Reference code: | PT/FB/BL-2004-033.05 |
Location: | Arquivo PCA - Pasta 15/2004
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Title:
| Variability of brain coordination dynamics in normal physiology and pathology
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Publication year: | 2006
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URL:
| http://www.societyforchaostheory.org/insc/2006/FinalINSC2006Web.pdf
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Abstract/Results: | ABSTRACT:
Fluctuations in phase synchrony have been characteristically found in recordings from both normal physiological brains as well as pathological ones. These fluctuations, characteristically termed as noise, are
logistically difficult to separate from true neuronal activity largely due to current recording and analysis methods. We propose that phase synchrony fluctuations serve to maintain brain activity in an optimal state for cognitive processing, thereby not allowing it to fall into long-term periodic behavior. We compared fluctuations from controls to those found in patients with epilepsy or traumatic brain injuries (TBI). Phase synchronization analysis using the Hilbert Transform was performed on magnetoencephalography (MEG) and electroencephalography (EEG) recordings from controls and patients. In the MEG study, 4 epileptic patients and 4 controls were tested. A total of 14 head-injured children and 2 controls were analyzed using scalp EEG, after performing a Laplacian Derivation. Results - Phase-locking patterns between brain areas were found to display fluctuations at different scales. Both epileptiform activity and TBI had relatively low levels of fluctuations in phase synchrony. This may contribute to the generation of synchronized states seen in patients with these brain disorders. Conclusions and Implications. Determination of phase-locking patterns and their variability in brain recordings reveals characteristics of the pathologies with which they are associated. While there is no clear distinction between noise and highdimensional dynamics, we propose that the examination of neuronal fluctuations at different levels will provide important insights into our understanding of the relationship between brain and behavior.
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Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Belkas, J.
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Secondary author(s):
| Guevara Erra, R., García Dominguez, L., Nenadovic, V., Wennberg, R., Hutchison, J., Perez Velazquez, J. L.
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Document type:
| Abstract book
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Number of reproductions:
| 1
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Reference:
| Belkas, J., Guevara Erra, R., García Dominguez, L., Nenadovic, V., Wennberg, R., Hutchison, J., & Perez Velazquez, J. L. (2006). Variability of brain coordination dynamics in normal physiology and pathology. In Conference book of the 2nd International Nonlinear Science Conference, Heraklion, Greece (p. 50).
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Indexed document: | No
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Keywords: | Psychophysiology / Synchrony fluctuations / Epilepsy
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Variability of brain coordination dynamics in normal physiology and pathology |