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BIAL Foundation
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TI:"Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states "
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Type Title Begin End
DocumentDichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states 2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.05
Location: BF-GMS
Title:
Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states
Publication year: 2021
URL:
https://advances.sciencemag.org/content/7/30/eabh2059
Abstract/Results: ABSTRACT:
The balance between exploiting known actions and exploring alternatives is critical for survival and hypothesized to rely on shifts in neuromodulation. We developed a behavioral paradigm to capture exploitative and exploratory states and imaged calcium dynamics in genetically identified dopaminergic and noradrenergic neurons. During exploitative states, characterized by motivated repetition of the same action choice, dopamine neurons in SNc encoding movement vigor showed sustained elevation of basal activity that lasted many seconds. This sustained activity emerged from longer positive responses, which accumulated during exploitative action-reward bouts, and hysteretic dynamics. Conversely, noradrenergic neurons in LC showed sustained inhibition of basal activity due to the accumulation of longer negative responses in LC. Chemogenetic manipulation of these sustained dynamics revealed that dopaminergic activity mediates action drive, whereas noradrenergic activity modulates choice diversity. These data uncover the emergence of sustained neural states in dopaminergic and noradrenergic networks that mediate dissociable aspects of exploitative bouts.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Article
Number of reproductions:
1
Reference:
Koralek, A. C., & Costa, R. M. (2021). Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states. Science Advances, 7(30): eabh2059. https://doi.org/10.1126/sciadv.abh2059
2-year Impact Factor: 14.980|2021
Times cited: 7|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Dopamine / Exploration / Action selection / Basal ganglia