects of psychoactive drugs, in particular tryptamine psychedelics, which has been incremented by the proposal that they have potential therapeutic benefits, based on their molecular mimicry of serotonin. It is widely believed that they act mainly through 5HT2A receptors but their effects on neural activation of distinct brain systems are not fully understood. We performed a quantitative meta-analysis of brain imaging studies to investigate the effects of substances within this class (e.g., LSD, Psilocybin, DMT, Ayahuasca) in the brain from a molecular and functional point of view. We investigated the question whether the changes in activation patterns and connectivity map into regions with larger 5HT1A/5HT2A receptor binding, as expected from indolaemine hallucinogens (in spite of the often reported emphasis only on 5HT2AR). We did indeed find that regions with changed connectivity and/or activation patterns match regions with high density of 5HT2A receptors, namely visual BA19, visual fusiform regions in BA37, dorsal anterior and posterior cingulate cortex, medial prefrontal cortex, and regions involved in theory of mind such as the surpramarginal gyrus, and temporal cortex (rich in 5HT1A receptors). However, we also found relevant patterns in other brain regions such as dorsolateral prefrontal cortex. Moreover, many of the above-mentioned regions also have a significant density of both 5HT1A/5HT2A receptors, and available PET studies on the effects of psychedelics on receptor occupancy are still quite scarce, precluding a metanalytic approach. Finally, we found a robust neuromodulatory effect in the right amygdala. In sum, the available evidence points towards strong neuromodulatory effects of tryptamine psychedelics in key brain regions involved in mental imagery, theory of mind and affective regulation, pointing to potential therapeutic applications of this class of substances.
Accessibility: Document exists in file
Language:
eng
Author:
Castelhano, J.
Secondary author(s):
Lima, G., Teixeira, M., Soares, C., Pais, M., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Castelhano, J., Lima, G., Teixeira, M., Soares, C., Pais, M., & Castelo-Branco, M. (2021). The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies. Frontiers in Pharmacology, 12, 739053. https://doi.org/10.3389/fphar.2021.739053
2-year Impact Factor: 5.988|2021
Times cited: 13|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: 5-hydroxytryptamine receptor 1A / 5-hydroxytryptamine receptor 2A / Cognition / Functional magnetic resonance imaging / Positron emission tomography / Psychedelic agents / Serotonin

The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies

The Effects of Tryptamine Psychedelics in the Brain: A meta-Analysis of Functional and Review of Molecular Imaging Studies
DocumentFinal report - Spiritual states induced by ayahuasca, and the involvement of the reward system2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.01
Location: BF-GMS
Title:
Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system
Publication year: 2022
Abstract/Results:
ABSTRACT:
BACKGROUND
DMT is an indole alkaloid best known by its presence in ayahuasca. It is a psychedelic tryptamine associated with intense visual phenomena, perception changes and profound spiritual
experiences.
AIMS
In this study we explored the neural correlates of these altered brain states during the experience produced by DMT using resting state fMRI and periodic visual stimuli.
METHOD
A within-subject design study with control and active treatment conditions was conducted, in 2 separate sessions: Control (no treatment) or Active treatment (inhaled DMT). In both sessions, pre and post measures of subjective experience were collected with the Spiritual Well Being Questionnaire, the Vividness of Visual Imagery Questionnaire, the Mystical Experience Questionnaire (MEQ-30) and the Hallucinogen Rating Scale (HRS). fMRI included resting state,
block design with a visual hallucination inducer paradigm, and visual population receptive field
(pRF) mapping.
RESULTS
Significant behavioural and psychological effects were observed for hallucinogen and mystical subjective experiences. A surprising intrinsic hyperconnectivity pattern was found within functionally segregated regions of the DMN and Salience networks.
Mean pRF size in V1 was statistically significantly higher in the DMT condition. Visual stimulation yielded increased BOLD activity in visual areas BA18, 19 and Precuneus for the active condition. This may explain perceptual distortions induced by psychedelics such as field blurring and the enlargement of nearby visual space, particularly at the visual periphery.
CONCLUSIONS
These results suggest a neural basis for the hallucinations evoked by Ayahuasca which occur concomitantly with significant behavioural and psychological effects.
Accessibility: Document exists in file
Language:
eng
Author:
Pais, M. L.
Secondary author(s):
Soares, C., Teixeira, M., Lima, G., Cabral, C., Petrella, L., Castelo-Branco, M.
Document type:
Final report
Number of reproductions:
3
Reference:
Pais, M. L., Soares, C., Teixeira, M., Lima, G., Cabral, C., Petrella, L., & Castelo-Branco, M. (2022). Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system
Indexed document: No
Keywords: Cognition / functional magnetic resonance imaging (fMRI) / Psychedelic agents / Serotonin / Spiritual states / Hallucinations

Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system

Final report - Spiritual states induced by ayahuasca, and the involvement of the reward system
DocumentThe role of serotonin in fear learning and memory: A systematic review of human studies2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-304
Location: BF-GMS
Title:
304 - Boosting and hindering action imitation by modulating spike-timing dependent plasticity
Researcher(s): Alessio Avenanti, Chiara Spaccasassi, Sonia Turrini, Antonio Cataneo
Institution(s): Department of Psychology, Alma Mater Studiorum - Università di Bologna (Italy)
Contents: Contents:
Application form
Correspondence
Language: eng
Author:
Avenanti, A.
Secondary author(s):
Spaccasassi, C., Turrini, S., Cataneo, A.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2022-304.04
Location: BF-GMS
Title:
The role of serotonin in fear learning and memory: A systematic review of human studies
Publication year: 2023
URL:
https://www.mdpi.com/2076-3425/13/8/1197
Abstract/Results: ABSTRACT:
Fear is characterized by distinct behavioral and physiological responses that are essential for the survival of the human species. Fear conditioning (FC) serves as a valuable model for studying the acquisition, extinction, and expression of fear. The serotonin (5-hydroxytryptamine, 5-HT) system is known to play a significant role in emotional and motivational aspects of human behavior, including fear learning and expression. Accumulating evidence from both animal and human studies suggests that brain regions involved in FC, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-HT receptors, implicating the crucial involvement of serotonin in aversive learning. Additionally, studies exploring serotonin gene polymorphisms have indicated their potential influence on FC. Therefore, the objective of this work was to review the existing evidence linking 5-HT with fear learning and memory in humans. Through a comprehensive screening of the PubMed and Web of Science databases, 29 relevant studies were included in the final review. These studies investigated the relationship between serotonin and fear learning using drug manipulations or by studying 5-HT-related gene polymorphisms. The results suggest that elevated levels of 5-HT enhance aversive learning, indicating that the modulation of serotonin 5-HT2A receptors regulates the expression of fear responses in humans. Understanding the role of this neurochemical messenger in associative aversive learning can provide insights into psychiatric disorders such as anxiety and post-traumatic stress disorder (PTSD), among others.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2018-160.09
Author: Tortora, F.
Secondary author(s):
Hadipour, A. L., Battaglia, S., Falzone, A., Avenanti, A., Vicario, C. M.
Document type:
Article-d
Number of reproductions:
1
Reference:
Tortora, F., Hadipour, A. L., Battaglia, S., Falzone, A., Avenanti, A., & Vicario, C. M. (2023). The role of serotonin in fear learning and memory: A systematic review of human studies. Brain Sciences, 13(8), 1197. https://doi.org/10.3390/brainsci13081197
2-year Impact Factor: 2.7|2023
Times cited: 25|2025-02-28
Indexed document: Yes
Quartile: Q3
Keywords: Human fear conditioning / Fear memory / Serotonin / 5-HT receptor / Selective serotonin reuptake inhibitors (SSRIs) / Acute tryptophan depletion (ATD) / 5-HTT polymorphisms

The role of serotonin in fear learning and mMemory: A systematic review of human studies

The role of serotonin in fear learning and mMemory: A systematic review of human studies
DocumentThe role of serotonin in fear learning and memory: A systematic review of human studies2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-160
Location: BF-GMS
Title:
160 - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction learning
Duration: 2019-04 - 2024-11
Researcher(s):
Carmelo Vicario, Michael A Nitsche, Vuk Markovic
Institution(s): Department of Psychology and Neuroscience, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany); Department of Cognitive Science, University of Messina (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Vicario, C.
Secondary author(s):
Nitsche, M. A., Markovic, V.
Number of reproductions:
1
Keywords:
tDCS / Fear extinction learning / Pre-frontal cortex / Psychophysiology

Reference code: PT/FB/BL-2018-160.09
Location: BF-GMS
Title:
The role of serotonin in fear learning and memory: A systematic review of human studies
Publication year: 2023
URL:
https://www.mdpi.com/2076-3425/13/8/1197
Abstract/Results: ABSTRACT:
Fear is characterized by distinct behavioral and physiological responses that are essential for the survival of the human species. Fear conditioning (FC) serves as a valuable model for studying the acquisition, extinction, and expression of fear. The serotonin (5-hydroxytryptamine, 5-HT) system is known to play a significant role in emotional and motivational aspects of human behavior, including fear learning and expression. Accumulating evidence from both animal and human studies suggests that brain regions involved in FC, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-HT receptors, implicating the crucial involvement of serotonin in aversive learning. Additionally, studies exploring serotonin gene polymorphisms have indicated their potential influence on FC. Therefore, the objective of this work was to review the existing evidence linking 5-HT with fear learning and memory in humans. Through a comprehensive screening of the PubMed and Web of Science databases, 29 relevant studies were included in the final review. These studies investigated the relationship between serotonin and fear learning using drug manipulations or by studying 5-HT-related gene polymorphisms. The results suggest that elevated levels of 5-HT enhance aversive learning, indicating that the modulation of serotonin 5-HT2A receptors regulates the expression of fear responses in humans. Understanding the role of this neurochemical messenger in associative aversive learning can provide insights into psychiatric disorders such as anxiety and post-traumatic stress disorder (PTSD), among others.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2022-304.04
Author: Tortora, F.
Secondary author(s):
Hadipour, A. L., Battaglia, S., Falzone, A., Avenanti, A., Vicario, C. M.
Document type:
Article
Number of reproductions:
1
Reference:
Tortora, F., Hadipour, A. L., Battaglia, S., Falzone, A., Avenanti, A., & Vicario, C. M. (2023). The role of serotonin in fear learning and Memory: A systematic review of human studies. Brain Sciences, 13(8), 1197. https://doi.org/10.3390/brainsci13081197
2-year Impact Factor: 2.7|2023
Times cited: 25|2025-02-28
Indexed document: Yes
Quartile: Q3
Keywords: Human fear conditioning / Fear memory / Serotonin / 5-HT receptor / Selective serotonin reuptake inhibitors (SSRIs) / Acute tryptophan depletion (ATD) / 5-HTT polymorphisms

The role of serotonin in fear learning and mMemory: A systematic review of human studies

The role of serotonin in fear learning and mMemory: A systematic review of human studies
DocumentRapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-252
Location: BF-GMS
Title:
252 - Spiritual states induced by ayahuasca, and the involvement of the reward system
Duration: 2019-10 - 2022-09
Researcher(s):
Miguel Castelo-Branco, Gisela Lima, Miguel Raimundo, Pedro Fonseca, Carla Cavaleiro, Lorena Petrella, Célia Cabral, Antero Abrunhosa
Institution(s): Institute for Nuclear Sciences Applied to Health - ICNAS, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Lima, G., Raimundo, M., Fonseca, P., Cavaleiro, C., Petrella, L., Cabral, C., Abrunhosa, A.
Number of reproductions:
3
Keywords:
Ayahuasca / Dopamine and reward / Spiritual experience / Hallucinations / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-252.10
Location: BF-GMS
Title:
Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields
Publication year: 2024
URL:
https://doi.org/10.1016/j.neuroimage.2024.120718
Abstract/Results: Abstract:
N, N-dimethyltryptamine (DMT) is a psychedelic tryptamine acting on 5-HT2A serotonin receptors, which is associated with intense visual hallucinatory phenomena and perceptual changes such as distortions in visual space. The neural underpinnings of these effects remain unknown. We hypothesised that changes in population receptive field (pRF) properties in the primary visual cortex (V1) might underlie visual perceptual experience. We tested this hypothesis using magnetic resonance imaging (MRI) in a within-subject design. We used a technique called pRF mapping, which measures neural population visual response properties and retinotopic maps in early visual areas. We show that in the presence of visual effects, as documented by the Hallucinogen
Rating Scale (HRS), the mean pRF sizes in V1 significantly increase in the peripheral visual field for active condition (inhaled DMT) compared to the control. Eye and head movement differences were absent across conditions. This evidence for short-term effects of DMT in pRF may explain perceptual distortions induced by psychedelics such as field blurring, tunnel vision (peripheral vision becoming blurred while central vision remains sharp) and the enlargement of nearby visual space, particularly at the visual locations surrounding the fovea. Our findings are also consistent with a mechanistic framework whereby gain control of ongoing and evoked activity in the visual cortex is controlled by activation of 5-HT2A receptors.
Accessibility: Document exists in file
Language:
eng
Author:
Pais, M. L.
Secondary author(s):
Teixeira, M., Soares, C., Lima, G., Rijo, P., Cabral, C., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
3
Reference:
Pais, M. L., Teixeira, M., Soares, C., Lima, G., Rijo, P., Cabral, C., & Castelo-Branco, M. (2024). Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields. NeuroImage, 297, 120718. https://doi.org/10.1016/j.neuroimage.2024.120718
2-year Impact Factor: 4.7|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 1|2025-02-19
Indexed document: Yes
Quartile: Q1
Keywords: Serotonin / 5-HT2A receptors / Psychedelics / Visual hallucinations / Population responses / Visual cortex

Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields

Rapid effects of tryptamine psychedelics on perceptual distortions and early visual cortical population receptive fields
File264 - Prefrontal serotonin 1A receptor activation as a key determinant of cognitive flexibility

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2024
Location: BF-GMS
Title:
2024 Grants
Start date: 2025-01

Reference code: PT/FB/BL-2024-264
Location: BF-GMS
Title:
264 - Prefrontal serotonin 1A receptor activation as a key determinant of cognitive flexibility
Researcher(s): Nuno Dinis Alves, João Bessa, Luisa Pinto, Miguel Castelo-Branco, Joana Gonçalves, Carina Cunha, Inês Ribeiro, Tawan Carvalho, Joana Macedo, Ana Luísa Ferraz
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Medicine, University of Minho, Braga (Portugal); Coimbra Institute for Biomedical Imaging and Translational Research - CIBIT, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project has not started yet
Author: Alves, N. D.
Secondary author(s):
Bessa, J., Pinto, L., Castelo-Branco, M., Gonçalves, J., Cunha, C., Ribeiro, I., Carvalho, T., Macedo, J., Ferraz, A. L.
Number of reproductions:
1
Keywords:
Serotonin / Post-synaptic 5-HT1A receptor / Cognitive flexibility / Psychophysiology