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File031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2007-042010-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

DocumentFinal report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3106.pdf
Abstract/Results: RESULTS:
The overall aim of this study was to investigate the influence of serotonin and dopamine receptor gene polymorphisms on various parameters relevant to the successful participation of obese people taking part in a diet and exercise obesity intervention. We demonstrated that serotonin receptor gene genotype has a significant influence on perception of hunger. We also showed that dopamine receptor gene polymorphisms significantly influence the drop out rate from an obesity intervention study, and suggest that this is due to the influence of these polymorphisms both on motivation to exercise and on restrained eating behaviours. Finally we demonstrated the efficacy of motivational interviewing in an obesity intervention programme and have shown that motivational interviews influence the relationship between measures of motivation or eating behaviours and weight loss measured by BMI change These novel findings indicate that serotonin plays a key role in determining appetite. They also indicate that extent of dopamine signalling may influence an individual's motivation to engage in weight-loss programmes. Further studies are required to confirm these findings and investigate the underlying mechanisms involved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Document type:
Final report
Indexed document:
No
Keywords: Psychophysiology / Genotype / Obesity / Motivation / Intervention program / Serotonin / Dopamine / Weight loss

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

DocumentThe use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.02
Location: Arquivo PCA - Pasta 17/2006
Title:
The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
To determine whether polymorphisms in serotonin or dopamine receptor genes influence changes in body mass index (BMI) or waist/hip ratio in participants of a diet and exercise programme, the extent of motivation of the participants in relation to exercise, and the participants eating behaviour scores.
METHODS:
100 obese participants of a 12-week exercise and diet intervention programme took part in the study. BMI and waist/hip ratio data were collected. The Three-factor Eating Questionnaire (TFEQ) was used to quantify eating behaviours, and the BREQ-2 questionnaire to quantify motivation in relation to exercise. Measures and questionnaires were repeated at the end of the programme. DNA was extracted from a buccal swab and genotyped for polymorphisms in serotonin and dopamine receptor genes.
RESULTS:
The results indicate that polymorphisms in serotonin receptor genes influence BMI and waist/hip ratio changes in the participants. Subjects with favourable combinations of serotonin receptor genotypes were more likely to reduce their BMI waist/hip ratio than subjects with the opposing genotypes. In addition dopamine receptor genotype influences the motivation of the participants to engage in exercise. Subjects with unfavourable genotypes were less likely to have improved their motivation score measured by the BREQ-2 questionnaire by the end of the study than those participants with a favourable genotype. Finally, both serotonin and dopamine receptor genotypes influence the subjects’ eating behaviour. Subjects with combinations of unfavourable genotypes were more likely to have eating behaviours known to be associated with weight gain compared to subjects with more favourable genotype combinations.
CONCLUSIONS:
These findings suggest that success when attempting to lose weight is influenced by polymorphisms in serotonin and dopamine receptor genes. This influence is mediated by the effect of these genes on eating behaviours and on motivation to participate in exercise. Further studies are required to investigate ways of personalising diet and exercise programmes to take into account the influence of these genetic factors.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Notes:
Abstract and respective poster in attachment
Author: Dalton, C.
Secondary author(s):
Breckon, J., Silva, N., Copeland, R., Hall, A., Kesterton, S., Reynolds, G.
Document type:
Conference abstract
Reference:
Dalton, C., Breckon, J., Copeland, R., Hall, B., & Reynolds, G. (2010). The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 202). Porto: Fundação Bial.
Indexed document: No
Keywords: Genotype / Obesity / Motivation / Three-factor eating questionnaire (TFEQ) / Behavioral regulation in exercise questionnaire-2 (BREQ-2)

Polymorphisms in serotonin and dopamine receptor genes influence weight loss, motivation and eating behaviours

Polymorphisms in serotonin and dopamine receptor genes influence weight loss, motivation and eating behaviours