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BIAL Foundation
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TI:"Reappearance of command-following is associated with the recovery of language and internal-awareness networks: A longitudinal multiple-case report"
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DocumentReappearance of command-following is associated with the recovery of language and internal-awareness networks: A longitudinal multiple-case report2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-38
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Reappearance of command-following is associated with the recovery of language and internal-awareness networks: A longitudinal multiple-case report
Publication year: 2019
URL:
https://www.frontiersin.org/articles/10.3389/fnsys.2019.00008/full
Abstract/Results: ABSTRACT
The recovery of patients with disorders of consciousness is a real challenge, especially at the chronic stage. After a severe brain injury, patients can regain some slight signs of consciousness, while not being able to functionally communicate. This entity is called the minimally conscious state (MCS), which has been divided into MCS- and MCS+, respectively based on the absence or presence of language-related signs of consciousness. In this series of cases we aimed to describe retrospectively the longitudinal recovery of specific language-related behaviors using neuroimaging measurement in severely brain-injured patients. Among 209 chronic MCS patients admitted to our center from 2008 to 2018, 19 were assessed at two time points by means of behavioral and neuroimaging assessments. Three of them met our inclusion criteria and were diagnosed as MCS- during their first stay and had recovered command-following when they were reassessed (i.e., MCS+). As compared to their first assessments, when the three patients were in a MCS+, they showed less hypometabolism and/or higher gray matter volume in brain regions such as the precuneus and thalamus, as well as the left caudate and temporal/angular cortices known to be involved in various aspects of semantics. According to these preliminary results, the reappearance of language-related behaviors was concomitant with the recovery of metabolism and gray matter in neural regions that have been associated with self-consciousness and language processing. Prospective studies should be conducted to deepen our understanding of the neural correlates of the recovery of language-related behaviors in chronic MCS.
Accessibility: Document exists in file
Language:
eng
Author:
Aubinet, C.
Secondary author(s):
Panda, R., Larroque, S. K., Cassol, H., Bahri, M. A., Carrière, M., Wannez, S., Majerus, S., Laureys, S., Thibaut, A.
Document type:
Article
Number of reproductions:
3
Reference:
Aubinet, C., Panda, R., Larroque, S. K., Cassol, H., Bahri, M. A., Carrière, M., ... Thibaut, A. (2019) Reappearance of command-following is associated with the recovery of language and internal-awareness networks: A longitudinal multiple-case report. Frontiers in System Neuroscience, 13:8. https://doi.org/10.3389/fnsys.2019.00008
2-year Impact Factor: 3.293|2019
Times cited: 16|2025-09-17
Indexed document: Yes
Quartile: Q2
Keywords: Minimally conscious state / Language / Consciousness / Positron emission tomography / Structural magnetic resonance imaging

Reappearance of command-following is associated with the recovery of language and internal-awareness networks: A longitudinal multiple-case report

Reappearance of command-following is associated with the recovery of language and internal-awareness networks: A longitudinal multiple-case report