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DocumentFinal report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3106.pdf
Abstract/Results: RESULTS:
The overall aim of this study was to investigate the influence of serotonin and dopamine receptor gene polymorphisms on various parameters relevant to the successful participation of obese people taking part in a diet and exercise obesity intervention. We demonstrated that serotonin receptor gene genotype has a significant influence on perception of hunger. We also showed that dopamine receptor gene polymorphisms significantly influence the drop out rate from an obesity intervention study, and suggest that this is due to the influence of these polymorphisms both on motivation to exercise and on restrained eating behaviours. Finally we demonstrated the efficacy of motivational interviewing in an obesity intervention programme and have shown that motivational interviews influence the relationship between measures of motivation or eating behaviours and weight loss measured by BMI change These novel findings indicate that serotonin plays a key role in determining appetite. They also indicate that extent of dopamine signalling may influence an individual's motivation to engage in weight-loss programmes. Further studies are required to confirm these findings and investigate the underlying mechanisms involved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Genotype / Obesity / Motivation / Intervention program / Serotonin / Dopamine / Weight loss

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
DocumentThe (un)pleasant intensity of taste: a glimpse into obesity2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.03
Location: Arquivo PCA - Pasta 14/2010
Title:
The (un)pleasant intensity of taste: a glimpse into obesity
Publication year: 2012
URL:
http://www.iaso.org/site_media/uploads/CON_OMH_program_F_6.pdf
Abstract/Results: ABSTRACT:
The relevance of orosensory factors for the pathophysiology of obesity were suggested by the report of changes in taste sensitivity in obese patients, after gastric bypass surgery. However, it is unclear if such changes are specific to this intervention. Here we report on taste intensity and pleasantness for sweet (sucrose), bitter (quinine), sour (citric acid) and salty (sodium chloride tastants, measured in severely obese patients, before and/or after a diet and exercise weight-loss program. Other measurements, such as the Beck Depression Scale, were also conducted. When compared to non-obese controls, we found that quinine and sucrose have a more intense and, respectively, unpleasant (bitter) or pleasant (sweet) taste in obese subjects. However, the effect for sweet taste seems to be, at least partially, dependent on the relationship between obesity and depression. Preliminary analyses in patients tested before and after weightloss further suggest that these taste changes are reversible. Additional experiments are now necessary to directly compare taste changes after surgical and behavioral weight-loss programs.
Accessibility: Document does not exist in file
Language:
eng
Author:
Fernandes, A.
Secondary author(s):
Paixão, V., Branco, T., Martins, S., Costa, R. M., Oliveira-Maia, A. J.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Fernandes, A., Paixão, V., Branco, T., Martins, S., Costa, R. M., & Oliveira-Maia, A. J. (2012). The (un)pleasant intensity of taste: a glimpse into obesity. In Conference program of Hot Topic Conference Obesity & Mental Health (p. 10). Toronto, Canada: International Association for the Study of Obesity (IASO)
Indexed document: No
Keywords: Obesity / Taste sensitivity / Depression / Weight loss

