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File015 - Pain control from the brain - Gene therapy in the treatment of chronic pain 2005-01 2009-01

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

DocumentFinal report - Pain control from the brain - Gene therapy in the treatment of chronic pain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.01
Location: Arquivo PCA - Pasta 21/2004
Title:
Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain
Publication year: 2008
URL:
http://www.bial.com/imagem/Bolsa1504_19022014.pdf
Abstract/Results: RESULTS:
The activity of the brain in pain modulation during chronic pain is changed. In general, the net balance of descending modulation during chronic pain consists on a decrease of descending inhibitory actions and an increase of facilitatory effects. Synchronous changes in neuronal responses at the spinal cord and pain control centres in the brain were detected. Variations in the expression of neurotransmitters and receptors in pain control centres of the brain may account for the effects of chronic pain. To target pain control centres of the brain, we elected a gene therapy approach based on the sustained and directed effects of the technique. The overexpression of pre-proenkephalin using a replication-defective vector derived from Herpes Simplex type 1 (HSV-1) in a pain control area of the brain (the caudal ventrolateral medulla), decreased behavioural responses in an inflammatory pain model, the formalin test, and inhibited nociceptive responses of spinal neurons. A reversal of behavioural pain responses was also induced in a traumatic neuropathic pain model using a HSV-1 vector in which a tissue-specific promoter (tyrosine hydroxylase; TH) controlled the expression oh the TH transgene inserted in an antisense sequence. Using this vector, the decrease in the release of noradrenaline in a pain facilitatory centre (the dorsal reticular nucleus) induced long-lasting antinociceptive effects, detected during 22 days. Gene therapy may be considered an excellent molecular tool to understand the effects of chronic pain installation in pain control circuits of the brain. Furthermore, based on detailed morphofunctional knowledge of pain control centres of the brain and by electing the vector type, determining the better promoter and the suitable transgene for the construct, the effects of chronic pain may be corrected using gene therapy approaches.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Chronic pain / Gene therapy / Brain

Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain

Final report - Pain control from the brain - Gene therapy in the treatment of chronic pain

DocumentCorrelation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: involvement of spino-medullary and intra-medullary connections2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.02
Location: Arquivo PCA - Pasta 21/2004
Title:
Correlation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: involvement of spino-medullary and intra-medullary connections
Publication year: 2006
URL:
http://www.sciencedirect.com/science/article/pii/S030439400600841X
Abstract/Results: ABSTRACT:
Chronic pain induces functional alterations of the endogenous pain control system namely in the modulation of nociceptive transmission at the spinal cord. We used the c-fos expression as a tool to study correlated neuronal activation, induced by bending the inflamed paw of monoarthritic animals, between the spinal dorsal horn and medullary centers belonging to the endogenous pain control system, namely the lateralmost reticular formation of the ventrolateral medulla (VLMlat), the lateral reticular nucleus (LRt), the dorsal reticular nucleus (DRt), the nucleus tractus solitarius (Sol) and the rostroventromedial medulla (RVM). Awake monoarthritic rats were subjected to 4 min of paw bending followed by anaesthesia and perfusion either immediately or 2 h later. The numbers of Fos immunoreactive neurons in the spinal dorsal horn and in the medulla oblongata were significantly correlated mainly immediately after stimulation: lamina I correlated with the VLMlat, LRt, Sol and RVM; lamina II correlated with the VLMlat, LRt and Sol; and laminae IV-V correlated with the VLMlat and LRt. Between medullary pain control centers significant correlations occurred immediately and 2 h after bending at the VLMlat-Sol and LRt-Sol, at the VLMlat-LRt and VLMlat-RVM in animals perfused immediately, and at the VLMlat-DRt and LRt-RVM in animals perfused 2 h later. These data demonstrate that the mobilization of a chronically inflamed paw triggers intense correlated neuronal activity in several areas of the somatosensory system, indicating functional relevant links in pain control.
Accessibility: Document does not exist in file
Language:
eng
Author:
Pinto, M.
Secondary author(s):
Lima, D., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Pinto, M., Lima, D., & Tavares, I. (2006). Correlation of noxious evoked c-fos expression in areas of the somatosensory system during chronic pain: involvement of spino-medullary and intra-medullary connections. Neuroscience Letters, 409(2), 100-105. doi: 10.1016/j.neulet.2006.08.031
2-year Impact Factor: 2.092|2006
Times cited: 10|2022-05-19
Indexed document: Yes
Quartile: Q3
Keywords: c-FOS / Spinal cord / Brainstem / Chronic pain

DocumentFrom neuroanatomy to gene therapy: Searching for new ways to manipulate the supraspinal endogenous pain modulatory system2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.03
Location: Arquivo PCA - Pasta 21/2004
Title:
From neuroanatomy to gene therapy: Searching for new ways to manipulate the supraspinal endogenous pain modulatory system
Publication year: 2007
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375764/pdf/joa0211-0261.pdf
Abstract/Results: ABSTRACT:
The endogenous pain modulatory system is a complex network of brain areas that control nociceptive transmission at the spinal cord by inhibitory and facilitatory actions. The balance between these actions ensures effective modulation of acute pain, while during chronic pain the pronociceptive effects appear to prevail. The mechanisms underlying this imbalance were studied as to the role of two medullary components of the pain modulatory system: the dorsal reticular nucleus and the caudal ventrolateral medulla, which function primarily as pronociceptive and antinociceptive centres, respectively. Both areas are connected with the spinal dorsal horn by closed reciprocal loops. In the spino-dorsal reticular nucleus loop, the ascending branch is strongly inhibited by spinal GABAergic neurons, which may act as a buffering system of the dorsal reticular nucleus-centred amplifying effect. In the spino-caudal ventrolateral medulla loop, the ascending branch is under potent excitation of substance P (SP) released from primary afferents, which is likely to trigger the intense descending inhibition detected in acute pain. During chronic pain, the activity in the lateral reticular formation of the caudal ventrolateral medulla changes, so that the action of the caudal ventrolateral medulla upon SP-responsive spinal neurons shifts from inhibitory to excitatory. The mechanisms of this modulatory shift are unknown but probably relate to the decresed expression of µ-opioid, d-opioid and GABAB receptors. Normalizing receptor expression in the caudal ventrolateral medulla or controlling noci-evoked activity at the dorsal reticular nucleus or caudal ventrolateral medulla by interfering with neurotransmitter release is now possible by the use of gene therapy, an approach that stands out as a unique tool to manipulate the supraspinal endogenous pain control system.
Accessibility: Document does not exist in file
Language:
eng
Author:
Tavares, I.
Secondary author(s):
Lima, D.
Document type:
Article
Number of reproductions:
1
Reference:
Tavares, I., & Lima, D. (2007). From neuroanatomy to gene therapy: Searching for new ways to manipulate the supraspinal endogenous pain modulatory system. Journal of Anatomy, 211(2) 261-268. doi: 10.1111/j.1469-7580.2007.00759.x
2-year Impact Factor: 2.547|2007
Times cited: 35|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Caudal ventrolateral medulla / Chronic pain / Dorsal reticular nucleus / Receptor systems

DocumentDynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.04
Location: Arquivo PCA - Pasta 21/2004
Title:
Dynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene
Publication year: 2008
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2008.06492.x/abstract
Abstract/Results: ABSTRACT:
Herpes Simplex Virus type 1 (HSV-1) vectors are known to inhibit nociceptive transmission at the spinal cord after peripheral applications. Similar approaches may also be useful when applied at the supraspinal pain control system as the system includes pronociceptive (facilitatory) components. We performed a study aimed to analyse the migration of HSV-1 along with the inhibition of pronociception from the medullary dorsal reticular nucleus (DRt), a major facilitatory component of the supraspinal pain control system. To study the migration, a HSV-1 vector expressing lacZ under control of the human cytomegalovirus (hCMV) promoter was injected in the DRt and the expression of ß-galactosidase (ß-gal) was detected at 2, 4, 7, 10 and 14 days. Numerous ß-gal-immunoreactive neurons were observed at the injection site until day 4, and at some of the brain areas projecting to the DRt until day 7. To block the pronociceptive effects of the DRt, a HSV-1 vector expressing the preproenkephalin transgene, under the control of hCMV promoter, was injected into the DRt. Behavioural evaluation was performed at the time-points referred above, using the paw withdrawal latency test to evaluate thermal nociceptive responses. Anti-hyperalgesic effects persisted during 4 days, decreasing after that time-point. The present study demonstrates that selective migration of HSV-1 should be considered in gene therapy strategies based on HSV-1 injections into the brain. The study also shows that it is possible to decrease pain facilitation from the brain using opioidergic inhibition of pronociceptive supraspinal areas.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Wilson, S. P., Lima, D., & Tavares, I. (2008). Dynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene. European Journal of Neuroscience, 28(10), 2075-2083. doi: 10.1111/j.1460-9568.2008.06492.x
2-year Impact Factor: 3.385|2008
Times cited: 16|2022-05-19
Indexed document: Yes
Quartile: Q2
Keywords: Descending modulation / Dorsal reticular nucleus / Pain control system / Pronociception / Rat

DocumentNeuronal activation at the spinal cord and medullary pain control centers after joint stimulation: a c-fos study in acute and chronic articular inflammation2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.05
Location: Arquivo PCA - Pasta 21/2004
Title:
Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: a c-fos study in acute and chronic articular inflammation
Publication year: 2007
URL:
http://www.sciencedirect.com/science/article/pii/S0306452207006628
Abstract/Results: ABSTRACT:
Chronic inflammatory pain induces short- and long-term central changes, which have been mainly studied at the spinal cord level. Supraspinal pain control centers intrinsically connected with the dorsal horn are also prone to be affected by chronic inflammatory pain. C-fos expression was used as a neuronal activation marker at spinal and supraspinal levels to i) compare acute and chronic articular inflammation, and ii) analyze the effects of brief innocuous or noxious stimulation of a chronically inflamed joint. Acute articular inflammation was induced by an inflammatory soup with prostaglandin E(2) and bradykinin, both at 10-5 M. Chronic articular inflammation consisted of 14 days of monoarthritis. Early c-fos expression was studied 4 min after inflammatory soup injection or stimulation of the arthritic joint whereas late c-fos expression was evaluated 2 h after those stimuli. At the spinal cord, the analysis was focused on the dorsal horn (laminae I–V) and supraspinally, five major regions of the endogenous pain control system were considered: the caudal ventrolateral medulla (VLM), the dorsal reticular nucleus (DRt), the ventral reticular nucleus (VRt), the nucleus of the solitary tract (Sol) and the rostroventromedial medulla (RVM). Acute articular inflammation induced early and late increases in c-fos expression at the spinal level and late increases supraspinally whereas the effects of monoarthritis were more moderate and restricted to the spinal cord. When monoarthritic animals were subjected to gentle touch or bending of the joint, early increases in c-fos expression were detected supraspinally, but not at the spinal level. In this region, noxious mechanical stimulation induced late increases in non-inflamed animals and both early and late increases in monoarthritic rats. Supraspinally, noxious stimulation induced only late increases in c-fos expression. The present results show complex differences in the patterns of c-fos expression between the spinal cord and medullary areas of the pain control system during articular inflammation, which indicate that the somatosensory system is differentially affected by the installation of chronic pain.
Accessibility: Document does not exist in file
Language:
eng
Author:
Pinto, M.
Secondary author(s):
Lima, D., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Pinto, M., Lima, D., & Tavares, I. (2007). Neuronal activation at the spinal cord and medullary pain control centers after joint stimulation: a c-fos study in acute and chronic articular inflammation. Neuroscience, 147(4), 1076-1089. doi: 10.1016/j.neuroscience.2007.05.019
2-year Impact Factor: 3.352|2007
Times cited: 26|2022-05-19
Indexed document: Yes
Quartile: Q2
Keywords: Supraspinal pain control areas / Central sensitization / Plasticity / Monoarthritis / Innocuous stimulation / Noxious stimulation

Document283 Neuropathic pain is attenuated by a viral vector targeting noradrenergic input to the dorsal reticular nucleus2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.06
Location: Arquivo PCA - Pasta 21/2004
Title:
283 Neuropathic pain is attenuated by a viral vector targeting noradrenergic input to the dorsal reticular nucleus
Publication year: 2007
URL:
http://www.sciencedirect.com/science/article/pii/S109038010700345X
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Araújo, S., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Martins, I., Araújo, S., Wilson, S. P., Lima, D., Tavares, I. (2007). 283 Neuropathic pain is attenuated by a viral vector targeting noradrenergic input to the dorsal reticular nucleus. European Journal of Pain, 11(Supplement 1), 125–126. doi: 10.1016/j.ejpain.2007.03.298
Indexed document: Yes
Keywords: Psychophysiology / Pain

DocumentDescending modulation of secondary hyperalgesia in the monoarthritic rat: role of antinociceptive and pronociceptive medullary centres in the differential nociceptive activation of NK1- and GABAB-expressing spinal cord neurons2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.07
Location: Arquivo PCA - Pasta 21/2004
Title:
Descending modulation of secondary hyperalgesia in the monoarthritic rat: role of antinociceptive and pronociceptive medullary centres in the differential nociceptive activation of NK1- and GABAB-expressing spinal cord neurons
Publication year: 2006
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={2F9BEFE2-C4F9-4FDE-B655-D811DBC6DE6D}&SKey={758FF20A-A555-4CC8-9BB3-3949330452BA}&MKey={D1974E76-28AF-4C1C-8AE8-4F73B56247A7}&AKey={3A7DC0B9-D787-44AA-BD08-FA7BB2FE9004}
Abstract/Results: ABSTRACT:
Secondary hyperalgesia is associated with an imbalance of excitatory and inhibitory effects mediated, respectively, by spinal NK1 and GABAB receptors. In the monoarthritic rat, nociceptive activation of NK1-expressing lamina I neurons increased whereas the opposite occurs with GABAB-expressing neurons. In the present study, we evaluated if the NK1/GABAB imbalance depends on descending modulation from an antinociceptive center or a pronociceptive center, respectively, the lateral part of the caudal ventrolateral medulla (VLMlat) and the dorsal reticular nucleus (DRt). Twelve days after intraarticular injection of Complete´s Freund Adjuvant in the tibiotarsal joint, each medullary region was unilaterally lesioned with quinolinic acid (0.5 µl of a 180 nmol/µl solution). Two days later, one group of animals was behaviourally evaluated by application of Frey filaments to a cutaneous area close to the injected joint whereas other experimental group was subjected to noxious mechanical stimulation of the same skin region, under pendobarbital anaesthesia. In this case, spinal sections from segments T13-L1 (receiving input from the area of secondary hyperalgesia) were immunoreacted for Fos, NK1 and GABAB. After VLMlat lesioning, von Frey thresholds were reverted to control levels. The percentual increase of NK1-immunoreactive neurons expressing Fos and the decrease in the percentage of GABAB-immunoreactive neurons with Fos, detected during secondary hyperalgesia, were reverted to control levels. After DRt lesions, von Frey responses were reverted to control levels and the NK1/GABAB imbalance was attenuated due to a reduction in nociceptive-activation of NK1-expressing neurons. These results suggest that the imbalance between excitatory and inhibitory actions mediated by spinal NK1 and GABAB receptors during secondary hyperalgesia depends on supraspinal modulatory influences, which appear to be differentially exerted according to neurochemical features of lamina I neurons.
Accessibility: Document exists in file (poster)
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Respective poster in attachment
Author: Lima, D.
Secondary author(s):
Castro, A. R., Tavares, I.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Lima, D., Castro, A. R., & Tavares, I. (2006). Descending modulation of secondary hyperalgesia in the monoarthritic rat: role of antinociceptive and pronociceptive medullary centres in the differential nociceptive activation of NK1- and GABAB-expressing spinal cord neurons. Program No. 248.13/R11. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience. Online.
Indexed document: No
Keywords: Psychophysiology / Pain / Secondary hyperalgesia

