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BIAL Foundation
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DocumentNon-invasive brain stimulation for the modulation of aggressive behavior - A systematic review of randomized sham-controlled studies2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-160
Location: BF-GMS
Title:
160 - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction learning
Duration: 2019-04 - 2024-11
Researcher(s):
Carmelo Vicario, Michael A Nitsche, Vuk Markovic
Institution(s): Department of Psychology and Neuroscience, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany); Department of Cognitive Science, University of Messina (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Vicario, C.
Secondary author(s):
Nitsche, M. A., Markovic, V.
Number of reproductions:
1
Keywords:
tDCS / Fear extinction learning / Pre-frontal cortex / Psychophysiology

Reference code: PT/FB/BL-2018-160.07
Location: BF-GMS
Title:
Non-invasive brain stimulation for the modulation of aggressive behavior - A systematic review of randomized sham-controlled studies
Publication year: 2023
URL:
https://www.mdpi.com/2075-1729/13/5/1220
Abstract/Results: ABSTRACT:
Intro: Aggressive behavior represents a significant public health issue, with relevant social, political, and security implications. Non-invasive brain stimulation (NIBS) techniques may modulate aggressive behavior through stimulation of the prefrontal cortex. Aims: To review research on the effectiveness of NIBS to alter aggression, discuss the main findings and potential limitations, consider the specifics of the techniques and protocols employed, and discuss clinical implications. Methods: A systematic review of the literature available in the PubMed database was carried out, and 17 randomized sham-controlled studies investigating the effectiveness of NIBS techniques on aggression were included. Exclusion criteria included reviews, meta-analyses, and articles not referring to the subject of interest or not addressing cognitive and emotional modulation aims. Conclusions: The reviewed data provide promising evidence for the beneficial effects of tDCS, conventional rTMS, and cTBS on aggression in healthy adults, forensic, and clinical samples. The specific stimulation target is a key factor for the success of stimulation on aggression modulation. rTMS and cTBS showed opposite effects on aggression compared with tDCS. However, due to the heterogeneity of stimulation protocols, experimental designs, and samples, we cannot exclude other factors that may play a confounding role.
Accessibility: Document exists in file
Language:
eng
Author:
Casula, A.
Secondary author(s):
Milazzo, B. M., Martino, G., Sergi, A., Lucifora, C., Tomaiuolo, F., Quartarone, A., Nitsche, M. A, Vicario, C. M
Document type:
Article
Number of reproductions:
1
Reference:
Casula, A., Milazzo, B. M., Martino, G., Sergi, A., Lucifora, C., Tomaiuolo, F., Quartarone, A., Nitsche, M. A., & Vicario, C. M. (2023). Non-invasive brain stimulation for the modulation of aggressive behavior - A systematic review of randomized sham-controlled studies. Life, 13(5), 1220. https://doi.org/10.3390/life13051220
2-year Impact Factor: 3.2|2023
Times cited: 11|2025-02-18
Indexed document: Yes
Quartile: Q1
Keywords: Non-invasive brain stimulation / Aggression / tDCS / rTMS / cTBS

Non-invasive brain stimulation for the modulation of aggressive behavior - A systematic review of randomized sham-controlled studies

