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DE:"Temporal lobe epilepsy"
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File180 - Cognitive mechanisms of word learning: Contributions from amnesic patients and healthy ageing2016-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-180
Location: BF-GMS
Title:
180 - Cognitive mechanisms of word learning: Contributions from amnesic patients and healthy ageing
Duration: 2016-02
Researcher(s):
Tânia Patrícia Gregório Fernandes, Ana Luísa Nunes Raposo, Maria Isabel Segurado Pavão Martins Catarino Petiz, Rita Isabel Saraiva Jerónimo
Institution(s): Faculdade de Psicologia da Universidade de Lisboa - FP-ULisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Notes: This project is still in progress
Author: Fernandes, T.
Secondary author(s):
Raposo, A., Martins, I. P. , Jerónimo, R.
Number of reproductions:
1
Keywords:
Word learning / Episodic and semantic memory / Temporal lobe epilepsy / Healthy ageing / Psychophysiology

DocumentIctal and preictal power changes outside of the seizure focus correlate with seizure generalization2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-220
Location: Arquivo PCA - Pasta 15/2012
Title:
220 - Consciousness disconnects during sleep
Duration: 2013-04 - 2016-05
Researcher(s):
Giovanni Piantoni
Institution(s): Cortical Physiology Lab, Massachusets General Hospital, Harvard Medical School (USA) and Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
1 article
Submitted papers
Language: eng
Author:
Piantoni, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams

Reference code: PT/FB/BL-2012-220.10
Location: Arquivo PCA - Pasta 15/2012
Title:
Ictal and preictal power changes outside of the seizure focus correlate with seizure generalization
Publication year: 2018
URL:
https://onlinelibrary.wiley.com/doi/pdf/10.1111/epi.14449
Abstract/Results: ABSTRACT:
OBJECTIVE:
The treatment of focal epilepsies is largely predicated on the concept that there is a "focus" from which the seizure emanates. Yet, the physiological context that determines if and how ictal activity starts and propagates remains poorly understood. To delineate these phenomena more completely, we studied activity outside the seizure-onset zone prior to and during seizure initiation.
METHODS:
Stereotactic depth electrodes were implanted in 17 patients with longstanding pharmacoresistant epilepsy for lateralization and localization of the seizure-onset zone. Only seizures with focal onset in mesial temporal structures were used for analysis. Spectral analyses were used to quantify changes in delta, theta, alpha, beta, gamma, and high gamma frequency power, in regions inside and outside the area of seizure onset during both preictal and seizure initiation periods.
RESULTS:
In the 78 seizures examined, an average of 9.26% of the electrode contacts outside of the seizure focus demonstrated changes in power at seizure onset. Of interest, seizures that were secondarily generalized, on average, showed power changes in a greater number of extrafocus electrode contacts at seizure onset (16.7%) compared to seizures that remained focal (3.8%). The majority of these extrafocus changes occupied the delta and theta bands in electrodes placed in the ipsilateral, lateral temporal lobe. Preictally, we observed extrafocal high-frequency power decrements, which also correlated with seizure spread.
SIGNIFICANCE:
This widespread activity at and prior to the seizure-onset time further extends the notion of the ictogenic focus and its relationship to seizure spread. Further understanding of these extrafocus, periictal changes might help identify the neuronal dynamics underlying the initiation of seizures and how therapies can be devised to control seizure activity.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Naftulin, J. S.
Secondary author(s):
Ahmed, O. J., Piantoni, G., Eichenlaub, J. B., Martinet, L. E., Kramer, M. A., Cash, S. S.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Naftulin, J. S., Ahmed, O. J., Piantoni, G., Eichenlaub, J. B., Martinet, L. E., Kramer, M. A., & Cash, S. S. (2018). Ictal and preictal power changes outside of the seizure focus correlate with seizure generalization. Epilepsia, 59(7), 1398-1409. https://doi.org/10.1111/epi.14449
2-year Impact Factor: 5.562|2018
Times cited: 21|2024-02-09
Indexed document: Yes
Quartile: Q1
Keywords: Epileptogenesis / Epileptogenic zone / Intracranial EEG / Partial seizure / Temporal lobe epilepsy

DocumentFinal report - Cognitive mechanisms of word learning: Contributions from amnesic patients and healthy ageing2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-180
Location: BF-GMS
Title:
180 - Cognitive mechanisms of word learning: Contributions from amnesic patients and healthy ageing
Duration: 2016-02
Researcher(s):
Tânia Patrícia Gregório Fernandes, Ana Luísa Nunes Raposo, Maria Isabel Segurado Pavão Martins Catarino Petiz, Rita Isabel Saraiva Jerónimo
Institution(s): Faculdade de Psicologia da Universidade de Lisboa - FP-ULisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Notes: This project is still in progress
Author: Fernandes, T.
Secondary author(s):
Raposo, A., Martins, I. P. , Jerónimo, R.
Number of reproductions:
1
Keywords:
Word learning / Episodic and semantic memory / Temporal lobe epilepsy / Healthy ageing / Psychophysiology

Reference code: PT/FB/BL-2014-180.01
Location: BF-GMS
Title:
Final report - Cognitive mechanisms of word learning: Contributions from amnesic patients and healthy ageing
Publication year: 2019
Abstract/Results:
ABSTRACT:
Word learning is a lifelong skill with two facets that differ in time course and neural underpinning. Phonological configurations swift depends on the hippocampus and episodic memory. Lexicalization emerges slowly, with neocortical underpinning, and involves lexical competition. Surprisingly, no study has hitherto examined the role of the hippocampus on lexicalization, in the transition from episodic to abstract lexical representations. We run two complementary studies: one with hippocampus-resection’s patients, the other with healthy older adults (> 60 yrs). We hypothesized that the presence of schemas (rich semantics) at encoding of new words facilitates lexicalization but only in hippocampus malfunctioning. In Study 1, epileptic patients vs. control adults were tested. In Study 2, young and old adults matched in critical variables. Both studies adopted the same paradigm. Participants were exposed to spoken new words with a visual item: orthographic (new-word’s form) or semantic (a picture of a real rare item). The two facets were assessed in Days 1, 2, and 8. Lexicalization was indirectly studied with semantic categorization of real words: if the new item (e.g., daffadat) were lexicalized, recognition of base-words (e.g., daffodil) would be slower than of control words (e.g., pelican). The pattern of results was similar in both studies. Phonological configuration was less influenced by the visual context in older than young adults. In contrast, lexicalization was only affected by the visual context in older adults. Both groups showed robust lexicalization effects on Day 8 but, for older adults, only for items in the semantic context. Lexicalization is preserved along ageing and in hippocampus malfunctioning thanks to semantic information.
Accessibility: Document exists in file
Language:
eng
Author:
Fernandes, T.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Word learning / Episodic and semantic memory / Temporal lobe epilepsy / Healthy ageing

Final report - Neural mechanisms of word learning: contributions from amnesic patients and fMRI on healthy ageing

Final report - Neural mechanisms of word learning: contributions from amnesic patients and fMRI on healthy ageing