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DocumentFinal report - Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-115
Location: Arquivo PCA - Pasta 25/2004
Title:
115 - Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system
Duration: 2006-01 - 2012-09
Researcher(s):
Florian Engert, André Valente, Bettina Reiter, Johann Bollmann, Adam Kampff, Michael Brian Orger
Institution(s): Harvard Biological Laboratories, Cambridge (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
1 Article
Language: eng
Author:
Engert, F.
Secondary author(s):
Valente, A., Reiter, B., Bollmann, J., Kampff, A., Orger, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Memory

Reference code: PT/FB/BL-2004-115.01
Location: Arquivo PCA - Pasta 25/2004
Title:
Final report - Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system
Publication year: 2010
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Engert, F.
Secondary author(s):
Valente, A., Reiter, B., Bollmann, J., Kampff, A., Orger, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Learning / Memory / Zebrafish / Conditioning / Development

Final report - Psychophysiological analysis of learning and memory using Zebrafish as an in vivo model system

Final report - Psychophysiological analysis of learning and memory using Zebrafish as an in vivo model system
DocumentOntogeny of classical and operant learning behaviors in zebrafish2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-115
Location: Arquivo PCA - Pasta 25/2004
Title:
115 - Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system
Duration: 2006-01 - 2012-09
Researcher(s):
Florian Engert, André Valente, Bettina Reiter, Johann Bollmann, Adam Kampff, Michael Brian Orger
Institution(s): Harvard Biological Laboratories, Cambridge (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
1 Article
Language: eng
Author:
Engert, F.
Secondary author(s):
Valente, A., Reiter, B., Bollmann, J., Kampff, A., Orger, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Memory

Reference code: PT/FB/BL-2004-115.02
Location: Arquivo PCA - Pasta 25/2004
Title:
Ontogeny of classical and operant learning behaviors in zebrafish
Publication year: 2012
URL:
http://learnmem.cshlp.org/content/19/4/170.full.pdf+html
Abstract/Results: ABSTRACT:
The performance of developing zebrafish in both classical and operant conditioning assays was tested with a particular focus on the emergence of these learning behaviors during development. Strategically positioned visual cues paired with electroshocks were used in two fully automated assays to investigate both learning paradigms. These allow the evaluation of the behavioral performance of zebrafish continuously throughout development, from larva to adult. We found that learning improves throughout development, starts reliably around week 3, and reaches adult performance levels at week 6. Adult fish quickly learned to perform perfectly, and the expression of the learned behavior is manifestly controlled by vision. The memory is behaviorally expressed in adults for at least 6 h and retrievable for at least 12 h.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Valente, A.
Secondary author(s):
Huang, K.-H., Portugues, R., Engert, F.
Document type:
Article
Number of reproductions:
1
Reference:
Valente, A., Huang, K. H., Portugues, R., & Engert, F. (2012). Ontogeny of classical and operant learning behaviors in zebrafish. Learning & Memory, 19(4), 170-177. https://doi.org/10.1101/lm.025668.112
2-year Impact Factor: 4.057|2012
Times cited: 120|2025-02-10
Indexed document: Yes
Quartile: Q2
Keywords: Learning / Memory / Development / Zebrafish / Conditioning

Ontogeny of classical and operant learning behaviors in zebrafish

Ontogeny of classical and operant learning behaviors in zebrafish
DocumentPsychophysiological analysis of learning and memory using zebrafish as an in vivo model system2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-115
Location: Arquivo PCA - Pasta 25/2004
Title:
115 - Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system
Duration: 2006-01 - 2012-09
Researcher(s):
Florian Engert, André Valente, Bettina Reiter, Johann Bollmann, Adam Kampff, Michael Brian Orger
Institution(s): Harvard Biological Laboratories, Cambridge (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
1 Article
Language: eng
Author:
Engert, F.
Secondary author(s):
Valente, A., Reiter, B., Bollmann, J., Kampff, A., Orger, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Memory

Reference code: PT/FB/BL-2004-115.03
Location: Arquivo PCA - Pasta 25/2004
Title:
Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
The zebrafish (Danio rerio) has been an excellent vertebrate model for genetic analysis of early development and has also been used to study aspects of neural development and function. It is known that fish exhibit a wide range of learning behaviors but it is not clear at what point during development they begin nor have these behaviors been analyzed systematically. Before moving on to in vivo 2-photon imaging of neural circuitry, we are answering questions related to the ontogenesis of the learning and memory behaviors we assay for – When do animals start learning and how does that correlate to their developmental biology and age range? How does the ability to learn correlate with it’s persistence and extinction?
METHODS:
The performance of developing zebrafish in both classical and operant conditioning assays was tested with a particular focus on the emergence of these learning behaviors during development. Strategically positioned visual cues paired with electro- shocks were used in two fully automated assays to investigate both paradigms. These allow the evaluation of the behavioral performance of zebrafish continuously throughout development, from larva to adult.
RESULTS:
We found that learning improves throughout development, starts reliably around week 3, and reaches adult performance levels at week 6. Adult fish quickly learned to perform perfectly, and the expression of the learned behavior is manifestly controlled by vision. The memory is behaviorally expressed in adults for at least 6 h and retrievable for at least 12 h.
CONCLUSIONS:
We have developed a computer-based automated behavioral assay which we can easily control and comprehensively analyze. Using this automated system we show that a strong ability to learn is already present in young juvenile fish and we further characterize the ontogenesis of learning and memory during zebrafish development.
DISCUSSION:
The transparency and small size of the larva combined with its vertebrate brain organization, is an exceptional model. The barin areas equivalent to the amygdala and hippocampus are much more exposed to manipulation and imaging than in mammals and its amenability to genetic screening and manipulation tools provide a unique experimental system to explore the psychophysiology of learning and memory in future studies.
PUBLICATIONS:
Valente A, Huang KH, Portugues R, Engert F. 2012. Ontogeny of classical and operant learning behaviors in zebrafish. Learning and Memory. In press. Cold Spring Harbor Laboratories Press.
Accessibility: Document does not exist in file
Language:
eng
Author:
Engert, F.
Secondary author(s):
Valente, A., Reiter, B., Bollmann, J., Kampff, A., Orger, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Engert, F., Valente, A., Reiter, B., Bollmann, J., Kampff, A., & Orger, M. (2012). Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 63). Porto: Fundação Bial.
Indexed document: No
Keywords: Learning / Memory / Zebrafish / Development / Conditioning

Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system

Psychophysiological analysis of learning and memory using zebrafish as an in vivo model system
DocumentEarly ablation of oxytocin-like peptides shapes adult zebrafish sociality2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-339
Location: BF-GMS
Title:
339 - Neural mechanisms of social cognition in zebrafish
Duration: 2015-05 - 2019-11
Researcher(s):
Ana Rita Silva Martins Nunes
Institution(s): Instituto Gulbenkian de Ciencia, Oeiras (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Language: eng
Author:
Nunes, A. R.
Number of reproductions:
1
Keywords:
Social cognition / Social dominance / Oxytocin / Biological motion / Psychophysiology

Reference code: PT/FB/BL-2014-339.05
Location: BF-GMS
Title:
Early ablation of oxytocin-like peptides shapes adult zebrafish sociality
Publication year: 2016
URL:
https://www.s4sn.org/wordpress/wp-content/uploads/2016/10/S4SN-2016-Annual-Meeting.pdf
Abstract/Results: ABSTRACT:
Oxytocin and vasopressin-like peptides (isotocin in fish, mesotocin in birds, reptiles and amphibian, and vasotocin) have been implicated in the regulation of social behavior across vertebrates [1]. Although vasopressin is more involved in aggression behavior while oxytocin-like peptides in pro-social behaviors, these neuropeptides and receptor subtypes are similar [2]. Using zebrafish as a model organism, we have been investigating the role of oxytocin-like peptides in the regulation of adult sociality. We have characterized how early relevant sociality, measured as a shoal preference, can be studied during zebrafish ontogeny. Our data shows that shoal preference emerges around the third week post-fertilization. In order to explore how isotocin can modulate the acquirement of social paradigms underlying social cognition, we have been using a genetic approach to specifically perturb the isotocinergic neuronal circuits and to study how loss of function of these neurons during embryonic development, or throughout the organism’s lifetime, modifies adult social behavior. Using an oxytocin neurons-specific transgenic system for conditional (i.e. temporal) and cell-specific ablation of oxytocin neurons, we demonstrated that early ablation, but not adult ablation, significantly alter shoal preference behavior in adulthood. Furthermore, early inhibition of isotocin vesicular release also impairs adult sociality in zebrafish. In conclusion, our findings suggest that the isotocin neuronal system is involved on a specific social behavior trait that becomes hardwire during early development.
Accessibility: Document exists in file
Language:
eng
Author:
Nunes, A. R.
Secondary author(s):
Gliskberg, M., Anbalagan, S., Wircer, E., Levkowitz, G., Oliveira, R.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Nunes, A. R., Gliskberg, M., Anbalagan, S., Wircer, E., Levkowitz, G., & Oliveira, R. (2016). B38 Early ablation of oxytocin-like peptides shapes adult zebrafish sociality. Abstract book of the Annual Meeting of The Society for Social Neuroscience (p. 61). San Diego, USA.
Indexed document: No
Keywords: Social Behavior / Zebrafish / Oxytocin