Non-invasive brain stimulation for the modulation of aggressive behavior - A systematic review of randomized sham-controlled studies
DocumentA scoping review on the use of non-invasive brain stimulation techniques for persistent post-concussive symptoms2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-123
Location: BF-GMS
Title:
A scoping review on the use of non-invasive brain stimulation techniques for persistent post-concussive symptoms
Publication year: 2024
URL:
https://doi.org/10.3390/biomedicines12020450
Abstract/Results: ABSTRACT:
Background:
In the context of managing persistent post-concussive symptoms (PPCS), existing treatments like pharmacotherapy, cognitive behavioral therapy, and physical rehabilitation show only moderate effectiveness. The emergence of neuromodulation techniques in PPCS management has led to debates regarding optimal stimulation parameters and their overall efficacy.
Methods: this scoping review involved a comprehensive search of PubMed and ScienceDirect databases, focusing on controlled studies examining the therapeutic potential of non-invasive brain stimulation (NIBS) techniques in adults with PPCS.
Results: Among the 940 abstracts screened, only five studies, encompassing 103 patients (12 to 29 per study), met the inclusion criteria. These studies assessed the efficacy of transcranial direct current stimulation (tDCS), or repetitive transcranial magnetic stimulation (rTMS), applied to specific brain regions (i.e., the left dorsolateral pre-frontal cortex (DLPFC) or left motor cortex (M1)) for addressing cognitive and psychological symptoms, headaches, and general PPCSs. The results indicated improvements in cognitive functions with tDCS. In contrast, reductions in headache intensity and depression scores were observed with rTMS, while no significant findings were noted for general symptoms with rTMS.
Conclusion: although these pilot studies suggest promise for rTMS and tDCS in PPCS management, further research with larger-scale investigations and standardized protocols is imperative to enhance treatment outcomes for PPCS patients.
Accessibility: Document exists in file
Language:
eng
Author:
Khosravi, M. H.
Secondary author(s):
Louras, M., Martens, G., Kaux, J. F., Thibaut, A., Lejeune, N.
Document type:
Article
Number of reproductions:
3
Reference:
Khosravi, M. H., Louras, M., Martens, G., Kaux, J. F., Thibaut, A., & Lejeune, N. (2024). A Scoping Review on the Use of Non-Invasive Brain Stimulation Techniques for Persistent Post-Concussive Symptoms. Biomedicines, 12(2), 450. https://doi.org/10.3390/biomedicines12020450
2-year Impact Factor: 3.9|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 1|2025-02-19
Indexed document: Yes
Quartile: Q1
Keywords: Non-invasive brain stimulation / Transcranial direct current stimulation / tDCS / transcranial magnetic stimulation / rTMS / Post-concussive symptoms

A scoping review on the use of non-invasive brain stimulation techniques for persistent post-concussive symptoms

A scoping review on the use of non-invasive brain stimulation techniques for persistent post-concussive symptoms
DocumentReply to commentaries on enhanced mind-matter interactions following rTMS induced frontal lobe inhibition2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-210
Location: BF-GMS
Title:
210 - Mind-matter interactions and the frontal lobes of the brain
Duration: 2019-07 - 2023-11
Researcher(s):
Morris Freedman, Robert Chen, Malcolm Binns
Institution(s): Division of Neurology, Baycrest Health Sciences, Toronto (Canada); Division of Neurology, University Health Network - UHN, Toronto (Canada)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Freedman, M.
Secondary author(s):
Chen, R., Binns, M.
Number of reproductions:
3
Keywords:
Mind-matter interaction / Frontal lobes / Repetitive Transcranial Magnetic Stimulation (rTMS) / Random event generator (REG) / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-210.03
Location: BF-GMS
Title:
Reply to commentaries on enhanced mind-matter interactions following rTMS induced frontal lobe inhibition
Publication year: 2024
URL:
https://doi.org/10.1016/j.cortex.2024.02.001
Abstract/Results: ABSTRACT:
We appreciate the interest that our paper (Freedman et al., 2024) has generated. Given its focus on the highly controversial topic of psi, it is not surprising that it has garnered a lot of attention. We want to thank those who submitted their commentaries, as well as the Editors of Cortex for allowing us the opportunity to respond. We shall address each of the main issues according to the themes raised.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Freedman, M.
Secondary author(s):
Binns, M. A., Meltzer, J. A., Hashimi, R., Chen, R.
Document type:
Article
Number of reproductions:
1
Reference:
Freedman, M., Binns, M. A., Meltzer, J. A., Hashimi, R., & Chen, R. (2024). Reply to commentaries on enhanced mind-matter interactions following rTMS induced frontal lobe inhibition. Cortex, 172, 249-253. https://doi.org/10.1016/j.cortex.2024.02.001
2-year Impact Factor: 3.3|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2025-02-27
Indexed document: Yes
Quartile: Q1
Keywords: rTMS / Frontal lobe inhibition / Mind-matter interactions