Novo ficheiro

Novo ficheiro

DocumentOpioid-mediated control of pain modulation from the medullary dorsal reticular nucleus: a gene therapy and pharmacological study in the monoarthritic rat2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.08
Location: Arquivo PCA - Pasta 21/2004
Title:
Opioid-mediated control of pain modulation from the medullary dorsal reticular nucleus: a gene therapy and pharmacological study in the monoarthritic rat
Publication year: 2006
URL:
http://www.abstractsonline.com/viewer/viewAbstractPrintFriendly.asp?CKey={03B744B2-A0B0-4E01-A414-306527CBA56E}&SKey={1134B7F4-DCFE-488D-8972-5C3ED52276BA}&MKey={D1974E76-28AF-4C1C-8AE8-4F73B56247A7}&AKey={3A7DC0B9-D787-44AA-BD08-FA7BB2FE9004}
Abstract/Results: ABSTRACT:
Chronic inflammation affects the activity of the supraspinal endogenous pain modulatory system, with an enhancement of facilitatory actions. A pronociceptive action, conveyed by a direct bulbospinal pathway, was ascribed to the dorsal reticular nucleus (DRt) in acute and sustained pain models, but the role of the DRt during chronic inflammation has never evaluated. Based on the expression of opioid receptors in spinally-projecting DRt neurons, we used the monoarthritic rat to evaluate the behavioural effects of local administration of a Herpes Simplex-type 1 vector encoding proenkephalin (HSV-1-PPE) in comparison with the opioid receptor agonists [D-Ala2, Glu4]deltorphin (DELT) and [D-Ala2, NMePhe4Gly-ol5]enkephalin (DAMGO). Male Wistar rats received an intraarticular injection of 50µl of saline (control) or complete Freund's adjuvant (monoarthritic) and 7 days later a guide cannula was implanted in the animals used in the pharmacological study. At the 14th day of monoarthritis, the animals used in the gene therapy study were injected in the DRt with 2µl of HSV-1-PPE or HSV-1 vector with lacZ. Paw withdrawal latencies (PWL) were determined 2, 4, 7, 10 and 14 days after viral injection. In the animals used in the pharmacological study, 0.6 µl of saline, DELT (1.2, 12,120 and 1200 ng) or DAMGO (0.1, 1, 25 and 50 ng) were injected in the DRt and PWL were determined at 15, 30, 45 and 60 minutes post-injections. A one-way ANOVA followed by the SNK post-hoc test was used for each time point studied. After HSV1-PPE injection, nociceptive thresholds were higher in controls at 2 days post-injection and lower in monoarthritic rats at 2 and 4 days. In control animals, PWL decreased after DELT or DAMGO injections, with maximal effects at longer times. In monoarthritic rats, the effects of DELT were similar whereas 50ng of DAMGO increased the PWL. The results suggest that the effects of HSV-1 are due both to actions upon DRt neurons and other brain afferents. The different effects of opioid modulation in control and monoarthritic animals support previous proposals of the adaptative mechanisms during chronic pain.
Accessibility: Document exists in file (poster)
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Respective poster in attachment
Author: Pinto, M.
Secondary author(s):
Tschudy, F., Sousa, M., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Pinto, M., Tschudy, F., Sousa, M., Wilson, S. P., Lima, D., & Tavares, I. (2006). Opioid-mediated control of pain modulation from the medullary dorsal reticular nucleus: a gene therapy and pharmacological study in the monoarthritic rat. Program No.249.21/S24. 2006 Neuroscience Meeting Planner. Atlanta, GA: Society for Neuroscience. Online
Indexed document: No
Keywords: Psychophysiology / Chronic pain

Novo ficheiro

Novo ficheiro

DocumentGene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.09
Location: Arquivo PCA - Pasta 21/2004
Title:
Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres
Publication year: 2005
URL:
http://www.nature.com/mt/journal/v11/n1s/abs/mt2005278a.html
Abstract/Results: ABSTRACT:
Subcutaneous application of Herpes Simplex Virus type 1 (HSV-1) vectors mediating enkephalin transfer to the sensory neurons of the dorsal root ganglia, were shown to induce analgesia and reduce hyperalgesic reactions. These results prompted to use these vectors in the treatment of chronic intractable pain and human clinical trials based on these approaches are expected in the near future. Since brainstem regions are major pain control centres, HSV-1 mediating gene transfer at supraspinal level could also represent a major breakthrough for pain relief. Taking this into consideration, our purpose is the activation of antinociceptive supraspinal centers and blockade of pronociceptive areas. Before attempting this, we studied the migration dynamics of a replication-defective HSV-1 vector containing the reporter gene lacZ, under control of the cytomegalovirus promoter, from the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt), respectively, antinociceptive and pronociceptive areas.
Male Wistar rats were stereotaxically injected in the VLM or DRt with a viral suspension of HSV-1 (2|[times]|106 PFUs). At 2, 4, 7, 10 and 14 days post-injection, brain sections were immunoreacted for beta-galactosidase (b-gal). To charaterize neurochemically transduced neurons, double-immunodetection of b-gal and tyrosine hydroxylase (TH) or met-enkephalin (m-ENK), the later immunocytochemical procedure using animals that received intraventricular colchicine injections, prior to sacrifice.
Neurons expressing b-gal were numerous in some of the VLM and DRt brain afferent sources, which included pain modulatory regions. After double immunodetection of b-gal and TH, numerous transduced noradrenergic neurons were observed after DRt injections in several pain control areas such as the locus coeruleus and the A5 cell group. The study of b-gal and m-ENK showed that transduced opioidergic neurons projecting to the DRt occurred mainly at deep cerebellar nuclei while those projecting to the VLM occurred at the medullar gigantocellular nucleus, an important pain control area.
These data indicate that restricting transgene expression in the brain is a suitable strategy to selectively target nociceptive pathways controlling the activity of the VLM and DRt namely by including tissue specific promoters in this viral construct. For the DRt, a TH promoter may allow to restrict transgene expression to noradrenergic pain control areas. Similarly, in the case of the VLM, a pre-proenkephalin promoter may be useful to restrict transgene expression to the gigantocellular nucleus. However, restricting opioidergic expression to deep cerebellar nuclei for pain control to modulate DRt activity, should include parallel evaluation of collateral motor effects.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Pereira, S., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Pereira, S., Wilson, S. P., Lima, D., & Tavares, I. (2005). Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres. Molecular Therapy, 11(Supplement 1), S63-S64. doi: 10.1016/j.ymthe.2005.06.162
Indexed document: Yes
Keywords: Psychophysiology / Pain

Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres

Gene therapy for chronic pain control: Perspectives of HSV-1 mediated gene transfer to supraspinal centres

DocumentGene therapy for pain control from supraspinal areas: Perspectives of directing transgene expression to noradrenergic pathways2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.10
Location: Arquivo PCA - Pasta 21/2004
Title:
Gene therapy for pain control from supraspinal areas: Perspectives of directing transgene expression to noradrenergic pathways
Publication year: 2005
Accessibility:
Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Tavares-Marques, A., Pereira, S., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Tavares-Marques, A., Pereira, S., Wilson, S. P., Lima, D., & Tavares, I. (2005). Gene therapy for pain control from supraspinal areas: Perspectives of directing transgene expression to noradrenergic pathways. In Abstracts of the 11th World Congress on Pain (p. 306). Seattle, WA: International Association for the Study of Pain.
Indexed document: No
Keywords: Psychophysiology / Pain

DocumentGene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.11
Location: Arquivo PCA - Pasta 21/2004
Title:
Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?
Publication year: 2005
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=1&cad=rja&ved=0CC0QFjAA&url=http%3A%2F%2Fwww.spneurologia.com%2Findex.php%3Foption%3Dcom_docman%26task%3Ddoc_download%26gid%3D40%26Itemid%3D56&ei=kTP5UZjPCa-I7AbB_ICgBA&usg=AFQjCNErqyNXcDOGZAvhf0HogdlL1jvI3Q&sig2=8Og5nL3tGQN91cfW5RArLQ&bvm=bv.49967636,d.ZWU
Abstract/Results: ABSTRACT:
Gene therapy with replication-defective forms of Herpes Simplex Virus, type 1 (HSV-1) has been used in gene therapy for nervous system diseases. In pain control field, several studies reported the benefits of peripheral applications of HSV-1 but equivalent studies were not extended to the supraspinal endogenous pain modulatory system. Since this system contains areas that strongly inhibit pain transmission at the spinal cord along with a few centers that exert pro-nociceptive effects, we reasoned that activation of antinociceptive centers combined with blockade of pronociceptive areas using gene therapy with HSV-1 as a tool may be a valuable strategy for pain relief. Before attempting this strategy, we studied the migration dynamics of HSV-1 containing the reporter gene lacZ, under control of the cytomegalovirus promoter, from the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt), respectively, antinociceptive and pronociceptive areas.
Male Wistar rats were stereotaxically injected in the VLM or DRt with a viral suspension (2x106 PFUs) of HSV-1. After 2, 4, 7, 10 or 14 days, the animals were perfused and brain sections were immunoreacted for beta-galactosidase (ß-gal), the product of lacZ expression. To characterize neurochemically the transduced neurons in the brain, double-immunodetection of ß-gal and tyrosine hydroxylase (TH) or met-enkephalin (m-ENK) was performed, the later immunocytochemical procedure using animals that received an intraventricular colchicine injection.
Neurons expressing ß-gal were numerous in some of the VLM and DRt brain afferent sources, which included pain modulatory regions. After double immunodetection of b-gal and TH, numerous transduced noradrenergic neurons from pain control areas were found to project to the DRt. The study of b-gal and m-ENK showed that transfected opioidergic neurons projecting to the DRt occurred mainly at deep cerebellar nuclei.
The present data show transgene expression upon HSV-1 injection into medullary pain centres, more widespread than expected from previous studies with that vector. Although this could represent a powerful amplification of the synaptic delivery of the transgene product, some of the putatively disadvantages of this widespread transfection may be overcome by directing transgene expression to transduced neurons of pain control areas. In the case of DRt manipulation, the use of TH-promoters in the viral construct may be a suitable strategy to restrict transduction to noradrenergic pathways while the effects of using opioid promoters should be evaluated as to collateral effects of transfecting motor control cerebellar centers.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Pinto, M., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Martins, I., Pinto, M., Wilson, S. P., Lima, D., & Tavares, I. (2005). Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1? Sinapse, 5(1), 105.
Indexed document: Yes
Keywords: Psychophysiology / Pain / Gene therapy

Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?

Gene therapy for pain control by manipulation of supraspinal areas: what did we learn from studies with replication defective forms of HSV-1?

DocumentC-fos expression in the spinal cord of monoarthritic rats induced by brief mobilization of the inflamed paw2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.12
Location: Arquivo PCA - Pasta 21/2004
Title:
C-fos expression in the spinal cord of monoarthritic rats induced by brief mobilization of the inflamed paw
Publication year: 2005
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&frm=1&source=web&cd=1&cad=rja&ved=0CC0QFjAA&url=http%3A%2F%2Fwww.spneurologia.com%2Findex.php%3Foption%3Dcom_docman%26task%3Ddoc_download%26gid%3D40%26Itemid%3D56&ei=kTP5UZjPCa-I7AbB_ICgBA&usg=AFQjCNErqyNXcDOGZAvhf0HogdlL1jvI3Q&sig2=8Og5nL3tGQN91cfW5RArLQ&bvm=bv.49967636,d.ZWU
Abstract/Results: ABSTRACT:
Chronic pain induces plastic changes in neuronal activity in spinal cord and supraspinal regions. We recently detected a rapid Fos induction in brainstem neurons upon brief mobilization of the inflamed joint in monoarthritic animals. Here we evaluate if spinal cord neurons present a similar ability for a rapid c-fos induction by studying Fos expression after 4 minutes of noxious or innocuous stimulation of the inflamed paw.
In accordance with international ethical guidelines, male Wistar rats received an intraarticular injection of saline (control animals)
or complete Freund´s adjuvant (monoarthritic rats-MA). After 14 days, MA animals were perfused without further manipulation or
subjected to 4 minutes of bending or pinching the inflamed ankle. These noxious stimulated animals were perfused immediately or 2 hours after the application of stimuli. The numbers of Fosimmunoreactive cells were counted at the dorsal horn of L4-L5 spinal segments and compared by the ANOVA test.
Control animals and MA rats without stimulation presented similar numbers of Fos positive neurons. According to the applied stimulus, a differential activation of c-fos in laminae I, II, III and IV-V was detected. Pinching an inflamed paw induced a 3-4 folds increase in the numbers of Fos-positive neurons in all laminae in relation to normal animals perfused 2h after stimulation. In MA animals subjected to innocuous stimulation and perfused immediately an increase in Fos expression was detected in laminae I, II and IV-V while in MA animals perfused 2h after the onset of the stimulus the increase occurred only in laminae I and IV-V.
An adequate time after the onset of noxious cutaneous stimulation is necessary for an increased noxious-evoked Fos expression in the spinal cord of MA animals. By contrast, innocuous articular stimulation appears to induce a rapid increase of c-fos. These data suggest that, during chronic pain, the pain control system undergoes several adaptative mechanisms in order to process different types of noxious stimulus.
Accessibility: Document exists in file (poster)
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Abstract and respective poster in attachment
Author: Pinto, M.
Secondary author(s):
Lima, D., Tavares, I.
Document type:
Abstract
Number of reproductions:
1
Reference:
Pinto, M., Lima, D., & Tavares, I. (2005). C-fos expression in the spinal cord of monoarthritic rats induced by brief mobilization of the inflamed paw. Sinapse, 5(1), 109.
Indexed document: Yes
Keywords: Psychophysiology / Chronic pain / c-FOS / Spinal cord

C-fos expression in the spinal cord of monoarthritic rats induced by brief mobilization of the inflamed paw

C-fos expression in the spinal cord of monoarthritic rats induced by brief mobilization of the inflamed paw

DocumentNociceptive activation of neurons in lamina I and supraspinal modulatory nuclei in response to brief stimulation of a chronically inflamed joint2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.13
Location: Arquivo PCA - Pasta 21/2004
Title:
Nociceptive activation of neurons in lamina I and supraspinal modulatory nuclei in response to brief stimulation of a chronically inflamed joint
Publication year: 2005
URL:
http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results: ABSTRACT:
Neurons in spinal lamina I establish reciprocal loops with brainstem areas involved in descending pain control, namely the caudal ventrolateral medulla (VLM) and the dorsal reticular nucleus (DRt). Since chronic pain induces plastic changes in neuronal activity both in spinal and supraspinal regions, we evaluated whether stimulation of an arthritic paw induces an activation pattern of lamina I neurons that can be related with those of VLM and DRt neurons.
All the experiments were performed according to the published ethical guidelines. Wistar rats received an intraarticular injection of saline (S) or complete Freund´s adjuvant (monoarthritic animals, MA). Fourteen days later, animals were either not manipulated or subjected to 4 minutes of bending or pinching of the inflamed paw. Animals were perfused immediately or 2h after the stimulation. The numbers of Fos-immunoreactive cells in spinal segments L4- L5, VLM and DRt were counted.
In the absence of stimulation, MA rats presented an increase in Fos numbers in lamina I while no differences occurred in the VLM and DRt. Immediately after bending, MA rats presented increases in Fos in the VLM and DRt, which were not detected in lamina I. Two hours after bending, an increase in Fos numbers was detected in lamina I while the numbers in the VLM and DRt decreased to basal levels. Two hours after pinching, an increase in Fos was detected in lamina I and VLM while no differences were found at the DRt.The different patterns of nociceptive activation in lamina I and modulatory brainstem nuclei during chronic pain suggest the existence of distinct adaptative mechanisms at spinal and supraspinal levels. The distinct patterns of neuronal activation in the VLM and DRt to noxious stimuli are probably related to the opposite roles of these centres in descending pain modulation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Pinto, M.
Secondary author(s):
Lima, D., Tavares, I.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Pinto, M., Lima, D., & Tavares, I. (2005). Nociceptive activation of neurons in lamina I and supraspinal modulatory nuclei in response to brief stimulation of a chronically inflamed joint. Program No.623.10. 2005. Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience. Online.
Indexed document: No
Keywords: Pain / Chronic / Brainstem / Spinal cord

