|Reference code: ||PT/FB/BL-2006-035.04|
|Location: ||Arquivo PCA - Pasta 17/2006|
|Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia|
|Publication year: ||2010|
We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia.
Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition.
Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size=0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p<0.05). The severity of problems on each of the individual antecedents comprising the antecedent triad did not relate strongly to performance on the neurocognitive domains.
Children aged 9-12 years who present multiple antecedents of schizophrenia display poorer neurocognition than healthy peers on several domains showing pronounced deficits in schizophrenia, first-episode psychosis, and youth with prodromal symptoms. Longitudinal follow-up is necessary to determine the extent to which poorer neurocognitive performance is specific to those who develop schizophrenia.
|Accessibility: ||Document exists in file (previous version submitted for publication)|
|Cullen, A. E.|
|Secondary author(s): |
|Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., Laurens, K. R.|
|Document type: |
|Cullen, A. E., Dickson, H., West, S. A., Morris, R., Mould, G. L., Hodgins, S., Murray, R., & Laurens, K. R. (2010). Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia. Schizophrenia Research, 121(1-3), 15-23. doi: 10.1016/j.schres.2010.05.034|
|2-year Impact Factor: ||4.374|2010|
|Times cited: ||30|2020-03-11|
|Indexed document: ||Yes|
|Keywords: ||High-risk / Psychosis / Intelligence / Executive function / Memory / Scholastic achievement|
Neurocognitive performance in children aged 9 – 12 years who present putative antecedents of schizophrenia