History
Processing, please wait...
Database
search
in
Filter year from
to
Language
Country
  • Enter your search phrase in the search box.
  • General search:
    • The Boolean operator AND between the terms is assumed by default. If you enter the words European Union in the search box, the system returns all records in which both words occur, regardless of their order.
    • When entering a set of words in quotes, e.g "european union", all records containing the literal term "European Union" will be retrieved.
  • Search by access fields (e.g. author, title, etc.):
    • To direct your search, choose the field in which you want to search the word or expression.
    • Search in the field assumes by default the expression in quotes, e.g. European union will retrieve all records containing the literal term "European Union"
  • To perform more complex searches, additional words or expressions may be added.
  • If you want to refine the search results, you can always access the link "search" in the upper left corner of the page of search results.
  • The search engine is not case sensitive. For example, the word congress has the same meaning that Congress or CONGRESS.
  • To truncate your search expression, use the $ character
  • You can filter the results of your search by a date or date range, filling the appropriate boxes.
Base:
BIAL Foundation
Search:
DE:"Ventromedial frontal cross-frequency coupling"
Results
1
to
1
from
1
found.
View
Selection Description
Type Title Begin End
DocumentA ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation2021

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2012-119.08
Location: Arquivo PCA - Pastas 20/2012
Title:
A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation
Publication year: 2021
URL:
https://www.brainstimjrnl.com/article/S1935-861X(21)00099-1/fulltext
Abstract/Results: ABSTRACT:
BACKGROUND
Obsessive-compulsive disorder (OCD) has consistently been linked to abnormal frontostriatal activity. The electrophysiological disruption in this circuit, however, remains to be characterized.
OBJECTIVE/HYPOTHESIS
The primary goal of this study was to investigate the neuronal synchronization in OCD patients. We predicted aberrant oscillatory activity in frontal regions compared to healthy control subjects, which would be alleviated by deep brain stimulation (DBS) of the nucleus accumbens (NAc).
METHODS
We compared scalp EEG recordings from nine patients with OCD treated with NAc-DBS with recordings from healthy controls, matched for age and gender. Within the patient group, EEG activity was compared with DBS turned off vs. stimulation at typical clinical settings (3.5 V, frequency of stimulation 130 Hz, pulse width 60 µs). In addition, intracranial EEG was recorded directly from depth macroelectrodes in the NAc in four OCD patients.
RESULTS
Cross-frequency coupling between the phase of alpha/low beta oscillations and amplitude of high gamma was significantly increased over midline frontal and parietal electrodes in patients when stimulation was turned off, compared to controls. Critically, in patients, beta (16–25 Hz) -gamma (110–166 Hz) phase amplitude coupling source localized to the ventromedial prefrontal cortex, and was reduced when NAc-DBS was active. In contrast, intracranial EEG recordings showed no beta-gamma phase amplitude coupling. The contribution of non-sinusoidal beta waveforms to this coupling are reported.
CONCLUSION
We reveal an increased beta-gamma phase amplitude coupling in fronto-central scalp sensors in patients suffering from OCD, compared to healthy controls, which may derive from ventromedial prefrontal regions implicated in OCD and is normalized by DBS of the nucleus accumbens. This aberrant cross-frequency coupling could represent a biomarker of OCD, as well as a target for novel therapeutic approaches.
Accessibility: Document exits in file
Language:
eng
Author:
Treu, S.
Secondary author(s):
Gonzalez-Rosa, J. J., Soto-Leon, V., Lozano-Soldevilla, D., Oliviero, A., Lopez-Sosa, F., Reneses-Prieto, B., Barcia, J. A., Strange, B. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
68.13|0.87
Reference:
Treu, S., Gonzalez-Rosa, J. J., Soto-Leon, V., Lozano-Soldevilla, D., Oliviero, A., Lopez-Sosa, F., …, Strange, B. A. (2021). A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation. Brain Stimulation, 14(4), 761-770. https://doi.org/10.1016/j.brs.2021.04.028
Impact Factor: 9.184|2021
Times cited: 13|2026-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Obsessive-compulsive disorder / Deep brain stimulation / EEG / Nucleus accumbens / Ventromedial frontal cross-frequency coupling

<!-- mm occ=1 guid=[8c7f6b1f63f7440356d5d06f712b3aae] WebBehavior$=[0] -->

A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation

A ventromedial prefrontal dysrhythmia in obsessive-compulsive disorder is attenuated by nucleus accumbens deep brain stimulation