The (un)pleasant intensity of taste: a glimpse into obesity

The (un)pleasant intensity of taste: a glimpse into obesity
DocumentEffects of weight-loss surgery in gustatory function2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.05
Location: Arquivo PCA - Pasta 14/2010
Title:
Effects of weight-loss surgery in gustatory function
Publication year: 2014
URL:
http://fens2014.meetingxpert.net/FENS_427/poster_103790/program.aspx
Abstract/Results: ABSTRACT:
While it has been suggested that weight-loss approaches could impact gustatory function, this question hasn´t been addressed in a longitudinal design. Here, we proposed to analyze changes in gustatory responses resulting from weight loss interventions. Specifically, we tested individuals involved in obesity treatment programs, before and at several time-points after one of two different interventions: i) 35 participants were undergoing intensive lifestyle modification of (diet + exercise), ii) 50 participants proposed for weight-loss surgery. Data was also compared to that obtained from 29 non-obese individuals. We assessed gustatory function using electrogustometry as well as subjective ratings of taste intensity and pleasantness on visual analogue scales. We found a significant positive correlation between BMI and mean sweet intensity ratings (r = 0.20; p = 0.02). Participants in the lifestyle modification program showed significant differences in sweet and salt pleasantness ratings, but not intensity, before and after weight loss. Longitudinal data collection after weight-loss surgery is on-going. However, even with a small number of subjects, after surgery we found scores on the Power of Food Scale and Food Addiction Scale to be significantly reduced. Our data suggests that gustatory function, in particular for sweet taste, is related to obesity and is modified after weight loss. In ongoing experiments we expect to assess to what degree weight loss is associated to changes in reward-related feeding behaviors.
Accessibility: Document does not exist in file
Language:
eng
Author:
Camacho, M.
Secondary author(s):
Fernandes, A., Castro, C., Branco, T., Costa, R. M., Oliveira-Maia, A. J.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Camacho, M., Fernandes, A., Castro, C., Branco, T., Costa, R. M., & Oliveira-Maia, A. J. (2014, July). Effects of weight-loss surgery in gustatory function. Poster presented at the 9th FENS Forum of European Neuroscience, Milan, Italy. Abstract retrieved from http://fens2014.meetingxpert.net/FENS_427/poster_103790/program.aspx
Indexed document: No
Keywords: Weight loss / Taste sensitivity
DocumentReward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort study2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.10
Location: Arquivo PCA - Pasta 14/2010
Title:
Reward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort study
Publication year: 2021
URL:
https://academic.oup.com/ajcn/advance-article/doi/10.1093/ajcn/nqaa349/6131431
Abstract/Results: ABSTRACT:
BAKGROUND
Reward sensitivity has been proposed as a potential mediator of outcomes for bariatric surgery.
OBJECTIVES
We aimed to determine whether gustatory and psychometric measures of reward-related feeding are predictors of bariatric-induced weight loss.
METHODS
A multicenter longitudinal cohort study was conducted in patients scheduled for bariatric surgery (surgical group), assessed at baseline and 2 follow-up assessments. Predictions of % weight loss from baseline (%WL) according to baseline gustatory measures, including intensity and pleasantness ratings of sweet and other tastants, and psychometric measures of reward-related feeding behavior, including hedonic hunger scores, were assessed with multivariable linear regression. Exploratory analyses were conducted to test for associations between %WL and changes in gustatory and psychophysical measures, as well as for comparisons with data from patients on the surgery waiting list (control group).
RESULTS
We included 212 patients, of whom 96 in the surgical group and 50 in the control group were prospectively assessed. The groups were similar at baseline and, as expected, bariatric surgery resulted in higher %WL (BTreatment-Time = 2.4; 95% CI: 2.1–2.8; P < 0.0001). While variation in gustatory measures did not differ between groups, in the surgery group baseline sweet intensity predicted %WL at the primary endpoint (11 to 18 months postoperatively; ß = 0.2; B = 0.2, 95% CI: 0.02 to 0.3; P = 0.02), as did hedonic hunger scores (ß = -0.2; B = -2.0, 95% CI: -3.8 to -0.3; P = 0.02). Furthermore, at this endpoint, postsurgical reduction of sweet taste intensity and acceptance of sweet foods were associated with %WL (ß = -0.3; B = -3.5, 95% CI: -5.8 to -1.3; P = 0.003, and ß = -0.2; B = -4.7, 95% CI: -8.5 to -0.8; P = 0.02, respectively). The use of sweet intensity as a predictor of weight change was confirmed in another bariatric cohort.
CONCLUSIONS
Sweet intensity ratings and hedonic hunger scores predict %WL after surgery. The variability of sweet intensity ratings is also associated with %WL, further suggesting they may reflect physiological processes that are variably modulated by bariatric surgery, influencing clinical outcomes.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, G.
Secondary author(s):
Camacho, M., Fernandes, A. B., Cotovio, G., Torres, S., Oliveira-Maia, A.
Document type:
Article
Number of reproductions:
1
Percentiles:
68.44|1.03
Reference:
Ribeiro, G., Camacho, M., Fernandes, A. B., Cotovio, G., Torres, S., Oliveira-Maia, A., & Food Reward in Bariatric Surgery Portuguese Study Group (2021). Reward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort study. The American Journal of Clinical Nutrition, nqaa349. https://doi.org/10.1093/ajcn/nqaa349
2-year Impact Factor: 7.045|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 21|2026-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Food reward / Feeding behavior / Sweet taste / Gustation / Psychometry / Weight loss / Bariatric surger

Reward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort study

Reward-related gustatory and psychometric predictors of weight loss following bariatric surgery: a multicenter cohort study