Early ablation of oxytocin-like peptides shapes adult zebrafish sociality

Early ablation of oxytocin-like peptides shapes adult zebrafish sociality
DocumentNeural mechanisms of social cognition in zebrafish: the role of oxytocin-like peptides in biological motion perception2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-339
Location: BF-GMS
Title:
339 - Neural mechanisms of social cognition in zebrafish
Duration: 2015-05 - 2019-11
Researcher(s):
Ana Rita Silva Martins Nunes
Institution(s): Instituto Gulbenkian de Ciencia, Oeiras (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Language: eng
Author:
Nunes, A. R.
Number of reproductions:
1
Keywords:
Social cognition / Social dominance / Oxytocin / Biological motion / Psychophysiology

Reference code: PT/FB/BL-2014-339.06
Location: BF-GMS
Title:
Neural mechanisms of social cognition in zebrafish: the role of oxytocin-like peptides in biological motion perception
Publication year: 2016
Abstract/Results:
ABSTRACT:
Biological motion perception is one of the fundamental aspects of social-cognitive processes that can help differentiate living organisms from other objects in the environment.
This competence is conserved across species and is critical for filial attachment, detection of predators, and perception of social dominance. Moreover, an evolutionary conserved mechanism for animacy detection seems to be present across different species (chimpanzees, chicken, medaka fish) and is probably innate. Therefore, we aim to characterize the underlying neural mechanisms for this cognitive ability and to test if it is regulated by oxytocin-like peptides (isotocin in fish) - a family of neuromodulators implicated in the regulation of sociality. We are using zebrafish as a vertebrate model organism since it exhibits robust social behaviour, relatively simple neuroanatomy and an available genetic toolbox that can allow a better understanding of the gain/loss of OXT-like neuronal function.
Using a two-choice test we have been able to show that adult zebrafish can detect animacy based on acceleration cues and that isotocin seems to play a role in biological motion perception.
In future experiments we plan to explore more complex motion stimuli using direction and agency cues and to disentangle the neural circuitry underlying this vision-­-based social cognition ability.
Accessibility: Document does not exist in file
Language:
eng
Author:
Carreira, L.
Secondary author(s):
Nunes, A. R., Oliveira, R.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Carreira, L., Nunes A. R., & Oliveira, R. (2016, October). Neural mechanisms of social cognition in zebrafish: the role of oxytocin-like peptides in biological motion perception. Paper presented at Sociedade Portuguesa de Etologia. Lisboa, Portugal
Indexed document: No
Keywords: Social Behavior / Zebrafish / Oxytocin
DocumentUnveiling the role of oxytocin-like peptides in the regulation of the zebrafish social behavior2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-339
Location: BF-GMS
Title:
339 - Neural mechanisms of social cognition in zebrafish
Duration: 2015-05 - 2019-11
Researcher(s):
Ana Rita Silva Martins Nunes
Institution(s): Instituto Gulbenkian de Ciencia, Oeiras (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Language: eng
Author:
Nunes, A. R.
Number of reproductions:
1
Keywords:
Social cognition / Social dominance / Oxytocin / Biological motion / Psychophysiology

