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File134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning2007-012010-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

DocumentFinal report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.01
Location: Arquivo PCA - Pasta 11/2006
Title:
Final report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa13406.pdf
Abstract/Results: RESULTS:
The data obtained in this project originates the following conclusions:
Chronic exposure to stress results in impaired goal-directed behavior and increased predisposition for habitual strategies.
Chronic stress triggers a divergent structural reorganization of corticostriatal circuits, suggesting that the induced damage to the associative network drives behavioral control to the more wired sensorimotor circuit. Our electrophysiological data in vivo indicates that the structural reorganization of corticostriatal circuits following chronic stress causes changes in neuronal activity in these networks.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Sousa, N.
Document type:
Final report
Indexed document:
No
Keywords: Psychophysiology / Chronic stress / Corticosteroids

Final report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

Final report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

DocumentChronic stress causes frontostriatal reorganization and affects decision-making2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.02
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress causes frontostriatal reorganization and affects decision-making
Publication year: 2009
URL:
http://www.sciencemag.org/content/325/5940/621.abstract
Abstract/Results: ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Sousa, J., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J., Costa, R. M., Sousa, N.
Document type:
Article
Reference:
Dias-Ferreira, E., Sousa, J., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J., ... Sousa, N. (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science, 325(5940), 621-625. doi: 10.1126/science.1171203
2-year Impact Factor: 29.747|2009
Times cited: 455|2020-03-10
Indexed document: Yes
Quartile: Q1
Keywords: Psychophysiology / Stress / Chronic stress / Decision-making / Striatum

DocumentChronic stress causes corticostriatal reorganization and affects decision-making2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.03
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress causes corticostriatal reorganization and affects decision-making
Publication year: 2008
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=f8fdb142-74dd-4797-95a8-b588d7016d51&cKey=78c9c63c-a5d0-4448-adcc-3a016fdd759d&mKey=%7bAFEA068D-D012-4520-8E42-10E4D1AF7944%7d
Abstract/Results: ABSTRACT:
Maladaptive responses to stress depend on the intensity and duration of stressors; chronic exposure to stressful events has been shown to predispose to several conditions raging from neuropsychiatric disorders to everyday lapses of attention. Several reports implicate chronic stress in executive function impairment. In this study, we investigated the impact that chronic stress (21 days of chronic unpredictable stress (CUS)) would have on corticostriatal circuits, which are critical for decision making. By 3-D analysis of Golgi stained neurons, we confirmed our previous results indicating that exposure to chronic stress results in dramatic reductions in the total length of apical dendrites in the pyramidal neurons in layer II/III of the prelimbic (PL) and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC). Interestingly, the impact of chronic stress on the striatum was not uniform: while we found a significant increase in the total length of dendrites in the medium spiny neurons (MSNs) of the dorsolateral striatum (DLS, or sensorimotor striatum), there was a trend to a decrease in the total length of dendrites in MSNs of the dorsomedial striatum (DMS). Taken together these data suggest that chronic stress causes opposing structural changes in associative and sensorimotor corticostriatal networks. These different circuits have been implicated in different types of actions: the PL cortex and the DMS have been implicated in goal-directed actions, which depend on the relation between the execution of the action and potential outcomes, and on the expected value of those outcomes. In contrast, the DLS has been implicated in the formation of habits, which are insensitive to changes in outcome value and changes in the contingency between action and outcome. Therefore, it is conceivable that chronic stress could play a role in decision-making driving the behavior control from actions to habits. In order to test this hypothesis, rats submitted to chronic stress were trained to press a lever for specific outcomes and subsequently tested for their action-outcome behavior. Using two different behavioral assays, we found that responses from animals submitted to chronic stress became insensitive to both outcome devaluation and contingency degradation. Taken together, our data suggests that chronic stress causes a dramatic structural reorganization of corticostriatal circuits, which results in impaired goal-directed behavior and increased predisposition for habit formation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Sousa, J., Melo, I., Mesquita, A. R., Cerqueira, J., Costa, R. M., Sousa, N.
Document type:
Online abstract
Reference:
Dias-Ferreira, E., Sousa, J., Melo, I., Mesquita, A. R., Cerqueira, J., Costa, R. M., & Sousa, N. (2008). Chronic stress causes corticostriatal reorganization and affects decision-making. Program No. 195.5/UU54. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience. Online.
Indexed document: No
Keywords: Chronic stress / Decision-making / Striatum / Corticosteroids

