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BIAL Foundation
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TI:"Final report - Effects of conditional Foxp2 deletion on motor-sequence learning"
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DocumentFinal report - Effects of conditional Foxp2 deletion on motor-sequence learning2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.01
Location: Arquivo PCA - Pasta 15/2012
Title:
Final report - Effects of conditional Foxp2 deletion on motor-sequence learning
Publication year: 2016
URL:
https://www.bial.com/imagem/Grant19212.pdf
Abstract/Results: ABSTRACT:
Disruptions of FOXP2 cause a speech and language disorder, a core deficit of which are problems in sequencing orofacial movements. The gene encodes a transcription factor that is expressed in cortico-striatal/ -cerebellar circuits which are required for sensorimotor integration and motor-skill learning, and imaging studies of affected individuals have identified structural abnormalities in these regions. FOXP2 is also highly conserved in several other vertebrate species including mice, where expression is seen in comparable brain areas during development and in adulthood. The aims of this study were to 1) establish the contributions of Foxp2 in specific brain regions to motor-sequence learning 2) examine Foxp2 functions in adulthood. We generated conditional mice with selective Foxp2 disruptions in the cortex, striatum or cerebellar Purkinje cells, and assessed effects on motor-sequence learning using an operant lever-pressing task. Foxp2 in each of the circuits contributed differentially to the speed and variability of lever-press sequences. Pronounced deficits were seen in cerebellar Purkinje cell mutants and, in collaboration with Prof. Chris De Zeeuw, we showed that Purkinje cells lacking Foxp2 have increased excitability and are atypically modulated in vivo during locomotion. We also used an inducible Cre to disrupt Foxp2 globally in adulthood. This resulted in the deaths of around one third of mutant mice, although surviving animals appeared healthy and executed lever-press sequences normally. In sum, we found that early Foxp2 expression is critical for motor-sequence learning and model-based decision making, but continued expression in mature animals is important for other behaviours such as sociability.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
French, C.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Motor-sequence learning / Foxp2 / Speech and language / Conditional gene disruption / in vivo electrophysiology