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BIAL Foundation
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Type Title Begin End
DocumentPhospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-253
Location: BF-GMS
Title:
253 - The impact of lipid signaling modulation in cognition
Duration: 2015-05 - 2019-09
Researcher(s):
Tiago Gil Rodrigues Oliveira, Isabel Maria Sousa Castanho, Neide Marina Vieira Pereira, Rita Catarina Ribeiro da Silva, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, T. G.
Secondary author(s):
Castanho, I., Pereira, N., Silva, R., Pinto, V.
Number of reproductions:
1
Keywords:
Lipids / Hippocampus / Cognition / Memory / Psychophysiology

Reference code: PT/FB/BL-2014-253.04
Location: BF-GMS
Title:
Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning
Publication year: 2020
URL:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)30283-7#secsectitle0025
Abstract/Results: ABSTRACT:
Phosphatidic acid (PA) is a signaling lipid involved in the modulation of synaptic structure and functioning. Based on previous work showing a decreasing PA gradient along the longitudinal axis of the rodent hippocampus, we asked whether the dorsal hippocampus (DH) and the ventral hippocampus (VH) are differentially affected by PA modulation. Here, we show that phospholipase D1 (PLD1) is a major hippocampal PA source, compared to PLD2, and that PLD1 ablation affects predominantly the lipidome of the DH. Moreover, Pld1 knockout (KO) mice show specific deficits in novel object recognition and social interaction and disruption in the DH-VH dendritic arborization differentiation in CA1/CA3 pyramidal neurons. Also, Pld1 KO animals present reduced long-term depression (LTD) induction and reduced GluN2A and SNAP-25 protein levels in the DH. Overall, we observe that PLD1-derived PA reduction leads to differential lipid signatures along the longitudinal hippocampal axis, predominantly affecting DH organization and functioning.
Accessibility: Document exists in file
Language:
eng
Author:
Marinha, L.
Secondary author(s):
Castanho, I., Silva, R. R., Bravo, F. V., Miranda, A. M., Meira, T., Morais-Ribeiro, R., Marques, F., Xu, Y., Point du Jour, K., Chan, R. B., Di Paolo, G., Pinto, V., Oliveira, T. G.
Document type:
Article
Number of reproductions:
1
Percentiles:
42.17|0.43
Reference:
Marinha, L., Castanho, I., Silva, R. R., Bravo, F. V., Miranda, A. M., Meira, T., ... Oliveira, T. G. (2020). Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning. Cell Reports, 30(12), 4197-4208. https://doi.org/10.1016/j.celrep.2020.02.102
2-year Impact Factor: 9.423|2020
Times cited: 15|2026-02-12
Indexed document: Yes
Quartile: Q1
Keywords: Phospholipase D / PLD1 / PLD2 / Dorsal hippocampus / Ventral hippocampus / Longitudinal hippocampal axis / Lipids / Lipidomics / Long-term depression / Social memory

Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning

Phospholipase D1 ablation disrupts mouse longitudinal hippocampal axis organization and functioning
DocumentStress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.05
Location: Arquivo PCA - Pasta 22/2008
Title:
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
Publication year: 2013
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2013.00127/full
Abstract/Results: ABSTRACT:
Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials (LFP) were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC, respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.
Accessibility: Document exists in file
Language:
eng
Author:
Jacinto, L. R.
Secondary author(s):
Reis, J. S., Dias, N. S., Cerqueira, J. J., Correia, J. H., Sousa, N.
Document type:
Article
Number of reproductions:
1
Percentiles:
87.13|1.58
Reference:
Jacinto, L. R., Reis, J. S., Dias, N. S., Cerqueira, J. J., Correia, J. H., & Sousa, N. (2013). Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization. Frontiers in Behavioral Neuroscience, 7, 127. https://doi.org/10.3389/fnbeh.2013.00127
2-year Impact Factor: 4.160|2013
Times cited: 60|2026-02-06
Indexed document: Yes
Quartile: Q1
Keywords: Stress / Anxiety / Local field potentials / Ventral hippocampus / Amygdala / Pre-frontal cortex

Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization