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File036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging2007-032010-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

DocumentFinal report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.01
Location: Arquivo PCA - Pasta 18/2006
Title:
Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3606_16102013.pdf
Abstract/Results: RESULTS:
This study evaluated 54 first psychotic episode patients and 46 healthy controls, using multimodal imaging (structural and functional), to identify the neuroanatomical and functional correlates of neurological performance.
Patients showed more neurological signs than controls. There were no significant differences in grey and white matter volumes between patients and controls, although patients had larger, at trend-level, CSF volumes. Global brain volumes were not correlated with performance at any of the neurological subscales.
Preliminary analysis of white matter tracts in patients showed that a worse performance in Primary signs, reflecting more “hard” neurological abnormalities, was associated with disruption of tracts integrity, and specifically with: increased Fractional Anisotropy (FA) of the Corpus Callosum, both Uncinate fasciculi, right Inferior Fronto-Occipital fasciculus (IFOF); left Inferior Longitudinal fasciculus (ILF). A worse performance on Motor Sequencing was associated with a shorter length of the right IFOF, and a worse performance in Sensory Integration was correlated with a reduction in right Mean Diffusivity of this fasciculus.
An Audio-Visual task was successfully developed to investigate sensory integration during functional MRI. Patients had longer reaction time, and gave more incorrect answers, and had larger frontal lobe activation than healthy controls, particularly so if they had a poorer response to treatment.
In conclusion, morpho-anatomical information alone are not sufficient to define the substrate of neurological dysfunction in psychosis, which is likely to reflect an altered structural, and possibly functional connectivity.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dazzan, P.
Document type:
Final report
Indexed document:
No
Keywords: Psychophysiology / Psychosis / Neurological signs / Functional magnetic resonance imaging (fMRI) / Sensory integration

Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imagin

Final report - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imagin

DocumentHigher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.02
Location: Arquivo PCA - Pasta 18/2006
Title:
Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20071148
Abstract/Results: ABSTRACT:
This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Pariante, C., Navari, S., Aas, M., D'Albenzio, A., Di Forti, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., Papadopoulos, A., Aitchison, K. J., Murray, R., Dazzan, P.
Document type:
Article
Reference:
Mondelli, V., Pariante, C., Navari, S., Aas, M., D'Albenzio, A., ... Dazzan, P. (2010). Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis. Schizophrenia Research, 119(1-3), 75-8. doi: 10.1016/j.schres.2009.12.021
2-year Impact Factor: 4.374|2010
Times cited: 82|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Hippocampus / Psychosis / Hypothalamic-pituitary-adrenal axis / Schizophrenia / Glucocorticoids

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

DocumentNeurological abnormalities and cognitive ability in first-episode psychosis2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.03
Location: Arquivo PCA - Pasta 18/2006
Title:
Neurological abnormalities and cognitive ability in first-episode psychosis
Publication year: 2008
URL:
http://bjp.rcpsych.org/content/193/3/197.full.pdf+html
Abstract/Results: ABSTRACT:
BACKGROUND:
It remains unclear if the excess of neurological soft signs, or of certain types of neurological soft signs, is common to all psychoses, and whether this excess is simply an epiphenomenon of the lower general cognitive ability present in psychosis.
AIMS:
To investigate whether an excess of neurological soft signs is independent of diagnosis (schizophrenia v. affective psychosis) and cognitive ability (IQ).
METHOD:
Evaluation of types of neurological soft signs in a prospective cohort of all individuals presenting with psychoses over 2 years (n=310), and in a control group from the general population (n=239).
RESULTS:
Primary (P<0.001), motor coordination (P<0.001), and motor sequencing (P<0.001) sign scores were significantly higher in people with any psychosis than in the control group. However, only primary and motor coordination scores remained higher when individuals with psychosis and controls were matched for premorbid and current IQ.
CONCLUSIONS:
Higher rates of primary and motor coordination signs are not associated with lower cognitive ability, and are specific to the presence of psychosis.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
Lloyd, T., Morgan, K., Zanelli, J., Morgan, C., Orr, K., Hutchinson, G., Fearon, P., Allin, M., Rifkin, L., McGuire, P., Doody, G. A., Holloway, J., Leff, J., Harrison, G., Jones, P., Murray, R.
Document type:
Article
Reference:
Dazzan, P., Lloyd, T., Morgan, K., Zanelli, J., Morgan, C., ... Murray, R. (2008). Neurological abnormalities and cognitive ability in first-episode psychosis. British Journal of Psychiatry, 193(3), 197-202. doi: 10.1192/bjp.bp.107.045450
2-year Impact Factor: 5.007|2008
Times cited: 42|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Psychophysiology / Psychosis / Neurological signs / Cognitive ability

Neurological abnormalities and cognitive ability in first-episode psychosis

Neurological abnormalities and cognitive ability in first-episode psychosis

DocumentCombining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.04
Location: Arquivo PCA - Pasta 18/2006
Title:
Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pubmed/19627645
Abstract/Results: ABSTRACT:
BACKGROUND:
There is good evidence that psychotic symptoms segregate into symptom dimensions. However, it is still unclear how these dimensions are associated with risk indicators and other clinical variables, and whether they have advantages over categorical diagnosis in clinical practice. We investigated symptom dimensions in a first-onset psychosis sample and examined their associations with risk indicators and clinical variables. We then examined the relationship of categorical diagnoses to the same variables.
METHOD:
We recruited 536 patients as part of a population-based, incidence study of psychosis. Psychopathology was assessed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN). A principal axis factor analysis was performed on symptom scores. The relationship of dimension scores with risk indicators and with clinical variables was then examined employing regression analyses. Finally, regression models were compared to assess the contribution of dimensions versus diagnosis in explaining these variables.
RESULTS:
Factor analysis gave rise to a five-factor solution of manic, reality distortion, negative, depressive and disorganization symptom dimensions. The scores of identified dimensions were differentially associated with specific variables. The manic dimension had the highest number of significant associations; strong correlations were observed with shorter duration of untreated psychosis, acute mode of onset and compulsory admission. Adding dimensional scores to diagnostic categories significantly increased the amount of variability explained in predicting these variables; the reverse was also true but to a lesser extent.
CONCLUSIONS:
Categorical and dimensional representations of psychosis are complementary. Using both appears to be a promising strategy in conceptualising psychotic illnesses.
Accessibility: Document does not exist in file
Language:
eng
Author:
Demjaha, A.
Secondary author(s):
Morgan, K., Morgan, C., Landau, S., Dean, K., Reichenberg, A., Sham, P., Fearon, P., Hutchinson, G., Jones, P., Murray, R., Dazzan, P.
Document type:
Article
Reference:
Demjaha, A., Morgan, K., Morgan, C., Landau, S., Dean, K., Reichenberg, A., . . . Dazzan, P. (2009). Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11? Psychological Medicine, 39(12), 1943-1955. doi: 10.1017/S0033291709990651
2-year Impact Factor: 5.012|2009
Times cited: 58|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Diagnostic categories / Dimensions / Factor analysis / First-episode psychosis / Risk indicators

Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?

Combining dimensional and categorical representation of psychosis: the way forward for DSM-V and ICD-11?

DocumentAbnormal cortisol awakening response predicts worse cognitive function in patients with first episode psychosis2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.05
Location: Arquivo PCA - Pasta 18/2006
Title:
Abnormal cortisol awakening response predicts worse cognitive function in patients with first episode psychosis
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20529412
Abstract/Results: ABSTRACT:
BACKGROUND:
Cognitive impairment, particularly in memory and executive function, is a core feature of psychosis. Moreover, psychosis is characterized by a more prominent history of stress exposure, and by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In turn, stress exposure and abnormal levels of the main HPA axis hormone cortisol are associated with cognitive impairments in a variety of clinical and experimental samples; however, this association has never been examined in first-episode psychosis (FEP).
METHOD:
In this study, 30 FEP patients and 26 controls completed assessment of the HPA axis (cortisol awakening response and cortisol levels during the day), perceived stress, recent life events, history of childhood trauma, and cognitive function. The neuropsychological battery comprised general cognitive function, verbal and non-verbal memory, executive function, perception, visuospatial abilities, processing speed, and general knowledge.
RESULTS:
Patients performed significantly worse on all cognitive domains compared to controls. In patients only, a more blunted cortisol awakening response (that is, more abnormal) was associated with a more severe deficit in verbal memory and processing speed. In controls only, higher levels of perceived stress and more recent life events were associated with a worse performance in executive function and perception and visuospatial abilities.
CONCLUSIONS:
These data support a role for the HPA axis, as measured by cortisol awakening response, in modulating cognitive function in patients with psychosis; however, this association does not seem to be related to the increased exposure to psychosocial stressors described in these patients.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aas, M.
Secondary author(s):
Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A., Di Forti, M., Fisher, H., Handley, R., Hepgul, N., Marques, T. R., Miorelli, A., Taylor, H., Russo, M., Wiffen, B., Papadopoulos, A., Aitchison, K. J., Morgan, C., Murray, R., Pariante, C.
Document type:
Article
Reference:
Aas, M., Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A.,Di Forti, M., . . . Pariante, C. (2010). Abnormal cortisol awakening response predicts worse cognitive function in patients with firstepisode psychosis. Psychological Medicine, 41(3), 463-476. doi: 10.1017/S0033291710001170
2-year Impact Factor: 5.200|2010
Times cited: 77|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Cognition / Cortisol / Hypothalamic-pituitary-adrenal axis / Psychosis / Schizophrenia / Stress

DocumentStress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.06
Location: Arquivo PCA - Pasta 18/2006
Title:
Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume
Publication year: 2011
URL:
http://article.psychiatrist.com/dao_1-login.asp?ID=10007410&RSID=37650944020304
Abstract/Results: ABSTRACT:
BACKGROUND:
Reduced brain-derived neurotrophic factor (BDNF) levels have been reported in the serum and plasma of patients with psychosis. The aim of this cross-sectional case-control study was to investigate potential causes and consequences of reduced BDNF expression in these patients by examining the association between BDNF levels and measures of stress, inflammation, and hippocampal volume in first-episode psychosis.
METHOD:
Brain-derived neurotrophic factor, interleukin (IL)-6, and tumor necrosis factor (TNF)-a messenger RNA levels were measured in the leukocytes of 49 first-episode psychosis patients (DSM-IV criteria) and 30 healthy controls, all aged 18 to 65 years, recruited between January 2006 and December 2008. Patients were recruited from inpatient and outpatient units of the South London and Maudsley National Health Service Foundation Trust in London, United Kingdom, and the healthy controls were recruited from the same catchment area via advertisement and volunteer databases. In these same subjects, we measured salivary cortisol levels and collected information about psychosocial stressors (number of childhood traumas, number of recent stressors, and perceived stress). Finally, hippocampal volume was measured using brain magnetic resonance imaging in a subsample of 19 patients.
RESULTS:
Patients had reduced BDNF (effect size, d = 1.3; P < .001) and increased IL-6 (effect size, d = 1.1; P < .001) and TNF-a (effect size, d = 1.7; P < .001) gene expression levels when compared with controls, as well as higher levels of psychosocial stressors. A linear regression analysis in patients showed that a history of childhood trauma and high levels of recent stressors predicted lower BDNF expression through an inflammation-mediated pathway (adjusted R(2) = 0.23, P = .009). In turn, lower BDNF expression, increased IL-6 expression, and increased cortisol levels all significantly and independently predicted a smaller left hippocampal volume (adjusted R(2) = 0.71, P < .001).
CONCLUSIONS:
Biological changes activated by stress represent a significant factor influencing brain structure and function in first-episode psychosis through an effect on BDNF.
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Cattaneo, A., Belvederi Murri, M., Di Forti, M., Handley, R., Hepgul, N., Miorelli, A., Navari, S., Papadopoulos, A., Aitchison, K. J., Morgan, C., Murray, R., Dazzan, P., Pariante, C.
Document type:
Article
Reference:
Mondelli, V., Cattaneo, A., Belvederi Murri, M., Di Forti, M., Handley, R., ... Pariante, C. (2011). Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. Journal of Clinical Psychiatry, 72(12), 1677-1684. doi: 10.4088/JCP.10m06745
2-year Impact Factor: 5.799|2011
Times cited: 156|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Brain-derived neurotrophic factor (BDNF) / First-episode psychosis / Stress / Hippocampal volume

DocumentHypothalamic pituitary adrenal axis and clinical symptoms in first-episode psychosis2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.07
Location: Arquivo PCA - Pasta 18/2006
Title:
Hypothalamic pituitary adrenal axis and clinical symptoms in first-episode psychosis
Publication year: 2011
URL:
http://www.psyneuen-journal.com/article/PIIS030645301100268X/abstract?rss=yes
Abstract/Results: ABSTRACT:
BACKGROUND:
Abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported in patients with psychosis, but it is still unclear how these are related to the clinical symptomatology. Inconsistent findings have emerged from previous studies on the association between cortisol levels and clinical symptoms. Methodological and/or clinical factors, such as patients' diagnosis or illness phase, might partially account for these inconsistencies. The aim of this study was to investigate the association between HPA axis activity and clinical symptoms in first-episode psychosis, taking into account diagnosis and illness phase.
METHOD:
Saliva samples were collected in 55 subjects with first-episode psychosis to assess the Cortisol Awakening Response (CAR) and diurnal cortisol levels (AUC-DAY). Severity of symptoms was assessed with the Positive and Negative Syndrome Scale (PANSS). Scores for subscales and symptom dimensions were used as predictors in multivariate analyses in different diagnostic subgroups and in clinically remitted patients. In addition, a systematic review of the literature on this topic was conducted.
RESULTS:
In subjects with schizophrenia (n=36), the CAR was predicted by the severity of positive symptoms (beta=0.47, p=0.04); in subjects with depressive psychoses (n=8) the CAR was predicted by excitement (beta=0.58, p=0.005), disorganization (beta=0.39, p=0.007) and depressive symptoms (beta=0.32, p=0.005). In patients with bipolar psychoses (n=11) AUC-DAY was predicted negatively by disorganization (beta=-2.82, p=0.009) and positively by excitement (beta=2.06, p=0.009) and positive symptoms (beta=1.28, p=0.02). In the sample in clinical remission (n=9), the CAR was associated with the severity of positive symptoms (beta=1.34, p=0.009) and, negatively, with excitement (beta=-1.05, p=0.04). The systematic review (on a total of 28 papers, including n=1022 patients), found that in patients with psychosis cortisol levels have been associated with the severity of multiple symptom dimensions.
CONCLUSIONS:
HPA axis activity is associated with the severity of multiple types of symptoms in first-episode psychosis. Patients' diagnosis and clinical phase partially influence these associations.
Accessibility: Document does not exist in file
Language:
eng
Author:
Belvederi Murri, M.
Secondary author(s):
Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., Mondelli, V.
Document type:
Article
Reference:
Belvederi Murri, M., Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., & Mondelli, V. (2011). Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis. Psychoneuroendocrinology, 37(5), 629-644. doi: 10.1016/j.psyneuen.2011.08.013
2-year Impact Factor: 5.809|2011
Times cited: 58|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Cortisol awakening response / Hypothalamic-pituitary-adrenal axis / Symptoms / Psychosis / Schizophrenia / Bipolar / Depression / Diagnosis / Remission / Neuroendocrinology

DocumentChildhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.08
Location: Arquivo PCA - Pasta 18/2006
Title:
Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients
Publication year: 2011
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8656010&fulltextType=RA&fileId=S0033291711002947
Abstract/Results: ABSTRACT:
BACKGROUND:
The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls.
METHOD:
Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors.
RESULTS:
Patients with childhood maltreatment had higher BMI [25.0 (S.E.=0.6) kg/m2] and C-reactive protein (CRP) levels [1.1 (S.E.=0.6) mg/dl] when compared with healthy controls [23.4 (S.E.=0.4) kg/m2, p=0.030 and 0.2 (S.E.=0.1) mg/dl, p=0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (S.E.=0.6) kg/m2, p=0.07] or CRP levels [0.5 (S.E.=0.2) mg/dl, p=0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F 2,58=3.6, p=0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue.
CONCLUSIONS:
Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Hepgul, N.
Secondary author(s):
Pariante, C., Dipasquale, S., Di Forti, M., Taylor, H., Marques, T. R., Morgan, C., Dazzan, P., Murray, R., Mondelli, V.
Document type:
Article
Reference:
Hepgul, N., Pariante, C., Dipasquale, S., Di Forti, M., Taylor, H., Marques, T. R., . . . Mondelli, V. (2012). Childhood maltreatment is associated with increased body mass index and increased C-reactive protein levels in first-episode psychosis patients. Psychological Medicine, 42(9), 1893-1901. doi: 10.1017/S0033291711002947
2-year Impact Factor: 5.587|2012
Times cited: 50|2020-03-11
Indexed document: Yes
Quartile: Q1
Keywords: Body mass index / Childhood maltreatment / Inflammation / Metabolic syndrome / Psychosis

