| Reference code: | PT/FB/BL-2014-339.05 |
| Location: | BF-GMS
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Title:
| Early ablation of oxytocin-like peptides shapes adult zebrafish sociality
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| Publication year: | 2016
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URL:
| https://www.s4sn.org/wordpress/wp-content/uploads/2016/10/S4SN-2016-Annual-Meeting.pdf
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| Abstract/Results: | ABSTRACT:
Oxytocin and vasopressin-like peptides (isotocin in fish, mesotocin in birds, reptiles and amphibian, and vasotocin) have been implicated in the regulation of social behavior across vertebrates [1]. Although vasopressin is more involved in aggression behavior while oxytocin-like peptides in pro-social behaviors, these neuropeptides and receptor subtypes are similar [2]. Using zebrafish as a model organism, we have been investigating the role of oxytocin-like peptides in the regulation of adult sociality. We have characterized how early relevant sociality, measured as a shoal preference, can be studied during zebrafish ontogeny. Our data shows that shoal preference emerges around the third week post-fertilization. In order to explore how isotocin can modulate the acquirement of social paradigms underlying social cognition, we have been using a genetic approach to specifically perturb the isotocinergic neuronal circuits and to study how loss of function of these neurons during embryonic development, or throughout the organism’s lifetime, modifies adult social behavior. Using an oxytocin neurons-specific transgenic system for conditional (i.e. temporal) and cell-specific ablation of oxytocin neurons, we demonstrated that early ablation, but not adult ablation, significantly alter shoal preference behavior in adulthood. Furthermore, early inhibition of isotocin vesicular release also impairs adult sociality in zebrafish. In conclusion, our findings suggest that the isotocin neuronal system is involved on a specific social behavior trait that becomes hardwire during early development.
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| Accessibility: | Document exists in file
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Language:
| eng
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Author:
| Nunes, A. R.
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Secondary author(s):
| Gliskberg, M., Anbalagan, S., Wircer, E., Levkowitz, G., Oliveira, R.
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Document type:
| Abstract book
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Number of reproductions:
| 1
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Reference:
| Nunes, A. R., Gliskberg, M., Anbalagan, S., Wircer, E., Levkowitz, G., & Oliveira, R. (2016). B38 Early ablation of oxytocin-like peptides shapes adult zebrafish sociality. Abstract book of the Annual Meeting of The Society for Social Neuroscience (p. 61). San Diego, USA.
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| Indexed document: | No
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| Keywords: | Social Behavior / Zebrafish / Oxytocin
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Early ablation of oxytocin-like peptides shapes adult zebrafish sociality |