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BIAL Foundation
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TI:"Involvement of phasic brainstem activity in the preferential anterior-to-posterior direction of traveling cortical slow waves in human sleep EEG "
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DocumentInvolvement of phasic brainstem activity in the preferential anterior-to-posterior direction of traveling cortical slow waves in human sleep EEG 2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-220
Location: Arquivo PCA - Pasta 15/2012
Title:
220 - Consciousness disconnects during sleep
Duration: 2013-04 - 2016-05
Researcher(s):
Giovanni Piantoni
Institution(s): Cortical Physiology Lab, Massachusets General Hospital, Harvard Medical School (USA) and Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
1 article
Submitted papers
Language: eng
Author:
Piantoni, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams

Reference code: PT/FB/BL-2012-220.04
Location: Arquivo PCA - Pasta 15/2012
Title:
Involvement of phasic brainstem activity in the preferential anterior-to-posterior direction of traveling cortical slow waves in human sleep EEG
Publication year: 2014
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=839ccbfd-050c-4315-b1eb-4b593af117b8&cKey=36a00cdf-d67d-4c90-ab1a-dff420912256&mKey=54c85d94-6d69-4b09-afaa-502c0e680ca7
Abstract/Results: ABSTRACT:
The slow waves of sleep arise from the alternation of periods of relative neuronal silence and periods of high neuronal activity. Intriguingly, slow waves travel preferentially from anterior to posterior cortical regions. It has been proposed that phasic activity of subcortical regions that modulate cortical excitability may be involved in state transitions. The neuronal mechanisms contributing to the directional preference of traveling however remain elusive. Since the active phase of the cortical slow wave can be preceded by phasic activity in the locus coeruleus (LC), we hypothesized that the LC, due to the anteroposterior gradient of the length and consequently axonal propagation duration of its cortically projecting fibers, might depolarize frontal cortical neurons slightly earlier than more posterior neurons and thus prime the cortex for a preferential propagation of slow waves along the anterior-to-posterior axis. High-density electroencephalography (EEG) and functional Magnetic Resonance Imaging (fMRI) were recorded in 14 participants while sleeping. Slow waves were automatically detected and classified according to their direction of propagation on the scalp as traveling either in the anterior-to-posterior or posterior-to-anterior direction. Statistical parameter mapping (SPM) analysis was used to evaluate to which extent these two event types were preceded by phasic activation in the brainstem. A brainstem area compatible with the right LC was significantly activated in association with slow waves traveling in the anterior-to-posterior direction, but not significantly with slow waves traveling in the opposite, posterior-to-anterior, direction. Phasic activity in the LC may thus contribute to the bias of slow waves to travel in an anterior-to-posterior direction.
Accessibility: Document does not exist in file
Language:
eng
Author:
Van Someren, E.
Secondary author(s):
Piantoni, G., Stoffers, D., Van Der Werf, Y., Dang-Vu, T., Maquet, P.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Van Someren, E., Piantoni, G., Stoffers, D., Van Der Werf, Y., Dang-Vu, T., & Maquet, P. (2014, November). Involvement of phasic brainstem activity in the preferential anterior-to-posterior direction of traveling cortical slow waves in human sleep EEG. Paper presented at the 2014 Society for Neuroscience meeting, Washington, D. C. Abstract retrieved from http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=839ccbfd-050c-4315-b1eb-4b593af117b8&cKey=36a00cdf-d67d-4c90-ab1a-dff420912256&mKey=54c85d94-6d69-4b09-afaa-502c0e680ca7
Indexed document: No
Keywords: Sleep / Locus coeruleus / Oscillations