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File067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas2000-122003-12

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

DocumentFinal report - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas2004

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.01
Location: Arquivo PCA - Pasta 10/2000
Title:
Final report - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Publication year: 2004
URL:
http://www.bial.com/imagem/Bolsa6700_19022014.pdf
Abstract/Results: RESULTS:
The project was designed to evaluate the possibility of using gene therapy at the central nervous system as an analgesic tool.
Pain suppression through central electrical stimulation, although effective as an analgesic tool, is impracticable since serious secondary effects occur due to stimulation of neurons involved in other brain functions. Viral vector transduction stands nowadays as a way of overcoming this problem by directing manipulation specifically to pain-control neurons. We focused on the possibility of concomitantly inhibit a pain facilitatory center (DRt) and stimulate a pain inhibitory center (VLM) by the use of multiple transduction from each site with the replication-defective herpes simplex virus (HSV-1).
The migration pattern following injection of HSV-1 in the DRt and VLM was studied. In parallel, information on the membrane receptors present in the neurons to be targeted (DRt and VLM pain processing neurons) and on the neurotransmitters used by the neurons to be transduced was collected.
The results collected allowed us to conclude that HSV-1 is particularly well suited for the purpose of the project since it transduces just a few brain areas projecting to the VLM and DRt, allowing a limited but still amplified action upon each one, and areas other than the DRt and VLM that receive axonal terminations of transduced neurons are few. The neurochemical data point to the use of vectors coding for the GABAB receptor, GAD and noradrenalin at the DRt, and of vectors coding for GABAB and a2 receptor antisense molecules at the VLM. Behavior and pharmacological studies aimed at elucidating the effect of appropriate drugs upon injection in the sites of termination of the transduced neurons are however still needed.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Lima, D.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Pain

Relatório final - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Relatório final - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

DocumentThe medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat2003

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.02
Location: Arquivo PCA - Pasta 10/2000
Title:
The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat
Publication year: 2003
URL:
http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02782.x/abstract
Contents: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=213&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results: ABSTRACT:
Single-unit spinal recordings combined with application of glutamate into the medullary dorsal reticular nucleus were used to assess the action of this nucleus upon deep dorsal horn neurons in rats. Injection of high glutamate concentrations (10 and 100 mm) induced a dramatic and long-lasting increase of the responses of wide-dynamic range neurons to electrical stimulation of the sciatic nerve in the noxious range, without affecting ongoing discharges. Post-stimulus time histograms revealed that this increase concerned the post-discharge, but not A- or C-fibre-mediated responses, which remained unchanged independently of the stimulation frequency applied. The onset of the glutamate-induced response enhancement occurred with a concentration-dependent time delay and developed slowly until its maximum. These data indicate that the medullary dorsal reticular nucleus exerts a facilitating action upon deep dorsal horn wide-dynamic range neurons by enhancing their capacity to respond to peripheral stimulation through prolongation of their discharge. This action is accompanied by the strengthening of wind-up of deep dorsal horn wide-dynamic range neurons, hence providing a plausible substrate for chronic pain states. These results are in agreement with previous behavioural studies suggesting a pronociceptive role for the dorsal reticular nucleus [Almeida et al. (1996) Brain Res. Bull., 39, 7-15; Almeida et al. (1999) Eur. J. Neurosci., 11, 110-122], and support the involvement of a reverberating circuit, previously described in morphological studies [Almeida et al. (1993) Neuroscience, 55, 1093-1106; Almeida et al. (2000) Eur. J. Pain, 4, 373-387], which probably operates only at a certain threshold of activation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dugast, C.
Secondary author(s):
Almeida, A., Lima, D.
Document type:
Article
Number of reproductions:
1
Reference:
Dugast, C., Almeida, A., & Lima, D. (2003). The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat. European Journal of Neuroscience, 18(3), 580-588. doi: 10.1046/j.1460-9568.2003.02782.x
2-year Impact Factor: 3.872|2003
Times cited: 28|2022-05-18
Indexed document: Yes
Quartile: Q1
Keywords: Electrophysiology / Facilitation / Pain / Wide-dynamic range / Wind-up

DocumentNoxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors2003

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.03
Location: Arquivo PCA - Pasta 10/2000
Title:
Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors
Publication year: 2003
URL:
http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02586.x/abstract
Contents: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=215&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results: ABSTRACT:
Modulation of nociceptive transmission at the brainstem involves several neurochemical systems. The precise location and specific characteristics of nociceptive neurons activated in each system was never reported. In this study, the presence of GABA(B), mu-opioid, and neurokinin-1 (NK-1) receptors in brainstem nociceptive neurons was investigated by double-immunocytochemical detection of each receptor and noxious-evoked induction of the c-fos proto-oncogene. Noxious cutaneous mechanical stimulation significantly increased the proportions of neurons double-labelled for Fos and GABA(B) receptors in several brainstem regions, namely, the reticular formation of the caudal ventrolateral medulla (VLMlat and VLMrf), lateral reticular nucleus, spinal trigeminal nucleus, pars caudalis (Sp5C), nucleus of the solitary tract, dorsal reticular nucleus, ventral reticular nucleus, raphe obscurus nucleus and dorsal parabrachial nucleus (DPB). For mu-opioid receptors, the proportions of double-labelled neurons in noxious-stimulated animals were higher than in controls only in the VLMlat, VLMrf, Sp5C, DPB and A5 noradrenergic cell group. As for the NK-1 receptor, no significant differences were found between control and stimulated animals. According to these results, neurons expressing GABA(B), mu-opioid and NK-1 receptors at several pain control centres of the brainstem are differentially involved in processing nociceptive mechanical input. The data provide the definition of new supraspinal targets for selective modulation of nociceptive neurons in order to define better strategies of pain control.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
PT/FB/BL-2000-67.08
Author: Pinto, M.
Secondary author(s):
Lima, D., Castro-Lopes, J. M., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Pinto, M., Lima, D., Castro-Lopes, J., & Tavares, I. (2003). Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABA(B), mu-opioid and NK-1 receptors. European Journal of Neuroscience, 17(7), 1393-1402. doi: 10.1046/j.1460-9568.2003.02586.x
2-year Impact Factor: 3.872|2003
Times cited: 35|2022-05-18
Indexed document: Yes
Quartile: Q1
Keywords: Antinociception / Double immunocytochemistry / Pain / Rat

Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors

Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors

DocumentPeripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation2002

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.04
Location: Arquivo PCA - Pasta 10/2000
Title:
Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation
Publication year: 2002
URL:
http://jn.physiology.org/content/88/4/2096.full.pdf
Contents: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=217&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results: ABSTRACT:
Reorganization of central networks and plasticity of neuronal representations have been implicated in recent years in the dynamic expression of somatosensory responses. The functional properties of spinal cells were shown to change in the scale of minutes after peripheral high-intensity stimulations and to undergo profound alterations in their responses in experimental models of chronic pain. These observations, however, are restricted to recordings from individual cells, and no information exists on how these changes may be reflected on the activity of somatosensory neuronal networks involved in pain processing. To understand how spinal cord networks may be altered after the onset of hyperalgesia, we extracellularly recorded from groups of five to nine neighboring neurons in the hindlimb representation area of the dorsal horn. The multineuronal activity evoked by cutaneous innocuous and noxious stimulation was compared before and for 3 h after the subcutaneous injection of diluted formalin. Formalin caused immediate changes in response properties and mechanical threshold of activation for the majority of the neurons and induced the incorporation of previously unresponsive neighboring neurons to the functional network. Analysis of the temporal correlation within the neuronal population revealed that formalin-induced inflammation increased the functional coherence of the network to the nonnociceptive stimulation but not to the painful stimuli. This increase in the tactile acuity of populations of nociceptive neurons may be a basis for the emergence of touch-evoked pain.
Accessibility: Document does not exist in file
Language:
eng
Author:
Galhardo, V.
Secondary author(s):
Apkarian, A. V., Lima, D.
Document type:
Article
Number of reproductions:
1
Reference:
Galhardo, V., Apkarian, A. V., & Lima, D. (2002). Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation. Journal of Neurophysiology, 88(4), 2096-2103. doi: 10.1152/jn.00720.2001
2-year Impact Factor: 3.743|2002
Times cited: 5|2022-05-18
Indexed document: Yes
Quartile: Q1
Keywords: Psychophysiology / Pain

Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation

Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation

DocumentWind-up of spinal cord wide-dynamic-range neurons is influenced by the medullary reticular nucleus2001

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.05
Location: Arquivo PCA - Pasta 10/2000
Title:
Wind-up of spinal cord wide-dynamic-range neurons is influenced by the medullary reticular nucleus
Publication year: 2001
URL:
http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results: ABSTRACT:
Description: Spinal cord wide-dynamic-range (WDR) neurons have been shown to display wind-up, a gradual frequency-dependent increase of their responses to repeated stimulation of primary afferent C-fibers. This phenomenon affects only C-fiber mediated responses and the post-discharge, and may involve a reverberatory activity. Recent electrophysiological studies have reported an increase in C-fiber evoked responses and post-discharge of lumbar WDR neurons following activation of the medullary dorsal reticular nucleus (DRt), while behavioral and morphological data suggest the existence of a putative reverberating loop between the DRt and the spinal nociceptive cells it innervates. The present study was aimed at evaluating the role of the DRt in spinal WDR neurons wind-up. The responses of spinal WDR neurons to sciatic nerve electrical stimulation with various frequencies and duration were recorded in L4-L5 spinal cord segments before, during and after glutamate injections into the DRt. Whatever the stimulation applied, glutamate injection increased the number of C-fiber evoked responses and the post-discharge. In addition, DRt glutamate-activation reduced the stimulation frequency and/or the number of stimulation pulses needed to trigger wind-up. Our results show that the DRt exerts a facilitatory action upon spinal WDR neurons and, therefore, contributes to the wind-up of these neurons.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dugast, C.
Secondary author(s):
Almeida, A., Lima, D.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Dugast, C., Almeida, A., & Lima, D. (2001). Wind-up of spinal cord wide-dynamic-range neurons is influenced by the medullary reticular nucleus. Program No. 161.1. Neuroscience Abstracts. San Diego, USA: Society for Neuroscience. Online
Indexed document: No
Keywords: Glutamate / Nociception / Facilitation / Spinal

DocumentNociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat2001

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.06
Location: Arquivo PCA - Pasta 10/2000
Title:
Nociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat
Publication year: 2001
Accessibility:
Document does not exist in file
Language:
eng
Author:
Dugast, C.
Secondary author(s):
Almeida, A., Lima, D.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dugast, C., Almeida, A., & Lima, D. (2001). Nociceptive facilitation from the medullary dorsal reticular nucleus (DRt): An electrophysiological study in the rat. Journal of Pain, 2(Suppl.1), 23.
Indexed document: Yes
Keywords: Psychophysiology / Pain

DocumentSpino-medullary circuitry in nociceptive cardiovascular integration2001

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.07
Location: Arquivo PCA - Pasta 10/2000
Title:
Spino-medullary circuitry in nociceptive cardiovascular integration
Publication year: 2001
URL:
http://www.physoc.org/proceedings/abstract/J%20Physiol%20536PS290
Contents: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=222&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results: ABSTRACT:
Nociceptive spinofugal pathways terminating at the caudal medulla oblongata target the dorsoreticular nucleus (DRt), the nucleus tractus solitarii (NTS) and the caudal ventrolateral reticular formation (VLM). While the spino-DRt pathway is involved in triggering pain-facilitating effects from the DRt, the spino-NTS and spino-VLM pathways have been implicated in nociceptive-cardiovascular integration. Spinal dorsal horn neurones involved are distributed through laminae I and IV-V. Curiously, the medullary projections of the two neuronal populations are in all cases segregated, pointing to differences in the role played by each of them. In the DRt, lamina I targets the ipsilateral dorsal-most portion, immediately beneath the cuneate nucleus, and laminae IV-V the remaining ventral two-thirds, bilaterally. In the NTS, lamina I targets the medial commissural subnucleus, bilaterally, and laminae IV-V the lateral subnucleus, ipsilaterally. In the VLM, lamina I targets the reticular formation (VLMlat) located between the lateral reticular nucleus (LRt) and the spinal trigeminal nucleus, pars caudalis, and laminae IV-V the lateral portion of the LRt. Furthermore, the structural types of lamina I neurones participating in the spino-NTS and spino-VLM pathways are the same (fusiform, pyramidal and flattened), while those projecting to the DRt differ, belonging mainly in the multipolar type followed by the pyramidal and flattened types. Both the NTS and VLM exert anti-nociceptive effects as revealed by the depression of nociceptive reflexes and inhibition of nociceptive responses of spinal neurones upon local stimulation. Direct pathways connect the NTS commissural subnucleus and the VLMlat with both superficial and deep spinal dorsal horn laminae. The VLMlat is also connected with the spinal cord through a disynaptic pathway relaying in the pontine A5 noradrenergic group, which is thought to convey the spinal a2-adrenoreceptor-mediated anti-nociception elicited from the VLM.
The well-known role of the NTS commissural subnucleus and the VLM in cardiovascular control, together with the demonstration that they are sites of termination of nociceptive spinal afferents, has been taken as a strong indication of the involvement of both areas in nociceptive and cardiovascular integration, namely in the genesis of autonomic reactions to pain. Taking into account their role in pain control, it is also possible that both areas can modulate spinal nociceptive transmission in response to changes in cardiovascular parameters. Hypertensive subjects, either humans or experimental animals, were shown to have higher pain thresholds than normotensive subjects. In spite of the large amount of data supporting those hypotheses, experimental studies aimed at their evaluation are lacking. We have recently addressed this issue by investigating the role of the VLM in hypertension-induced hypoalgesia. In rats in which hypertension was produced by either pharmacological (L-NAME) or surgical (renal artery constriction) means, spinal c-fos induction following noxious mechanical stimulation of the skin was reduced compared with normotensive animals. Lesioning the VLM in hypertensive animals prior to noxious stimulation prevented the decrease in spinal c-fos expression. Since the hypertension-induced hypoalgesia is mediated by spinal a2-adrenoreceptors, and the noradrenergic anti-nociceptive effects of the VLM are conveyed by the VLMlat-A5-spinal circuit, the observed VLM-dependent decrease of spinal c-fos expression in response to rises in blood presure is most likely accounted for by the VLMlat. On the other hand, the VLMlat by itself is capable of exerting the vasodepressor effects normally attributed to the VLM, as revealed by decrease in blood pressure and heart rate upon local stimulation and the opposite effect after lesioning. The VLMlat thus seems to be not only the VLM site in charge of pain control through both direct or indirect spinopetal pathways, but also an important centre for nociceptive and cardiovascular integration.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Lima, D., & Tavares, I. (2001). Spino-medullary circuitry in nociceptive cardiovascular integration. Journal of Physiology-London, 536(Suppl.), 18S-19S.
Indexed document: Yes
Keywords: Psychophysiology / Pain

DocumentNoxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors2002

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.08
Location: Arquivo PCA - Pasta 10/2000
Title:
Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors
Publication year: 2002
URL:
http://fens2002.neurosciences.asso.fr/pages/posters/R6/A183_15.html
Abstract/Results: ABSTRACT:
Pain processing is modulated at several brainstem regions through various neurochemical systems. Pharmacological studies have shown that local instillation of agents that interfere with distinct receptors, differentially affect responses to pain. However, characterisation of local nociceptive neurones as to their surface receptors was never attempted. This study investigates the nociceptive nature of brainstem neurones containing mu-opioid, GABAB and NK1 receptors, using noxious-evoked expression of the c-fos proto-oncogene.
Male Wistar rats were anaesthetised with sodium pentobarbital (50mg/Kg) and subjected to noxious mechanical stimulation of the hindlimb (stimulated group). Two hours after, the animals were perfused. Frozen sections of the brain were immunoreacted for each receptor, by the avidin-biotin-DAB method, and for the Fos protein, by the avidin-streptavidin-fast blue method. In brainstem regions with raises in Fos expression as compared to controls (perfused after 2 hours of anaesthesia), the proportions of neurones double-labelled for each receptor and for Fos protein were determined in the total number of neurones expressing the receptor.
For mu-opioid receptor, double-labelled cells increased in stimulated animals at the ventrolateral medulla (VLM), spinal trigeminal nucleus (Sp5C), dorsal portion of the parabrachial nucleus (DPB) and A5 noradrenergic region. The proportion of GABAB double-labelled cells was increased in the VLM, Sp5C, nucleus of the tractus solitarii, dorsal reticular nucleus, ventral reticular nucleus, raphe obscurus nucleus and DPB. No differences were detected for NK1 receptor -immunoreactive cells. These results point to a differential involvement in pain processing of neurones displaying mu-opioid, GABAB and NK1 receptors at different pain control centres. (Supported by Gulbenkian Pain Programme and Bial Foundation).
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2000-67.03
Author: Pinto, M.
Secondary author(s):
Tavares, I., Castro-Lopes, J. M., Lima, D.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Pinto, M., Tavares, I., Castro-Lopes, J. M., & Lima, D. (2002). Noxious evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK1 receptors. FENS Abstr.1, 465.
Indexed document: No
Keywords: Psychophysiology / Pain modulation / Sensory systems

DocumentActivation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat2003

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.09
Location: Arquivo PCA - Pasta 10/2000
Title:
Activation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat
Publication year: 2003
URL:
http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results: ABSTRACT:
Previous studies have shown that chronic pain induces changes in the spinal cord, namely in what concerns the neurochemistry of dorsal horn circuits. It has not been yet addressed whether similar changes occur supraspinally namely at the endogenous pain modulatory system. In this study, we investigated the brainstem regions expressing the protooncogene c-fos as a result of mobilization of a chronically inflamed joint and further studied the expression of NK1 receptors in those neurons of those regions.
Male Wistar rats were injected in the tiobiotarsal joint with 50 µl of saline (control) or Complete´s Freund Adjuvant (monoarthritic). After 14 days of daily training the animals were subjected to 4 minutes of repeated extensions of the inflamed hindlimb and brainstem frozen sections were double-immunoreacted for Fos protein and NK1 receptors.
Monoarthritic rats presented an increase of Fos-immunoreactive neurons in the caudal ventrolateral medulla, lateral, dorsal and ventral reticular nuclei, spinal trigeminal nucleus, nucleus of the solitary tract, raphe obscurus, gracile, cuneate, ambiguous, vestibular and tegmental nuclei. No differences were found in the number of Fos neurons expressing NK1 receptors.
Mobilization of a chronically inflamed paw induces functional activation of several areas of the endogenous pain control system, reinforcing the importance of the system in chronic pain. In a manner similar to what occurs in acute pain (Pinto et al., 2003), NK1 receptors do not appear to be involved in supraspinal processing of chronic pain.
Pinto M et al., 2003 Noxious-evoked c-fos expression in brainstem neurons immunoreactive for GABAB, µ-opioid and NK-1 receptors. Europ. J. Neurosci., 17: 1393-1402.
Accessibility: Document does not exist in file
Language:
eng
Author:
Tavares, I.
Secondary author(s):
Pinto, M., Lima, D.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Tavares, I., Pinto, M., & Lima, D. (2003). Activation of brainstem neurons by mobilization of a chronically inflamed paw: a c-Fos study in the rat. Program No. 66.13. 2003 Neuroscience Meeting Planner. New Orleans, LA: Society for Neuroscience. Online.
Indexed document: No
Keywords: Pain / Monoarthritis / NK1 receptors