Reference code: PT/FB/BL-2014-339.07
Location: BF-GMS
Title:
Unveiling the role of oxytocin-like peptides in the regulation of the zebrafish social behavior
Publication year: 2016
Abstract/Results:
ABSTRACT:
An elementary cognitive ability for social behaviour is the recognition of other behavioral agents in the environment. Point lights placed on the main joints of a walking person or even simple visual
displays (e.g. moving geometric-shapes) can originate a high-level percept of animacy. This ability is conserved across species and is critical for filial attachment, detection of predators, and perception
of social dominance. We aim to characterize the neural mechanisms underlying animacy, and to test if this ability is regulated by oxytocin-like peptides (oxytocin in mammals, isotocin in fish), which are a family of neuromodulators implicated in the regulation of social behavior across vertebrates.
Using zebrafish as an organism model, we developed new genetic tools that allow us to study the role of oxytocin in social behavior. We first characterized the ontogeny of sociality, measured by a
robust shoal preference test, and showed that it emerges around the third-week post fertilization. To explore how oxytocin affects the acquisition and modulation of sociality, we have specifically
perturbed oxytocinergic neuronal circuits and examined how loss of function of these neurons during development modifies social behavior. We observed that ablation of these neurons at a critical developmental period, but not during adulthood, significantly reduces shoal preference. Next, we found preliminary evidences for zebrafish ability to discriminate animacy cues, namely acceleration.
In the near future we plan to explore the role of oxytocin-like peptides in the regulation of animacy detection.
Accessibility: Document does not exist in file
Language:
eng
Author:
Nunes, A. R.
Secondary author(s):
Correia, L., Levkowitz, G., Oliveira, R.
Document type:
Unpublished abstract
Number of reproductions:
1
Reference:
Nunes, A. R., Correia, L., Levkowitz, G., & Oliveira, R. (2016). Unveiling the role of oxytocin-like peptides in the regulation of the zebrafish social behavior. Paper presented at the Rovereto Workshop on Cognition and Evolution V edition, CIMeC. Center for Mind/Brain Sciences, University of Trento, Italy.
Indexed document: No
Keywords: Zebrafish / Oxytocin
DocumentStructure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-185
Location: Arquivo PCA - Pasta 24/2012
Title:
185 - Circuit mechanisms of spatial attention in the zebrafish midbrain
Duration: 2013-06 - 2017-07
Researcher(s):
Michael Brian Orger, Sabine L. Renninger
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
3 Articles
Language: eng
Author:
Orger, M.
Secondary author(s):
Renninger, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Attention / Brain structure and function

Reference code: PT/FB/BL-2012-185.05
Location: Arquivo PCA - Pasta 24/2012
Title:
Structure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering
Publication year: 2018
URL:
https://www.sciencedirect.com/science/article/pii/S0960982217316044
Abstract/Results: ABSTRACT:
An important concept in ethology is that complex behaviors can be constructed from a set of basic motor patterns. Identifying the set of patterns available to an animal is key to making quantitative descriptions of behavior that reflect the underlying motor system organization. We addressed these questions in zebrafish larvae, which swim in bouts that are naturally segmented in time. We developed a robust and general purpose clustering method (clusterdv) to ensure accurate identification of movement clusters and applied it to a dataset consisting of millions of swim bouts, captured at high temporal resolution from a comprehensive set of behavioral contexts. We identified a set of thirteen basic swimming patterns that are used flexibly in various combinations across different behavioral contexts and show that this classification can be used to dissect the sensorimotor transformations underlying larval social behavior and hunting. Furthermore, using the same approach at different levels in the behavioral hierarchy, we show that the set of swim bouts are themselves constructed from a basic set of tail movements and that bouts are executed in sequences specific to different behaviors.
Accessibility: Document does not exist in file
Language:
eng
Author:
Marques, J. C.
Secondary author(s):
Lackner, S., Félix, R., Orger, M. B.
Document type:
Article
Number of reproductions:
1
Reference:
Marques, J. C., Lackner, S., Félix, R., & Orger, M. B. (2018). Structure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering. Current Biology, 28(2), 181-195. https://doi.org/10.1016/j.cub.2017.12.002
2-year Impact Factor: 9.193|2018
Times cited: 122|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: Zebrafish / Behavior / Locomotion / Cluster analysis / Unsupervised machine / Learning / Visual behavior / Motor control / Sequences / Behavioral motifs / Clusterdv
DocumentPerceptual mechanisms of social affiliation in zebrafish2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-339
Location: BF-GMS
Title:
339 - Neural mechanisms of social cognition in zebrafish
Duration: 2015-05 - 2019-11
Researcher(s):
Ana Rita Silva Martins Nunes
Institution(s): Instituto Gulbenkian de Ciencia, Oeiras (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Language: eng
Author:
Nunes, A. R.
Number of reproductions:
1
Keywords:
Social cognition / Social dominance / Oxytocin / Biological motion / Psychophysiology