DocumentPain control from the brain: Gene therapy in the treatment of chronic pain2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.14
Location: Arquivo PCA - Pasta 21/2004
Title:
Pain control from the brain: Gene therapy in the treatment of chronic pain
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES: Develop new methods of manipulation of the supraspinal pain control system to correct the neurobiological changes induced by chronic pain. The studies were focused on two components of the supraspinal pain control system: the dorsal reticular nucleus (DRt) and the caudal ventrolateral medulla(VLM). These two areas were elected based on the profound knowledge of their participation in pain modulation at the spinal cord level. The DRt is involved in pain facilitation whereas the VLM appears to be involved in mixed effects (facilitatory and inhibitory).
METHODS:
Transduction of neurons by HSV-1 (Herpes-Simplex Virus, type 1) or lentiviral based constructs (replication- defective forms) and evaluation of nociceptive behaviours in sustained and chronic pain models. In the case of the DRt, three studies were performed using the following constructs and pain models: 1) HSV-1 vectors
overexpressing pre-proenkephalin in monoarthritic animals; 2) HSV-1 vectors overexpressing mu-opioid receptors (MOR) in a neuropathic pain model; 3) HSV-1 vectors that reduce the release of noradrenaline in a neuropathic pain model. In the VLM, we studied the effect of overexpressing pre-proenkephalin in an inflammatory pain model.
RESULTS:
In summary, the studies demonstrated that chronic pain affects descending modulation and that gene transfer can correct those effects in a sustained manner. The studies indicate that during chronic pain, a depression in the expression of MOR at the DRt is associated with hyperalgesic effects induced by local injection of opioids. The hyeperalgesia induced by overexpression of enkephalins at the DRt can be switched to analgesia by overexpression of MOR. It is possible that the VLM does not undergo similar changes since local overexpression of enkephalins induces analgesia. A decrease of noradrenaline release at the DRt is analgesic probably because chronic pain increases the tonus of noradrenergic input to the DRt and facilitates pain modulation from this nucleus.
CONCLUSION:
By allowing sustained and directed manipulation, gene transfer is an effective tool to study pain modulation from the brain. Vector constructs produced taking into account the specific changes induced by chronic pain in the brain will continue to be developed.
PUBLICATIONS (full papers):
1. Pinto M, Lima D, Tavares I. (2007). Neuronal activation at the spinal cord and medullary pain control centres after brief stimulation of an inflamed joint: a c-fos study in the monoarthritic rat. Neuroscience, 147:1076-1089.
2. Pinto M, Castro AR, Tushdy F, Wilson SP, Lima D, Tavares I. (2008). Opioids modulate pain facilitation from the dorsal reticular nucleus. Mol. Cell Neurosci, 39: 508-518.
3. Pinto M, Sousa M, Lima D, Tavares I. (2008) Expression of µ-opioid, GABAB and NK1 receptors in spinally-projecting neurons of the caudal medulla oblongata: implications for descending modulation of nociceptive transmission. J. Comp. Neurol., 510: 175-187.
4. Tavares I, Lima D. (2007). From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system. J. Anatomy, 211: 261-268.
5. Martins I, Pinto M, Lima D, Wilson SP, Tavares I. (2008). Dynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene". Eur. J. Neurosci., 28: 2075-2083.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Lima, D., Tavares, I., Pinto, M., & Martins, I. (2010). Pain control from the brain: Gene therapy in the treatment of chronic pain. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundaçăo Bial (pp. 184-185). Porto: Fundaçăo Bial.
Indexed document: No
Keywords: Receptor expression / Animal models / Gene transfer / Viral vectors

Pain control from the brain: Gene therapy in the treatment of chronic pain

Pain control from the brain: Gene therapy in the treatment of chronic pain

DocumentOpioids modulate pain facilitation from the dorsal reticular nucleus2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.15
Location: Arquivo PCA - Pasta 21/2004
Title:
Opioids modulate pain facilitation from the dorsal reticular nucleus
Publication year: 2008
URL:
http://www.sciencedirect.com/science/article/pii/S1044743108001863
Abstract/Results: ABSTRACT:
During chronic pain, the supraspinal pain modulatory system undergoes plastic changes with enhancement of facilitation transmission at the spinal cord. The changes induced by chronic pain at descending modulation often affect opioidergic modulation, and were never described for a key facilitatory component of the system, the dorsal reticular nucleus (DRt). Neurochemical characterization of the DRt-spinal pathway showed that d-opioid receptors are positioned as to indirectly modulate the activity of non-projecting DRt neurons, whereas neurons expressing µ-opioid receptors project to the spinal dorsal horn or act as interneurons, the latter of which co-expressing GABAB receptors. In monoarthritic rats, the expression of µ-opioid receptors decreased in the DRt whereas the levels of endogenous enkephalin remained unaltered. To increase the opioidergic inhibition of the DRt, we locally injected selective agonists of d- and µ-opioid receptors or a viral vector containing the human preproenkephalin transgene. Injection of the Herpes Simplex viral vector encoding preproenkephalin induced thermal hypoalgesia in non-inflamed animals and hyperalgesia in monoarthritic rats. The opioid agonists [D-Ala2, Glu4]-deltorphin (DELT) and [D-Ala2, NMePhe4Gly-ol5]-enkephalin (DAMGO) induced thermal hyperalgesia in both non-inflamed and monoarthritic rats, but with lower doses in the latter group. The present study shows that opioidergic neurons at the DRt are modulated by GABAergic cells herein controlling the descending facilitation of pain transmission. The DRt exhibits plastic changes during chronic inflammatory pain, with decrease opioid receptor expression which may account for increased descending facilitation during chronic pain.
Accessibility: Document does not exist in file
Language:
eng
Author:
Pinto, M.
Secondary author(s):
Castro, A. R., Tushdy, F., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Pinto, M., Castro, A. R., Tushdy, F., Wilson, S. P., Lima, D., & Tavares, I. (2008). Opioids modulate pain facilitation from the dorsal reticular nucleus. Molecular and Cellular Neuroscience, 39(4), 508-518. doi: 10.1016/j.mcn.2008.07.008
2-year Impact Factor: 3.934|2008
Times cited: 26|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Psychophysiology / Chronic pain / Viral vectors

DocumentParticipation of µ-opioid, GABAB, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.16
Location: Arquivo PCA - Pasta 21/2004
Title:
Participation of µ-opioid, GABAB, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission
Publication year: 2008
URL:
http://onlinelibrary.wiley.com/doi/10.1002/cne.21793/abstract
Abstract/Results: ABSTRACT:
Several brain areas modulate pain transmission through direct projections to the spinal cord. The descending modulation is exerted by neurotransmitters acting both at spinally projecting neurons and at interneurons that target the projection neurons. We analyzed the expression of µ-opioid (MOR), ?-aminobutyric acid GABAB, and NK1 receptors in spinally projecting neurons of major medullary pain control areas of the rat: rostroventromedial medulla (RVM), dorsal reticular nucleus (DRt), nucleus of the solitary tract, ventral reticular nucleus, and lateralmost part of the caudal ventrolateral medulla. The retrograde tracer cholera toxin subunit B (CTb) was injected into the spinal dorsal horn, and medullary sections were processed by double immunocytochemistry for CTb and each receptor. The RVM contained the majority of double-labeled neurons followed by the DRt. In general, high percentages of MOR- and NK1-expressing neurons were retrogradely labeled, whereas GABAB receptors were mainly expressed in neurons that were not labeled from the cord. The results suggest that MOR and NK1 receptors play an important role in direct and indirect control of descending modulation. The co-localization of MOR and GABAB in DRt neurons also demonstrated by the present study suggests that the pronociceptive effects of this nucleus may be controlled by local opoidergic and GABAergic inhibition of the pronociception increased during chronic pain
Accessibility: Document does not exist in file
Language:
eng
Author:
Pinto, M.
Secondary author(s):
Sousa, M., Lima, D., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Pinto, M., Sousa, M., Lima, D., & Tavares, I. (2008). Participation of µ-opioid, GABAB, and NK1 receptors of major pain control medullary areas in pathways targeting the rat spinal cord: Implications for descending modulation of nociceptive transmission. Journal of Comparative Neurology, 510(2), 175-187. doi: 10.1002/cne.21793
2-year Impact Factor: 3.743|2008
Times cited: 39|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Opioid receptors / Substance P / Dorsal reticular nucleus / Endogenous pain control system / Antinociception / Pronociception

DocumentReversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.17
Location: Arquivo PCA - Pasta 21/2004
Title:
Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain
Publication year: 2010
URL:
https://journals.lww.com/pain/Abstract/2010/10000/Reversal_of_neuropathic_pain_by_HSV_1_mediated.23.aspx
Abstract/Results: ABSTRACT:
Descending modulation of nociceptive transmission depends on the release of noradrenaline at the spinal cord. The role of noradrenaline in the control of nociceptive transmission at the supraspinal pain control system remains understudied. As chronic pain is associated with enhanced descending facilitation of nociceptive transmission, we sought to determine the role of noradrenaline in pain facilitation from the brain during neuropathic pain. We determined the action of the noradrenergic input to the dorsal reticular nucleus (DRt), a unique pain facilitatory area, using the spared nerve injury model. Injections of the a1-adrenoreceptor agonist phenylephrine into the DRt induced hyperalgesia and allodynia, indicating that a1-adrenoreceptors enhance the facilitatory action of the nucleus. This led us to reduce noradrenaline release at the DRt using a viral vector derived from the Herpes Simplex virus type 1 (HSV-1) which carried the tyrosine hydroxylase (TH) transgene in antisense orientation. The reduction of noradrenaline release, confirmed by microdialysis experiments, induced a long-lasting attenuation of pain responses, which was reverted by the local administration of phenylephrine. The present study indicates that the noradrenergic modulation of a pronociceptive area at the supraspinal pain control system accounts for pain facilitation, through the activation of a1-adrenoreceptors. The study also shows that sustained effects on chronic pain can be achieved by decreasing the release of noradrenaline in a pain facilitatory centre of the brain using gene transfer.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I.
Secondary author(s):
Costa-Araújo, S., Fadel, J., Wilson, S. P., Lima, D., Tavares, I.
Document type:
Article
Number of reproductions:
1
Reference:
Martins, I., Costa-Araújo, S., Fadel, J., Wilson, S. P., Lima, D., & Tavares, I. (201). Reversal of neuropathic pain by HSV-1-mediated decrease of noradrenaline in a pain facilitatory area of the brain. Pain, 151(1), 137-145. doi: 10.1016/j.pain.2010.06.027
2-year Impact Factor: 5.355|2010
Times cited: 32|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Pain control system / Gene transfer / Pronociception / Tyrosine hydroxylase / Rat