DocumentNeural correlates of audio-visual integration: An fMRI study2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.09
Location: Arquivo PCA - Pasta 18/2006
Title:
Neural correlates of audio-visual integration: An fMRI study
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Handley, R.
Secondary author(s):
Reinders, S., Marques, T. R., Pariante, C., McGuire, P., Dazzan, P.
Document type:
Abstract
Reference:
Handley, R., Reinders, S., Marques, T. R., Pariante, C., McGuire, P., & Dazzan, P. (2008). Neural correlates of audio-visual integration: An fMRI study. Early Intervention in Psychiatry, 2(Suppl. 1), A97. doi: 10.1111/j.1751-7893.2008.00096.x
2-year Impact Factor: 1.169|2010
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Psychophysiology / Sensory integration / Functional magnetic resonance imaging (fMRI)

DocumentNeural correlates of audio-visual integration: An fMRI study2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.10
Location: Arquivo PCA - Pasta 18/2006
Title:
Neural correlates of audio-visual integration: An fMRI study
Publication year: 2008
Accessibility:
Document does not exist in file
Language:
eng
Author:
Handley, R.
Secondary author(s):
Reinders, S., Marques, T. R., McGuire, P., Pariante, C., Dazzan, P.
Document type:
Abstract
Reference:
Handley, R., Reinders, S., Marques, T. R., McGuire, P., Pariante, C., & Dazzan, P. (2008). Neural correlates of audio-visual integration: An fMRI study. Schizophrenia Research, 102(1, Suppl. 2), 105. doi: 10.1016/S0920-9964(08)70316-5
2-year Impact Factor: 4.374|2010
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Psychophysiology / Sensory integration / Functional magnetic resonance imaging (fMRI)

DocumentPsychosis, neurological soft signs and their meaning2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.11
Location: Arquivo PCA - Pasta 18/2006
Title:
Psychosis, neurological soft signs and their meaning
Publication year: 2009
URL:
http://library.wfsbp.org/fileadmin/user_upload/wfsbp2009-abstracts.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure.
METHODS:
We evaluated 49 individuals (mean age 27 years +-8; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods.
RESULTS:
Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (p=0.007).
Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (p=0.05 and p=0.072 respectively).
CONCLUSIONS:
Primary and motor coordination deficits may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dazzan, P.
Document type:
Abstract book
Reference:
Dazzan, P. (2009). Psychosis, neurological soft signs and their meaning. In Abstracts of the 9th World Congress of Biological Psychiatry (pp. 47-48). Paris, France: World Federation of Societies of Biological Psychiatry. doi: 10.3284/wfsbp.2009.1
Indexed document: No
Keywords: Neurological signs / Psychosis / Brain structure / Functional magnetic resonance imaging (fMRI)

Psychosis, neurological soft signs and their meaning

Psychosis, neurological soft signs and their meaning

DocumentChanges in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.12
Location: Arquivo PCA - Pasta 18/2006
Title:
Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results: ABSTRACT:
Introduction: An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure. Methods: We evaluated 49 individuals (mean age 27 years 68; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods. Results: Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (P = .007). Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (P = .05 and P = .07 respectively). Conclusions: Primary and motor coordination deficits
may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., Hutchinson, G., McGuire, P., Jones, P., Leff, J., Fearon, P., Murray, R., Lappin, J.
Document type:
Abstract
Reference:
Dazzan, P., Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., . . . Lappin, J. (2009). Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode. Schizophrenia Bulletin, 35(Suppl. 1), 207-207.
2-year Impact Factor: 8.800|2011
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Neurological signs / Psychosis / Schizophrenia / Functional magnetic resonance imaging (fMRI) / Trait markers

Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode

Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode

DocumentStress and the hypothalamic pituitary adrenal axis activity in first episode psychosis2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.13
Location: Arquivo PCA - Pasta 18/2006
Title:
Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
Hypothalamic-pituitary-adrenal (HPA) axis is the main biological system involved in the stress response. The aim of our study was to evaluate objective and subjective stress together with HPA axis activity in first-episode psychosis patients and healthy controls.
METHODS:
We recruited 40 first-episode psychosis patients (mean +/- SEM age: 29.4 +/-1.2 yrs; gender: 35% females) and 30 controls (mean age: 27.4 +/- 1.0 yrs; gender: 23.3% females) as part of the large Genetic And Psychosis (GAP) study, carried out in South London. Information about childhood trauma, recent stressful events and perceived stress were collected using validated schedules. Salivary cortisol was obtained at awakening, at 15, 30, and 60 minutes after awakening, and at 12 pm, and 8 pm. We calculated the Areas Under the Curve to investigate the cortisol levels during the day and the cortisol response to awakening. An independent t-test and was used to analyze differences in the stress variables and cortisol secretion. Correlation analyses were run to investigate the association between stress variables and cortisol secretion.
RESULTS:
First-episode psychosis patients reported more childhood trauma, recent stressful events, and higher perceived stress compared with controls (P < .001). Patients showed no significant difference in cortisol levels during the day compared with controls (P = .2). However, patients showed a significantly lower cortisol awakening response than controls (P = .034). A positive correlation was found between number of recent stressors or perceived stress and cortisol during the day in controls (r = .377, P = .04 and r = .321, P = .08). In contrast, a negative correlation between number of recent stressors or perceived stress and cortisol during the day was found in patients (r = -.413, P = .01 and r = -.356, P = .04).
CONCLUSIONS:
Our data show that first episode psychosis patients have higher number of stressful events but similar cortisol levels during the day when compared with healthy controls. First episode psychosis patients have an impaired HPA axis response to stress as shown by the blunted cortisol response to awakening and by the negative correlation between measures of recent stress and cortisol secretion during the day.
ACKNOWLEDGMENT:
This research is funded by NARSAD Mental Health Research Association, British Academy, and NIHR Biomedical Research Centre Institute of Psychiatry (Kings’ College London).
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Aas, M., D'Albenzio, A., Di Forti, M., Di Nicola, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., David, A. S., Dazzan, P., Murray, R., Pariante, C.
Document type:
Abstract
Reference:
Mondelli, V., Aas, M., D’Albenzio, A., Di Forti, M., Di Nicola, M., Handley, R., . . . Pariante, C. (2009). Stress and the hypothalamic-pituitary-adrenal axis activity in first episode psychosis. Schizophrenia Bulletin, 35(Suppl. 1), 149-149.
2-year Impact Factor: 8.800|2011
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Hypothalamic-pituitary-adrenal axis / Stress / First-episode psychosis / Childhood trauma

Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis

Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis

DocumentThe effects of haloperidol and aripiprazole on audio-visual matching in healthy volunteers: an fMRI study2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.14
Location: Arquivo PCA - Pasta 18/2006
Title:
The effects of haloperidol and aripiprazole on audio-visual matching in healthy volunteers: an fMRI study
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results: ABSTRACT:
Deficits in the integration of information from different sensory modalities are present in excess in patients with schizophrenia. The contribution of antipsychotic medication to such deficits, independent of the pathophysiology of the disorder, remains poorly understood. This study investigates the functional impact of antipsychotics in healthy volunteers. Haloperidol (3mg) and Aripiprazole (10mg) were administered to 10 healthy Caucasian, right handed males (age: 21, SD:3) in a repeated measures, counterbalanced placebo controlled design. Volunteers had no past psychiatric history and abstained from smoking and recreational drug use for at least 3 months prior to the study. Images were acquired on a 1.5T scanner whilst a computerised version of the audio-visual integration sub-test of the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989) was administered. In this task volunteers listened to an auditory paced tone sequence (varying in length), then selected either the visual representation of the auditory sequence from three different options, or selected the ‘forced choice’. Random effects analysis was performed in SPM5. Haloperidol significantly reduced overall activation in the left superior and right middle temporal gyri and left cerebellum compared with placebo, and in the right superior temporal gyrus and left cerebellum compared with Aripiprazole. In the experimental relative to control condition, activation was greater after Aripiprazole in the right insula compared with Haloperidol and in the cerebellum bilaterally, compared with placebo. Reduced activation in the right inferior frontal gyrus was observed in the experimental relative to rest condition, in the Haloperidol group compared with placebo. In accordance with the literature in individuals with psychosis, compared with placebo and Aripiprazole, Haloperidol was associated with reduced activation in regions known to be involved in audio-visual matching (frontal, temporal, cerebellar, insula). Although structural abnormalities in these areas have been identified in patients, evidence for the contribution of antipsychotics
to sensory integration deficits are mixed. These findings indicate that sensory integration functioning is altered by even a single dose of antipsychotic medication. This implicates a role for antipsychotics in sensory integration deficits observed in treated patients with Schizophrenia.
Accessibility: Document does not exist in file
Language:
eng
Author:
Handley, R.
Secondary author(s):
Reinders, S., Marques, T. R., Pariante, C., McGuire, P., Dazzan, P.
Document type:
Abstract
Reference:
Handley, R., Reinders, S., Marques, T. R., Pariante, C., McGuire, P., & Dazzan, P. (2009). The effects of haloperidol and aripiprazole on audio-visual matching in healthy volunteers: an fMRI study. Schizophrenia Bulletin, 35(Suppl. 1), 184-185.
2-year Impact Factor: 8.800|2011
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Antipsychotics / Healthy volunteers / Sensory integration functioning / Schizophrenia

The effects of haloperidol and aripiprazole on audio-visual matching in healthy volunteers: an fMRI study

The effects of haloperidol and aripiprazole on audio-visual matching in healthy volunteers: an fMRI study

DocumentIs there a link between a history of childhood trauma and cognitive impairment in first-episode psychosis?2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.15
Location: Arquivo PCA - Pasta 18/2006
Title:
Is there a link between a history of childhood trauma and cognitive impairment in first-episode psychosis?
Publication year: 2009
URL:
http://conferenceservices.elsevier.nl/09ecnp/index.cfm?fuseaction=CIS2002&hoofdnav=Search&content=zk.results_all&topicselected=*&searchtext=Aas&what=AUTHOR&selection=ALL&abstrnbr=P.7.a.007
Abstract/Results: ABSTRACT:
BACKGROUND:
Previous research show that a history of childhood trauma is more prevalent in people suffering from psychosis compared with the general population. Childhood trauma has also been linked to cognitive abnormalities in adulthood, and cognitive abnormalities, in turn, are one of the key clinical features of psychosis. Therefore, the aim of this study is to test whether there is a relationship between childhood trauma and cognitive function in patients with first episode psychosis.
METHODS:
We recruited 50 patients with first episode psychosis (mean±age:28.6±8.1; gender 62% males) and 60 controls (age: 26.5±5.5 yrs; gender: 58.3% males) as part of the large Genetic and Psychosis (GAP) study, carried out in South London. 6 of the patients were drug naive or medication free, 39 were on atypical antipsychotics, and 5 were on typical antipsychotic. Information about a history of childhood physical abuse, sexual abuse, separation and loss (up to and including age 11) were obtained by the Childhood Experience of Care and Abuse Questionnaire (CECA.Q). Furthermore, patients and controls underwent neuropsychological assessments from the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), several working memory and executive tasks, together with the Wechsler Memory Scale-Third Edition (WMS-III), and the National Adult Reading Test (NART). Chi-square test was used to compare categorical variables (e.g. childhood trauma) between patients and controls. Pearson's correlation was used to investigate the relationship between childhood trauma and cognitive function. Furthermore, a one way ANOVA was performed to covariate for possible confounders, such as education, ethnicity, Premorbid IQ, medication, and diagnosis in the patients (schizophreniform versus “other psychosis”).
RESULTS:
As expected, patients scored significantly worse on all the cognitive tasks presented compared to controls (p < 0.05), and showed a significantly higher incidence of childhood trauma than controls (p = 0.008). Particularly, two types of childhood trauma, physical and sexual abuse were related to worse cognitive performance in a dose dependent manner for specific task from the WAIS-III (Block design, r = -0.26, p = 0.077), and working memory tasks/executive function (trail B; r = 0.30, p = 0.054; trail B-A; r = 0.36, p = 0.020, Spatial Working Memory strategy; r = 0.33, p = 0.028, and Stockings of Cambridge mean subsequent thinking time; r = 0.30, P = 0.048). Also in controls, a negative correlation was observed between particular types of childhood trauma and cognitive function.
CONCLUSIONS:
Our data suggest that patients with first episode psychosis with a history of childhood trauma of physical or sexual abuse show greater cognitive impairment on several cognitive domains, particularly working memory, compared to patients without childhood trauma. The data presented above could be part of a possible understanding of the aetiology of cognitive dysfunction in psychosis.
Acknowledgment: This research is funded by the British Academy and the South London and Maudsley NHS Foundation Trust & Institute of Psychiatry NIHR Biomedical Research Centre for Mental Health.
REFERENCES:
1. Perez, C. M., Widom, C. S., 1994. Childhood victimization and long-term intellectual and academic outcomes. Child Abuse Negl. 18, 617–633.
2. Read, J., van, O. J., Morrison, A. P., Ross, C. A., 2005. Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatr. Scand. 112, 330–350.
3. Reichenberg, A., Harvey, P. D., 2007. Neuropsychological impairments in schizophrenia: Integration of performance-based and brain imaging findings. Psychol. Bull. 133, 833–858.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aas, M.
Secondary author(s):
Mondelli, V., Reichenberg, A., Di Forti, M., Wiffen, B., Handley, R., Taylor, H., Murray, R., Dazzan, P., Pariante, C.
Document type:
Abstract
Reference:
Aas, M., Mondelli, V., Reichenberg, A., Di Forti, M., Wiffen, B., Handley, R., . . . Pariante, C. (2009). Is there a link between a history of childhood trauma and cognitive impairment in first-episode psychosis? European Neuropsychopharmacology, 19(Suppl. 3), S682-S682.
2-year Impact Factor: 4.406|2011
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: History / Schizophrenia / Clinical / Stress

DocumentThe effect of stress and antipsychotic treatment on inflammatory and metabolic markers in first-episode psychosis2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.16
Location: Arquivo PCA - Pasta 18/2006
Title:
The effect of stress and antipsychotic treatment on inflammatory and metabolic markers in first-episode psychosis
Publication year: 2009
URL:
http://conferenceservices.elsevier.nl/09ecnp/index.cfm?fuseaction=CIS2002&hoofdnav=Search&content=zk.results_all&topicselected=*&searchtext=Aas&what=AUTHOR&selection=ALL&abstrnbr=P.3.a.011
Abstract/Results: ABSTRACT:
BACKGROUND:
The high incidence of metabolic syndrome and physical illness in patients with psychosis has been mainly attributed to the treatment with antipsychotics (Allison and Casey, 2001). However, it has been recently suggested that psychological stress may also play a role in physical illnesses, inducing a chronic inflammatory process which may predispose to the development of metabolic abnormalities and cardiovascular problems (Dinan, 2004; Black, 2003). The aim of this cross-sectional study was to investigate the association between stress, inflammatory and metabolic markers in subjects with first episode psychosis and healthy controls.
METHODS:
We recruited 30 first episode psychosis patients (mean±SEM age: 27.7±1.0 years; gender: 66.7% males) and 30 healthy controls (age: 26.3±0.7 years; gender: 70% males) as part of the large “Genetics And Psychosis” study carried out in South-East London. We collected information about childhood trauma, recent stressful events and perceived stress, using Childhood Experience of Care and Abuse (CECA) questionnaire, the Brief Life Events Questionnaire and the Perceive Stress Scale. We measured weight, height, body mass index (BMI), waist circumference, and collected blood samples to measure leptin, IL-6, TNF-a, HbA1c, total cholesterol, HDL, LDL, triglycerides, hs-CRP levels in all subjects. An independent t-test was used to analyze differences in these parameters between patients and controls. In order to investigate the possible effect of antipsychotic treatment, a one-way ANOVA was conducted to analyze differences in inflammatory and metabolic parameters among controls, patients with less than 2 weeks of antipsychotic treatment and patients with more that 2 weeks of treatment. Correlation analyses were conducted to investigate the association between stress measurements and inflammatory and metabolic parameters. Results are expressed as mean±SEM.
RESULTS:
Patients had higher levels of stress and childhood trauma compared with controls (p < 0.001). Patients showed significantly higher leptin (17.2±3.5 vs 5.7±1.0 ng/ml, p = 0.002) and hsCRP levels (0.6±0.2 vs 0.1±0.1 mg/dl, p = 0.048) while they did not differ significantly in other inflammatory or metabolic parameters. Patients with less than 2 weeks of antipsychotic treatment presented significantly higher IL-6 levels (5.7±2.3 pg/ml) when compared with both patients treated for longer than 2 weeks (1.4±0.3 pg/ml) and controls (1.5±0.4 pg/ml, p = 0.006). Both patients with less and more than 2 weeks of treatment presented higher leptin levels compared with controls (respectively 16.2±8.7, 17.8±2.9 and 5.7±1.0 ng/ml, p = 0.008). The number of stressful life events was significantly positively correlated with triglycerides levels (p = 0.04) and negatively with HDL (p = 0.04) and leptin levels (p = 0.04) in the patients' group. Patients reporting childhood trauma, in particular physical and sexual abuse, had greater weight (p = 0.03) and waist circumference (p = 0.07).
CONCLUSION:
Our findings suggest that an activation of the inflammatory system is already present in early course of psychosis and precedes clinically relevant changes in metabolic status, which have been observed in patients after longer antipsychotic treatment. Stressful events only partially influence metabolic parameters in first episode psychosis, and this effect does not seem mediated by the inflammatory markers explored in this study. Further studies are needed to clarify underlying mechanisms.
Acknowledgement: This research is funded by NARSAD Mental Health Research Association, British Academy, and NIHR Biomedical Research Centre Institute of Psychiatry (King's College London).
REFERENCES:
1. Allison DB, Casey DE (2001). Antipsychotic-induced weight gain: a review of the literature. J Clin Psychiatry, 62(suppl &):22–31.
2. Black PH (2003). The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain Behav Immun, 17(5):350–64.
3. Dinan T (2004). Stress and the genesis of diabetes mellitus in schizophrenia. Br J Psychiatry Suppl, 47:S72–5.
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Aas, M., Di Forti, M., Fisher, H., Handley, R., Reis Marques, T., Taylor, H., Dazzan, P., Murray, R., Pariante, C.
Document type:
Abstract
Reference:
Mondelli, V., Aas, M., Di Forti, M., Fisher, H., Handley, R., Reis Marques, T., Taylor, H., Dazzan, P., Murray, R., & Pariante, C. (2009). The effect of stress and antipsychotic treatment on inflammatory and metabolic markers in first-episode psychosis. European Neuropsychopharmacology, 19(Suppl. 3), S486-S486.
2-year Impact Factor: 4.406|2011
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Neuroleptics / Antipsychotics / Clinical / Schizophrenia / Stress

DocumentThe effects of single dose aripiprazole and haloperidol on resting blood flow in healthy volunteers2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.17
Location: Arquivo PCA - Pasta 18/2006
Title:
The effects of single dose aripiprazole and haloperidol on resting blood flow in healthy volunteers
Publication year: 2009
URL:
http://conferenceservices.elsevier.nl/09ecnp/index.cfm?fuseaction=CIS2002&hoofdnav=Search&content=zk.results_all&topicselected=*&searchtext=Handley&what=AUTHOR&selection=ALL&abstrnbr=P.3.d.012
Abstract/Results: ABSTRACT:
The direct effects of typical and atypical antipsychotics on blood flow remain unclear. PET, SPECT and cerebrography have been used to indirectly explore the effects of antipsychotic drugs on blood flow by studying metabolism. These studies suggest that typical and atypical antipsychotics may have differential effects in the striatal and frontal cortices but more similar effects on temporal cortex metabolism. Unfortunately, most studies have evaluated individuals with psychosis in which the pathology of the disorder and previous antipsychotic treatment history play a role in the findings. Furthermore, most studies have not directly compared the effects of typical and atypical antipsychotics. In this study we directly compare the differential effects of typical and atypical antipsychotics on resting blood flow in healthy individuals. Studying healthy individuals, in whom perfusion alterations are not confounded by pathophysiological factors, allows us to better estimate the direct effects of these drugs on brain physiology.
Single doses of haloperidol (3 mg) and aripiprazole (10 mg) were administered to 17 healthy Caucasian, right handed males (mean age 23yrs, SD3) in a repeated measures, randomised, double-blind, placebo controlled design. Volunteers had no current or past psychiatric history themselves or in their first degree relatives. Volunteers abstained from substance use and smoking for at least 3 months prior to the study. Four hours post treatment, a continuous arterial spin labeling sequence was used to obtain a direct measure of blood flow using a 1.5 Tesla scanner. Sixty-four volumes were acquired with a slice thickness of 3.3 mm (including inter-slice gap) over 6 minutes. A perfusion-weighted image was produced via the subtraction of the image in which blood had been labeled from that in which it had not and co-registered with a high resolution structural image. Between-subject analysis was performed on global perfusion using a random effects model at the second level.
Compared with placebo, haloperidol significantly increased perfusion in the putamen bilaterally, in the right parahippocampal gyrus and in the medial frontal cortex bilaterally (p < 0.001, corrected; effect size=0.8). Compared with placebo, aripiprazole increased perfusion in the left putamen only (p < 0.001, corrected; effect size=0.6).
Similar to the findings for metabolism in patients, striatal blood flow increased with both typical and atypical antipsychotics. This change was more widespread following haloperidol. Unexpectedly, haloperidol was also associated with increased blood flow in the frontal and temporal regions, whereas no such changes were found following aripiprazole.
This study provides the first evidence that regional, antipsychotic-specific alterations in rCBF occur within 4 hours of administration of a single antipsychotic dose in healthy volunteers. Furthermore, these alterations in perfusion are independent from pathophysiological processes, and provide important insight into basal brain function in populations receiving different antipsychotic medications.
The findings have important implications for the interpretation of functional and structural imaging findings in schizophrenia and for understanding the different side effect profiles for these drugs.
Accessibility: Document does not exist in file
Language:
eng
Author:
Handley, R.
Secondary author(s):
Zelaya, F., Reinders, S., Marques, T. R., Kapur, S., Murray, R., McGuire, P., Williams, S., Pariante, C., Dazzan, P.
Document type:
Abstract
Reference:
Handley, R., Zelaya, F., Reinders, S., Marques, T. R., Kapur, S., Murray, R., McGuire, P., Williams, S., Pariante, C., & Dazzan, P. (2009). The effects of single dose aripiprazole and haloperidol on resting blood flow in healthy volunteers. European Neuropsychopharmacology, 19(Suppl. 3), S560-S561.
2-year Impact Factor: 4.046|2011
Times cited: 0|2019-06-07
Indexed document: Yes
Keywords: Neuroimaging / Neuroleptics / Antipsychotics / Schizophrenia / Functional magnetic resonance imaging (fMRI)

