Reference code: | PT/FB/BL-2016-264.08 |
Location: | BF-GMS
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Title:
| Microglia-dependent remodeling of neuronal circuits
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Publication year: | 2022
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URL:
| https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.15689
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Abstract/Results: | Abstract
Microglia are tissue-resident macrophages responsible for the surveillance, neuronal support, and immune defense of the brain parenchyma. Recently, the role played by microglia in the formation and function of neuronal circuits has garnered substantial attention. During development, microglia have been shown to engulf neuronal precursors and participate in pruning mechanisms while, in the mature brain, they influence synaptic signaling, provide trophic support and shape synaptic plasticity. Recently, studies have unveiled different microglial characteristics associated with specific brain regions. This emerging view suggests that the maturation and function of distinct neuronal circuits may be potentially associated with the molecular identity microglia adopts across the brain. Here, we review and summarize the known role of these cells in the thalamus, hippocampus, cortex, and cerebellum. We focus on in vivo studies to highlight the characteristics of microglia that may be important in the remodeling of these neuronal circuits and in relation to neurodevelopmental and neuropsychiatric disorders.
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Accessibility: | Document exists in the file
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Language:
| eng
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Author:
| Guedes, J. R.
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Secondary author(s):
| Ferreira, P., Costa, J., Cardoso, A. L., Peça, J.
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Document type:
| Article-d
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Number of reproductions:
| 1
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Reference:
| Guedes, J. R., Ferreira, P., Costa, J., Cardoso, A. L., & Peça, J. (2022). Microglia-dependent remodeling of neuronal circuits. Journal of Neurochemistry. doi: 10.1111/jnc.15689
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2-year Impact Factor: | 5.546|2021
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Impact factor notes: | Impact factor not available yet for 2022
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Times cited: | 0|2022-10-11
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Indexed document: | Yes
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Quartile: | Q2
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Keywords: | Brain wiring / Cerebellum / Cortex / Hippocampus / Microglia / Neurodevelopment / Thalamus
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Microglia-dependent remodeling of neuronal circuits |