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BIAL Foundation
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TI:"Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain"
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DocumentFinal report - Pain control from the brain - Gene therapy in the treatment of chronic pain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.01
Location: Arquivo PCA - Pasta 21/2004
Title:
Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain
Publication year: 2008
URL:
http://www.bial.com/imagem/Bolsa1504_19022014.pdf
Abstract/Results: RESULTS:
The activity of the brain in pain modulation during chronic pain is changed. In general, the net balance of descending modulation during chronic pain consists on a decrease of descending inhibitory actions and an increase of facilitatory effects. Synchronous changes in neuronal responses at the spinal cord and pain control centres in the brain were detected. Variations in the expression of neurotransmitters and receptors in pain control centres of the brain may account for the effects of chronic pain. To target pain control centres of the brain, we elected a gene therapy approach based on the sustained and directed effects of the technique. The overexpression of pre-proenkephalin using a replication-defective vector derived from Herpes Simplex type 1 (HSV-1) in a pain control area of the brain (the caudal ventrolateral medulla), decreased behavioural responses in an inflammatory pain model, the formalin test, and inhibited nociceptive responses of spinal neurons. A reversal of behavioural pain responses was also induced in a traumatic neuropathic pain model using a HSV-1 vector in which a tissue-specific promoter (tyrosine hydroxylase; TH) controlled the expression oh the TH transgene inserted in an antisense sequence. Using this vector, the decrease in the release of noradrenaline in a pain facilitatory centre (the dorsal reticular nucleus) induced long-lasting antinociceptive effects, detected during 22 days. Gene therapy may be considered an excellent molecular tool to understand the effects of chronic pain installation in pain control circuits of the brain. Furthermore, based on detailed morphofunctional knowledge of pain control centres of the brain and by electing the vector type, determining the better promoter and the suitable transgene for the construct, the effects of chronic pain may be corrected using gene therapy approaches.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Chronic pain / Gene therapy / Brain

Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain

Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain