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BIAL Foundation
TI:"Insights into local properties and synchrony of sleep spindles from ECoG in humans "
Selection Description
Type Title Begin End
DocumentInsights into local properties and synchrony of sleep spindles from ECoG in humans 2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
BIAL Foundation Archive
Start date: 1994
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-220
Location: Arquivo PCA - Pasta 15/2012
220 - Consciousness disconnects during sleep
Duration: 2013-04 - 2016-05
Giovanni Piantoni
Institution(s): Cortical Physiology Lab, Massachusets General Hospital, Harvard Medical School (USA) and Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Progress reports
Final reports
1 article
Submitted papers
Language: eng
Piantoni, G.
Number of reproductions:
Psychophysiology / Brain structure and function / Sleep and dreams

Reference code: PT/FB/BL-2012-220.03
Location: Arquivo PCA - Pasta 15/2012
Insights into local properties and synchrony of sleep spindles from ECoG in humans
Publication year: 2014
Abstract/Results: ABSTRACT:
During non-REM sleep, neuronal firing is grouped by the slow oscillations at around 1 Hz, and sleep spindles, 0.5-2s long bursts of oscillatory activity between 11 and 18 Hz. Spindles are thought to arise from the interplay between thalamic and cortical neurons and are hypothesized to be involved in a wide variety of fundamental processes including the solidification of learning during sleep. However many of the physiological mechanisms and characteristics of spindles remain poorly understood. The spatial extent of spindle activity, as one key feature, has been the object of substantial debate, with conflicting evidence pointing both to an increase in synchronization, assessed with scalp EEG, and to strong regional localization, as measured by MEG and intraparenchymal depth electrode recordings (iEEG). Here, we examine spindle localization and synchrony across broad areas of neocortex using recordings from, on average, 80 electrodes (ECoG) placed directly on the pial surface in six patients undergoing evaluation for intractable epilepsy. The research was approved by the local institutional review board and electrode placement was determined solely by clinical criteria. At least one hour of visually scored sleep was included in the analysis. Spindles were automatically detected on each electrode independently, based on custom code. Spindles were considered synchronous when two spindles on separate channels overlapped in time. We observed that spindles were more likely than expected by chance to appear at the same time over multiple cortical locations. However, when we estimated the distribution of spindles in relation to the number of active electrodes, we observed that there was a strong positive skew. This indicates that most spindles were synchronous only in one or a few channels at the same time but some spindles were widely distributed. This distinction between focal spindles and distributed spindles was further investigated by measuring the spreading over cortical regions with a 3D reconstruction of the electrode locations and by comparing it with the underlying anatomical structures. These results indicate a dynamic interplay between local properties of focal spindles and widespread synchrony of global spindles. We suggest that the multiple spatial scales at which sleep oscillations operate might provide a flexible framework to support the many functions ascribed to sleep and to spindles in particular, such as sensory gating, memory consolidation, and synaptic homeostasis.
Accessibility: Document does not exist in file
Piantoni, G.
Secondary author(s):
Halgren, E., Cash, S.
Document type:
Online abstract
Number of reproductions:
Piantoni, G., Halgren, E., & Cash, S. (2014, November). Insights into local properties and synchrony of sleep spindles from ECoG in humans. Poster presented at the 2014 Society for Neuroscience meeting, Washington, D. C. Abstract retrieved from
Indexed document: No
Keywords: Sleep / Electrophysiology / Oscillations