DocumentChronic stress affects decision-making strategies: Structural and physiological correlates2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.04
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress affects decision-making strategies: Structural and physiological correlates
Publication year: 2009
URL:
http://www.frontiersin.org/10.3389/conf.neuro.01.2009.11.008/event_abstract
Abstract/Results: ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats and mice submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, we found that chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). In addition, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:
Online abstract
Reference:
Dias-Ferreira, E., Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Chronic stress affects decision-making strategies: Structural and physiological correlates. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.008
Indexed document: No
Keywords: Psychophysiology / Chronic stress / Decision-making / Striatum / Corticosteroids

DocumentPhysiological correlates of chronic stress-induced bias in behavioral strategies2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.05
Location: Arquivo PCA - Pasta 11/2006
Title:
Physiological correlates of chronic stress-induced bias in behavioral strategies
Publication year: 2009
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=80a99356-34a9-4640-a575-08d0e09e6fbf&cKey=4580efbc-0687-4abc-9b00-c7a4909f06ef&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d
Abstract/Results: ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. We previously showed that chronic stress biases decision-making strategies, affecting the ability of stressed rats to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats and now confirmed for mice submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). Therefore, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Sousa, J., Jin, X., Melo, I., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:
Online abstract
Reference:
Dias-Ferreira, E., Sousa, J., Jin, X., Melo, I., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Physiological correlates of chronic stress-induced bias in behavioral strategies. Program No. 476.7/FF47. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. Online.
Indexed document: No
Keywords: Corticosterone / Decision-making / Multielectrode recordings

DocumentChronic stress affects decision-making strategies: Structural and physiological correlates2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.06
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress affects decision-making strategies: Structural and physiological correlates
Publication year: 2009
URL:
http://www.frontiersin.org/10.3389/conf.neuro.06.2009.03.348/39/Computational_and_systemsneu/all_events/event_abstract
Abstract/Results: ABSTRACT:
The stress response is vital to maintain homeostasis. However, chronic exposure to stress can trigger maladaptive response and predispose to conditions ranging from neuropsychiatric disorders to everyday lapses of attention. Even though previous reports have implicated chronic stress in executive function impairment, a conceivable role in decision-making processes remains to be clarified. Competing corticostriatal circuits are thought to control heterogeneous decision strategies: while the prelimbic (PL) cortex and the dorsomedial striatum (DMS, or associative striatum) have been implicated in goal-directed actions, the dorsolateral striatum (DLS, or sensorimotor striatum) has been implicated in automatic or habitual choices. Here we show that chronic stress impairs the decision-making process, predisposing to habitual behavior in detriment of goal-directed strategies. Using two different criteria to test for action-outcome behavior in a lever pressing task, we found that responses from rats and mice submitted to chronic stress became insensitive to both outcome devaluation and contingency degradation. Furthermore, we found that chronic stress causes opposing structural changes in associative and sensorimotor corticostriatal circuits. Whereas chronic exposure to stress resulted in selective atrophy of pyramidal neurons in layer II/III of the PL and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC) and in medium spiny neurons (MSNs) of the DMS, it triggered an opposite effect in MSNs of the DLS. To determine if this structural reorganization of frontostriatal circuits has functional consequences, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits underlie changes in neural activity in these circuits that could explain the bias from goal-directed towards habitual behavior observed in stressed subjects.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:
Online abstract
Reference:
Dias-Ferreira, E., Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Chronic stress affects decision-making strategies: Structural and physiological correlates. Front. Syst. Neurosci. Conference Abstract: Computational and systems neuroscience 2009. doi: 10.3389/conf.neuro.01.2009.11.008
Indexed document: No
Keywords: Psychophysiology / Chronic stress / Decision-making / Striatum / Corticosteroids

DocumentThe role of stress in cortico-basal ganglia loop processing and instrumental conditioning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.07
Location: Arquivo PCA - Pasta 11/2006
Title:
The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. In this project, we investigated if chronic stress biases decision-making strategies, affecting the ability of stressed rats to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats, and now confirmed for mice, submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, we demonstrated that chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). Therefore, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit. In conclusion, the results obtained throughout this project demonstrate that chronic stress influences decision-making processes, through changes in the structure and activity of corticostriatal networks.
Accessibility: Document does not exist in file
Language:
eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Document type:
Conference abstract
Reference:
Sousa, N., Costa, R. M., Dias-Ferreira, E., Cerqueira, J., & Teixeira, P. (2010). The role of stress in cortico-basal ganglia loop processing and instrumental conditioning. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (pp. 231-232). Porto: Fundação Bial.
Indexed document: No
Keywords: Corticosteroids / Decision-making / Plasticity / Striatum / Multielectrode recordings

The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

The role of stress in cortico-basal ganglia loop processing and instrumental conditioning