|Reference code: ||PT/FB/BL-2006-031.02|
|Location: ||Arquivo PCA - Pasta 17/2006|
|The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme|
|Publication year: ||2010|
To determine whether polymorphisms in serotonin or dopamine receptor genes influence changes in body mass index (BMI) or waist/hip ratio in participants of a diet and exercise programme, the extent of motivation of the participants in relation to exercise, and the participants eating behaviour scores.
100 obese participants of a 12-week exercise and diet intervention programme took part in the study. BMI and waist/hip ratio data were collected. The Three-factor Eating Questionnaire (TFEQ) was used to quantify eating behaviours, and the BREQ-2 questionnaire to quantify motivation in relation to exercise. Measures and questionnaires were repeated at the end of the programme. DNA was extracted from a buccal swab and genotyped for polymorphisms in serotonin and dopamine receptor genes.
The results indicate that polymorphisms in serotonin receptor genes influence BMI and waist/hip ratio changes in the participants. Subjects with favourable combinations of serotonin receptor genotypes were more likely to reduce their BMI waist/hip ratio than subjects with the opposing genotypes. In addition dopamine receptor genotype influences the motivation of the participants to engage in exercise. Subjects with unfavourable genotypes were less likely to have improved their motivation score measured by the BREQ-2 questionnaire by the end of the study than those participants with a favourable genotype. Finally, both serotonin and dopamine receptor genotypes influence the subjects’ eating behaviour. Subjects with combinations of unfavourable genotypes were more likely to have eating behaviours known to be associated with weight gain compared to subjects with more favourable genotype combinations.
These findings suggest that success when attempting to lose weight is influenced by polymorphisms in serotonin and dopamine receptor genes. This influence is mediated by the effect of these genes on eating behaviours and on motivation to participate in exercise. Further studies are required to investigate ways of personalising diet and exercise programmes to take into account the influence of these genetic factors.
|Accessibility: ||Document exists in file|
|Abstract and respective poster in attachment|
|Author: ||Dalton, C.|
|Secondary author(s): |
|Breckon, J., Silva, N., Copeland, R., Hall, A., Kesterton, S., Reynolds, G.|
|Document type: |
|Dalton, C., Breckon, J., Copeland, R., Hall, B., & Reynolds, G. (2010). The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 202). Porto: Fundação Bial.|
|Indexed document: ||No|
|Keywords: ||Genotype / Obesity / Motivation / Three-factor eating questionnaire (TFEQ) / Behavioral regulation in exercise questionnaire-2 (BREQ-2)|
Polymorphisms in serotonin and dopamine receptor genes influence weight loss, motivation and eating behaviours