Reference code: PT/FB/BL-2014-339.08
Location: BF-GMS
Title:
Perceptual mechanisms of social affiliation in zebrafish
Publication year: 2020
URL:
https://www.nature.com/articles/s41598-020-60154-8
Abstract/Results: ABSTRACT:
Social living animals need to recognize the presence of conspecifics in the environment in order to engage in adaptive social interactions. Social cues can be detected through different sensory modalities, including vision. Two main visual features can convey information about the presence of conspecifics: body form and biological motion (BM). Given the role that oxytocin plays in social behavior regulation across vertebrates, particularly in the salience and reward values of social stimuli, we hypothesized that it may also be involved in the modulation of perceptual mechanisms for conspecific detection. Here, using videoplaybacks, we assessed the role of conspecific form and BM in zebrafish social affiliation, and how oxytocin regulates the perception of these cues. We demonstrated that while each visual cue is important for social attraction, BM promotes a higher fish engagement than the static conspecific form alone. Moreover, using a mutant line for one of the two oxytocin receptors, we show that oxytocin signaling is involved in the regulation of BM detection but not conspecific form recognition. In summary, our results indicate that, apart from oxytocin role in the regulation of social behaviors through its effect on higher-order cognitive mechanisms, it may regulate social behavior by modulating very basic perceptual mechanisms underlying the detection of socially-relevant cues.
Accessibility: Document exists in file
Language:
eng
Author:
Nunes, A. R.
Secondary author(s):
Carreira, L., Anbalagan, S., Blechman, J., Levkowitz, G., Oliveira, R. F.
Document type:
Article
Number of reproductions:
1
Reference:
Nunes, A. R., Carreira, L., Anbalagan, S., Blechman, J., Levkowitz, G., & Oliveira, R. F. (2020). Perceptual mechanisms of social affiliation in zebrafish. Scientific Reports, 10, 3642. https://doi.org/10.1038/s41598-020-60154-8
2-year Impact Factor: 4.379|2020
Times cited: 40|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Oxytocin / Zebrafish / Social cues

Perceptual mechanisms of social affiliation in zebrafish

Perceptual mechanisms of social affiliation in zebrafish
DocumentShort telomeres drive pessimistic judgement bias in zebrafish2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-130
Location: Arquivo PCA - Pasta 29/2012
Title:
130 - Neural mechanisms of cognitive bias
Duration: 2013-09 - 2020-11
Researcher(s):
Rui Filipe Nunes Pais de Oliveira, Ana Félix, Sara Cardoso
Institution(s): ISPA, CRL, Lisbon and Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Oliveira, R.
Secondary author(s):
Felix, A., Cardoso, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2012-130.02
Location: Arquivo PCA - Pasta 29/2012
Title:
Short telomeres drive pessimistic judgement bias in zebrafish
Publication year: 2021
URL:
https://royalsocietypublishing.org/doi/10.1098/rsbl.2020.0745?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#d1e1069
Abstract/Results: ABSTRACT:
The role of telomerase reverse transcriptase has been widely investigated in the contexts of ageing and age-related diseases. Interestingly, decreased telomerase activities (and accelerated telomere shortening) have also been reported in patients with emotion-related disorders, opening the possibility for subjective appraisal of stressful stimuli playing a key role in stress-driven telomere shortening. In fact, patients showing a pessimistic judgement bias have shorter telomeres. However, in humans the evidence for this is correlational and the causal directionality between pessimism and telomere shortening has not been established experimentally yet. We have developed and validated a judgement bias experimental paradigm to measure subjective evaluations of ambiguous stimuli in zebrafish. This behavioural assay allows classification of individuals in an optimistic–pessimistic dimension (i.e. from individuals that consistently evaluate ambiguous stimuli as negative to others that perceive them as positive). Using this behavioural paradigm we found that telomerase-deficient zebrafish (tert-/-) were more pessimistic in response to ambiguous stimuli than wild-type zebrafish. The fact that individuals with constitutive shorter telomeres have pessimistic behaviours demonstrates for the first time in a vertebrate model a genetic basis of judgement bias.
Accessibility: Document exists in file
Language:
eng
Author:
Espigares, F.
Secondary author(s):
Abad-Tortosa, D., Varela, S. A. M., Ferreira, M. G., Oliveira, R. F.
Document type:
Article
Number of reproductions:
1
Reference:
Espigares, F., Abad-Tortosa, D., Varela, S. A. M., Ferreira, M. G., & Oliveira, R. F. (2021). Short telomeres drive pessimistic judgement bias in zebrafish. Biology Letters, 17(3): 20200745. https://doi.org/10.1098/rsbl.2020.0745
2-year Impact Factor: 3.904|2021
Times cited: 17|2025-02-14
Indexed document: Yes
Quartile: Q2
Keywords: Judgement bias / Pessimistic / Telomere shortening / Telomerase reverse transcriptase / Zebrafish

