| Reference code: | PT/FB/BL-2016-292.16 |
| Location: | BF-GMS
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Title:
| Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study
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| Publication year: | 2023
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URL:
| https://journals.sagepub.com/doi/full/10.1177/02698811231158233?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
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| Abstract/Results: | ABSTRACT:
Background:
Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT’s effect on the temporal profile of ANS activity at rest is yet to be described.
Aims:
We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions.
Methods:
We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest.
Results:
In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65–100 min, and as an exploratory finding, an increased HF-HRV in the 80–85 min time window.
Conclusions:
We suggest there is a role of OT in PNS regulation that may be consistent with OT’s currently theorized role in the facilitation of alertness and approach behavior.
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| Accessibility: | Document exists in file
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Language:
| eng
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Author:
| Cosme, G.
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Secondary author(s):
| Arriaga, P., Rosa, P. J., Mehta, M. A., Prata, D.
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Document type:
| Article
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Number of reproductions:
| 1
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Reference:
| Cosme, G., Arriaga, P., Rosa, P. J., Mehta, M. A., & Prata, D. (2023). Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study. Journal of Psychopharmacology, 37(6), 566-576. https://doi.org/10.1177/02698811231158233
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| 2-year Impact Factor: | 4.5|2023
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| Times cited: | 0|2025-09-26
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| Indexed document: | Yes
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| Quartile: | Q2
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| Keywords: | Electrocardiography / Neuropeptide / Pharmacodynamics / Pupil unrest / Resting state
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Temporal profile of intranasal oxytocin in the human autonomic nervous system at rest: An electrocardiography and pupillometry study |