| Reference code: | PT/FB/BL-2006-134.07 |
| Location: | Arquivo PCA - Pasta 11/2006
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Title:
| The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
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| Publication year: | 2010
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URL:
| http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
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| Abstract/Results: | ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. In this project, we investigated if chronic stress biases decision-making strategies, affecting the ability of stressed rats to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats, and now confirmed for mice, submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, we demonstrated that chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). Therefore, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit. In conclusion, the results obtained throughout this project demonstrate that chronic stress influences decision-making processes, through changes in the structure and activity of corticostriatal networks.
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| Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Sousa, N.
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Secondary author(s):
| Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
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Document type:
| Conference abstract
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Number of reproductions:
| 1
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Reference:
| Sousa, N., Costa, R. M., Dias-Ferreira, E., Cerqueira, J., & Teixeira, P. (2010). The role of stress in cortico-basal ganglia loop processing and instrumental conditioning. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (pp. 231-232). Porto: Fundação Bial.
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| Indexed document: | No
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| Keywords: | Corticosteroids / Decision-making / Plasticity / Striatum / Multielectrode recordings
|
The role of stress in cortico-basal ganglia loop processing and instrumental conditioning |