DocumentDynamics of a recombinant HSV-1 vector migration from the medulla oblongata: implications for gene therapy of pain2004

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.10
Location: Arquivo PCA - Pasta 10/2000
Title:
Dynamics of a recombinant HSV-1 vector migration from the medulla oblongata: implications for gene therapy of pain
Publication year: 2004
URL:
http://fens2004.neurosciences.asso.fr/posters/R6/A192_20.html
Abstract/Results: ABSTRACT:
Gene therapy for pain control with viral vectors was addressed at peripheral and spinal cord levels. Since several brainstem regions are major pain control centers, the use of equivalent strategies at the supraspinal level may be useful for pain control. The caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt) outstand, respectively, as major antinociceptive and pro-nociceptive centers at the medulla oblongata. Before attempting gene therapy by combined VLM activation and DRt blockade, we performed a time-course study of the dynamics of migration of a replication-defective Herpes Simplex Virus type 1 (HSV-1) expressing the reporter gene lacZ under control of the human cytomegalovirus promoter. Wistar rats received an injection of HSV-1 in the VLM or the DRt. Upon 2, 4, 7, 10 and 14 days post-injection, brains were serially cut and beta-galactosidase was detected by immunocytochemistry. The results showed that HSV-1 transfects efficiently neurons at the injection site and migrates selectively in some of the VLM and DRt afferents. The rostroventrolateral reticular nucleus is mainly transfected from the VLM, the cerebellum and vestibular nucleus mostly from the DRt while the parabrachial nuclei, locus coeruleus, nucleus tractus solitarius and A5 noradrenergic cell group are infected from both injection sites. The expression of lacZ decreased at the injection sites at 2-4 days post-injection and at 7-10 days post-injection in most encephalic areas. By combining detection of beta-galactosidase with immunostaining for tyrosine hydroxylase, we verified that the infected afferents were not exclusively catecholaminergic. These results suggest that an improvement of the promoter to obtain a long-term transgene expression and a better understanding of the neurochemical features of the transfected pathways may allow future use of this tool in gene therapy for pain.
Supported by project POCTI/NSE/38952/2001 of FCT and Bial Foundation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Wilson, S. P., Lima, D., & Tavares, I. (2004). Dynamics of a recombinant HSV-1 vector migration from the medulla oblongata: implications for gene therapy of pain. FENS Abstr., vol2, A192.20.
Indexed document: No
Keywords: Psychophysiology / Pain control / Gene therapy / Sensory systems / Brainstem pathways

DocumentExpressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato2001

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.11
Location: Arquivo PCA - Pasta 10/2000
Title:
Expressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato
Publication year: 2001
Accessibility:
Document does not exist in file
Language:
por
Author:
Pinto, M.
Document type:
Master's thesis
Number of reproductions:
1
Reference:
Pinto, M. (2001). Expressão de receptores GABAB, ópioides tipo µ e NK1 em neurónios nociceptivos do encéfalo. Um estudo pelo c-fos no rato (Unpublished master´s thesis). Portugal: Faculdade de Medicina da Universidade de Lisboa.
Indexed document: No
Keywords: Psychophysiology / Pain

