Reference code: | PT/FB/BL-2010-170.05 |
Location: | Arquivo PCA - Pasta 9/2010
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Title:
| Unbalanced resting-state networks activity in psychophysiological insomnia
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Publication year: | 2017
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URL:
| https://link.springer.com/article/10.1007/s41105-017-0096-8
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Abstract/Results: | ABSTRACT:
Psychophysiological insomnia (PI) is a clinical condition characterized by sleep-related disturbing cognitive activity and biased self-related information processing. This hypothetical cognitive arousal has been hypothesized to be associated with overactivation within different brain areas and networks, especially when individuals are at rest, e.g., in the absence of any attention-demanding task. In this study, we carried out a resting-state fMRI experiment aimed at investigating activity of the different resting-state networks in PI. Our pool of participants was compound of 5 PI patients and 5 sex- and age-matched healthy controls recruited from the community. Participants from both groups also completed a set of self-report measures, including the sleep diary, Insomnia Severity Index (ISI), dysfunctional beliefs and attitudes about sleep (DBAS-30), and the World Health Organization Quality of Life Measure (WHOQOL-Bref). Our results showed that insomnia patients presented altered activation in the default-mode network (DMN), visual and auditory networks, and bilateral fronto-parietal networks. In the DMN, the patients presented a pattern of both decreased (right superior frontal gyrus, left medial frontal gyrus, and right middle temporal gyrus) and increased activation (left superior frontal gyrus, left anterior and posterior cingulate, right precuneus, left cingulate gyrus, and left middle temporal gyrus). Our findings on unbalanced resting-state networks in PI, with special emphasis on the DMN, may lay grounds to better understanding of the cognitive arousal experienced by PI patients and might help to further improve the clinical management of insomnia.
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Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Marques, D.
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Secondary author(s):
| Gomes, A., Clemente, V., dos Santos, J. M., Duarte, I. C., Caetano, G., Castelo-Branco, M.
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Document type:
| Article
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Number of reproductions:
| 1
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Percentiles:
| 7
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Reference:
| Marques, D., Gomes, A., Clemente, V., dos Santos, J. M., Duarte, I. C., Caetano, G., & Castelo-Branco, M. (2017). Unbalanced resting-state networks activity in psychophysiological insomnia. Sleep and Biological Rhythms, 15(2), 167-177. https://doi.org/10.1007/s41105-017-0096-8
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2-year Impact Factor: | 0.655|2017
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Times cited: | 10|2024-02-08
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Indexed document: | Yes
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Quartile: | Q4
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Keywords: | Insomnia / Resting-state networks / Neural activation / Default-mode network / Neuroimaging / fMRI
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