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BIAL Foundation
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TI:"Final report - Structural biology of human brain CNP, a protein essential for axonal survival"
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DocumentFinal report - Structural biology of human brain CNP, a protein essential for axonal survival2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-009
Location: Arquivo PCA - Pasta 8/2004
Title:
009 - Structural biology of human brain CNP, a protein essential for axonal survival
Duration: 2005-02 - 2007-04
Researcher(s):
Andreas Hofmann
Institution(s): Institute of Cell & Molecular Biology, The University of Edinburgh (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Hofmann, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-009.01
Location: Arquivo PCA - Pasta 8/2004
Title:
Final report - Structural biology of human brain CNP, a protein essential for axonal survival
Publication year: 2007
URL:
http://www.bial.com/imagem/Bolsa0904_03122012.pdf
Abstract/Results: RESULTS:
Our study was originally concerned with full-length brain Cyclic Nucleotide Phosphodiesterase (CNP), a member of the 2H phosphodiesterase family, which is found abundantly in the myelin of oligodendrocytes in the central nervous system, and has been shown to be of major importance for axonal survival. As such, CNP is believed to be implicated in diseases such as multiple sclerosis and schizophrenia. The three-dimensional structure of the full-length protein is anticipated to yield new insights into the molecular mechanisms of the protein.
We have developed a protocol for expression and purification of the recombinant full-length protein, verified the integrity of the protein by mass spectrometry, and checked the fold and its stability by circular dichroism and fluorescence spectroscopy. Extensive crystallisation trials did not yield crystals suitable for X-ray diffraction so far. In selected trials, protein self-organisation was observed, probably indicating epitaxy-like formation of nanostructures on the glass plates.
Another family of brain proteins are the Visinin-like Proteins (VILIPs) that are neuronal calcium sensor proteins and an important factor for synaptic plasticity. They are involved in schizophrenia, neurodegenerative diseases such as Alzheimer’s and other disorders.
To obtain further insights into the molecular level mechanisms of VILIPs, homology models were generated and modelling techniques were used to elucidate the binding mechanisms of these proteins to specific membrane components (PIPs). We have developed the first three-dimensional model of VILIP:PIP complexesm, and propose a mechanism whereby recognition of specific PIP derivatives contributes to the targeting of VILIPs to subcellular locations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Hofmann, A.
Secondary author(s):
Zhou, L., Kämäräinen, O.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Psychopathology / Visinin-like proteins / Neuronal calcium sensors

Final report - Structural biology of human brain CNP, a protein essential for axonal survival

Final report - Structural biology of human brain CNP, a protein essential for axonal survival