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File093 - An investigation of effects of dreams on physiological measures of stress2005-062007-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology
DocumentFinal report - An investigation of effects of dreams on physiological measures of stress2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.01
Location: Arquivo PCA - Pasta 15/2004
Title:
Final report - An investigation of effects of dreams on physiological measures of stress
Publication year: 2007
URL:
http://www.bial.com/imagem/Bolsa9304.pdf
Abstract/Results: RESULTS:
PART 1
Baseline questionnaires showed that patients in both sleep disorder groups had significantly higher levels of anxiety and sleep disturbance and lower levels of general health compared with normal sleepers; the insomnia group had significantly higher depression ratings. Absolute levels of morning salivary cortisol were higher in both sleep disordered groups than in controls. Insomnia patients and parasomnia patients on ‘good’ nights had higher waking cortisol levels than controls, and similar levels to controls at 30min post waking. There was a variable response on parasomnia ‘bad’ nights with most patients waking with higher cortisol levels and some even having a fall rather than a rise 30 minutes after waking. Cortisol levels on awakening showed higher variability in those subjects reporting anxiety dreams during the night. We demonstrated
a significant relationship between cortisol levels and subjective measures of poor sleep quality. Occurrence of episodes of parasomnia was associated with awakening cortisol response unlike that of controls and insomnia patients.
PART2
The automatic sampling system was reliable and effective in obtaining frequent blood cortisol samples without interfering with sleep. Cortisol levels fell during the first few hours of sleep and then showed a rise independent of sleep stage about halfway through the night, consistent with the literature. In addition, both awakenings and REM sleep tended to increase cortisol level. There was evidence of both circadian and sleep-stage-dependent regulation of night-time cortisol level. Awakening cortisol response was detected in both plasma and saliva samples but the size of the response was different using the 2 methods.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Wilson, S. J.
Secondary author(s):
Lightman, S., Nutt, D. J.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Sleep and dreams / Endocrinology

Final report - An investigation of effects of dreams on physiological measures of stress

Final report - An investigation of effects of dreams on physiological measures of stress
DocumentMorning cortisol response in patients with parasomnias and insomnia2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.04
Location: Arquivo PCA - Pasta 15/2004
Title:
Morning cortisol response in patients with parasomnias and insomnia
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Dickens, R.
Secondary author(s):
Dickens, R., Jessop, D., Lightman, S., Nutt, D. J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Wilson, S. J., Dickens, R., Jessop, D., Lightman, S., & Nutt, D. J. (2008). P.8.a.030 Morning cortisol response in patients with parasomnias and insomnia. European Neuropsychopharmacology, 18(Suppl. 4), S584-S584. https://doi.org/10.1016/S0924-977X(08)70894-0
Indexed document: Yes
Keywords: Psychophysiology / Sleep disorders / Endocrinology
DocumentAn investigation of effects of dreams on physiological measures of stress2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.05
Location: Arquivo PCA - Pasta 15/2004
Title:
An investigation of effects of dreams on physiological measures of stress
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Part 1 - to compare morning salivary cortisol response, sleep questionnaires and dream reports between patients with parasomnias, normal subjects and patients with insomnia.
Part 2 – to pilot the use of automatic blood sampling overnight for cortisol assay synchronized with polysomnography in 6 normal subjects, to assess the minute by minute effect of sleep stage on cortisol measures, and to compare morning dream reports with plasma cortisol and salivary cortisol on awakening.
METHODS:
Part 1 - patients with sleep disorders and healthy good sleepers were provided with a pack containing
cotton swabs for saliva sampling and overnight sleep and dreaming questionnaires. Patients with parasomnias were sent sample kits for 2 nights, 1 with and 1 without an episode (eg night terror). 16 patients and 15 healthy good sleepers returned the packs and salivary cortisol concentration was measured in-house using radio-immunoassay.
Part 2 - 6 healthy volunteers slept in the sleep laboratory. An automated sampling machine has been developed at Bristol University to minimise interference with study subjects when taking blood samples. They were prepared for polysomnography (PSG) and had an indwelling cannula connected ‘through the wall’ to the sampling machine. Blood samples (1ml) were taken every 10 minutes, synchronised with the PSG recording. Samples were later assayed for cortisol. Sleep was scored and the cortisol levels related to different sleep stages.
RESULTS:
Part 1- morning cortisol response was as expected in healthy normal sleepers with a rise between waking
and 30 minutes later. Insomnia patients and parasomnia patients on a ‘good’ night had a similar response with both readings being slightly higher. On the ‘bad’ nights readings were very variable with no consistent rise between the 2 time periods. Waking cortisol levels correlated with complaints of waking too early. Dream report analysis will be presented.
Part 2 – synchronized hypnograms and cortisol profiles will be presented. Cortisol levels fell during the first few hours of sleep and then showed a rise independent of sleep stage about halfway through the night, consistent with the literature. In addition, both awakenings and REM sleep tended to increase cortisol level. Awakening cortisol response occurred from any stage of sleep and at any time of day.
CONCLUSIONS:
Part 1 - Insomnia and parasomnia subjects had higher cortisol levels than controls but this was not
statistically significant. However we demonstrated a significant relationship between cortisol levels and subjective measures of sleep quality and early awakening. Dreaming effects will be discussed.
Part 2 – The automatic sampling method was reliable and effective in obtaining frequent cortisol samples without interfering with sleep. There was evidence of both circadian and sleep-stage-dependent regulation of night-time cortisol level.
Accessibility: Document does not exist in file
Language:
eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Wilson, S. J., Nutt, D. J., & Lightman, S. (2008). An investigation of effects of dreams on physiological measures of stress. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Sleep / Parasomnias / Hypothalamic-pituitary-adrenal axis / Cortisol / Stress / Endocrinology