DocumentThe psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.18
Location: Arquivo PCA - Pasta 18/2006
Title:
The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
This project investigated the anatomical and functional correlates of one of the few objective clinical correlate of psychosis, neurological abnormalities. These are abnormalities of sensory and motor function found in excess in patients with psychosis, and, to a lesser extent, in the general population. These neurological abnormalities may represent a specific clinical sign of the perturbed cortical-subcortical connectivity that putatively underlies psychotic disorders.
METHODS:
In a sample of patients at the first-episode of psychosis and in healthy controls we evaluated neurological function in four functional areas: 1) “Primary neurological dysfunction” (dysfunction that can be identified by a standard neurological examination); 2) “Sensory integration dysfunction” (dysfunction in the integration of sensory information); 3) “Motor coordination dysfunction” (motor incoordination); 4) “Motor sequencing dysfunction” (performance of complex motor sequences). We also used: structural Magnetic Resonance Imaging (sMRI) to estimate volumes of grey and white matter, and cerebro-spinal fluid (CSF); Diffusion Tensor Imaging (DTI) and DTI Tractography to estimate white matter integrity of Corpus Callosum, Uncinate Fasciculus, Inferior Fronto-occipital Fasciculus, Inferior Longitudinal Fasciculus; functional Magnetic Resonance Imaging (fMRI) for brain activation during an Audio-visual integration task and a Motor movement task.
RESULTS:
A total of 54 patients and 46 healthy individuals were recruited in the study. Patients showed significantly higher scores than healthy individuals in all areas of neurological performance (p<0.05), with the exception of motor coordination. Global volumes of grey and white matter, and CSF were not correlated with performance on any neurological subscale. In contrast, a worse performance in Primary signs was consistently associated with disruption of white matter integrity of the Corpus Callosum (p=0.05), Uncinate fasciculus (p=0.059), Inferior Fronto-Occipital fasciculus (p=0.049), and Inferior Longitudinal fasciculus (p=0.01).
CONCLUSIONS:
Neurological signs in psychoses are likely to reflect the alteration in connectivity that has been suggested to be one of the key pathophysiological processes occurring in these disorders. In the next step, the analysis will focus on the functional data, to evaluate whether the areas connected by these tracts are also impaired in function.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Document type:
Conference abstract
Reference:
Dazzan, P., McGuire, P., Pariante, C., Di Forti, M., Lappin, J., & Mondelli, V. (2010). The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 204). Porto: Fundação Bial.
Indexed document: No
Keywords: Neurological signs / Schizophrenia / Psychosis / Functional magnetic resonance imaging (fMRI) / Diffusion tensor imaging (DTI)

The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging

DocumentPsychometric comparability of self-report by children aged 9–10 versus 11 years on the Strengths and Difficulties Questionnaire (SDQ)2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.19
Location: Arquivo PCA - Pasta 18/2006
Title:
Psychometric comparability of self-report by children aged 9–10 versus 11 years on the Strengths and Difficulties Questionnaire (SDQ)
Publication year: 2019
URL:
https://link.springer.com/article/10.1007/s12187-019-09633-7#citeas
Abstract/Results: ABSTRACT
The 25-item Strengths and Difficulties Questionnaire (SDQ) is a popular screening instrument that assesses childhood psychopathology and prosocial behaviour. While the value of acquiring multi-informant perspectives in the assessment of childhood psychopathology is recognised, the use of the self-report version of the questionnaire is recommended only for children aged 11 years and older. This study aimed to evaluate the psychometric comparability of self-report on the SDQ by children aged 9–10 years relative to children aged 11 years using item response modelling. Item response models were used in a community sample of 7959 children to investigate the structure, item characteristics, and age differences related to self-report by children aged 9–10 years (n?=?6004), relative to children aged 11 years (n?=?1955), on the SDQ. Internalizing, externalizing, and prosocial factors explained the covariance of the questionnaire items. There were statistically significant age-related differences on only two items (the “worries” and “distractible” items), but these differences were small in magnitude and did not affect the precision of measurement of the SDQ. Self-report by children aged 9 and 10 years on the SDQ is psychometrically comparable to reports by children aged 11 years after controlling for differences in latent severity. This work expands the utility of the self-report SDQ to children aged as young as 9 years.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2012-194.10
Author: Hobbs, M.
Secondary author(s):
Laurens, K.
Document type:
Article-d
Reference:
Hobbs, M., & Laurens, K. (2020). Psychometric comparability of self-report by children aged 9–10 versus 11 years on the Strengths and Difficulties Questionnaire (SDQ). Child Indicators Research, 3, 301–318. doi: 10.1007/s12187-019-09633-7
2-year Impact Factor: 1.656|2018
Impact factor notes: Impact factor not available yet for 2019
Times cited: 2|2020-04-03
Indexed document: Yes
Quartile: Q2
Keywords: Differential item functioning / Latent structure / Development / Psychopathology / Community screening