Short telomeres drive pessimistic judgement bias in zebrafish

Short telomeres drive pessimistic judgement bias in zebrafish
DocumentA behavioural assay to investigate judgment bias in zebrafish2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-130
Location: Arquivo PCA - Pasta 29/2012
Title:
130 - Neural mechanisms of cognitive bias
Duration: 2013-09 - 2020-11
Researcher(s):
Rui Filipe Nunes Pais de Oliveira, Ana Félix, Sara Cardoso
Institution(s): ISPA, CRL, Lisbon and Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Oliveira, R.
Secondary author(s):
Felix, A., Cardoso, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2012-130.03
Location: BF-GMS
Title:
A behavioural assay to investigate judgment bias in zebrafish
Publication year: 2022
URL:
https://doi.org/10.21769/BioProtoc.4327
Abstract/Results: ABSTRACT:
In this protocol, we describe for the first time a judgment bias paradigm to phenotype the way zebrafish assess ambiguous stimuli. We have developed and validated a protocol for a judgment bias test based on a Go/No-go task, and performed using a half radial maze. After a habituation phase, fish are trained to discriminate between two reference arms [positive (P) and negative (N)]. For this purpose, they experience a positive event (food reward in P), when presented with a specific location/color cue, and a negative event (chasing with net in N), when presented with a different location/color cue. Acquisition of the discrimination learning between P and N is revealed by the latencies to enter the experimental arms of the behavioral maze being significantly lower for the P arm than for the N arm. Once zebrafish are able to discriminate between P and N arms, their latency to enter other maze arms spatially located between P and N [(Near Positive (NP), Ambiguous (A) = half-way between P and N, and Near Negative (NN)] is analyzed. Latencies (L) to enter NP, A and NN maze arms are interpreted as indicating the individual expectancy to experience a reward/punishment on each of them. A judgment bias score (JBS) is calculated from the latencies to enter the P, N, and A arms for each fish [JBS = (LA-LP)*100/(LN-LP)], based on which fish can be classified into an optimistic/pessimistic axis. A JBS below 50 indicates that fish perceive the ambiguous stimulus as a positive one (optimistic bias), while JBS above 50 indicates that fish perceive the ambiguous stimulus as a negative one (pessimistic bias). However, for classification criteria, it could be advantageous to use the method of selecting extreme phenotypes (e.g., upper and lower quartiles of the JBS), since JBS in zebrafish falls into a bimodal distribution (unpublished data). Therefore, this protocol provides a unique, inexpensive, and effective alternative to other methods of measuring affective states in zebrafish that might be of great interest to a broad target audience and have a large number of applications. Graphic abstract: Flow chart of the judgment bias protocol in zebrafish.
Accessibility: Document exists in file
Language:
eng
Author:
Espigares, F.
Secondary author(s):
Martins, R. R., Oliveira, R. F.
Document type:
Article
Number of reproductions:
1
Reference:
Espigares, F., Martins, R. R., & Oliveira, R. F. (2022). A behavioural assay to investigate judgment bias in zebrafish. Bio-protocol, 12(4), e4327. https://doi.org/10.21769/BioProtoc.4327
2-year Impact Factor: 0.8|2022
Times cited: 6|2025-02-25
Indexed document: Yes
Quartile: Q3
Keywords: Affective state / Judgment bias / Optimism / Pessimism / Welfare / Zebrafish

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