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BIAL Foundation
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TI:"Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females"
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DocumentExpectations of increased and decreased pain explain the effect of conditioned pain modulation in females2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.27
Location: Arquivo PCA - Pasta 12/2006
Title:
Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females
Publication year: 2012
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442740/pdf/jpr-5-289.pdf
Abstract/Results: ABSTRACT:
OBJECTIVE:
Chronic pain is believed to be related to a dysfunction of descending pain modulatory mechanisms. Functioning of descending pain modulation can be assessed by various methods, including conditioned pain modulation (CPM). CPM refers to the inhibition of one source of pain by a second noxious stimulus, termed the conditioning stimulus. This procedure can activate an endogenous pain inhibitory mechanism that inhibits early nociceptive processing. Chronic pain and anxiety disorders are more prevalent among females and it has been hypothesized that females react with more negative emotions towards unpleasant stimuli and this might be part of the explanation of greater pain sensitivity in females. The present study investigated whether expectations modulate the effect of conditioning stimulation on pain, subjective stress, and heart rate. In addition, we investigated whether the modulation of CPM by expectations differed between males and females.
METHODS:
Seventy-two subjects (including 36 women) received six noxious heat stimuli to the forearm. During three of these stimuli, a conditioning stimulus (cold-water bath) was applied to the contralateral arm in order to activate CPM. One third of the subjects were told that this would reduce pain (analgesia group), one-third that it would increase pain (hyperalgesia group), and one third received no information about its effect (no info group).
RESULTS:
Information that conditioning stimulation decreased or enhanced pain had the corresponding effect in females, but not in males. Conditioning stimulation increased stress, but not heart rate in females in the hyperalgesia group. A higher expectation of analgesia and lower stress during conditioning stimulation was associated with larger inhibitory CPM.
CONCLUSION:
These results suggest that reduced inhibitory CPM can be due to contextually induced cognitive and emotional factors and not necessarily a dysfunction of descending inhibitory pathways.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Article
Number of reproductions:
1
Reference:
Bjørkedal, E., & Flaten, M. (2012). Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females. Journal of Pain Research, 5, 289-300. https://doi.org/10.2147/JPR.S33559
2-year Impact Factor: N/A
Impact factor notes: Impact factor computed since 2015
Times cited: N/A
Indexed document: Yes
Quartile: N/A
Keywords: Pain / Conditioned pain modulation / Expectancy / Placebo analgesia / Nocebo hyperalgesia

DocumentExpectations of increased and decreased pain explain the effect of conditioned pain modulation in females2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-186
Location: Arquivo PCA - Pasta 12/2010
Title:
186 - Brain mechanisms of placebo analgesia
Duration: 2011-03 - 2014-01
Researcher(s):
Magne Arve Flaten, Per M. Aslaksen, Torgil R. Vangberg, Odd Petter Eldevik, Jan Bergdahl, Sara Vambheim, Just C. Thoner
Institution(s): University of Tromsø and University Hospital of North Norway, Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form + 12 articles (previous project team publications)
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Flaten, M.
Secondary author(s):
Aslaksen, P., Vangberg, T., Eldevik, O., Bergdahl, J., Vambheim, S., Thoner, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion / Brain structure and function

Reference code: PT/FB/BL-2010-186.16
Location: Arquivo PCA - Pasta 10/2010
Title:
Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females
Publication year: 2012
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442740/
Abstract/Results: ABSTRACT:
OBJECTIVE:
Chronic pain is believed to be related to a dysfunction of descending pain modulatory mechanisms. Functioning of descending pain modulation can be assessed by various methods, including conditioned pain modulation (CPM). CPM refers to the inhibition of one source of pain by a second noxious stimulus, termed the conditioning stimulus. This procedure can activate an endogenous pain inhibitory mechanism that inhibits early nociceptive processing. Chronic pain and anxiety disorders are more prevalent among females and it has been hypothesized that females react with more negative emotions towards unpleasant stimuli and this might be part of the explanation of greater pain sensitivity in females. The present study investigated whether expectations modulate the effect of conditioning stimulation on pain, subjective stress, and heart rate. In addition, we investigated whether the modulation of CPM by expectations differed between males and females.
METHODS:
Seventy-two subjects (including 36 women) received six noxious heat stimuli to the forearm. During three of these stimuli, a conditioning stimulus (cold-water bath) was applied to the contralateral arm in order to activate CPM. One third of the subjects were told that this would reduce pain (analgesia group), one-third that it would increase pain (hyperalgesia group), and one third received no information about its effect (no info group).
RESULTS:
Information that conditioning stimulation decreased or enhanced pain had the corresponding effect in females, but not in males. Conditioning stimulation increased stress, but not heart rate in females in the hyperalgesia group. A higher expectation of analgesia and lower stress during conditioning stimulation was associated with larger inhibitory CPM.
CONCLUSION:
These results suggest that reduced inhibitory CPM can be due to contextually induced cognitive and emotional factors and not necessarily a dysfunction of descending inhibitory pathways.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bjørkedal, E.
Secondary author(s):
Flaten, M.
Document type:
Article-d
Number of reproductions:
1
Reference:
Bjørkedal, E. & Flaten, M. A. (2012). Expectations of increased or decreased pain explain the effect of conditioned pain modulation in females. Journal of Pain Research, 5, 289-300. https://doi.org/10.2147/JPR.S33559
2-year Impact Factor: N/A
Times cited: N/A
Indexed document: Yes
Quartile: N/A
Keywords: Pain / Conditioned pain modulation / Expectations / Placebo analgesia / Nocebo hyperalgesia

Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females

Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females