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BIAL Foundation
TI:"Assessing cognitive function in a rat model of glial pathology"
Selection Description
Type Title Begin End
DocumentAssessing cognitive function in a rat model of glial pathology2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
BIAL Foundation Archive
Start date: 1994
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-061
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
061 - Translation of neuron-glia interactions in complex cognitive functions
Duration: 2011-05 - 2015-07
João Filipe Pedreira de Oliveira, Nuno Sérgio Mendes Dias, Luis Ricardo Monteiro Jacinto
Institution(s): Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Ciências da Saúde, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Financial report and expenditure documents
Progress reports
Final report
3 Articles
1 Poster
Language: eng
Oliveira, J. F.
Secondary author(s):
Dias, N., Jacinto, L. R.
Number of reproductions:
Psychophysiology / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2010-061.03
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Assessing cognitive function in a rat model of glial pathology
Publication year: 2012
Abstract/Results: ABSTRACT:
Astrocytes are being recognized as active elements concerning information flow in the brain, however their role in cognition is still unknown. In this study we aimed to understand the influence of astrocytic function in complex cognitive processes that depend on the medial prefrontal cortex (mPFC). The rationale consisted in analysing the cognitive performance of animals with induced glial pathology in the mPFC. This animal model was obtained by bilateral intracranial injections of L-a-aminoadipate to cause astrocyte ablation in Wistar-Han rats. Cognitive functions dependent on the mPFC, such as attention set-shifting and reversal learning of non-spatial working memory, were assessed by the attentional set-shifting task (ASST). Animals with mPFC-glial pathology showed no differences in learning how to perform the task, however they learnt faster the compound discrimination stages, when compared to the controls. Regarding the reversal learning stages, drug injected animals presented more difficulties than controls. Glial pathology seems to affect the function of neuro-glial networks, which may be translated in altered behavioural outputs.
Accessibility: Document exists in file (poster)
By permission
Lima, A.
Secondary author(s):
Reis, M., Cerqueira, J., Sousa, N., Oliveira, J. F.
Document type:
Online abstract
Number of reproductions:
Lima, A., Reis, M., Cerqueira, J., Sousa, N., & Oliveira, J. F. (2012, July). Assessing cognitive function in a rat model of glial pathology. Poster presented at the 8th FENS Forum Neuroscience, Barcelona, Spain. Abstract retrieved from
Indexed document: No
Keywords: Astrocyte / Cognition / Learning / Prefrontal cortex

Assessing cognitive function in a rat model of glial pathology

Assessing cognitive function in a rat model of glial pathology