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File168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy2005-022007-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams
DocumentFinal report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.01
Location: Arquivo PCA - Pasta 13/2004
Title:
Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Publication year: 2007
URL:
http://www.bial.com/imagem/Bolsa%2016804.pdf
Abstract/Results: RESULTS:
Using the opportunity to record parahippocampal activity with foramen ovale electrodes in epilepsy patients we examined high-frequency activity and its relation to NREM sleep-slow oscillations and sleep spindles. Parahippocampal high-frequency activity was organized into bursts which were consistently associated with interictal epileptic spikes. Ripple density was higher during Non-REM than REM sleep (p<0.001). Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations (p<0.001), whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak (p<0.001). Coordinated occurrence of hippocampal ripples, sleep spindles and slow oscillations have already been reported in animals yet the present results provide first evidence for such a temporal coupling in humans. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Halász, P.
Secondary author(s):
Borbély, C., Fabó, D., Eross, L., Entz, L.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Epilepsy / Sleep / Hippocampus

Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy

Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
DocumentTemporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.02
Location: Arquivo PCA - Pasta 13/2004
Title:
Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans
Publication year: 2007
URL:
http://www.ncbi.nlm.nih.gov/pubmed/17615093
Abstract/Results: ABSTRACT:
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel with sleep spindles, ripple activity is suppressed during the hyperpolarized down-state and enhanced during the depolarized up-state. The temporal coupling between slow oscillations, spindles and ripples has been suggested to serve a hippocampo-neocortical dialogue underlying memory consolidation during sleep. Here, we examined whether a similar coupling exists between these oscillatory phenomena in humans. In sleep recordings from seven epileptic patients, scalp-recorded slow oscillations and spindles as well as parahippocampal ripples recorded from foramen ovale electrodes were identified by automatic algorithms. Additionally, ripple and spindle root mean square activity was determined for relevant frequency bands. Ripple density was higher during Non-REM than REM sleep (P < 0.001). Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations (P < 0.001), whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak (P < 0.001). Ripples were consistently associated with interictal spikes suggesting that spike-ripple complexes represent an epileptic transformation of sharp wave-ripple complexes in the epileptic hippocampus. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Mölle, M., Eross, L., Barsi, P., Halász, P., Born, J.
Document type:
Article
Number of reproductions:
1
Reference:
Clemens, Z., Mölle, M., Eross, L., Barsi, P., Halász, P., & Born, J. (2007). Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans. Brain, 130, 2868-2878. https://doi.org/10.1093/brain/awm146
2-year Impact Factor: 8.568|2007
Times cited: 295|2024-02-05
Indexed document: Yes
Quartile: Q1
Keywords: Sleep / Hippocampus / Sharp-wave ripples / Slow oscillation / Epilepsy

Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans

Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans
DocumentTwenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.03
Location: Arquivo PCA - Pasta 13/2004
Title:
Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles
Publication year: 2006
URL:
http://www.ncbi.nlm.nih.gov/pubmed/16714084
Abstract/Results: ABSTRACT:
Recent evidence suggests that the sleep-dependent consolidation of declarative memories relies on the non-rapid eye movement (NREM) rather than the rapid eye movement (REM) phase of sleep. Moreover, a few studies both at the cellular and the behavioural levels have suggested the involvement of sleep spindles, the most synchronous oscillatory waveforms during NREM sleep stage 2, in this process. Our previous study showed that overnight verbal memory retention correlates with the total number of sleep spindles in left frontocentral areas, while spindling in other regions did not correlate with mnemonic retention. In the present study, we show that retention of visuospatial memories over a 24-h period correlates with the total number of sleep spindles detected over parietal regions during the intervening night-time sleep. This result provides further evidence for the association between sleep spindle activity and declarative memory consolidation, and suggests that visuospatial and verbal memory retention differ in the topographic distribution of the NREM spindle activity with which they are associated.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Fabó, D., Halász, P.
Document type:
Article
Number of reproductions:
1
Reference:
Clemens, Z., Fabó, D., & Halász, P. (2006). Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles. Neuroscience Letters, 403(1-2), 52-56. https://doi.org/10.1016/j.neulet.2006.04.035
2-year Impact Factor: 2.092|2006
Times cited: 115|2024-02-05
Indexed document: Yes
Quartile: Q3
Keywords: Sleep spindles / Rey-Osterrieth complex figure task / Memory consolidation / Oscillations / Hippocampus / Declarative memory

Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles

Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles
DocumentIncreased parahippocampal delta activity characterises virtual navigation and REM sleep in humans2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.04
Location: Arquivo PCA - Pasta 13/2004
Title:
Increased parahippocampal delta activity characterises virtual navigation and REM sleep in humans
Publication year: 2006
URL:
http://fens2006.neurosciences.asso.fr/abstracts/R1/A018_3.html
Abstract/Results: ABSTRACT:
Hippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviours and rapid-eye-movement (REM) sleep is a characteristic and salient oscillatory rhythm in animals. By contrast, much controversy exists regarding the existence and the characteristics of this activity in humans. Some studies argued that human hippocampal theta activity appears in short and phasic bursts. On the contrary, earlier we showed that REM-dependent RSA recorded from the parahippocampal region is continuous like in animals but instead of the theta it falls in the delta frequency range. Here, we examined parahippocampal activity in 10 epilepsy patients implanted with foramen ovale electrodes while they were engaged in a virtual navigation task. Navigation was tested according to three conditions: an acquisition, a recall and a non-learning route-following condition. Recordings were also sampled from resting and REM sleep. For analyses, spectral power densities (SPD) were calculated for each 1 Hz wide frequency bin up to 10 Hz. During acquisition, SPD significantly increased in the 1 Hz, 2 Hz and the 3 Hz frequency bins when compared with resting. A similar but more robust increase was present in the 1 Hz, 2 Hz, 3 Hz, 4 Hz and 5 Hz frequency bins during REM sleep. Thus, increase was present in similar frequencies during the two conditions and these frequency ranges were below the traditional theta band. At the same time, other features of this activity, such as state-dependency and tonicity made this activity comparable to that seen in animals and suggest this activity to be the human analogue hippocampal theta in animals.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Borbély, C., Fabó, D., Halász, P.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Clemens, Z., Borbély, C., Fabó, D., & Halász P. (2006). Increased parahippocampal delta activity characterises virtual navigation and REM sleep in humans. FENS Abstr., vol.3, A018.3, 2006. Abstract retrieved from http://fens2006.neurosciences.asso.fr/abstracts/R1/A018_3.html
Indexed document: No
Keywords: Parahippocampal activity / Epilepsy / Virtual navigation / Sleep / Learning
DocumentTemporal coupling of parahippocampal ripples and sleep spindles in humans2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.05
Location: Arquivo PCA - Pasta 13/2004
Title:
Temporal coupling of parahippocampal ripples and sleep spindles in humans
Publication year: 2006
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.2006.00540_57.x/pdf
Abstract/Results: ABSTRACT:
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during NREM sleep. In rodents they occur in association with sharp waves and are known to be grouped by the cortical slow oscillation such that their occurrence is maximal during the surface positive, up states. Ripples were also shown to be temporally linked to sleep spindles. Importantly, coordinated spindleripple events have been suggested to provide a framework for information transfer between the hippocampus and the neocortex underlying memory consolidation. Our aim was to examine whether ripples recorded via parahippocampal electrocorticography are also temporally linked with slow oscillations and sleep spindles in epileptic
humans. Whole-night recordings from seven epilepsy patients implanted with foramen ovale (FO) electrodes were analysed. Negative half waves of the slow oscillation and sleep spindles recorded on the scalp as well as ripples in FO recordings were detected by an automatic algorithm. Ripple activity was also measured as root mean square (RMS) of the 80–140 Hz activity. Compared to baseline both ripple measures showed a significant increase time-locked to sleep spindles. In the three patients without temporal structural alterations ripple activity decreased time-locked to slow oscillation negative half waves. In the four other patients exhibiting hippocampal sclerosis, modulation of ripple activity by the negative half waves was much less clear. Ripples significantly increased during NREM sleep and were consistently associated with interictal epileptic spikes. This suggests that ripple/spike complexes represent an epileptic exaggeration of ripple/sharp wave complexes in the human epileptic hippocampus. Whether ripples are epileptically transformed or not, the present data provide first evidence for a temporal coupling between hippocampal ripples and neocortical spindles in humans.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Mölle, M., Eröss, L., Barsi, P., Halász, P., Born, J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Clemens, Z., Molle, M., Eross, L., Barsi, P., Halasz, P., & Born, J. (2006). Temporal coupling of parahippocampal ripples and sleep spindles in humans. Journal of Sleep Research, 15(Suppl. 1), 242-242. https://doi.org/10.1111/j.1365-2869.2006.00540_57.x
Indexed document: Yes
Keywords: Sleep / Hippocampus / Sharp-wave ripples / Epilepsy

Temporal coupling of parahippocampal ripples and sleep spindles in humans

Temporal coupling of parahippocampal ripples and sleep spindles in humans
DocumentElectrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.06
Location: Arquivo PCA - Pasta 13/2004
Title:
Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-
REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel with sleep spindles, ripple activity is suppressed during the hyperpolarized down-state and enhanced during the depolarized up-state. The temporal coupling between these oscillations has been suggested to serve a hippocampo-neocortical dialogue underlying memory consolidation during sleep. Here we examined whether a similar coupling exists between these oscillatory phenomena in humans. We based our investigations on epilepsy patients undergoing presurgical evaluation implanted with foramen ovale electrodes. Recording with foramen ovale electrodes is a unique technique allowing parahippocampal electrocorticography in a semi-invasive way. In sleep recordings from seven epileptic patients, scalp-recorded slow oscillations and spindles as well as parahippocampal ripples recorded from foramen ovale electrodes were identified by automatic algorithms. Additionally, ripple and spindle root mean square activity was determined for relevant frequency bands. Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations, whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak. Ripples were consistently associated with interictal spikes suggesting that spike/ripple complexes represent an epileptic transformation of sharp wave/ripple complexes in the epileptic hippocampus. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
PUBLICATIONS:
Clemens Z, Mölle M, Eross L, Barsi P, Halász P, Born J. Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans. 2007 Brain, 130:2868-2878.
Accessibility: Document does not exist in file
Language:
eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Halász, P., Clemens, Z., Borbély, C., & Fabó, D. (2008). Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundaçăo Bial. Porto: Fundaçăo Bial.
Indexed document: No
Keywords: Hippocampus / Oscillations / Memory consolidation

Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain

Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain