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File035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia2008-012011-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders
DocumentFinal report - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Publication year: 2011
URL:
http://www.bial.com/imagem/Bolsa3506_21022014.pdf
Abstract/Results: RESULTS:
We have developed a feasible and cost-effective method of identifying children who may be at high-risk for the development of schizophrenia spectrum disorders because they present multiple putative antecedents of schizophrenia. Our method involves screening community samples of children aged 9-12 years, using child and caregiver questionnaires, to identify children who experience the antecedents, including (i) psychotic-like experiences (PLEs), (ii) a social, emotional, or behavioural problem, and (iii) a delay/abnormality in speech and/or motor development. We have screened 8,000 children and 1,500 of their caregivers, with 9.4% of children (13.4% boys, 5.8% girls) presenting the triad of antecedents. Only longitudinal follow-up of the children can establish the degree to which experiencing these antecedents predicts later schizophrenia, but we have established that these children are characterised by several features that are observed in adults with schizophrenia: (1) the prevalence of antecedents is elevated among African-Caribbean and Black African individuals in the UK, as is the prevalence of schizophrenia; (2) preliminary data indicate that the children present a reduction in the amplitude of the error-related negativity event-related potential component, generated in the anterior cingulate, that indexes internal monitoring of behaviour; (3) the children present impaired intellectual and cognitive function (including working memory, executive function, and verbal memory); and (4) the children present involuntary dyskinetic movement abnormalities. We are currently following the development of the children longitudinally in order to establish how strongly and specifically the antecedent triad predicts schizophrenia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Murray, R., Taylor, E., Collier, D., Rutter, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Developmental psychology / Psychopathology / Schizophrenia / Antecedents / Prevention and early intervention

Final report - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia

Final report - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
DocumentPsychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: An item response theory analysis2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.02
Location: Arquivo PCA - Pasta 17/2006
Title:
Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: An item response theory analysis
Publication year: 2012
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8594191
Abstract/Results: ABSTRACT:
BACKGROUND:
Psychotic-like experiences (PLEs) in the general population are common, particularly in childhood, and may constitute part of a spectrum of normative development. Nevertheless, these experiences confer increased risk for later psychotic disorder, and are associated with poorer health and quality of life.
METHOD:
This study used factor analytic methods to determine the latent structure underlying PLEs, problem behaviours and personal competencies in the general child population, and used item response theory (IRT) to assess the psychometric properties of nine PLE items to determine which items best represented a latent psychotic-like construct (PSY). A total of 7966 children aged 9-11 years, constituting 95% of eligible children, completed self-report questionnaires.
RESULTS:
Almost two-thirds of the children endorsed at least one PLE item. Structural analyses identified a unidimensional construct representing psychotic-like severity in the population, the full range of which was well sampled by the nine items. This construct was discriminable from (though correlated with) latent dimensions representing internalizing and externalizing problems. Items assessing visual and auditory hallucination-like experiences provided the most information about PSY; delusion-like experiences identified children at more severe levels of the construct.
CONCLUSIONS:
Assessing PLEs during middle childhood is feasible and supplements information concerning internalizing and externalizing problems presented by children. The hallucination-like experiences constitute appropriate items to screen the population to identify children who may require further clinical assessment or monitoring. Longitudinal follow-up of the children is required to determine sensitivity and specificity of the PLE items for later psychotic illness.
Accessibility: Document exists in file (previous version submitted for publication)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Hobbs, M. J., Sunderland, M., Green, M. J., Mould, G. L.
Document type:
Article
Number of reproductions:
1
Reference:
Laurens, K. R., Hobbs, M. J., Sunderland, M., Green, M. J., & Mould, G. L. (2012). Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: An item response theory analysis. Psychological Medicine, 42(7), 1495-1506. https://doi.org/10.1017/S0033291711002108
2-year Impact Factor: 5.587|2012
Times cited: 137|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Delusions / Development / Hallucinations / Latent construct / Psychopathology / Questionnaire / Screening / Symptom dimension

Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: An item response theory analysis

Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: An item response theory analysis
DocumentMovement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.03
Location: Arquivo PCA - Pasta 17/2006
Title:
Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?
Publication year: 2012
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8443224
Abstract/Results: ABSTRACT:
BACKGROUND:
Both involuntary dyskinetic movements and psychotic-like experiences (PLEs) are reported to be antecedents of schizophrenia that may reflect dysfunctional dopaminergic activity in the striatum. The present study compared dyskinetic movement abnormalities displayed by children with multiple antecedents of schizophrenia (ASz), including speech and/or motor developmental lags or problems, internalising/externalising problems in the clinical range, and PLEs, with those displayed by children with no antecedents (noASz).
METHOD:
The sample included 21 ASz and 31 noASz children, aged 9-12 years old. None had taken psychotropic medication or had relatives with psychosis. The antecedents of schizophrenia were assessed using questionnaires completed by children and caregivers. A trained rater, blind to group status, coded dyskinetic movement abnormalities using a validated tool from videotapes of interviews with the children.
RESULTS:
ASz children reported, on average, 'certain experience' of 2.5 PLEs, while noASz children, by definition, reported none. The ASz children, as compared with noASz children, displayed significantly more dyskinetic movement abnormalities in total, and in the facial and the upper-body regions, after controlling for sex and age. Receiver operator characteristics analyses yielded high area under the curve values for the total score (0.94), facial score (0.91) and upper-body score (0.86), indicating that these scores distinguished between the ASz and noASz children with great accuracy.
CONCLUSIONS:
Brief questionnaires identified children with multiple antecedents of schizophrenia who displayed significantly more involuntary dyskinetic movement abnormalities than children without antecedents. The presence of PLEs and dyskinesias could reflect early disruption of striatal dopamine circuits.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
MacManus, D.
Secondary author(s):
Laurens, K. R., Walker, E. F., Brasfield, J., Riaz, M., Hodgins, S.
Document type:
Article
Number of reproductions:
1
Reference:
MacManus, D., Laurens, K. R., Walker, E. F., Brasfield, J., Riaz, M., & Hodgins, S. (2012). Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia? Psychological Medicine, 42(1), 99-109. https://doi.org/10.1017/S0033291711001085
2-year Impact Factor: 5.587|2012
Times cited: 27|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Antecedents / Dopamine / Dyskinesia / Psychosis / Risk factors

Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?

Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?
DocumentNeurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.04
Location: Arquivo PCA - Pasta 17/2006
Title:
Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia
Publication year: 2010
URL:
http://www.sciencedirect.com/science/article/pii/S0920996410013551
Abstract/Results: ABSTRACT:
BACKGROUND:
We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia.
METHODS:
Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition.
RESULTS:
Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size=0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p<0.05). The severity of problems on each of the individual antecedents comprising the antecedent triad did not relate strongly to performance on the neurocognitive domains.
CONCLUSIONS:
Children aged 9-12 years who present multiple antecedents of schizophrenia display poorer neurocognition than healthy peers on several domains showing pronounced deficits in schizophrenia, first-episode psychosis, and youth with prodromal symptoms. Longitudinal follow-up is necessary to determine the extent to which poorer neurocognitive performance is specific to those who develop schizophrenia.
Accessibility: Document exists in file (previous version submitted for publication)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Cullen, A. E.
Secondary author(s):
Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Cullen, A. E., Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., & Laurens, K. R. (2010). Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia. Schizophrenia Research, 121(1-3), 15-23. https://doi.org/10.1016/j.schres.2010.05.034
2-year Impact Factor: 4.374|2010
Times cited: 34|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: High-risk / Psychosis / Intelligence / Executive function / Memory / Scholastic achievement

Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia

Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia
DocumentError-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.05
Location: Arquivo PCA - Pasta 17/2006
Title:
Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia
Publication year: 2010
URL:
http://www.sciencedirect.com/science/article/pii/S0006322309009081
Abstract/Results: ABSTRACT:
BACKGROUND:
Intervention aimed at preventing schizophrenia may be most effective if targeted at specific, but modifiable, functional impairments that present during childhood. We have developed a novel method of screening community samples aged 9 to 12 years to identify children who present a triad of putative antecedents of schizophrenia (ASz), defined as 1) speech and/or motor development lags/problems; 2) internalizing, externalizing, and/or peer-relationship problems in the clinical range; and 3) psychotic-like experiences. This study examined whether ASz children display brain function abnormalities during error processing that are similar to those exhibited by adults with schizophrenia.
METHODS:
Twenty-two ASz children and 26 typically developing (TD) children with no antecedents of schizophrenia completed an error-inducing Go/NoGo task during event-related potential recording. Group differences were examined in the amplitude and latency of four event-related potential components: the initial error-related negativity (ERN) and later error-positivity (Pe) elicited on false-alarm responses to NoGo trials, and the corresponding initial correct response negativity (CRN) and later correct response positivity (Pc) elicited during processing of correct responses to Go trials.
RESULTS:
Relative to TD children, ASz children were characterized by reduced ERN amplitude but unaffected CRN, Pe, and Pc amplitudes. No group differences were observed in the latency of any component.
CONCLUSIONS:
Children presenting a triad of putative antecedents of schizophrenia show error-processing dysfunction mimicking that observed in adults with schizophrenia using the same Go/NoGo paradigm. The ASz children displayed specific early error-processing deficits rather than a generalized deficit in self-monitoring.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Mould, G. L., West, S. A., Schoenberg, P. L., Murray, R., Taylor, E.
Document type:
Article
Number of reproductions:
1
Reference:
Laurens, K. R., Hodgins, S., Mould, G. L., West, S. A., Schoenberg, P. L., Murray, R., & Taylor, E. (2010). Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia. Biological Psychiatry, 67(3), 238-245. https://doi.org/10.1016/j.biopsych.2009.07.030
2-year Impact Factor: 8.674|2010
Times cited: 47|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Child psychopathology / Error positivity / Error-related negativity / Event-related potential (ERP) / High-risk / Psychosis

Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia

Error-related processing dysfunction in children aged 9-12 years presenting putative antecedents of schizophrenia
DocumentPsychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.06
Location: Arquivo PCA - Pasta 17/2006
Title:
Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom
Publication year: 2008
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1927620
Abstract/Results: ABSTRACT:
BACKGROUND:
The incidence of schizophrenia and the prevalence of psychotic symptoms in the general adult population are elevated in migrant and ethnic minority groups relative to host populations. These increases are particularly prominent among African-Caribbean migrants to the UK. This study examined the associations of ethnicity and migrant status with a triad of putative antecedents of schizophrenia in a UK community sample of children aged 9–12 years. The antecedent triad comprised: (i) psychotic-like experiences; (ii) a speech and/or motor developmental delay or abnormality; and (iii) a social, emotional or behavioural problem.
METHOD:
Children (n=595) and their primary caregivers, recruited via schools and general practitioners in southeast London, completed questionnaires. Four indices of risk were examined for associations with ethnicity and migrant status: (i) certain experience of at least one psychotic-like experience; (ii) severity of psychotic-like experiences (total psychotic-like experience score); (iii) experience of the antecedent triad; and (iv) severity of antecedent triad experiences (triad score).
RESULTS:
African-Caribbean children, as compared to white British children, experienced greater risk on all four indices. There were trends for South Asian and Oriental children to present lowered risk on several indices, relative to white British children. Migration status was unrelated to any risk index.
CONCLUSION:
Prevalence of the putative antecedents of schizophrenia is greater among children of African-Caribbean origin living in the UK than among white British children. This parallels the increased incidence of schizophrenia and elevated prevalence of psychotic symptoms among adults of African-Caribbean origin.
Accessibility: Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
West, S. A., Murray, R., Hodgins, S.
Document type:
Article
Number of reproductions:
1
Reference:
Laurens, K. R., West, S. A., Murray, R., & Hodgins, S. (2008). Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom. Psychological Medicine, 38(8), 1103-1112. https://doi.org/10.1017/S0033291707001845
2-year Impact Factor: 4.718|2008
Times cited: 56|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Developmental psychopathology / Psychosis / Risk factors
DocumentCommunity screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.07
Location: Arquivo PCA - Pasta 17/2006
Title:
Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
Publication year: 2007
URL:
http://www.sciencedirect.com/science/article/pii/S0920996406004804
Abstract/Results: ABSTRACT:
Prospective longitudinal investigations are needed to identify causal processes leading to schizophrenia. However, there is presently no cost-effective way to identify children who are at risk of developing schizophrenia spectrum disorders: Although having a family history of schizophrenia is associated with elevated risk for developing spectrum disorders, the majority of individuals with schizophrenia do not have an afflicted relative. The present study aimed to test the feasibility of screening a community sample of children, aged 9 to 12 years, to identify children who experienced a triad of putative antecedents of schizophrenia that had been identified from previous research, including: (1) speech and/or motor development lags or problems; (2) social, emotional, or behavioural problems; and (3) psychotic-like-experiences (PLEs). 548 children and 264 caregivers completed questionnaires. 9.2% of boys and 4.1% of girls displayed the triad of antecedents. 58.9% of the children reported "certain experience" of one or more PLEs. The results suggest that questionnaire screening of community samples of children for the putative antecedents of schizophrenia spectrum disorders is feasible. Accuracy of identification will only be established by follow-up studies.
Accessibility: Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Maughan, B., Murray, R., Rutter, M., Taylor, E.
Document type:
Article
Number of reproductions:
1
Reference:
Laurens, K. R., Hodgins, S., Maughan, B., Murray, R., Rutter, M., & Taylor, E. (2007). Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years. Schizophrenia Research, 90(1-3), 130-146. https://doi.org/10.1016/j.schres.2006.11.006
2-year Impact Factor: 4.240|2007
Times cited: 187|2025-02-04
Indexed document: Yes
Quartile: Q1
Keywords: Childhood / Antecedents / Schizophrenia / Community screening / Questionnaire
DocumentIs earlier intervention for schizophrenia possible? Identifying antecedents of schizophrenia in children aged 9-12 years2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.08
Location: Arquivo PCA - Pasta 17/2006
Title:
Is earlier intervention for schizophrenia possible? Identifying antecedents of schizophrenia in children aged 9-12 years
Publication year: 2011
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Taylor, E., Murray, R.
Document type:
Book chapter
Number of reproductions:
1
Reference:
Laurens, K. R., Hodgins, S., Taylor, E., & Murray, R. (2011). Is earlier intervention for schizophrenia possible? Identifying antecedents of schizophrenia in children aged 9-12 years. In A. S. David, S. Kapur, & P. McGuffin (Eds.), Schizophrenia: The Final Frontier (pp. 19-32). London, UK: Psychology Press.
Indexed document: No
Keywords: Psychopathology / Schizophrenia / Antecedents / Childhood

Is earlier intervention for schizophrenia possible? Identifying antecedents of schizophrenia in children aged 9-12 years

Is earlier intervention for schizophrenia possible? Identifying antecedents of schizophrenia in children aged 9-12 years
DocumentGrey matter abnormalities in children aged 9–13 years presenting antecedents of schizophrenia: a voxel-based morphometry study2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.09
Location: Arquivo PCA - Pasta 17/2006
Title:
Grey matter abnormalities in children aged 9–13 years presenting antecedents of schizophrenia: a voxel-based morphometry study
Publication year: 2010
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7893.2010.00230.x/abstract
Abstract/Results: ABSTRACT:
BACKGROUND:
Voxel-based morphometry (VBM) studies have identified widespread grey matter abnormalities in individuals with schizophrenia and less extensive abnormalities in first-episode patients and high-risk individuals defined by familial/genetic vulnerability or ultra high-risk criteria (Chan et al., in press. Schizophrenia Bulletin). Using a novel community screening method, we identified children who present multiple putative antecedents of schizophrenia (ASz) who may bear elevated risk for developing the disorder. We aimed to determine whether ASz children show grey matter abnormalities relative to typically-developing (TD) children with no antecedents.
METHODS:
Thirty TD (Mage = 10.6 years) and nineteen ASz (Mage = 10.5 years) children completed structural MRI scanning (3T GE). Paediatric templates were created from sample demographics (age and gender) using the Template-O-Matic toolbox (Wilke et al, 2008; NeuroImage 41: 903–913). Differences in grey matter volume (GMV) and concentration (GMC) were examined using VBM methods implemented in Statistical Parametric Mapping (SPM5).
RESULTS:
GMC and GMV were signifi cantly decreased (P < 0.01, corrected) in ASz children in the right middle frontal gyrus and increased in the left superior temporal gyrus, relative to TD children. Additionally, signifi cant GMC decreases were apparent in ASz children in the right inferior frontal and left precentral gyrii.
CONCLUSIONS:
ASz children aged 9–13 years show grey matter abnormalities in frontal and temporal brain regions that are consistent with those
observed in adults with schizophrenia. Furthermore, individuals with schizophrenia have been shown to experience functional abnormality in these same regions during working memory, inhibition and motor function tasks and during auditory hallucinations.
Accessibility: Document does not exist in file
Language:
eng
Author:
Cullen, A. E.
Secondary author(s):
Brito, S., Gregory, S., Williams, S., Murray, R., Hodgins, S., Laurens, K. R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Cullen, A. E., Brito, S., Gregory, S., Williams, S., Murray, R., Hodgins, S., & Laurens, K. R. (2010). Grey matter abnormalities in children aged 9–13 years presenting antecedents of schizophrenia: a voxel-based morphometry study. POSTER ABSTRACTS. Early Intervention in Psychiatry, 4(Suppl. 1), 45. https://doi.org/10.1111/j.1751-7893.2010.00230.x
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Community screening / Grey matter abnormalities

Grey matter abnormalities in children aged 9–13 years presenting antecedents of schizophrenia: a voxel-based morphometry study

Grey matter abnormalities in children aged 9–13 years presenting antecedents of schizophrenia: a voxel-based morphometry study
DocumentFace emotion processing in children aged 9–14 years presenting putative antecedents of schizophrenia2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.10
Location: Arquivo PCA - Pasta 17/2006
Title:
Face emotion processing in children aged 9–14 years presenting putative antecedents of schizophrenia
Publication year: 2010
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1751-7893.2010.00230.x/abstract
Abstract/Results: ABSTRACT:
BACKGROUND:
Deficits in face emotion processing are observed in individuals with schizophrenia and in “high-risk” young relatives of schizophrenia
patients (Eack et al., 2010, Schizophrenia Bulletin, in press). We recently established a novel questionnaire method of identifying children who present multiple putative antecedents of schizophrenia (ASz) who may bear elevated risk of developing the disorder (Laurens et al., 2007, Schizophrenia Research 90: 130–146). The current study aimed to determine whether ASz children show deficits in face emotion processing compared to typically-developing (TD) children who do not present with the antecedents.
METHODS:
Twenty ASz (6 female, mean age 12 years 3 months) and 33 TD children (17 female, mean age 12 years 7 months) completed the Penn Emotion Recognition Task, comprising 40 colour photographs of happy, sad, angry, scared or neutral emotions presented serially. Participants selected the emotion label that most accurately refl ected the emotion in each displayed face.
RESULTS:
Preliminary analyses indicate that, when compared to TD children, ASz children make more emotion recognition errors overall (P =
0.05), over-attribute emotions to neutral faces (P = 0.02), and significantly more often misattribute neutral faces as negative (P = 0.01). The majority of misattributions of neutral faces to negative emotions were due to ASz children mislabelling neutral faces as sad (78%).
CONCLUSIONS:
Children presenting multiple putative antecedents of schizophrenia show similar face emotion processing deficits to young relatives at familial high-risk for schizophrenia. Only longitudinal followup of ASz children will establish whether these deficits are a potential marker for schizophrenia.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dickson, H.
Secondary author(s):
Calkins, M. E., Kohler, C., Hodgins, S., Laurens, K. R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dickson, H., Calkins, M. E., Kohler, C., Hodgins, S., & Laurens, K. R. (2010). Face emotion processing in children aged 9–14 years presenting putative antecedents of schizophrenia. POSTER ABSTRACTS. Early Intervention in Psychiatry, 4(Suppl. 1), 45. https://doi.org/10.1111/j.1751-7893.2010.00230.x
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Emotion recognition

Face emotion processing in children aged 9–14 years presenting putative antecedents of schizophrenia

Face emotion processing in children aged 9–14 years presenting putative antecedents of schizophrenia
DocumentCharacterising putatively "at-risk" children who present psychotic-like experiences and other antecedents of schizophrenia2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.11
Location: Arquivo PCA - Pasta 17/2006
Title:
Characterising putatively "at-risk" children who present psychotic-like experiences and other antecedents of schizophrenia
Publication year: 2010
Abstract/Results:
ABSTRACT:
BACKGROUND:
Recognising and intervening with individuals at risk for schizophrenia prior to illness onset may minimise or prevent disability, but elucidating risk status is challenging. We have developed a novel method of screening community samples to identify children who present multiple putative antecedents of schizophrenia that distinguish individuals who later develop illness from those who do not [1].
METHODS:
We used questionnaires to identify children, aged 9-12 years, who present a triad of antecedents, namely: (i) psychotic-like experiences [PLEs]; (ii) a speech/motor development delay or abnormality; and (iii) a social, emotional, or behavioural problem.
RESULTS:
Data from 1,347 child and caregiver dyads indicate that 9.5% (13.2% boys, 6.1% girls) present the antecedent triad. Among these, 69% report experiencing distress or impairment associated with PLEs. Only longitudinal follow-up can ascertain the degree to which the triad predicts later schizophrenia, yet, we have established that these children already present features present in schizophrenia, including: (i) brain dysfunction during event-related potential (ERP) recordings of error processing and of involuntary attention orienting; (ii) similar neurocognitive deficits as observed in prodromal and first-episode samples; (iii) increased involuntary dyskinetic movements of the face and upper body; (iv) fewer positive and more negative parenting experiences; and (v) triad prevalence is elevated among UK children of African-Caribbean
and black African ethnicity, mimicking the increased prevalence of schizophrenia among these groups in the UK.
CONCLUSIONS:
These children may constitute appropriate targets for preventive interventions for schizophrenia. Longitudinal follow-up of the children, with additional measures, is ongoing.
Reference 1. Laurens K et al. Schizophr. Res. 2007;90:130–146.
Accessibility: Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Taylor, E., Hodgins, S., Murray, R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Laurens, K. R., Taylor, E., Hodgins, S., & Murray, R. (2010). Characterising putatively "at-risk" children who present psychotic-like experiences and other antecedents of schizophrenia. Australian and New Zealand Journal of Psychiatry, 44(Supplement 1), A22-A23.
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Community screening / Preventive interventions
DocumentBrain function abnormalities in 9-to-11 year old children presenting putative antecedents of schizophrenia: Evidence from event-related potential recordings2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.12
Location: Arquivo PCA - Pasta 17/2006
Title:
Brain function abnormalities in 9-to-11 year old children presenting putative antecedents of schizophrenia: Evidence from event-related potential recordings
Publication year: 2009
Accessibility:
Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Mould, G. L., Murray, R., Taylor, E.
Document type:
Abstract
Number of reproductions:
1
Reference:
Laurens, K. R., Hodgins, S., Mould, G. L., Murray, R., & Taylor, E. (2009). Brain function abnormalities in 9-to-11 year old children presenting putative antecedents of schizophrenia: Evidence from event-related potential recordings. European Archives of Psychiatry and Clinical Neuroscience, 259(Suppl. 1), S29-S30. https://doi.org/10.1007/s00406-009-0041-1
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Event-related potential (ERP)
DocumentCognitive performance of 9 to 11 year old children who present putative antecedents of schizophrenia2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.13
Location: Arquivo PCA - Pasta 17/2006
Title:
Cognitive performance of 9 to 11 year old children who present putative antecedents of schizophrenia
Publication year: 2009
Accessibility:
Document does not exist in file
Language:
eng
Author:
Cullen, A. E.
Secondary author(s):
Dickson, H., Hodgins, S., Morris, R., Murray, R., Laurens, K. R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Cullen, A. E., Dickson, H., Hodgins, S., Morris, R., Murray, R., & Laurens, K. R. (2009). Cognitive performance of 9 to 11 year old children who present putative antecedents of schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 259(Suppl. 1), S30. https://doi.org/10.1007/s00406-009-0041-1
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Cognitive perfomance
DocumentMotor abnormalities presented by 9 to 11 year old children who present the putative antecedents of schizophrenia2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.14
Location: Arquivo PCA - Pasta 17/2006
Title:
Motor abnormalities presented by 9 to 11 year old children who present the putative antecedents of schizophrenia
Publication year: 2009
Accessibility:
Document does not exist in file
Language:
eng
Author:
Dickson, H.
Secondary author(s):
MacManus, D., Cullen, A. E., Laurens, K. R., Hodgins, S.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dickson, H., MacManus, D., Cullen, A. E., Laurens, K. R., & Hodgins, S. (2009). Motor abnormalities presented by 9 to 11 year old children who present the putative antecedents of schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 259(Suppl. 1), S30. https://doi.org/10.1007/s00406-009-0041-1
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Motor abnormalities
DocumentIntellectual and cognitive dysfunctions in children who present psychotic-like experiences and other antecedents of schizophrenia2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.15
Location: Arquivo PCA - Pasta 17/2006
Title:
Intellectual and cognitive dysfunctions in children who present psychotic-like experiences and other antecedents of schizophrenia
Publication year: 2009
URL:
http://schizophreniabulletin.oxfordjournals.org/content/35/suppl_1/1.full.pdf+html
Abstract/Results: ABSTRACT:
We have proposed that children who present psychotic-like experiences as part of a triad of antecedents of schizophrenia (including also a speech and/or motor developmental delay or abnormality, and a social, emotional, or behavioural problem) may experience elevated risk for the development of schizophrenia (Laurens et al. 2007). While only longitudinal follow-up will establish the degree to which the triad of antecedents predicts later schizophrenia, the present study examined whether children experiencing the triad also present intellectual and cognitive deficits that characterise first-episode patients with schizophrenia and ‘‘high-risk’’ (prodromal) youth. Questionnaire data from 5 158 children aged 9–12 years and 1 133 of their primary caregivers demonstrated that 9% of children (12% of boys, 6% of girls) present the triad of antecedents. Fifty-eight children (21 presenting the antecedent triad and 37 control children without the antecedents) subsequently completed standardised assessments of IQ (WASI), scholastic achievement (reading, spelling, numerical operations; WIAT), memory (verbal, visual, and working memory; WRAML2) and executive function (verbal fluency, and inhibition; D-KEFS). Children presenting the antecedent triad experienced
moderate deficits in cognitive function (mean effect size -0.65, range -0.56 to -0.77) relative to control children, with significant performance decrements observed in all domains (excepting a non-significant trend in visual memory performance). Children who present antecedents of schizophrenia demonstrate moderate intellectual and cognitive impairments that are comparable to those observed in prodromal youth (mean effect size ;0.8), but less marked than deficits apparent in first-episode patients (mean effect sizes;1.1–1.8). Children experiencing the antecedents of schizophrenia might represent a ‘‘high-risk’’ population who may benefit
from preventive interventions for schizophrenia. Acknowledgements: NIHR Career Development Fellowship, NARSAD Young Investigator Award, BMA Margaret Temple Award, BIAL Foundation.
Reference 1. Laurens, et al. Schizophr Res. 2007;90:130–46. ID: 550487
Accessibility: Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Cullen, A. E., Dickson, H., Hodgins, S., Morris, R., Murray, R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Laurens, K. R., Cullen, A. E., Dickson, H., Hodgins, S., Morris, R., & Murray, R. (2009). Intellectual and cognitive dysfunctions in children who present psychotic-like experiences and other antecedents of schizophrenia. Schizophrenia Bulletin, 35(Suppl. 1), 276-276.
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Cognitive impairment

Intellectual and cognitive dysfunctions in children who present psychotic-like experiences and other antecedents of schizophrenia

Intellectual and cognitive dysfunctions in children who present psychotic-like experiences and other antecedents of schizophrenia
DocumentChildren presenting putative antecedents of schizophrenia: Are they potential targets for preventative interventions?2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.16
Location: Arquivo PCA - Pasta 17/2006
Title:
Children presenting putative antecedents of schizophrenia: Are they potential targets for preventative interventions?
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Murray, R., Taylor, E., West, S. A., Hodgins, S.
Document type:
Abstract
Number of reproductions:
1
Reference:
Laurens, K. R., Murray, R., Taylor, E., West, S. A., & Hodgins, S. (2008). Children presenting putative antecedents of schizophrenia: Are they potential targets for preventative interventions? Early Intervention in Psychiatry, 2(Suppl. 1), A56-A56. https://doi.org/10.1111/j.1751-7893.2008.00095.x
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia / Preventive interventions
DocumentPrevalence and correlates of psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.17
Location: Arquivo PCA - Pasta 17/2006
Title:
Prevalence and correlates of psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
West, S. A., Taylor, E., Murray, R., Hodgins, S.
Document type:
Abstract
Number of reproductions:
1
Reference:
Laurens, K. R., West, S. A., Taylor, E., Murray, R., & Hodgins, S. (2008). Prevalence and correlates of psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9-12 years. European Psychiatry, 23(Suppl. 2), S17-S18. https://doi.org/10.1016/j.eurpsy.2008.01.064
Indexed document: Yes
Keywords: Childhood / Antecedents / Schizophrenia
DocumentPersisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.18
Location: Arquivo PCA - Pasta 17/2006
Title:
Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
Publication year: 2013
URL:
http://www.schres-journal.com/article/S0920-9964(12)00701-3/abstract
Abstract/Results: ABSTRACT:
BACKGROUND:
Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9–11years at study commencement.
METHODS:
8099 children (mean age 10.4years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later.
RESULTS:
Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13–3.34) and externalising (OR=1.97; 95% CI 1.19–3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs.
CONCLUSIONS:
Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common childhood psychopathology.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Downs, J. M.
Secondary author(s):
Cullen, A. E., Barragan, M., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Downs, J. M., Cullen, A. E., Barragan, M., & Laurens, K. R. (2013). Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort. Schizophrenia Research, 144(1), 99-104. https://doi.org/10.1016/j.schres.2012.12.009
2-year Impact Factor: 4.426|2013
Times cited: 68|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Childhood / Adolescence / Developmental psychopathology / Community sample / Risk factors / Psychosis

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
DocumentSystematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.19
Location: Arquivo PCA - Pasta 17/2006
Title:
Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0022395613000964
Abstract/Results: ABSTRACT:
Social withdrawal is a robust childhood risk factor for later schizophrenia. The aims of this paper were to assess the evidence for childhood social withdrawal among adults with schizophrenia and, comparatively, in children aged 9–14 years who are putatively at-risk of developing schizophrenia. We conducted a meta-analysis, including cohort and case-control studies reporting social withdrawal measured by the Child Behavior Checklist (CBCL) in adults with schizophrenia vs. controls. Further, an experimental study compared CBCL withdrawal scores from typically-developing children with scores from two groups of putatively at-risk children: (i) children displaying a triad of replicated antecedents for schizophrenia, and (ii) children with at least one first- or second-degree relative with schizophrenia or schizoaffective disorder. Six studies met inclusion criteria for the meta-analysis (N = 3828), which demonstrated a large effect of increased childhood social withdrawal in adults with schizophrenia (standardized mean difference [SMD] score = 1.035, 95% CI = 0.304–1.766, p = 0.006), with no indication of publication bias, but considerable heterogeneity (I2 = 91%). Results from the experimental study also indicated a large effect of increased social withdrawal in children displaying the antecedent triad (SMD = 0.743, p = 0.001), and a weaker effect in children with a family history of schizophrenia (SMD = 0.442, p = 0.051). Childhood social withdrawal may constitute a vulnerability marker for schizophrenia in the presence of other antecedents and/or genetic risk factors for schizophrenia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Matheson, S. L.
Secondary author(s):
Vijayan, H., Dickson, H., Shepherd, A. M., Carr, V. J., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Matheson, S. L., Vijayan, H., Dickson, H., Shepherd, A. M., Carr, V. J., & Laurens, K. R. (2013). Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years. Journal of Psychiatric Research, 47(8), 1061-1068. https://doi.org/10.1016/j.jpsychires.2013.03.013
2-year Impact Factor: 4.092|2013
Times cited: 48|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Child Behavior Checklist (CBCL) / Antecedents / Risk factors / Psychosis / Developmental psychopathology

Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years

Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years