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BIAL Foundation
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TI:"Final report - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings"
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DocumentFinal report - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.01
Location: Arquivo PCA - Pastas 20/2012
Title:
Final report - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Publication year: 2016
Abstract/Results:
ABSTRACT:
BACKGROUND
Deep-brain stimulation (DBS) is being increasingly used to treat medication resistant neurological and psychiatric diseases. However, the cognitive effects of DBS are not well understood.
AIM OF THE STUDY
To determine the effects of DBS to the human nucleus accumbens (NAc) on cognitive function.
METHOD
During the project period, 11 patients (10 with obsessive-compulsive disorder and 1 with major depression) underwent bilateral implantation of DBS electrodes. Intra-operatively, we recorded single-unit activity from the NAc during an auditory oddball task. Post-operatively, patients performed 3 behavioural tasks, with NAc DBS (130Hz, 3.5V, 60µs pulse-width) applied at 2 intervals during the task (On/Off design). In the third study, we simultaneously acquired scalp electroencephalography (EEG) recordings.
RESULTS & CONCLUSIONS
Intra-operative recordings - Different forms of salience evoke a change in human NAc single neuron firing rate, at a latency ~200 ms. Risky decision-making - We found that NAc DBS disrupts the normal relation between probability of reward and choice in 4 patients, resulting in a shift towards more risk seeking behaviour. Memory encoding - In all 6 patients tested, we found that NAc DBS during encoding of images increases the probability that these images will be later recognised. The magnitude of this memory enhancement predicts memory improvement in a neuropsychological test of verbal memory after 2 months of chronic DBS. Target detection during sustained attention - In 6 patients tested with the AX-type continuous performance task (AX-CPT), NAc DBS evoked a reduction of total numbers of errors in the ON relative to OFF state. In the EEG, NAc DBS produced an increase in the distribution of sources generating the P3 potential during Go trials. NAc DBs has profound effects on cognitive function.
Accessibility: Deocument exists in file
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Deep-brain stimulation, Intracranial recordings, Nucleus accumbens, Electroencephalogram (EEG)
Author: Strange, B.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Deep brain stimulation / Intracranial recordings / Nucleus accumbens / Electroencephalogram (EEG)