DocumentÉtude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler2003

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.12
Location: Arquivo PCA - Pasta 10/2000
Title:
Étude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler
Publication year: 2003
Accessibility:
Document does not exist in file
Language:
fre
Author:
Martins, I.
Document type:
Master's thesis
Number of reproductions:
1
Reference:
Martins, I. (2003). Étude de la migration d´une forme recombinante de HSV-1 dans le cerveau depuis le bulbe: implications pour la therapie génique de la douler (Unpublished master´s thesis). Conservatoire National des Arts et Métiers, Paris.
Indexed document: No
Keywords: Psychophysiology / Pain / Therapy

DocumentPain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas2002

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.13
Location: Arquivo PCA - Pasta 10/2000
Title:
Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Publication year: 2002
URL:
http://www.bial.com/pt/fundacao_bial.11/simposios.19/edicoes_anteriores.75/4%C2%BA_simposio.a110.html
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Cobos, A., Pinto, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Lima, D., Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Cobos, A., & Pinto, M. (2002). Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 4th Symposium of Fundação Bial (p. 451). Porto: Fundação Bial.
Indexed document: No
Keywords: Psychophysiology / Pain

Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

DocumentPain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas2004

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.14
Location: Arquivo PCA - Pasta 10/2000
Title:
Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Publication year: 2004
URL:
http://www.bial.com/pt/fundacao_bial.11/simposios.19/edicoes_anteriores.75/5%C2%BA_simposio.a111.html
Abstract/Results: ABSTRACT:
The pain system is endowed with control mechanisms that modulate the ascending transmission of nociceptive input by either depressing or enhancing the responsiveness of nociceptive spinal neurons. Although effective, manipulation of brain pain-control centers as an analgesic procedure has no clinical value since it simultaneously affects neurons involved in brain functions other than pain control. In this project we explore the possibility of using viral vectors as a way of targeting specifically pain control neurons through transfection of neuronal cells that establish synaptic contacts with them. The targets chosen were the VLM and DRt because of their potent inhibitory and facilitatory effects, respectively.
The studies performed so far aimed at defining a transfection strategy that results in stimulation of the VLM and inhibition of the DRt. A replication-defective Herpes Simplex Virus was chosen since, by being retrogradely transported, it allows transfection of several brain regions projecting to the VLM and DRt, hence amplifying the effect upon each target. The migration dynamics of the virus was studied in order to identify both the brain regions that are putative sources of synaptically mediated pharmacological actions upon each target (soma exhibiting the virus product) and the regions that also receive input from the transfected neurons (axonal arborizations exhibiting the virus product). These data help in selecting the regions to be transfected from the VLM and the DRt as those that project mainly or solely to one of the two areas and do not project significantly to other brain regions. The results point to the A 5 and RVL as areas to be transfected from the VLM, and to the cerebelum, NTS, Ve and Cu as areas to be transfected from the DRt.
Complementary studies of the neurochemical nature of the transfected neurons are now in progress as a way of defining the viral construction that better conciliates the desired action upon the neurons in one target without affecting either the other target or neurons that are not involved in pain control. It was already verified that the LC contains noradrenergic neurons transfected from the VLM and DRt, and the A1
and A5 groups contain noradrenergic neurons transfected from the DRt. The surface receptor properties of VLM and DRt nociceptive neurons were evaluated in order to identify the neurotransmitters whose synthesis should be amplified or blocked by the vectors acting upon each target. GABA B receptors were found to occur in nociceptive neurons of both the VLM and DRt, and opioid receptors only in the VLM. These data point to the use of a pré-pro-enkephalin and GABAB antisense construction at the VLM and a GABA precursor construction at the DRt.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Lima, D., Tavares, I., Almeida, A., Dugast, C., Galhardo, V., & Pinto, M. (2004). Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 5th Symposium of Fundação Bial (pp. 309-310). Porto: Fundação Bial.
Indexed document: No
Keywords: Psychophysiology / Pain / Viral vectors

Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas

Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas