Reference code: | PT/FB/BL-2006-134.05 |
Location: | Arquivo PCA - Pasta 11/2006
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Title:
| Physiological correlates of chronic stress-induced bias in behavioral strategies
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Publication year: | 2009
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URL:
| http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=80a99356-34a9-4640-a575-08d0e09e6fbf&cKey=4580efbc-0687-4abc-9b00-c7a4909f06ef&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d
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Abstract/Results: | ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. We previously showed that chronic stress biases decision-making strategies, affecting the ability of stressed rats to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats and now confirmed for mice submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). Therefore, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit.
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Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Dias-Ferreira, E.
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Secondary author(s):
| Sousa, J., Jin, X., Melo, I., Cerqueira, J., Sousa, N., Costa, R. M.
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Document type:
| Online abstract
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Number of reproductions:
| 1
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Reference:
| Dias-Ferreira, E., Sousa, J., Jin, X., Melo, I., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Physiological correlates of chronic stress-induced bias in behavioral strategies. Program No. 476.7/FF47. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. Online.
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Indexed document: | No
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Keywords: | Corticosterone / Decision-making / Multielectrode recordings
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