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BIAL Foundation
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cod:"PT/FB/BL-2006-030$"
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File030 - Does calcium leak in the brain cause mental retardation?2007-012009-12

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-030
Location: Arquivo PCA - Pasta 17/2006
Title:
030 - Does calcium leak in the brain cause mental retardation?
Duration: 2007-01 - 2009-12
Researcher(s):
Xander Wehrens, Subeena Sood, Priyanka Desai
Institution(s): Baylor College of Medicine, Texas (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wehrens, X.
Secondary author(s):
Sood, S., Desai, P.
Keywords:
Psychophysiology / Biopsychological problems / Childhood and adolescent disorders / Mental retardation / Diseases/Injuries / Chromosomal abnormalities

DocumentFinal report - Does calcium leak in the brain cause mental retardation?2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-030
Location: Arquivo PCA - Pasta 17/2006
Title:
030 - Does calcium leak in the brain cause mental retardation?
Duration: 2007-01 - 2009-12
Researcher(s):
Xander Wehrens, Subeena Sood, Priyanka Desai
Institution(s): Baylor College of Medicine, Texas (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wehrens, X.
Secondary author(s):
Sood, S., Desai, P.
Keywords:
Psychophysiology / Biopsychological problems / Childhood and adolescent disorders / Mental retardation / Diseases/Injuries / Chromosomal abnormalities

Reference code: PT/FB/BL-2006-030.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - Does calcium leak in the brain cause mental retardation?
Publication year: 2009
URL:
http://www.bial.com/imagem/Bolsa30-06_03012014.pdf
Abstract/Results: RESULTS:
Some patients with inherited mutations in the ryanodine receptor (RyR2) only develop cardiac arrhythmias, whereas others also develop mental retardation. We tested the hypothesis that mutation R176Q in RyR2 – identified in patients with arrhythmias – also exhibit defects in learning and memory.
First, the passive avoidance test was performed for contextual and emotional memory. The R176Q/+ mutant mice did not show decreased latencies to enter the dark side in the passive avoidance test.
Second, general anxiety evaluated with the passive avoidance task was normal. We conducted an open field test as a control experiment, to measure anxiety and locomotor activity. Wildtype and R176Q/+ mice behaved similarly in the open field test. The light-dark test revealed that R176Q/+ mice did not demonstrate altered exploratory behavior. Moreover, the R176Q/+ mice did not show altered exploratory behavior.
Third, the Morris Water Maze was performed to test for learning and memory. There were no significant differences between WT and R176Q/+ mice. Moreover, there were no significant differences in the time to reaching the visible platform comparing both groups. The Rotarod test was performed a control for the Morris water maze test. Our results show that R176Q/+ mice have similar learning performance to WT mice on the rotarod.
In conclusion, our results show that knockin mice with the R176Q/+ mutation, found in patients with cardiac arrhythmias, exhibit normal learning and memory abilities. These findings suggest that mutations of different residues within RyR2 may either cause cardiac or neuronal defects.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Wehrens, X.
Document type:
Final report
Indexed document:
No
Keywords: Psychophysiology / Psychopathology / Mental retardation / Calcium dysregulation

Final report - Does calcium leak in the brain cause mental retardation?

Final report - Does calcium leak in the brain cause mental retardation?

DocumentDoes calcium leak in the brain cause mental retardation?2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-030
Location: Arquivo PCA - Pasta 17/2006
Title:
030 - Does calcium leak in the brain cause mental retardation?
Duration: 2007-01 - 2009-12
Researcher(s):
Xander Wehrens, Subeena Sood, Priyanka Desai
Institution(s): Baylor College of Medicine, Texas (USA)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wehrens, X.
Secondary author(s):
Sood, S., Desai, P.
Keywords:
Psychophysiology / Biopsychological problems / Childhood and adolescent disorders / Mental retardation / Diseases/Injuries / Chromosomal abnormalities

Reference code: PT/FB/BL-2006-030.02
Location: Arquivo PCA - Pasta 17/2006
Title:
Does calcium leak in the brain cause mental retardation?
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
Mental retardation (MR) is a symptom of multiple etiologies including chromosomal abnormalities, genetic defects and perinatal causes. MR refers to substantial limitations in present functioning and has important psychological implications for affected individuals. Disruption of the cellular calcium homeostasis has been
associated with the pathogenesis of impaired cognition in human pathological conditions such as MR and Alzheimer’s disease. Calcium signaling in neurons is tightly controlled to ensure proper functioning of numerous Ca-dependent processes. Two major sources contribute to cytosolic calcium signals: an extracellular pool entering via plasma membrane channels, and an internal reservoir in the endoplasmic reticulum (ER) liberated through intracellular Ca release channels. The ryanodine receptor (RyR2) is a major Ca release channel in the brain and the heart, and is activated by cytosolic Ca resulting in a regenerative process of Ca-induced Ca release (CICR), which enables interactions between these pathways. Dysfunction of RyR2 function has been suggested to contribute to impairments in learning and memory, although the details are poorly understood. In addition, the enzyme CaMKII has been implicated in the pathogenesis of memory loss. Inherited mutations in the RyR2 gene have been associated with cardiac arrhythmias and sudden death, but some a few patients were also shown to develop mental retardation. Therefore, we hypothesized that a gain-of-function defect in RyR2 may lead to cognitive dysfunction. We have recently generated mice with a constitutively activated CaMKII phosphorylation site of RyR2 (S2814D). RyR2 channels with mutation S2814D exhibit an increased open probability, which is associated with enhanced intracellular calcium leak in a cellular environment. A comprehensive behavioral analysis of homozygous S2814D mice and their wildtype littermates was conducted to determine their activity levels, contextual conditioned fear, memory and sensory functions. Our studies revealed no significant differences between S2814D and wildtype mice. In the near future, similar studies will be performed in a mouse carrying a human RyR2 mutation identified in patients with MR. These studies may provide the first insights into the potential link between calcium dysregulation and mental retardation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Wehrens, X.
Secondary author(s):
Sood, S., Desai, P.
Document type:
Conference abstract
Reference:
Wehrens, X., Sood, S., & Desai, P. (2010). Does calcium leak in the brain cause mental retardation? In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 201). Porto: Fundação Bial.
Indexed document: No
Keywords: Psychophysiology / Psychopathology / Mental retardation / Calcium dysregulation

Does calcium leak in the brain cause mental retardation?

Does calcium leak in the brain cause mental retardation?