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BIAL Foundation
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DocumentFinal report - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-234
Location: BF-GMS
Title:
234 - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control
Duration: 2016-01 - 2020-09
Researcher(s):
José Augusto Simões Gonçalves Leitão, Ana Cardoso Allen Gomes, Chiara Guerrini, Isabel Maria Barbas dos Santos
Institution(s): Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo-Comportamental - CINEICC, Universidade de Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Leitão, J.
Secondary author(s):
Gomes, A., Guerrini, C., Santos, I. M.
Number of reproductions:
1
Keywords:
Cognitive Inhibition / Aging / Chronotype x time-of-day interaction / Event Related Brain Potentials / Psychophysiology

Reference code: PT/FB/BL-2014-234.01
Location: BF-GMS
Title:
Final report - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control
Publication year: 2020
URL:
https://www.bial.com/media/3327/inhibitory-processing-in-the-aging-brain.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Chronotype (Chr) and time-of-day (ToD) cause (a)synchrony effects, i.e., differences between off/on-peak (ToD (mis)/matching Chr) performance. Conditional automaticity (CA) reflects the enhancement of pathways linked, but not directly relevant, to the control structure of an ongoing task. Ageing, via hindered control efficiency, likely magnifies this enhancement and modulates its interaction with (a)synchrony.
AIMS
To develop a CA-based processing model of the modulations of (a)synchrony by ageing, and test its predictions, viz.: 1. off-peak benefits are restricted to CA processes, and are coupled with off-peak impediment of the CA-linked control process 2. Ageing amplifies (a)synchrony effects 3. Specific ERP signatures index the processes in the model and their modulation by ageing.
METHOD
Young adults (YA) (21 evening-types (E-T); 19 morning-types (M-T)) and older adults (OA) (19 E-T; 21 M-T) performed, on- or off-peak, a spatial Stroop task probing controlled inhibition and CA. EEGs were recorded and ERPs extracted.
RESULTS
Behavioral data supported predictions 1&2. As for 3: YA showed accrued onvs off-peak control (on-peak P200) whereas OA’s CA was augmented onpeak and control lessened off-peak (on-peak P300); when all action-plans were predicted to be momentarily inhibited, this P300 was also present in YA; in YA a late positivity (LP) indexed conditions predicted to foster unduly suppression of the correct action-plan and its subsequent renewal; when all action-plans were momentarily inhibited, this LP was also present in OA.
CONCLUSIONS
The predictions derived from our processing model were largely borne out; further data should be collected to probe potentially important differences between E-T and M-T.
Accessibility: Document exists in file
Language:
eng
Author:
Leitão, J.
Secondary author(s):
Gomes, A., Guerrini, C., Santos, I. M.
Document type:
Final report
Number of reproductions:
1
Reference:
Leitão, J., Gomes, A., Guerrini, C., & Santos, I. M. (2020). Final report - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control.
Indexed document: No
Keywords: Chronotype / Synchrony and asynchrony effects / Conditional automaticity / Spatial Stroop task / Event Related Potentials

Final report - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control

Final report - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control
DocumentProbing the processing underpinnings of asynchrony and synchrony effects with a conflict task2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-234
Location: BF-GMS
Title:
234 - Inhibitory processing in the aging brain: Disentangling the effects of age, chronotype, time of day and executive control
Duration: 2016-01 - 2020-09
Researcher(s):
José Augusto Simões Gonçalves Leitão, Ana Cardoso Allen Gomes, Chiara Guerrini, Isabel Maria Barbas dos Santos
Institution(s): Centro de Investigação do Núcleo de Estudos e Intervenção Cognitivo-Comportamental - CINEICC, Universidade de Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Leitão, J.
Secondary author(s):
Gomes, A., Guerrini, C., Santos, I. M.
Number of reproductions:
1
Keywords:
Cognitive Inhibition / Aging / Chronotype x time-of-day interaction / Event Related Brain Potentials / Psychophysiology

Reference code: PT/FB/BL-2014-234.04
Location: BF-GMS
Title:
Probing the processing underpinnings of asynchrony and synchrony effects with a conflict task
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/abs/pii/S1389945719307233?via%3Dihub
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Leitão, J.
Secondary author(s):
Pires, L., Santos, I. M., Buekenhout, I., Guerrini, C., Gomes, A.
Document type:
Abstract
Number of reproductions:
1
Reference:
Leitão, J., Pires, L., Santos, I. M., Buekenhout, I., Guerrini, C., & Gomes, A. (2019). Probing the processing underpinnings of asynchrony and synchrony effects with a conflict task. Sleep Medicine, 64 (Suppl. 1), S132-S133. doi: 10.1016/j.sleep.2019.11.362
Indexed document: Yes
Keywords: Chronotype / Synchrony and asynchrony effects / Spatial Stroop task