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DocumentFinal report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-296
Location: BF-GMS
Title:
296 - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens
Duration: 2017-09 - 2021-11
Researcher(s):
Stephen Martin, Rosalina Fonseca
Institution(s): Division of Neuroscience, School of Medicine, University of Dundee (UK); Centro de Estudos de Doenças Crónicas, NOVA Medical School, Faculdade de Ciências Médicas – Universidade NOVA de Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Martin, S. J.
Secondary author(s):
Fonseca, R.
Number of reproductions:
1
Keywords:
Nucleus accumbens / Hippocampus / Prefrontal cortex / Synaptic plasticity / Psychophysiology

Reference code: PT/FB/BL-2016-296.01
Location: BF-GMS
Title:
Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens
Publication year: 2021
Abstract/Results:
ABSTRACT:
BACKGROUND
Synaptic changes underlie memory formation in many brain areas; ventral hippocampal (vHPC) and prefrontal cortex (PFC) projections to the nucleus accumbens (NAc) are a potential site of storage for associations between environmental stimuli and reward.
AIMS
Our goals were to identify learning-related changes in synaptic strength in inputs to the NAc during associative learning, and to characterise the interactions between PFC and vHPC projections.
METHOD
Rats were implanted with electrodes to record synaptic potentials in the vHPC-NAc pathway, and spontaneous oscillatory activity. They underwent place-preference training in which a distinctive context was associated with morphine injection. In parallel experiments, fluorescent viral constructs were injected into vHPC or PFC. Rats were later sacrificed, and their brains were sectioned and imaged to determine the distribution of projections from vHPC and PFC to the NAc.
RESULTS
Training did not cause an overall change in synaptic strength, but morphine caused an acute increase in evoked responses, and a progressive increase in gamma-frequency activity. The tracing experiments revealed that vHPC projects almost exclusively to the NAc shell, whereas the PFC projects predominantly to the core.
CONCLUSIONS
Our results do not support the idea that changes in synaptic strength in the vHPC-NAc projection underlie context-reward associations. However, the morphine-induced increase in gamma-frequency activity may be related to the ‘incentive sensitisation’ that occurs with repeated opioid administration. Fluorescent tracing indicates that there is limited overlap between vHPC and PFC inputs to the NAc; direct interactions between these inputs are thus unlikely to mediate the formation of context-reward associations.
Accessibility: Document exists in file
Language:
eng
Author:
Martin, S. J.
Secondary author(s):
Fonseca, R.
Document type:
Final report
Number of reproductions:
1
Reference:
Martin, S. J., & Fonseca, R. (2021). Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens.
Indexed document: No
Keywords: Hippocampus / Nucleus accumbens / Prefrontal cortex / Reward / Synaptic plasticity

Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens

Final report - Synaptic competition and cooperation in reward learning: The role of hippocampal and prefrontal inputs to the nucleus accumbens