An investigation of effects of dreams on physiological measures of stress

An investigation of effects of dreams on physiological measures of stress
DocumentSleep stages and automatic overnight cortisol sampling2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.06
Location: Arquivo PCA - Pasta 15/2004
Title:
Sleep stages and automatic overnight cortisol sampling
Publication year: 2008
Abstract/Results:
ABSTRACT:
Sleep and the hypothalamic-pituitary-adrenal (HPA) axis have a complicated relationship that is the subject of much research. Plasma cortisol is the end point which is often used to investigate the HPA axis response to stressful stimuli. An automated blood sampling machine has been used at Bristol University in the investigation of the rat HPA axis for a number of years (Windle et al. 1997) and the technology is now developed so that automated sampling can be carried out in humans. A peristaltic pump is linked to a computer and fraction collector designed to enable the collection of multiple samples of small volumes blood at specified time points over a long period of time i.e. 24 h. The objective of this study was to pilot the use of automatic blood sampling overnight for cortisol assay synchronized with polysomnography in 6 normal subjects, to assess the minute by minute effect of sleep stage on cortisol measures, and to compare plasma cortisol and salivary cortisol on awakening. Six healthy volunteers slept in the sleep laboratory. They were prepared for polysomnography (PSG) and had an indwelling cannula connected ‘through the wall’ to the
sampling machine. Blood samples (1 mL) were taken every 10 min, synchronised with the PSG recording. Samples were later assayed for cortisol. Sleep was scored and the cortisol levels related to different sleep stages Cortisol levels fell during the first few hours of sleep and then showed a rise independent of sleep stage about halfway through the night, consistent with the literature. In addition, both awakenings and REM sleep tended to increase cortisol level. An increase in cortisol similar to that seen in the normal wakening response could be found from any stage of sleep and at any time of day/night. The automatic sampling method was reliable and effective in obtaining frequent cortisol samples without interfering with sleep. There was evidence of both circadian and sleep-stage-dependent regulation of night-time cortisol level.
Accessibility: Document does not exist in file
Language:
eng
Author:
Phillips, S.
Secondary author(s):
Lightman, S., Nutt, D. J., Wilson, S. J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Phillips, S., Lightman, S., Nutt, D. J., & Wilson, S. J. (2008). Sleep stages and automatic overnight cortisol sampling. Journal of Sleep Research, 17(Suppl. 1), 228-228.
Indexed document: Yes
Keywords: Psychophysiology / Sleep stages / Cortisol / Endocrinology
DocumentSleep stages and automatic overnight cortisol sampling2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.07
Location: Arquivo PCA - Pasta 15/2004
Title:
Sleep stages and automatic overnight cortisol sampling
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Wilson, S. J.
Secondary author(s):
Phillips, S., Lightman, S., Nutt, D. J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Wilson, S. J., Phillips, S., Lightman, S., & Nutt, D. J. (2008). P.8.a.031 Sleep stages and automatic overnight cortisol sampling. European Neuropsychopharmacology, 18(Suppl. 4), S584-S585. https://doi.org/10.1016/S0924-977X(08)70895-2
Indexed document: Yes
Keywords: Psychophysiology / Sleep stages / Cortisol / Endocrinology
DocumentMorning cortisol response in patients with parasomnia and insomnia2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.08
Location: Arquivo PCA - Pasta 15/2004
Title:
Morning cortisol response in patients with parasomnia and insomnia
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Dickens, R.
Secondary author(s):
Jessop, D., Lightman, S., Nutt, D. J., Wilson, S. J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dickens, R., Jessop, D., Lightman, S., Nutt, D., & Wilson, S. J. (2008). Morning cortisol response in patients with parasomnia and insomnia. Journal of Sleep Research, 17(Suppl. 1), 193-193.
Indexed document: Yes
Keywords: Psychophysiology / Sleep disorders / Endocrinology